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  1. Article ; Online: Generalizable machine learning for stress monitoring from wearable devices: A systematic literature review.

    Vos, Gideon / Trinh, Kelly / Sarnyai, Zoltan / Rahimi Azghadi, Mostafa

    International journal of medical informatics

    2023  Volume 173, Page(s) 105026

    Abstract: Introduction: Wearable sensors have shown promise as a non-intrusive method for collecting biomarkers that may correlate with levels of elevated stress. Stressors cause a variety of biological responses, and these physiological reactions can be measured ...

    Abstract Introduction: Wearable sensors have shown promise as a non-intrusive method for collecting biomarkers that may correlate with levels of elevated stress. Stressors cause a variety of biological responses, and these physiological reactions can be measured using biomarkers including Heart Rate Variability (HRV), Electrodermal Activity (EDA) and Heart Rate (HR) that represent the stress response from the Hypothalamic-Pituitary-Adrenal (HPA) axis, the Autonomic Nervous System (ANS), and the immune system. While Cortisol response magnitude remains the gold standard indicator for stress assessment [1], recent advances in wearable technologies have resulted in the availability of a number of consumer devices capable of recording HRV, EDA and HR sensor biomarkers, amongst other signals. At the same time, researchers have been applying machine learning techniques to the recorded biomarkers in order to build models that may be able to predict elevated levels of stress.
    Objective: The aim of this review is to provide an overview of machine learning techniques utilized in prior research with a specific focus on model generalization when using these public datasets as training data. We also shed light on the challenges and opportunities that machine learning-enabled stress monitoring and detection face.
    Methods: This study reviewed published works contributing and/or using public datasets designed for detecting stress and their associated machine learning methods. The electronic databases of Google Scholar, Crossref, DOAJ and PubMed were searched for relevant articles and a total of 33 articles were identified and included in the final analysis. The reviewed works were synthesized into three categories of publicly available stress datasets, machine learning techniques applied using those, and future research directions. For the machine learning studies reviewed, we provide an analysis of their approach to results validation and model generalization. The quality assessment of the included studies was conducted in accordance with the IJMEDI checklist [2].
    Results: A number of public datasets were identified that are labeled for stress detection. These datasets were most commonly produced from sensor biomarker data recorded using the Empatica E4 device, a well-studied, medical-grade wrist-worn wearable that provides sensor biomarkers most notable to correlate with elevated levels of stress. Most of the reviewed datasets contain less than twenty-four hours of data, and the varied experimental conditions and labeling methodologies potentially limit their ability to generalize for unseen data. In addition, we discuss that previous works show shortcomings in areas such as their labeling protocols, lack of statistical power, validity of stress biomarkers, and model generalization ability.
    Conclusion: Health tracking and monitoring using wearable devices is growing in popularity, while the generalization of existing machine learning models still requires further study, and research in this area will continue to provide improvements as newer and more substantial datasets become available.
    MeSH term(s) Humans ; Wearable Electronic Devices ; Wrist ; Machine Learning ; Heart Rate/physiology ; Biomarkers
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-02-28
    Publishing country Ireland
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 1466296-6
    ISSN 1872-8243 ; 1386-5056
    ISSN (online) 1872-8243
    ISSN 1386-5056
    DOI 10.1016/j.ijmedinf.2023.105026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Ensemble machine learning model trained on a new synthesized dataset generalizes well for stress prediction using wearable devices.

    Vos, Gideon / Trinh, Kelly / Sarnyai, Zoltan / Rahimi Azghadi, Mostafa

    Journal of biomedical informatics

    2023  Volume 148, Page(s) 104556

    Abstract: Introduction: Advances in wearable sensor technology have enabled the collection of biomarkers that may correlate with levels of elevated stress. While significant research has been done in this domain, specifically in using machine learning to detect ... ...

