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  1. Article ; Online: A Patient Guides Her Provider: A Dialogue Over Cultural Awareness.

    Ullian, Michael E / Wilson, Odessa M

    American journal of kidney diseases : the official journal of the National Kidney Foundation

    2022  Volume 80, Issue 3, Page(s) A16–A17

    MeSH term(s) Communication ; Cultural Competency ; Female ; Humans ; Professional-Patient Relations
    Language English
    Publishing date 2022-07-15
    Publishing country United States
    Document type Editorial
    ZDB-ID 604539-x
    ISSN 1523-6838 ; 0272-6386
    ISSN (online) 1523-6838
    ISSN 0272-6386
    DOI 10.1053/j.ajkd.2022.04.003
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1669: Show issues Location:
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  2. Article ; Online: Hyperkalemia in chronic peritoneal dialysis patients.

    Elliott, Andrew B / Soliman, Karim M M / Ullian, Michael E

    Renal failure

    2022  Volume 44, Issue 1, Page(s) 217–223

    Abstract: ... ...

    Abstract Background
    MeSH term(s) Adult ; Aged ; Female ; Humans ; Hyperkalemia/blood ; Hyperkalemia/epidemiology ; Hyperkalemia/etiology ; Hypokalemia/blood ; Hypokalemia/epidemiology ; Hypokalemia/etiology ; Incidence ; Male ; Middle Aged ; Peritoneal Dialysis/adverse effects ; Potassium/blood ; Retrospective Studies
    Chemical Substances Potassium (RWP5GA015D)
    Language English
    Publishing date 2022-02-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 632949-4
    ISSN 1525-6049 ; 0886-022X
    ISSN (online) 1525-6049
    ISSN 0886-022X
    DOI 10.1080/0886022X.2022.2032151
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1331: Show issues Location:
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  3. Article ; Online: Administer but Do Not Dispense: Effect of Change in Medication Handling by Nurses on Outcomes of Home Dialysis Patients.

    Ullian, Michael E / Martin, Cynthia A / Ullian, David M

    The American journal of the medical sciences

    2016  Volume 351, Issue 6, Page(s) 595–600

    Abstract: Background: To come into compliance with South Carolina statute, we changed how nurses handle medications (antibiotics, erythropoietin [EPO], calcitriol and heparin) in our outpatient home dialysis clinic. Nurses continued to administer medications in ... ...

    Abstract Background: To come into compliance with South Carolina statute, we changed how nurses handle medications (antibiotics, erythropoietin [EPO], calcitriol and heparin) in our outpatient home dialysis clinic. Nurses continued to administer medications in the clinic but no longer dispensed medications for patients to take home; instead, medications were dispensed from pharmacies to the patients by mail. We hypothesized that the abovementioned change in medication handling worsened clinical outcomes. There is very little medical literature on this topic.
    Materials and methods: A retrospective case series of quality and safety in 31 patients in a community-based, medical center-affiliated home dialysis program was performed. We compared laboratory values and adverse clinical events relevant to the medications mentioned above during 4-8 months before and during 5 months after September 1, 2014 (the day when medication handling was changed).
    Results: We observed no changes in the incidences of dialysis access dysfunction, access infections, antibiotic inaccessibility to patients for access-related infections, infection outcomes, parathyroid hormone concentrations, hemoglobin concentrations, monthly EPO dose and missed monthly clinic visits after September 1, 2014. However, we noted significantly fewer subcutaneous EPO administrations per month and less time between phlebotomy and laboratory review with patients by their nephrologists at monthly clinic visits after September 1, 2014.
    Conclusions: The change in handling of medications by nurses in our outpatient home dialysis program to comply with the state statute did not worsen patient outcomes relevant to the affected medications and in fact caused several unexpected improvements.
    MeSH term(s) Adult ; Aged ; Ambulatory Care ; Ambulatory Care Facilities ; Anti-Bacterial Agents/administration & dosage ; Anticoagulants/administration & dosage ; Bone Density Conservation Agents/administration & dosage ; Calcitriol/administration & dosage ; Drug and Narcotic Control/legislation & jurisprudence ; Erythropoietin/administration & dosage ; Female ; Heparin/administration & dosage ; Home Care Services ; Humans ; Kidney Failure, Chronic/nursing ; Male ; Middle Aged ; Nurses/legislation & jurisprudence ; Peritoneal Dialysis/nursing ; Pharmacies ; Postal Service/methods ; Quality of Health Care ; Renal Dialysis/nursing ; Retrospective Studies ; Self Administration ; South Carolina
    Chemical Substances Anti-Bacterial Agents ; Anticoagulants ; Bone Density Conservation Agents ; Erythropoietin (11096-26-7) ; Heparin (9005-49-6) ; Calcitriol (FXC9231JVH)
    Language English
    Publishing date 2016-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 82078-7
    ISSN 1538-2990 ; 0002-9629
    ISSN (online) 1538-2990
    ISSN 0002-9629
    DOI 10.1016/j.amjms.2016.02.024
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    In stock of ZB MED Cologne/Königswinter

