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  1. Article ; Online: Diagnosis of non-tuberculous mycobacterial pulmonary disease (NTM-PD): modern challenges.

    Musaddaq, Besma / Cleverley, Joanne R

    The British journal of radiology

    2019  Volume 93, Issue 1106, Page(s) 20190768

    Abstract: Non-tuberculous mycobacterial pulmonary disease is growing in incidence and prevalence. However, it is frequently overlooked as a differential diagnosis by both clinicians and radiologists alike due to its non-specific clinical features, wide spectrum of ...

    Abstract Non-tuberculous mycobacterial pulmonary disease is growing in incidence and prevalence. However, it is frequently overlooked as a differential diagnosis by both clinicians and radiologists alike due to its non-specific clinical features, wide spectrum of radiological findings and difficulty in isolating the causative organism. The aim of this article is to illustrate the spectrum and follow-up of the radiological findings of non-tuberculous mycobacterial pulmonary disease and the challenges involved in making a diagnosis.
    MeSH term(s) Diagnosis, Differential ; Humans ; Mycobacterium Infections, Nontuberculous/diagnostic imaging ; Nontuberculous Mycobacteria ; Practice Guidelines as Topic ; Tomography, X-Ray Computed ; Tuberculosis, Pulmonary/diagnostic imaging
    Language English
    Publishing date 2019-12-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2982-8
    ISSN 1748-880X ; 0007-1285
    ISSN (online) 1748-880X
    ISSN 0007-1285
    DOI 10.1259/bjr.20190768
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  2. Article ; Online: The role of chest radiography in confirming covid-19 pneumonia.

    Cleverley, Joanne / Piper, James / Jones, Melvyn M

    BMJ (Clinical research ed.)

    2020  Volume 370, Page(s) m2426

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/diagnostic imaging ; Humans ; Lung/diagnostic imaging ; Lung/pathology ; Pandemics ; Pneumonia, Viral/diagnostic imaging ; Radiography, Thoracic ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-07-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.m2426
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  4. Book ; Online: The role of chest radiography in confirming covid-19 pneumonia

    Cleverley, Joanne / Piper, James / Jones, Melvyn M

    2020  

    Keywords PRACTICE ; covid19
    Language English
    Publishing date 2020-07-16 02:26:24.0
    Publisher BMJ Publishing Group Ltd
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: The role of chest radiography in confirming covid-19 pneumonia

    Cleverley, Joanne / Piper, James / Jones, Melvyn M

    BMJ

    2020  , Page(s) m2426

    Keywords covid19
    Language English
    Publisher BMJ
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.m2426
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  6. Article ; Online: The Blood Neutrophil Count After 1 Month of Treatment Predicts the Radiologic Severity of Lung Disease at Treatment End.

    Jones, Timothy P W / Dabbaj, Susannah / Mandal, Indrajeet / Cleverley, Joanne / Cash, Charlotte / Lipman, Marc C I / Lowe, David M

    Chest

    2021  Volume 160, Issue 6, Page(s) 2030–2041

    Abstract: Background: Lung disease after tuberculous confers significant morbidity. However, the determinants of persistent lung damage in TB are not well established. We investigated associations between TB-associated radiologic changes and sociodemographic ... ...

