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  1. Article ; Online: TIL Therapy Entering the Mainstream.

    Coukos, George

    The New England journal of medicine

    2022  Volume 387, Issue 23, Page(s) 2185–2186

    Language English
    Publishing date 2022-12-07
    Publishing country United States
    Document type Editorial
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMe2214655
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    Ua VI Zs.34: Show issues Location:
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  2. Article ; Online: Neoadjuvant immune-checkpoint blockade in resectable colon cancer.

    Coukos, George

    Nature medicine

    2020  Volume 26, Issue 4, Page(s) 473–474

    MeSH term(s) Colonic Neoplasms ; Humans ; Immunologic Factors ; Immunotherapy ; Neoadjuvant Therapy
    Chemical Substances Immunologic Factors
    Language English
    Publishing date 2020-04-06
    Publishing country United States
    Document type News ; Comment
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/s41591-020-0826-3
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  3. Article ; Online: Genetics and anatomy sculpt immune-cell partners of ovarian cancer.

    Dangaj Laniti, Denarda / Coukos, George

    Nature

    2022  Volume 612, Issue 7941, Page(s) 634–636

    MeSH term(s) Humans ; Female ; Ovarian Neoplasms/genetics ; Genetic Predisposition to Disease
    Language English
    Publishing date 2022-12-14
    Publishing country England
    Document type News ; Comment
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-022-04169-3
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    Zs.MO 244: Show issues

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  4. Article: Inhibitory G protein alpha subunit (Gi alpha) expression and localization during human trophoblast differentiation.

    Daiter, E / Makrigiannakis, A / Coukos, G / Woolkalis, M J / Coutifaris, C

    European journal of obstetrics, gynecology, and reproductive biology

    2000  Volume 88, Issue 2, Page(s) 165–169

    Abstract: ... associated with trophoblast syncytialization. As guanosine triphosphate (GTP)-binding regulatory proteins (G ... of the alpha subunit of inhibitory G protein (Gi alpha) during human trophoblast differentiation in vitro ...

    Abstract Objective: Cyclic adenosine monophosphate (cAMP) participates in the regulation of processes associated with trophoblast syncytialization. As guanosine triphosphate (GTP)-binding regulatory proteins (G-proteins) modulate adenylate cyclase activity, the present study investigated the expression and regulation of the alpha subunit of inhibitory G protein (Gi alpha) during human trophoblast differentiation in vitro.
    Study design: Protein levels and the immunolocalization of the protein at a subcellular-level were assessed.
    Results: Expression of Gi alpha protein decreased during syncytialization. Moreover, Gi alpha transmigrated from a predominantly cell membrane-associated to a predominantly perinuclear location during the process.
    Conclusion: These results suggest that Gi alpha is regulated and may be implicated in cAMP-dependent events during the terminal differentiation of human trophoblasts.
    MeSH term(s) Adenosine Diphosphate Ribose/metabolism ; Autoradiography ; Cell Differentiation ; Cell Membrane/metabolism ; Cell Nucleus/metabolism ; Culture Techniques ; Fluorescent Antibody Technique, Indirect ; GTP-Binding Protein alpha Subunits, Gi-Go/analysis ; GTP-Binding Protein alpha Subunits, Gi-Go/metabolism ; Humans ; NAD/metabolism ; Time Factors ; Trophoblasts/chemistry ; Trophoblasts/physiology
    Chemical Substances NAD (0U46U6E8UK) ; Adenosine Diphosphate Ribose (20762-30-5) ; GTP-Binding Protein alpha Subunits, Gi-Go (EC 3.6.5.1)
    Language English
    Publishing date 2000-02
    Publishing country Ireland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 190605-7
    ISSN 1872-7654 ; 0301-2115 ; 0028-2243
    ISSN (online) 1872-7654
    ISSN 0301-2115 ; 0028-2243
    DOI 10.1016/s0301-2115(99)00134-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 837: Show issues Location:
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  5. Article ; Online: Towards next-generation TIL therapy: TILs enriched in neoepitope-specific T cells.

    Arnaud, Marion / Coukos, George / Harari, Alexandre

    Clinical and translational medicine

    2023  Volume 13, Issue 1, Page(s) e1174

    MeSH term(s) T-Lymphocytes ; Lymphocytes, Tumor-Infiltrating ; Immunotherapy, Adoptive
    Language English
    Publishing date 2023-01-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2697013-2
    ISSN 2001-1326 ; 2001-1326
    ISSN (online) 2001-1326
    ISSN 2001-1326
    DOI 10.1002/ctm2.1174
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  6. Article ; Online: Lighting up the tumor fire with low-dose irradiation.