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  4. Article: The potential additive role of PleurX drainage system in an end-stage renal disease patient on hemodialysis with persisting cardiac ascites.

    Okamoto, Keisuke / Perry, Amy M / Jenssen, Fredrik / Ullian, Michael E / Fülöp, Tibor

    Clinical nephrology

    2020  Volume 94, Issue 5, Page(s) 271–272

    Language English
    Publishing date 2020-09-29
    Publishing country Germany
    Document type Letter
    ZDB-ID 185101-9
    ISSN 0301-0430
    ISSN 0301-0430
    DOI 10.5414/CN110262
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 873: Show issues Location:
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  5. Article ; Online: Granulin loss of function in human mature brain organoids implicates astrocytes in TDP-43 pathology.

    de Majo, Martina / Koontz, Mark / Marsan, Elise / Salinas, Nir / Ramsey, Arren / Kuo, Yien-Ming / Seo, Kyounghee / Li, Huinan / Dräger, Nina / Leng, Kun / Gonzales, Santiago L / Kurnellas, Michael / Miyaoka, Yuichiro / Klim, Joseph R / Kampmann, Martin / Ward, Michael E / Huang, Eric J / Ullian, Erik M

    Stem cell reports

    2023  Volume 18, Issue 3, Page(s) 706–719

    Abstract: Loss of function (LoF) of TAR-DNA binding protein 43 (TDP-43) and mis-localization, together with TDP-43-positive and hyperphosphorylated inclusions, are found in post-mortem tissue of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) ...

    Abstract Loss of function (LoF) of TAR-DNA binding protein 43 (TDP-43) and mis-localization, together with TDP-43-positive and hyperphosphorylated inclusions, are found in post-mortem tissue of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) patients, including those carrying LoF variants in the progranulin gene (GRN). Modeling TDP-43 pathology has been challenging in vivo and in vitro. We present a three-dimensional induced pluripotent stem cell (iPSC)-derived paradigm-mature brain organoids (mbOrg)-composed of cortical-like-astrocytes (iA) and neurons. When devoid of GRN, mbOrgs spontaneously recapitulate TDP-43 mis-localization, hyperphosphorylation, and LoF phenotypes. Mixing and matching genotypes in mbOrgs showed that GRN
    MeSH term(s) Humans ; Amyotrophic Lateral Sclerosis/pathology ; Frontotemporal Dementia/genetics ; Granulins/genetics ; Granulins/metabolism ; Progranulins/genetics ; Progranulins/metabolism ; Astrocytes/metabolism ; Mutation ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Brain/metabolism
    Chemical Substances Granulins ; Progranulins ; DNA-Binding Proteins
    Language English
    Publishing date 2023-02-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2720528-9
    ISSN 2213-6711 ; 2213-6711
    ISSN (online) 2213-6711
    ISSN 2213-6711
    DOI 10.1016/j.stemcr.2023.01.012
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  6. Article: CRISPRi-based screens in iAssembloids to elucidate neuron-glia interactions.

    Li, Emmy / Benitez, Camila / Boggess, Steven C / Koontz, Mark / Rose, Indigo V L / Draeger, Nina / Teter, Olivia M / Samelson, Avi J / Ullian, Erik M / Kampmann, Martin

    bioRxiv : the preprint server for biology

    2023  

    Abstract: The sheer complexity of the brain has complicated our ability to understand its cellular mechanisms in health and disease. Genome-wide association studies have uncovered genetic variants associated with specific neurological phenotypes and diseases. In ... ...

