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Article ; Online: Role of enterocyte Enpp2 and autotaxin in regulating lipopolysaccharide levels, systemic inflammation, and atherosclerosis.

Chattopadhyay, Arnab / Mukherjee, Pallavi / Sulaiman, Dawoud / Wang, Huan / Girjalva, Victor / Dorreh, Nasrin / Jacobs, Jonathan P / Delk, Samuel / Moolenaar, Wouter H / Navab, Mohamad / Reddy, Srinivasa T / Fogelman, Alan M

Journal of lipid research

2023 Volume 64, Issue 5, Page(s) 100370

Abstract: Conversion of lysophosphatidylcholine to lysophosphatidic acid (LPA) by autotaxin, a secreted phospholipase D, is a major pathway for producing LPA. We previously reported that feeding ... ...

Abstract	Conversion of lysophosphatidylcholine to lysophosphatidic acid (LPA) by autotaxin, a secreted phospholipase D, is a major pathway for producing LPA. We previously reported that feeding Ldlr
MeSH term(s)	Mice ; Animals ; Lysophosphatidylcholines ; Enterocytes/metabolism ; Lipopolysaccharides ; Reactive Oxygen Species ; Lysophospholipids/metabolism ; Phosphoric Diester Hydrolases/genetics ; Phosphoric Diester Hydrolases/metabolism ; Diet, Western ; Inflammation/genetics ; Dyslipidemias/metabolism ; Atherosclerosis/genetics ; Anti-Infective Agents
Chemical Substances	Lysophosphatidylcholines ; Lipopolysaccharides ; Reactive Oxygen Species ; Lysophospholipids ; Phosphoric Diester Hydrolases (EC 3.1.4.-) ; Anti-Infective Agents
Language	English
Publishing date	2023-04-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	80154-9
ISSN	1539-7262 ; 0022-2275
ISSN (online)	1539-7262
ISSN	0022-2275
DOI	10.1016/j.jlr.2023.100370
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Zs.A 175: Show issues

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Article ; Online: Subchronic inhalation exposure to ultrafine particulate matter alters the intestinal microbiome in various mouse models.

Chang, Candace / Gupta, Rajat / Sedighian, Farzaneh / Louie, Allen / Gonzalez, David M / Le, Collin / Cho, Jae Min / Park, Seul-Ki / Castellanos, Jocelyn / Ting, To-Wei / Dong, Tien S / Arias-Jayo, Nerea / Lagishetty, Venu / Navab, Mohamad / Reddy, Srinivasa / Sioutas, Constantinos / Hsiai, Tzung / Jacobs, Jonathan P / Araujo, Jesus A

Environmental research

2024 Volume 248, Page(s) 118242

Abstract: Exposure to ultrafine particles (UFPs) has been associated with multiple adverse health effects. Inhaled UFPs could reach the gastrointestinal tract and influence the composition of the gut microbiome. We have previously shown that oral ingestion of UFPs ...

Abstract	Exposure to ultrafine particles (UFPs) has been associated with multiple adverse health effects. Inhaled UFPs could reach the gastrointestinal tract and influence the composition of the gut microbiome. We have previously shown that oral ingestion of UFPs alters the gut microbiome and promotes intestinal inflammation in hyperlipidemic Ldlr
MeSH term(s)	Mice ; Animals ; Particulate Matter/analysis ; Gastrointestinal Microbiome ; Air Pollutants/toxicity ; Inhalation Exposure/analysis ; RNA, Ribosomal, 16S ; Cross-Sectional Studies ; Mice, Inbred C57BL ; Disease Models, Animal ; Inflammation/chemically induced
Chemical Substances	Particulate Matter ; Air Pollutants ; RNA, Ribosomal, 16S
Language	English
Publishing date	2024-01-18
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2024.118242
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Zs.A 726: Show issues

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Article ; Online: Oxidized phospholipids cause changes in jejunum mucus that induce dysbiosis and systemic inflammation.

Mukherjee, Pallavi / Chattopadhyay, Arnab / Grijalva, Victor / Dorreh, Nasrin / Lagishetty, Venu / Jacobs, Jonathan P / Clifford, Bethan L / Vallim, Thomas / Mack, Julia J / Navab, Mohamad / Reddy, Srinivasa T / Fogelman, Alan M

Journal of lipid research

2021 Volume 63, Issue 1, Page(s) 100153

Abstract: We previously reported that adding a concentrate of transgenic tomatoes expressing the apoA-I mimetic peptide 6F (Tg6F) to a Western diet (WD) ameliorated systemic inflammation. To determine the mechanism(s) responsible for these observations, ... ...