    Herrera, Fernanda G / Romero, Pedro / Coukos, George

    Trends in immunology

    2022  Volume 43, Issue 3, Page(s) 173–179

    Abstract: Current efforts combining immunotherapy and radiation have focused on high-dose radiation delivered to few tumor lesions, aiming to generate diffuse abscopal effects; however, these effects are uncommon in patients. Three recent studies in mouse tumor ... ...

    Abstract Current efforts combining immunotherapy and radiation have focused on high-dose radiation delivered to few tumor lesions, aiming to generate diffuse abscopal effects; however, these effects are uncommon in patients. Three recent studies in mouse tumor models and human cancer patients show that low-dose radiation (LDRT) delivered to all tumor lesions effectively mobilizes innate and adaptive immunity and synergizes with immunotherapy. These new findings suggest LDRT's potential as an immune amplifier capable of reprogramming the tumor microenvironment, instigating inflammation, and sensitizing 'cold' tumors to immune checkpoint blockade responsiveness.
    MeSH term(s) Adaptive Immunity ; Animals ; Disease Models, Animal ; Humans ; Immunotherapy ; Mice ; Neoplasms/radiotherapy ; Tumor Microenvironment
    Language English
    Publishing date 2022-01-31
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2036831-8
    ISSN 1471-4981 ; 1471-4906
    ISSN (online) 1471-4981
    ISSN 1471-4906
    DOI 10.1016/j.it.2022.01.006
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    Zs.MG 2: Show issues

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  7. Article ; Online: Trabectedin and Durvalumab Combination Is Feasible and Active in Relapsing Ovarian Cancer.

    Digklia, Antonia / Coukos, George / Homicsko, Krisztian

    Clinical cancer research : an official journal of the American Association for Cancer Research

    2022  Volume 28, Issue 9, Page(s) 1745–1747

    Abstract: The combination of chemotherapy and immune therapies still promises to synergize for prolonged tumor control. However, the quest for optimal combinations tailored for tumor histology remains ongoing. A recent study provides evidence on the feasibility of ...

    Abstract The combination of chemotherapy and immune therapies still promises to synergize for prolonged tumor control. However, the quest for optimal combinations tailored for tumor histology remains ongoing. A recent study provides evidence on the feasibility of the trabectedin/durvalumab combination and reports on interesting preliminary efficacy. See related article by Toulmonde et al., p. 1765.
    MeSH term(s) Antibodies, Monoclonal ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Carcinoma, Ovarian Epithelial/drug therapy ; Dioxoles/adverse effects ; Female ; Humans ; Neoplasm Recurrence, Local/drug therapy ; Ovarian Neoplasms/drug therapy ; Ovarian Neoplasms/pathology ; Sarcoma/drug therapy ; Soft Tissue Neoplasms/drug therapy ; Tetrahydroisoquinolines/adverse effects ; Trabectedin
    Chemical Substances Antibodies, Monoclonal ; Dioxoles ; Tetrahydroisoquinolines ; durvalumab (28X28X9OKV) ; Trabectedin (ID0YZQ2TCP)
    Language English
    Publishing date 2022-02-17
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1225457-5
    ISSN 1557-3265 ; 1078-0432
    ISSN (online) 1557-3265
    ISSN 1078-0432
    DOI 10.1158/1078-0432.CCR-21-4592
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4223: Show issues Location:
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  8. Article ; Online: IL-2 engineered MSCs rescue T cells in tumours.

    Irving, Melita / Ortiz-Miranda, Yaquelin / Coukos, George

    Nature cell biology

    2022  Volume 24, Issue 12, Page(s) 1689–1691

    MeSH term(s) Humans ; T-Lymphocytes ; Interleukin-2 ; Neoplasms/genetics ; Neoplasms/therapy ; Signal Transduction
    Chemical Substances Interleukin-2
    Language English
    Publishing date 2022-12-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 1474722-4
    ISSN 1476-4679 ; 1465-7392
    ISSN (online) 1476-4679
    ISSN 1465-7392
    DOI 10.1038/s41556-022-01029-0
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  9. Article ; Online: Immunobiology of high-grade serous ovarian cancer: lessons for clinical translation.

    Kandalaft, Lana E / Dangaj Laniti, Denarda / Coukos, George

    Nature reviews. Cancer

    2022  Volume 22, Issue 11, Page(s) 640–656

    Abstract: Treatment of high-grade serous ovarian cancer (HGSOC) remains challenging. Although HGSOC can potentially be responsive to immunotherapy owing to endogenous immunity at the molecular or T cell level, immunotherapy for this disease has fallen short of ... ...