    Abstract The sheer complexity of the brain has complicated our ability to understand its cellular mechanisms in health and disease. Genome-wide association studies have uncovered genetic variants associated with specific neurological phenotypes and diseases. In addition, single-cell transcriptomics have provided molecular descriptions of specific brain cell types and the changes they undergo during disease. Although these approaches provide a giant leap forward towards understanding how genetic variation can lead to functional changes in the brain, they do not establish molecular mechanisms. To address this need, we developed a 3D co-culture system termed iAssembloids (induced multi-lineage assembloids) that enables the rapid generation of homogenous neuron-glia spheroids. We characterize these iAssembloids with immunohistochemistry and single-cell transcriptomics and combine them with large-scale CRISPRi-based screens. In our first application, we ask how glial and neuronal cells interact to control neuronal death and survival. Our CRISPRi-based screens identified that GSK3β inhibits the protective NRF2-mediated oxidative stress response in the presence of reactive oxygen species elicited by high neuronal activity, which was not previously found in 2D monoculture neuron screens. We also apply the platform to investigate the role of APOE-ε4, a risk variant for Alzheimer's Disease, in its effect on neuronal survival. This platform expands the toolbox for the unbiased identification of mechanisms of cell-cell interactions in brain health and disease.
    Language English
    Publishing date 2023-04-27
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.04.26.538498
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  7. Article ; Online: Evaluation of the impact of guideline communication from the Centers for Disease Control and Prevention and the Centers for Medicare and Medicaid Services among US healthcare providers: COVID-19 prevention counselling guidance.

    Taylor, Melanie M / Deb, Arkaprava / Frazier, Bernita / Lueken, James Reiss / Das, Mansi / Molke, Joanna / Fitzgerald, Erin / Ullian, Tom / Nair, Ridhu / Couch, Marion / Turbyfill, Caitlin / Horter, Libby / Joshi, Cecilia / DeLuca, Nickolas

    Nursing open

    2023  Volume 10, Issue 11, Page(s) 7437–7445

    Abstract: Aim: To evaluate healthcare provider awareness and uptake of the Centers for Medicare & Medicaid Services (CMS) billing for coronavirus disease 2019 (COVID-19) prevention counselling and the delivery of prevention counselling to patients awaiting severe ...

    Abstract Aim: To evaluate healthcare provider awareness and uptake of the Centers for Medicare & Medicaid Services (CMS) billing for coronavirus disease 2019 (COVID-19) prevention counselling and the delivery of prevention counselling to patients awaiting severe acute respiratory syndrome coronavirus 2 test results.
    Design: Cross sectional survey of US-based healthcare providers in February 2021.
    Methods: Analysis of associations with healthcare provider-reported awareness of CMS prevention counselling guidance and billing with provider type, specialty, and work setting.
    Results: A total of 1919 healthcare providers responded to the survey. Overall, 38% (726/1919) of providers reported awareness of available CMS reimbursement for COVID-19 patient counselling and 29% (465/1614) of CMS billing-eligible providers reported billing for this counselling. Among physicians, those aware of CMS guidance were significantly more likely to bill (58%) versus those unaware (10%). Among RNSights respondents eligible for CMS billing (n = 114), 31% of those aware of the guidance reported billing as compared to 0% of those not aware.
    MeSH term(s) Aged ; Humans ; United States ; Medicare ; Centers for Medicare and Medicaid Services, U.S. ; Cross-Sectional Studies ; COVID-19 ; Health Personnel ; Centers for Disease Control and Prevention, U.S.
    Language English
    Publishing date 2023-05-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2809556-X
    ISSN 2054-1058 ; 2054-1058
    ISSN (online) 2054-1058
    ISSN 2054-1058
    DOI 10.1002/nop2.1862
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  8. Article ; Online: Bacteremia, sepsis, and peritonitis with Pasteurella multocida in a peritoneal dialysis patient.