    Abstract Introduction: Advances in wearable sensor technology have enabled the collection of biomarkers that may correlate with levels of elevated stress. While significant research has been done in this domain, specifically in using machine learning to detect elevated levels of stress, the challenge of producing a machine learning model capable of generalizing well for use on new, unseen data remain. Acute stress response has both subjective, psychological and objectively measurable, biological components that can be expressed differently from person to person, further complicating the development of a generic stress measurement model. Another challenge is the lack of large, publicly available datasets labeled for stress response that can be used to develop robust machine learning models. In this paper, we first investigate the generalization ability of models built on datasets containing a small number of subjects, recorded in single study protocols. Next, we propose and evaluate methods combining these datasets into a single, large dataset to study the generalization capability of machine learning models built on larger datasets. Finally, we propose and evaluate the use of ensemble techniques by combining gradient boosting with an artificial neural network to measure predictive power on new, unseen data. In favor of reproducible research and to assist the community advance the field, we make all our experimental data and code publicly available through Github at https://github.com/xalentis/Stress. This paper's in-depth study of machine learning model generalization for stress detection provides an important foundation for the further study of stress response measurement using sensor biomarkers, recorded with wearable technologies.
    Methods: Sensor biomarker data from six public datasets were utilized in this study. Exploratory data analysis was performed to understand the physiological variance between study subjects, and the complexity it introduces in building machine learning models capable of detecting elevated levels of stress on new, unseen data. To test model generalization, we developed a gradient boosting model trained on one dataset (SWELL), and tested its predictive power on two datasets previously used in other studies (WESAD, NEURO). Next, we merged four small datasets, i.e. (SWELL, NEURO, WESAD, UBFC-Phys), to provide a combined total of 99 subjects, and applied feature engineering to generate additional features utilizing statistical summaries, with sliding windows of 25 s. We name this large dataset, StressData. In addition, we utilized random sampling on StressData combined with another dataset (EXAM) to build a larger training dataset consisting of 200 synthesized subjects, which we name SynthesizedStressData. Finally, we developed an ensemble model that combines our gradient boosting model with an artificial neural network, and tested it using Leave-One-Subject-Out (LOSO) validation, and on two additional, unseen publicly available stress biomarker datasets (WESAD and Toadstool).
    Results: Our results show that previous models built on datasets containing a small number (<50) of subjects, recorded in single study protocols, cannot generalize well to new, unseen datasets. Our presented methodology for generating a large, synthesized training dataset by utilizing random sampling to construct scenarios closely aligned with experimental conditions demonstrate significant benefits. When combined with feature-engineering and ensemble learning, our method delivers a robust stress measurement system capable of achieving 85% predictive accuracy on new, unseen validation data, achieving a 25% performance improvement over single models trained on small datasets. The resulting model can be used as both a classification or regression predictor for estimating the level of perceived stress, when applied on specific sensor biomarkers recorded using a wearable device, while further allowing researchers to construct large, varied datasets for training machine learning models that closely emulate their exact experimental conditions.
    Conclusion: Models trained on small, single study protocol datasets do not generalize well for use on new, unseen data and lack statistical power. Machine learning models trained on a dataset containing a larger number of varied study subjects capture physiological variance better, resulting in more robust stress detection. Feature-engineering assists in capturing these physiological variance, and this is further improved by utilizing ensemble techniques by combining the predictive power of different machine learning models, each capable of learning unique signals contained within the data. While there is a general lack of large, labeled public datasets that can be utilized for training machine learning models capable of accurately measuring levels of acute stress, random sampling techniques can successfully be applied to construct larger, varied datasets from these smaller sample datasets, for building robust machine learning models.
    MeSH term(s) Humans ; Machine Learning ; Neural Networks, Computer ; Wearable Electronic Devices ; Biomarkers
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-12-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2057141-0
    ISSN 1532-0480 ; 1532-0464
    ISSN (online) 1532-0480
    ISSN 1532-0464
    DOI 10.1016/j.jbi.2023.104556
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Ketogenic Therapy in Serious Mental Illness: Emerging Evidence.

    Sarnyai, Zoltán / Palmer, Christopher M

    The international journal of neuropsychopharmacology

    2020  Volume 23, Issue 7, Page(s) 434–439

    MeSH term(s) Food ; Humans ; Ketosis ; Mental Disorders
    Language English
    Publishing date 2020-06-23
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1440129-0
    ISSN 1469-5111 ; 1461-1457
    ISSN (online) 1469-5111
    ISSN 1461-1457
    DOI 10.1093/ijnp/pyaa036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Allele-specific effect of various dietary fatty acids and ETS1 transcription factor on SCD1 expression.