Abstract	We previously reported that adding a concentrate of transgenic tomatoes expressing the apoA-I mimetic peptide 6F (Tg6F) to a Western diet (WD) ameliorated systemic inflammation. To determine the mechanism(s) responsible for these observations, Ldlr
MeSH term(s)	Dysbiosis
Language	English
Publishing date	2021-11-20
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	80154-9
ISSN	1539-7262 ; 0022-2275
ISSN (online)	1539-7262
ISSN	0022-2275
DOI	10.1016/j.jlr.2021.100153
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Article ; Online: Protection against ischemia/reperfusion injury by high-density lipoprotein and its components.

Fogelman, Alan M / Reddy, Srinivasa T / Navab, Mohamad

Circulation research

2013 Volume 113, Issue 12, Page(s) 1281–1282

MeSH term(s)	Animals ; Antioxidants/metabolism ; Apolipoproteins D/blood ; Coronary Artery Disease/blood ; Female ; Humans ; Myocardium/metabolism ; Myocytes, Cardiac/metabolism
Chemical Substances	Antioxidants ; Apolipoproteins D
Language	English
Publishing date	2013-12-06
Publishing country	United States
Document type	Comment ; Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	80100-8
ISSN	1524-4571 ; 0009-7330 ; 0931-6876
ISSN (online)	1524-4571
ISSN	0009-7330 ; 0931-6876
DOI	10.1161/CIRCRESAHA.113.302943
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Ui IV Zs.70: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Ui IV Zs.60: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Reducing plasma cholesterol is not the end of the quest.

Navab, Mohamad / Shabihkhani, Maryam / Navab, Kaveh Daniel / Vazirian, Samra / Haghnegahdar, Maryam / Reddy, Srinivasa T

Atherosclerosis

2013 Volume 227, Issue 1, Page(s) 35–36

MeSH term(s)	Animals ; Apolipoproteins E/secretion ; Atherosclerosis/prevention & control ; Female ; Humans ; Lipoproteins/pharmacology ; Peptide Fragments/pharmacology ; Peptides/pharmacology ; Receptors, LDL/genetics
Chemical Substances	Ac-hE18A-NH(2) ; Apolipoproteins E ; Lipoproteins ; Peptide Fragments ; Peptides ; Receptors, LDL ; mR18L peptide
Language	English
Publishing date	2013-03
Publishing country	Ireland
Document type	Comment ; Journal Article
ZDB-ID	80061-2
ISSN	1879-1484 ; 0021-9150
ISSN (online)	1879-1484
ISSN	0021-9150
DOI	10.1016/j.atherosclerosis.2012.12.034
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Zs.A 226: Show issues

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Article ; Online: Involvement of Low-Density Lipoprotein Receptor in the Pathogenesis of Pulmonary Hypertension.

Umar, Soban / Ruffenach, Gregoire / Moazeni, Shayan / Vaillancourt, Mylene / Hong, Jason / Cunningham, Christine / Cao, Nancy / Navab, Sara / Sarji, Shervin / Li, Min / Lee, Lisa / Fishbein, Greg / Ardehali, Abbas / Navab, Mohamad / Reddy, Srinivasa T / Eghbali, Mansoureh

Journal of the American Heart Association

2020 Volume 9, Issue 2, Page(s) e012063

Abstract: Background Recently, we and others have reported a causal role for oxidized lipids in the pathogenesis of pulmonary hypertension (PH). However, the role of low-density lipoprotein receptor (LDL-R) in PH is not known. Methods and Results We examined the ... ...