    Mugambi, S M / Ullian, M E

    Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis

    2010  Volume 30, Issue 3, Page(s) 381–383

    MeSH term(s) Adult ; Bacteremia/etiology ; Bacteremia/microbiology ; Female ; Humans ; Pasteurella Infections ; Pasteurella multocida/isolation & purification ; Peritonitis/etiology ; Peritonitis/microbiology ; Sepsis/etiology ; Sepsis/microbiology ; Systemic Inflammatory Response Syndrome/etiology ; Systemic Inflammatory Response Syndrome/microbiology
    Language English
    Publishing date 2010-04-26
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 645010-6
    ISSN 1718-4304 ; 0896-8608
    ISSN (online) 1718-4304
    ISSN 0896-8608
    DOI 10.3747/pdi.2009.00186
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1936: Show issues Location:
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  9. Article ; Online: Angiotensin II receptors and peritoneal dialysis-induced peritoneal fibrosis.

    Morinelli, Thomas A / Luttrell, Louis M / Strungs, Erik G / Ullian, Michael E

    The international journal of biochemistry & cell biology

    2016  Volume 77, Issue Pt B, Page(s) 240–250

    Abstract: ... i.e. highly concentrated, hyperosmotic glucose, acidic pH as well as large volumes ...

    Abstract The vasoactive hormone angiotensin II initiates its major hemodynamic effects through interaction with AT1 receptors, a member of the class of G protein-coupled receptors. Acting through its AT1R, angiotensin II regulates blood pressure and renal salt and water balance. Recent evidence points to additional pathological influences of activation of AT1R, in particular inflammation, fibrosis and atherosclerosis. The transcription factor nuclear factor κB, a key mediator in inflammation and atherosclerosis, can be activated by angiotensin II through a mechanism that may involve arrestin-dependent AT1 receptor internalization. Peritoneal dialysis is a therapeutic modality for treating patients with end-stage kidney disease. The effectiveness of peritoneal dialysis at removing waste from the circulation is compromised over time as a consequence of peritoneal dialysis-induced peritoneal fibrosis. The non-physiological dialysis solution used in peritoneal dialysis, i.e. highly concentrated, hyperosmotic glucose, acidic pH as well as large volumes infused into the peritoneal cavity, contributes to the development of fibrosis. Numerous trials have been conducted altering certain components of the peritoneal dialysis fluid in hopes of preventing or delaying the fibrotic response with limited success. We hypothesize that structural activation of AT1R by hyperosmotic peritoneal dialysis fluid activates the internalization process and subsequent signaling through the transcription factor nuclear factor κB, resulting in the generation of pro-fibrotic/pro-inflammatory mediators producing peritoneal fibrosis.
    MeSH term(s) Animals ; Humans ; Molecular Targeted Therapy ; Peritoneal Dialysis/adverse effects ; Peritoneal Fibrosis/drug therapy ; Peritoneal Fibrosis/etiology ; Peritoneal Fibrosis/metabolism ; Receptors, Angiotensin/metabolism
    Chemical Substances Receptors, Angiotensin
    Language English
    Publishing date 2016
    Publishing country Netherlands
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 1228429-4
    ISSN 1878-5875 ; 1357-2725
    ISSN (online) 1878-5875
    ISSN 1357-2725
    DOI 10.1016/j.biocel.2016.04.016
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    Zs.A 431: Show issues Location:
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  10. Article ; Online: Prostate cancer metastatic to the peritoneum in a peritoneal dialysis patient.

    Talwar, M / Self, S E / Ullian, M E

    Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis

    2012  Volume 32, Issue 5, Page(s) 570–572

    MeSH term(s) Humans ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/therapy ; Male ; Middle Aged ; Neoplasm Metastasis ; Peritoneal Dialysis, Continuous Ambulatory/adverse effects ; Peritoneal Neoplasms/complications ; Peritoneal Neoplasms/secondary ; Peritoneum/pathology ; Prostatic Neoplasms/complications ; Prostatic Neoplasms/pathology
    Language English
    Publishing date 2012-09-18
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 645010-6
    ISSN 1718-4304 ; 0896-8608
    ISSN (online) 1718-4304
    ISSN 0896-8608
    DOI 10.3747/pdi.2011.00281
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