    Tibori, Kinga / Zámbó, Veronika / Orosz, Gabriella / Szelényi, Péter / Sarnyai, Farkas / Tamási, Viola / Rónai, Zsolt / Csala, Miklós / Kereszturi, Éva

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 177

    Abstract: Overnutrition and genetic predisposition are major risk factors for various metabolic disorders. Stearoyl-CoA desaturase-1 (SCD1) plays a key role in these conditions by synthesizing unsaturated fatty acids (FAs), thereby promoting fat storage and ... ...

    Abstract Overnutrition and genetic predisposition are major risk factors for various metabolic disorders. Stearoyl-CoA desaturase-1 (SCD1) plays a key role in these conditions by synthesizing unsaturated fatty acids (FAs), thereby promoting fat storage and alleviating lipotoxicity. Expression of SCD1 is influenced by various saturated and cis-unsaturated FAs, but the possible role of dietary trans FAs (TFAs) and SCD1 promoter polymorphisms in its regulations has not been addressed. Therefore, we aimed to investigate the impact of the two main TFAs, vaccenate and elaidate, and four common promoter polymorphisms (rs1054411, rs670213, rs2275657, rs2275656) on SCD1 expression in HEK293T and HepG2 cell cultures using luciferase reporter assay, qPCR and immunoblotting. We found that SCD1 protein and mRNA levels as well as SCD1 promoter activity are markedly elevated by elaidate, but not altered by vaccenate. The promoter polymorphisms did not affect the basal transcriptional activity of SCD1. However, the minor allele of rs1054411 increased SCD1 expression in the presence of various FAs. Moreover, this variant was predicted in silico and verified in vitro to reduce the binding of ETS1 transcription factor to SCD1 promoter. Although we could not confirm an association with type 2 diabetes mellitus, the FA-dependent and ETS1-mediated effect of rs1054411 polymorphism deserves further investigation as it may modulate the development of lipid metabolism-related conditions.
    MeSH term(s) Humans ; Transcription Factors/genetics ; Diabetes Mellitus, Type 2/genetics ; Alleles ; HEK293 Cells ; Fatty Acids/metabolism ; Fatty Acids, Unsaturated ; Fatty Acids, Monounsaturated ; Stearoyl-CoA Desaturase/genetics ; Stearoyl-CoA Desaturase/metabolism ; Proto-Oncogene Protein c-ets-1/genetics
    Chemical Substances Transcription Factors ; Fatty Acids ; Fatty Acids, Unsaturated ; Fatty Acids, Monounsaturated ; Stearoyl-CoA Desaturase (EC 1.14.19.1) ; ETS1 protein, human ; Proto-Oncogene Protein c-ets-1 ; SCD1 protein, human (EC 1.14.19.1)
    Language English
    Publishing date 2024-01-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-50700-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Allostatic load and systemic comorbidities in psychiatric disorders.

    Finlay, Sabine / Rudd, Donna / McDermott, Brett / Sarnyai, Zoltán

    Psychoneuroendocrinology

    2022  Volume 140, Page(s) 105726

    Abstract: Psychiatric disorders are complex, disabling, and chronic conditions that are often accompanied by one or more systemic medical comorbidities. In this narrative review, we provide an overview of the allostatic load concept, which represents a multi- ... ...

    Abstract Psychiatric disorders are complex, disabling, and chronic conditions that are often accompanied by one or more systemic medical comorbidities. In this narrative review, we provide an overview of the allostatic load concept, which represents a multi-system dysregulation in response to chronic stress and link it to systemic comorbidities associated with psychiatric disorders. We synthesized published literature gathered using Medline (Ovid), Scopus, and PsychInfo and identified a high frequency of systemic comorbidities for both mood and psychotic disorders. The identified cardiovascular, metabolic, and immune comorbidities may represent the result of chronic wear and tear caused by a complex interaction between chronic psychosocial stress, health risk behaviors, pharmacological stressors, and the biological systems involved in the development of allostatic load. These findings support the notion that psychiatric disorders should be re-conceptualized as systemic disorders, affecting the brain and systemic biological pathways in an interconnected fashion to result in systemic comorbidities. We suggest that the multi-systemic and multi-dimensional approach that drives the allostatic load concept should be considered for understanding comorbidities in vulnerable psychiatric patients.
    MeSH term(s) Allostasis/physiology ; Brain ; Comorbidity ; Humans ; Mental Disorders ; Stress, Psychological/psychology
    Language English
    Publishing date 2022-03-16
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 197636-9
    ISSN 1873-3360 ; 0306-4530
    ISSN (online) 1873-3360
    ISSN 0306-4530
    DOI 10.1016/j.psyneuen.2022.105726
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Childhood adversity, allostatic load, and adult mental health: Study protocol using the Avon Longitudinal Study of Parents and Children birth cohort.