    Abstract Background: Lung disease after tuberculous confers significant morbidity. However, the determinants of persistent lung damage in TB are not well established. We investigated associations between TB-associated radiologic changes and sociodemographic factors, surrogates of bacillary burden, and blood inflammatory markers at initiation of therapy and after 1 month.
    Research question: What are the predictors of radiologic severity at the end of TB treatment for TB?
    Study design and methods: We collected data from patients treated for drug-sensitive pulmonary TB at our center over a 5.5-year period. We recorded age, sex, ethnicity, smoking status, symptom duration, sputum smear grade, time to culture positivity, and blood results (C-reactive protein and neutrophil count) at baseline and after 1 month of treatment. Chest radiographs obtained at baseline, 2 months, and end of treatment were assessed independently by two radiologists and scored using a validated system. Relationships between predictor variables and radiologic outcomes were assessed using linear or binary logistic regression.
    Results: We assessed 154 individuals with a mean age of 37 years, 63% of whom were men. In a multivariate analysis, baseline radiologic severity correlated with sputum smear grade (P = 0.003) and neutrophil count (P < 0.001). At end of treatment, only the 1-month neutrophil count was associated significantly with overall radiologic severity in the multivariate analysis (r = 0.34; P = 0.003) and remained significant after controlling for baseline radiologic scores. The 1-month neutrophil count also was the only independent correlate of volume loss and pleural thickening at the end of treatment and was significantly higher in patients with persistent cavitation or effusion vs those without.
    Interpretation: Persistent neutrophilic inflammation after 1 month of TB therapy is associated with poor radiologic outcome, suggesting a target for interventions to minimize lung disease after tuberculous.
    MeSH term(s) Adult ; Antitubercular Agents/therapeutic use ; Biomarkers/blood ; Female ; Humans ; Male ; Neutrophils/pathology ; Radiography, Thoracic ; Severity of Illness Index ; Sputum/microbiology ; Tuberculosis, Pulmonary/diagnostic imaging ; Tuberculosis, Pulmonary/drug therapy ; Tuberculosis, Pulmonary/pathology
    Chemical Substances Antitubercular Agents ; Biomarkers
    Language English
    Publishing date 2021-07-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2021.07.041
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  7. Article ; Online: Current and future management of non-tuberculous mycobacterial pulmonary disease (NTM-PD) in the UK.

    Lipman, Marc / Cleverley, Joanne / Fardon, Tom / Musaddaq, Besma / Peckham, Daniel / van der Laan, Roald / Whitaker, Paul / White, Jacqui

    BMJ open respiratory research

    2020  Volume 7, Issue 1

    Abstract: A rising number of non-tuberculous mycobacterial (NTM) isolates are being identified in UK clinical practice. There are many uncertainties around the management of non-tuberculous mycobacterial pulmonary disease (NTM-PD), including its epidemiology, ... ...

    Abstract A rising number of non-tuberculous mycobacterial (NTM) isolates are being identified in UK clinical practice. There are many uncertainties around the management of non-tuberculous mycobacterial pulmonary disease (NTM-PD), including its epidemiology, diagnosis, treatment and prevention. Regional variations in how patients with NTM-PD are managed reflects the lack of standardised pathways in the UK. Service optimisation and multidisciplinary working can improve the quality of care for patients with NTM-PD, including (1) better identification of patients at risk of NTM-PD and modification of risk factors where applicable; (2) standardisation of reference laboratory testing to offer clinicians access to accurate and prompt information on NTM species and drug sensitivities; (3) development of recognised specialist NTM nursing care; (4) standardisation of NTM-PD imaging strategies for monitoring of treatment and disease progression; (5) establishment of a hub-and-spoke model of care, including clear referral and management pathways, dedicated NTM-PD multidisciplinary teams, and long-term patient follow-up; (6) formation of clinical networks to link experts who manage diseases associated with NTM; (7) enabling patients to access relevant support groups that can provide information and support for their condition; and (8) development of NTM research groups to allow patient participation in clinical trials and to facilitate professional education.
    MeSH term(s) Aged ; Biomedical Research/trends ; Disease Progression ; Female ; Humans ; Mycobacterium Infections, Nontuberculous/diagnosis ; Mycobacterium Infections, Nontuberculous/epidemiology ; Mycobacterium Infections, Nontuberculous/prevention & control ; Mycobacterium Infections, Nontuberculous/therapy ; Nontuberculous Mycobacteria/isolation & purification ; Quality of Health Care/organization & administration ; Quality of Health Care/trends ; Tuberculosis, Pulmonary/diagnosis ; Tuberculosis, Pulmonary/epidemiology ; Tuberculosis, Pulmonary/prevention & control ; Tuberculosis, Pulmonary/therapy ; United Kingdom
    Language English
    Publishing date 2020-06-20
    Publishing country England
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2736454-9
    ISSN 2052-4439 ; 2052-4439
    ISSN (online) 2052-4439
    ISSN 2052-4439
    DOI 10.1136/bmjresp-2020-000591
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  8. Article ; Online: Carcinoid tumour presenting as recurrent pneumonia.