Abstract	Background Recently, we and others have reported a causal role for oxidized lipids in the pathogenesis of pulmonary hypertension (PH). However, the role of low-density lipoprotein receptor (LDL-R) in PH is not known. Methods and Results We examined the role of LDL-R in the development of PH and determined the efficacy of high-density lipoprotein mimetic peptide 4F in mitigating PH. Explanted human lungs and plasma from patients with PH and control subjects were analyzed for gene expression, histological characteristics, and lipoprotein oxidation. Male LDL-R null (LDL-R knockout) mice (12-15 months old) were fed chow, Western diet (WD), WD with 4F, and WD with scramble peptide for 12 weeks. Serial echocardiography, cardiac catheterization, oxidized LDL assay, real-time quantitative reverse transcription-polymerase chain reaction, and histological analysis were performed. The effect of LDL-R knockdown and oxidized LDL on human pulmonary artery smooth muscle cell proliferation was assessed in vitro. LDL-R and CD36 expression levels were significantly downregulated in the lungs of patients with PH. Patients with PH also had increased lung lipid deposits, oxidized LDL, E06 immunoreactivity, and plasma oxidized LDL/LDL ratio. LDL-R knockout mice on WD developed PH, right ventricular hypertrophy, right ventricular dysfunction, pulmonary vascular remodeling, fibrosis, and lipid deposition in lungs, aortic atherosclerosis, and left ventricular dysfunction, which were prevented by 4F. Interestingly, PH in WD group preceded left ventricular dysfunction. Oxidized LDL or LDL-R knockdown significantly increased proliferation of human pulmonary artery smooth muscle cells in vitro. Conclusions Human PH is associated with decreased LDL-R in lungs and increased oxidized LDL in lungs and plasma. WD-fed LDL-R knockout mice develop PH and right ventricular dysfunction, implicating a role for LDL-R and oxidized lipids in PH.
MeSH term(s)	Animals ; Apolipoprotein A-I/pharmacology ; CD36 Antigens/metabolism ; Case-Control Studies ; Cells, Cultured ; Disease Models, Animal ; Fibrosis ; Hemodynamics/drug effects ; Humans ; Hypertension, Pulmonary/genetics ; Hypertension, Pulmonary/metabolism ; Hypertension, Pulmonary/physiopathology ; Hypertension, Pulmonary/prevention & control ; Lipoproteins, LDL/metabolism ; Male ; Mice, Knockout ; Pulmonary Artery/drug effects ; Pulmonary Artery/metabolism ; Pulmonary Artery/physiopathology ; Receptors, LDL/genetics ; Receptors, LDL/metabolism ; Signal Transduction ; Vascular Remodeling/drug effects ; Ventricular Dysfunction, Left/metabolism ; Ventricular Dysfunction, Left/physiopathology ; Ventricular Dysfunction, Right/metabolism ; Ventricular Dysfunction, Right/physiopathology
Chemical Substances	Apolipoprotein A-I ; CD36 Antigens ; CD36 protein, human ; D-4F peptide ; LDLR protein, human ; Lipoproteins, LDL ; Receptors, LDL ; oxidized low density lipoprotein
Language	English
Publishing date	2020-01-09
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2653953-6
ISSN	2047-9980 ; 2047-9980
ISSN (online)	2047-9980
ISSN	2047-9980
DOI	10.1161/JAHA.119.012063
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Article ; Online: Apolipoprotein A-I mimetics.

Reddy, Srinivasa T / Navab, Mohamad / Anantharamaiah, Gattadahalli M / Fogelman, Alan M

Current opinion in lipidology

2014 Volume 25, Issue 4, Page(s) 304–308

Abstract: Purpose of review: To summarize recent publications in the field of apolipoprotein mimetics.: Recent findings: Apolipoprotein mimetic peptides continue to show efficacy in a number of animal models of disease and demonstrate properties that make them ...

Abstract	Purpose of review: To summarize recent publications in the field of apolipoprotein mimetics. Recent findings: Apolipoprotein mimetic peptides continue to show efficacy in a number of animal models of disease and demonstrate properties that make them attractive as potential therapeutic agents. A number of new apolipoprotein mimetics have been described recently. A major site of action of apolipoprotein mimetic peptides was found to be in the small intestine in which they decrease the levels of proinflammatory bioactive lipids. A major problem related to the use of apolipoprotein mimetic peptides is their cost, particularly those that need to be generated by solid phase synthesis with chemical addition of end-blocking groups. Novel approaches to apolipoprotein mimetic therapy have emerged recently that show promise in overcoming these barriers. Summary: Despite the recent failure of therapies designed to raise HDL-cholesterol in humans, an approach to therapy using mimetics of HDL and its components continues to show promise.
MeSH term(s)	Animals ; Apolipoprotein A-I/chemistry ; Biomimetics/methods ; Disease ; Humans ; Peptidomimetics/pharmacology ; Peptidomimetics/therapeutic use
Chemical Substances	Apolipoprotein A-I ; Peptidomimetics
Language	English
Publishing date	2014-06-30
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	1045394-5
ISSN	1473-6535 ; 0957-9672
ISSN (online)	1473-6535
ISSN	0957-9672
DOI	10.1097/MOL.0000000000000092
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Zs.A 3010: Show issues