    Finlay, Sabine / Juster, Robert-Paul / Adegboye, Oyelola / Rudd, Donna / McDermott, Brett / Sarnyai, Zoltán

    Frontiers in psychiatry

    2023  Volume 13, Page(s) 976140

    Abstract: Introduction: The cumulative burden of chronic stress and life events has been termed allostatic load. Elevated allostatic load indices are associated with different mental health conditions in adulthood. To date, however, the association between ... ...

    Abstract Introduction: The cumulative burden of chronic stress and life events has been termed allostatic load. Elevated allostatic load indices are associated with different mental health conditions in adulthood. To date, however, the association between elevated allostatic load in childhood and later development of mental health conditions has not been investigated.
    Methods: Using data from the Avon Longitudinal Study of Parents and Children (ALSPAC), we will calculate allostatic load indices using biomarkers representing the cardiovascular, metabolic, immune, and neuroendocrine systems, at the ages of 9 and 17 years. Bivariate and multivariable logistic regression models will be used to investigate the association between allostatic load and psychiatric disorders in adulthood. Furthermore, the role of adverse childhood experiences as a modifier will be investigated.
    Discussion: This protocol describes a strategy for investigating the association between elevated allostatic load indices in childhood at the age of 9 years old and psychiatric disorders in adulthood at 24 years old.
    Language English
    Publishing date 2023-01-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2022.976140
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Protocol for the Use of the Ketogenic Diet in Preclinical and Clinical Practice.

    Kraeuter, Ann-Katrin / Guest, Paul C / Sarnyai, Zoltán

    Methods in molecular biology (Clifton, N.J.)

    2020  Volume 2138, Page(s) 83–98

    Abstract: Many age-related diseases are associated with metabolic abnormalities, and dietary interventions may have some benefit in alleviating symptoms or in delaying disease onset. Here, we review the commonly used best practices involved in applications of the ... ...

    Abstract Many age-related diseases are associated with metabolic abnormalities, and dietary interventions may have some benefit in alleviating symptoms or in delaying disease onset. Here, we review the commonly used best practices involved in applications of the ketogenic diet to facilitate its translation into clinical use. The findings reveal that better education of physicians is essential for applying the optimum diet and monitoring its effects in clinical practice. In addition, investigators should carefully consider potential confounding factors prior to commencing studies involving a ketogenic diet. Most importantly, current studies should improve their reporting on ketone levels as well as on the intake of both macro- and micronutrients. Finally, more detailed studies on the mechanism of action are necessary to help identify potential biomarkers for response prediction and monitoring, and to uncover new drug targets to aid the development of novel treatments.
    MeSH term(s) Animals ; Biomarkers/metabolism ; Diet, Ketogenic/methods ; Humans
    Chemical Substances Biomarkers
    Language English
    Publishing date 2020-03-27
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-0471-7_4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: The Gut Microbiome in Psychosis From Mice to Men: A Systematic Review of Preclinical and Clinical Studies.

    Kraeuter, Ann-Katrin / Phillips, Riana / Sarnyai, Zoltán

    Frontiers in psychiatry

    2020  Volume 11, Page(s) 799

    Abstract: The gut microbiome is rapidly becoming the focus of interest as a possible factor involved in the pathophysiology of neuropsychiatric disorders. Recent understanding of the pathophysiology of schizophrenia emphasizes the role of systemic components, ... ...