    Dharmagunawardena, Ruvini / Lipman, Marc / Cleverley, Joanne / Cash, Charlotte

    BMJ case reports

    2013  Volume 2013

    MeSH term(s) Adult ; Bronchiectasis/etiology ; Carcinoid Tumor/complications ; Carcinoid Tumor/diagnosis ; Carcinoid Tumor/diagnostic imaging ; Diagnosis, Differential ; Female ; Humans ; Lung/diagnostic imaging ; Lung Neoplasms/complications ; Lung Neoplasms/diagnosis ; Lung Neoplasms/diagnostic imaging ; Pneumonia/diagnosis ; Tomography, X-Ray Computed
    Language English
    Publishing date 2013-11-20
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2013-202203
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  9. Article ; Online: Wegener's granulomatosis with multiple pulmonary nodules - diagnostic difficulties.

    José, Ricardo Jorge / Dilworth, John Paul / Cleverley, Joanne / Young, Martin / Stratton, Richard / Lipman, Marc

    JRSM short reports

    2010  Volume 1, Issue 4, Page(s) 34

    Language English
    Publishing date 2010-09-24
    Publishing country England
    Document type Case Reports
    ZDB-ID 2563002-7
    ISSN 2042-5333 ; 2042-5333
    ISSN (online) 2042-5333
    ISSN 2042-5333
    DOI 10.1258/shorts.2010.010043
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  10. Article ; Online: British Society for Medical Mycology best practice recommendations for the diagnosis of serious fungal diseases.

    Schelenz, Silke / Barnes, Rosemary A / Barton, Richard C / Cleverley, Joanne R / Lucas, Sebastian B / Kibbler, Christopher C / Denning, David W

    The Lancet. Infectious diseases

    2015  Volume 15, Issue 4, Page(s) 461–474

    Abstract: Invasive fungal diseases are an important cause of morbidity and mortality in a wide range of patients, and early diagnosis and management are a challenge. We therefore did a review of the scientific literature to generate a series of key recommendations ...

    Abstract Invasive fungal diseases are an important cause of morbidity and mortality in a wide range of patients, and early diagnosis and management are a challenge. We therefore did a review of the scientific literature to generate a series of key recommendations for the appropriate use of microbiological, histological, and radiological diagnostic methods for diagnosis of invasive fungal diseases. The recommendations emphasise the role of microscopy in rapid diagnosis and identification of clinically significant isolates to species level, and the need for susceptibility testing of all Aspergillus spp, if treatment is to be given. In this Review, we provide information to improve understanding of the importance of antigen detection for cryptococcal disease and invasive aspergillosis, the use of molecular (PCR) diagnostics for aspergillosis, and the crucial role of antibody detection for chronic and allergic aspergillosis. Furthermore, we consider the importance of histopathology reporting with a panel of special stains, and emphasise the need for urgent (<48 hours) and optimised imaging for patients with suspected invasive fungal infection. All 43 recommendations are auditable and should be used to ensure best diagnostic practice and improved outcomes for patients.
    MeSH term(s) Clinical Laboratory Techniques/methods ; Early Diagnosis ; Humans ; Mycoses/diagnosis ; Pathology/methods ; Practice Guidelines as Topic ; Radiology/methods ; United Kingdom
    Language English
    Publishing date 2015-04
    Publishing country United States
    Document type Journal Article ; Practice Guideline ; Review
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(15)70006-X
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