    Abstract Treatment of high-grade serous ovarian cancer (HGSOC) remains challenging. Although HGSOC can potentially be responsive to immunotherapy owing to endogenous immunity at the molecular or T cell level, immunotherapy for this disease has fallen short of expectations to date. This Review proposes a working classification for HGSOC based on the presence or absence of intraepithelial T cells, and elaborates the putative mechanisms that give rise to such immunophenotypes. These differences might explain the failures of existing immunotherapies, and suggest that rational therapeutic approaches tailored to each immunophenotype might meet with improved success. In T cell-inflamed tumours, treatment could focus on mobilizing pre-existing immunity and strengthening the activation of T cells embedded in intraepithelial tumour myeloid niches. Conversely, in immune-excluded and immune-desert tumours, treatment could focus on restoring inflammation by reprogramming myeloid cells, stromal cells and vascular epithelial cells. Poly(ADP-ribose) polymerase (PARP) inhibitors, low-dose radiotherapy, epigenetic drugs and anti-angiogenesis therapy are among the tools available to restore T cell infiltration in HGSOC tumours and could be implemented in combination with vaccines and redirected T cells.
    MeSH term(s) Female ; Humans ; Cystadenocarcinoma, Serous/drug therapy ; Cystadenocarcinoma, Serous/pathology ; Immunotherapy ; Ovarian Neoplasms/therapy ; Ovarian Neoplasms/genetics ; Poly(ADP-ribose) Polymerase Inhibitors/pharmacology ; Poly(ADP-ribose) Polymerase Inhibitors/therapeutic use
    Chemical Substances Poly(ADP-ribose) Polymerase Inhibitors
    Language English
    Publishing date 2022-09-15
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2062767-1
    ISSN 1474-1768 ; 1474-175X
    ISSN (online) 1474-1768
    ISSN 1474-175X
    DOI 10.1038/s41568-022-00503-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: CAR T cells targeting the ganglioside NGcGM3 control ovarian tumors in the absence of toxicity against healthy tissues.

    Cribioli, Elisabetta / Giordano Attianese, Greta Maria Paola / Coukos, George / Irving, Melita

    Frontiers in immunology

    2022  Volume 13, Page(s) 951143

    Abstract: Chimeric antigen receptor (CAR) T cells have emerged as a powerful immunotherapeutic tool against certain hematological malignancies but a significant proportion of patients either do not respond or they relapse, sometimes as a result of target antigen ... ...

    Abstract Chimeric antigen receptor (CAR) T cells have emerged as a powerful immunotherapeutic tool against certain hematological malignancies but a significant proportion of patients either do not respond or they relapse, sometimes as a result of target antigen loss. Moreover, limited clinical benefit has been reported for CAR therapy against epithelial derived solid tumors. A major reason for this is the paucity of solid tumor antigens identified to date that are broadly, homogeneously and stably expressed but not found on healthy tissues. To address this, here we describe the development and evaluation of CAR T cells directed against N-glycoslylated ganglioside monosialic 3 (NGcGM3). NGcGM3 derives from the enzymatic hydroxylation of N-acetylneuraminic acid (NAc) GM3 (NAcGM3) and it is present on the surface of a range of cancers including ovarian, breast, melanoma and lymphoma. However, while NAcGM3 is found on healthy human cells, NGcGM3 is not due to the 7deletion of an exon in the gene encoding for the enzyme cytidine monophospho-N-acetylneuraminic acid hydroxylase (CMAH). Indeed, unlike for most mammals, in humans NGcGM3 is considered a neoantigen as its presence on tumors is the result of metabolic incorporation from dietary sources. Here, we have generated 3 CARs comprising different single chain variable fragments (scFvs) originating from the well-characterized monoclonal antibody (mAb) 14F7. We show reactivity of the CAR T cells against a range of patient tumor fragments and we demonstrate control of NGcGM3
    MeSH term(s) Animals ; Female ; G(M3) Ganglioside/metabolism ; Humans ; Immunotherapy, Adoptive ; Mammals/metabolism ; Mice ; Neoplasm Recurrence, Local ; Ovarian Neoplasms/therapy ; T-Lymphocytes
    Chemical Substances G(M3) Ganglioside
    Language English
    Publishing date 2022-08-05
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.951143
    Database MEDical Literature Analysis and Retrieval System OnLINE

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