    Abstract The gut microbiome is rapidly becoming the focus of interest as a possible factor involved in the pathophysiology of neuropsychiatric disorders. Recent understanding of the pathophysiology of schizophrenia emphasizes the role of systemic components, including immune/inflammatory and metabolic processes, which are influenced by and interacting with the gut microbiome. Here we systematically review the current literature on the gut microbiome in schizophrenia-spectrum disorders and in their animal models. We found that the gut microbiome is altered in psychosis compared to healthy controls. Furthermore, we identified potential factors related to psychosis, which may contribute to the gut microbiome alterations. However, further research is needed to establish the disease-specificity and potential causal relationships between changes of the microbiome and disease pathophysiology. This can open up the possibility of. manipulating the gut microbiome for improved symptom control and for the development of novel therapeutic approaches in schizophrenia and related psychotic disorders.
    Language English
    Publishing date 2020-08-11
    Publishing country Switzerland
    Document type Systematic Review
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2020.00799
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Ketogenic therapy in neurodegenerative and psychiatric disorders: From mice to men.

    Kraeuter, Ann-Katrin / Phillips, Riana / Sarnyai, Zoltán

    Progress in neuro-psychopharmacology & biological psychiatry

    2020  Volume 101, Page(s) 109913

    Abstract: Ketogenic diet is a low carbohydrate and high fat diet that has been used for over 100 years in the management of childhood refractory epilepsy. More recently, ketogenic diet has been investigated for a number of metabolic, neurodegenerative and ... ...

    Abstract Ketogenic diet is a low carbohydrate and high fat diet that has been used for over 100 years in the management of childhood refractory epilepsy. More recently, ketogenic diet has been investigated for a number of metabolic, neurodegenerative and neurodevelopmental disorders. In this comprehensive review, we critically examine the potential therapeutic benefits of ketogenic diet and ketogenic agents on neurodegenerative and psychiatric disorders in humans and translationally valid animal models. The preclinical literature provides strong support for the efficacy of ketogenic diet in a variety of diverse animal models of neuropsychiatric disorders. However, the evidence from clinical studies, while encouraging, particularly in Alzheimer's disease, psychotic and autism spectrum disorders, is limited to case studies and small pilot trials. Firm conclusion on the efficacy of ketogenic diet in psychiatric disorders cannot be drawn due to the lack of randomised, controlled clinical trials. The potential mechanisms of action of ketogenic therapy in these disorders with diverse pathophysiology may include energy metabolism, oxidative stress and immune/inflammatory processes. In conclusion, while ketogenic diet and ketogenic substances hold promise pre-clinically in a variety of neurodegenerative and psychiatric disorders, further studies, particularly randomised controlled clinical trials, are warranted to better understand their clinical efficacy and potential side effects.
    MeSH term(s) Animals ; Clinical Trials as Topic/methods ; Diet, Ketogenic/methods ; Diet, Ketogenic/psychology ; Disease Models, Animal ; Energy Metabolism/physiology ; Humans ; Mental Disorders/diet therapy ; Mental Disorders/metabolism ; Mental Disorders/psychology ; Mice ; Neurodegenerative Diseases/diet therapy ; Neurodegenerative Diseases/metabolism ; Neurodegenerative Diseases/psychology
    Language English
    Publishing date 2020-03-06
    Publishing country England
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 781181-0
    ISSN 1878-4216 ; 0278-5846
    ISSN (online) 1878-4216
    ISSN 0278-5846
    DOI 10.1016/j.pnpbp.2020.109913
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Oxytocin as a potential mediator and modulator of drug addiction.

    Sarnyai, Zoltán

    Addiction biology

    2011  Volume 16, Issue 2, Page(s) 199–201

    MeSH term(s) Animals ; Brain/physiopathology ; Brain Mapping ; Dopamine/physiology ; Humans ; Motivation/physiology ; Oxytocin/physiology ; Serotonin/physiology ; Street Drugs ; Substance-Related Disorders/physiopathology ; Translational Medical Research
    Chemical Substances Street Drugs ; Serotonin (333DO1RDJY) ; Oxytocin (50-56-6) ; Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2011-04
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 1324314-7
    ISSN 1369-1600 ; 1355-6215
    ISSN (online) 1369-1600
    ISSN 1355-6215
    DOI 10.1111/j.1369-1600.2011.00332.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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