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Article ; Online: Vasculitis, Atherosclerosis, and Altered HDL Composition in Heme-Oxygenase-1-Knockout Mice.

Ishikawa, Kazunobu / Navab, Mohamad / Lusis, Aldons J

International journal of hypertension

2012 Volume 2012, Page(s) 948203

Abstract: To elucidate roles of heme oxygenase-1 (HO-1) in cardiovascular system, we have analyzed one-year-old HO-1-knockout mice. Homozygous HO-1-knockout mice had severe aortitis and coronary arteritis with mononuclear cellular infiltration and fatty streak ... ...

Abstract	To elucidate roles of heme oxygenase-1 (HO-1) in cardiovascular system, we have analyzed one-year-old HO-1-knockout mice. Homozygous HO-1-knockout mice had severe aortitis and coronary arteritis with mononuclear cellular infiltration and fatty streak formation even on a standard chow diet. Levels of plasma total cholesterol and HDL were similar among the three genotypes. However, homozygous HO-1-knockout mice had lower body weight and plasma triglyceride. HO-1-deficiency resulted in alteration of the composition of HDL. The ratio of apolipoprotein AI to AII in HO-1-knockout mice was reduced about 10-fold as compared to wild-type mice. In addition, paraoxonase, an enzyme against oxidative stress, was reduced less than 50% in HO-1-knockout mice. The knockout mice also exhibited significant elevation of plasma lipid hydroperoxides. This study using aged HO-1-knockout mice strengthened the idea that HO-1 functions to suppress systemic inflammation in artery wall and prevents plasma lipid peroxidation.
Language	English
Publishing date	2012-02-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2573167-1
ISSN	2090-0392 ; 2090-0384
ISSN (online)	2090-0392
ISSN	2090-0384
DOI	10.1155/2012/948203
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Article: Searching for a successful HDL-based treatment strategy.

Reddy, Srinivasa T / Navab, Mohamad / Anantharamaiah, G M / Fogelman, Alan M

Biochimica et biophysica acta

2013 Volume 1841, Issue 1, Page(s) 162–167

Abstract: Despite strong evidence that HDL-cholesterol levels predict atherosclerotic events in a population, attempts at using and HDL-based treatment strategy have not yet been successful. Most of the efforts to date have focused on raising plasma HDL- ... ...

Abstract	Despite strong evidence that HDL-cholesterol levels predict atherosclerotic events in a population, attempts at using and HDL-based treatment strategy have not yet been successful. Most of the efforts to date have focused on raising plasma HDL-cholesterol levels. This brief review focuses on a different strategy, which is based on the use of 18-amino acid apoA-I-mimetic peptides. The story of these peptides spans decades and illustrates the remarkable complexity of HDL-based treatment strategies, but suggests that such a strategy may still be successful.
MeSH term(s)	Animals ; Cholesterol, HDL/blood ; Humans ; Peptides/therapeutic use ; Peptidomimetics/therapeutic use
Chemical Substances	Cholesterol, HDL ; Peptides ; Peptidomimetics ; apolipoprotein A-I mimetic peptide 4F
Language	English
Publishing date	2013-12-24
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	60-7
ISSN	1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
ISSN (online)	1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
ISSN	0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
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Uc I Zs.247: Show issues

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Article ; Online: Vasculitis, Atherosclerosis, and Altered HDL Composition in Heme-Oxygenase-1-Knockout Mice

Kazunobu Ishikawa / Mohamad Navab / Aldons J. Lusis

International Journal of Hypertension, Vol

2012 Volume 2012

Keywords	Diseases of the circulatory (Cardiovascular) system ; RC666-701 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Cardiovascular ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Language	English
Publishing date	2012-01-01T00:00:00Z
Publisher	Hindawi Publishing Corporation
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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