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Article ; Online: Current reviews depicting therapeutic potential of novel drug delivery system in rheumatoid arthritis

Singh Sricha / Pamma Parul / Bose Sujit / Sharma Sapna / Sharma Sakshi

BIO Web of Conferences, Vol 86, p

2024 Volume 01035

Abstract: Modern advancement in science and technology has altered the way we detect, treat and prevent different diseases in all aspects of human life. Rheumatoid Arthritis (RA) is chronic progressive autoimmune disease in which body’s immune system has role to ... ...

Abstract	Modern advancement in science and technology has altered the way we detect, treat and prevent different diseases in all aspects of human life. Rheumatoid Arthritis (RA) is chronic progressive autoimmune disease in which body’s immune system has role to protect the health by attacking foreign bacteria but the virus mistakenly attacking the joints as a result thickened synovium, pannus formation, & destruction of bone, cartilage occurs. Researchers are still researching but are unable to know the exact reason for the disease. Although, it is believed that genes and environmental factors play an important role in the development of RA. In this review the pathophysiology, predictors and factors involved in pathogenesis of RA have been investigated. The conventional drug therapeutic agents and emerging novel drug delivery system (NDDS) like nanoparticles, dendrimers, micelles, microspheres, liposomes and so on are discussed, as these are the tools which show promising effect in overcoming the limitations associated with conventional drug delivery systems. Although several NDDS have been used for various purposes, liposomes have been focused and found to have its potential applications in RA diagnosis and therapy. In addition, the therapeutic effectiveness, and challenges for RA by using these novel drug delivery systems have been reviewed along with its future perspectives.
Keywords	Microbiology ; QR1-502 ; Physiology ; QP1-981 ; Zoology ; QL1-991
Subject code	610
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Design and analysis of heat melt refuse compactor for solid waste with E-control mechanism

Ajay Kumar / Sujit Kumar Verma / Kamal Sharma / Andrés Z. Mendiburu

Environmental Challenges, Vol 12, Iss , Pp 100740- (2023)

2023

Abstract: As a technology, a Heat Melt Refuse Compactor (HMRC) has been developed to process municipal solid waste by converting into tiles and on-site valuable products. The HMRC compacts, heats the solid waste to 200°C and recovers the water from the MSW. The ... ...

Abstract	As a technology, a Heat Melt Refuse Compactor (HMRC) has been developed to process municipal solid waste by converting into tiles and on-site valuable products. The HMRC compacts, heats the solid waste to 200°C and recovers the water from the MSW. The heating causes volatile contaminants to be released into the air. The model has evaluated the design and testing parametrs for MSW processing and analysis. HMRC testing has demonstrated water recovery upto 99%, waste volume reduction upto 80%, tile stabilization for long-term, passive separation of liquid/gas phase, and operations with low maintenance cost.Heat melt refuse compactor has designed to compress by compaction process, encapsulate the waste bi-product, residual gas/water at atmoshpheric pressure, waste volume reduction and microbial stabilization. The model design shows the benefit of a heat melt refuse compactor on-site use by converting the solid waste into valuable products with thermal and compression technique. HMRC model has processed ∼1300 kg of solid waste; which produced ∼700 kg of tile, recovered ∼400 kg of water, and ∼200 kg of gaseous and residual waste. The compression ratio (Cc) of solid waste has been estimated with a compression cell with a diameter between 65 to 100 mm, mesoscale data for a diameter of 195 mm to 265 mm and high-scale data for a diameter of 300 to 400 mm. Cc is a more sensitive variable in formation of bi-products from MSW. Ground base HMRC has designed for Cc stress ranges from 20 to 300 kPa to function within the physical and environmental constraints.E-control contaminant removal mechanism keeps the environment clean and safe.
Keywords	Muncipal solid waste ; Contaminant control ; Microbial stabilization ; Electronic data control ; Heat exchanger ; Environmental sciences ; GE1-350
Subject code	670
Language	English
Publishing date	2023-08-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Comparative performance analysis of flat plate solar collector having circular &trapezoidal corrugated absorber plate designs

Sharma, Harish K. / Kumar, Satish / Verma, Sujit Kumar

Energy. 2022 Aug., v. 253 p.124137-

2022

Abstract: Flat plate Solar collectors are in use for a long time and have well-established technologies for low-temperature thermal applications. Use of newglazing materials, absorber plate designs, selective coatings, and advanced working fluids, thermal ... ...

Abstract	Flat plate Solar collectors are in use for a long time and have well-established technologies for low-temperature thermal applications. Use of newglazing materials, absorber plate designs, selective coatings, and advanced working fluids, thermal conversion efficiencies of these devices can be further improved. Design modification always comes under top priority because it brings auxiliary changes that further modify the system's overall efficiency. Increasing energy demand puts extra attention on the researchers to develop solar thermal energy-based systems. The presented experimental analysis is based on the design modification of the collector absorber plate to modify the contact area between the absorber plate and collector tubes. We performed a comparative performance of the circular absorber surface and the trapezoidal surface of contact with absorber tubes. The following results indicate that the trapezoidal absorber surface serves better over circular and plate absorber surfaces.Thermal efficiency increases by 8.74% and 12.85% for absorber plate's circular and trapezoidal corrugated surfaces. Exergy efficiency is improved by 16.88, 23.31%, and the overall heat loss coefficient decreases by 7.49 and 8.72% for circular and trapezoidal corrugated surfaces, respectively. The collector's heat removal factor is also significantly higher for trapezoidal corrugated absorber plate than the normal collector absorber surface.
Keywords	exergy ; heat ; solar collectors ; Solar-thermal ; Trapezoidal-surface ; Circular-surface ; Innovative design ; Thermal efficiency
Language	English
Dates of publication	2022-08
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	2019804-8
ISSN	0360-5442 ; 0360-5442
ISSN (online)	0360-5442
ISSN	0360-5442
DOI	10.1016/j.energy.2022.124137
Database	NAL-Catalogue (AGRICOLA)

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Article: Comparative Evaluation of Quality Management Practices in the Public and Private Hospitals in Visakhapatnam District: An Original Research.

Tiwari, Rahul V C / Sharma, Sandesh K / Sahoo, Sujit R / Velthuru, Srujan K / Basavarajaiah, Jeevan Matada / Kazi, Madiha / Dixit, Heena

Journal of pharmacy & bioallied sciences

2024 Volume 16, Issue Suppl 1, Page(s) S592–S597

Abstract: Background: In the Visakhapatnam District, this study compares the quality management procedures used by public and private hospitals. Knowing how these practices are similar and different from one another can help inform policy decisions and improve ... ...

Abstract	Background: In the Visakhapatnam District, this study compares the quality management procedures used by public and private hospitals. Knowing how these practices are similar and different from one another can help inform policy decisions and improve the quality of health care. Materials and methods: A cross-sectional study design was used, and 100 hospitals from both public (50 hospitals) and private (50 hospitals) were included in the sample size. A standardized questionnaire that evaluated different aspects of quality management practices was used to gather the data. Descriptive statistics and inferential tests were used in the quantitative analysis. Results: Significant variations in quality management procedures between public and private hospitals were found. In terms of patient happiness, service responsiveness, and technological use, private hospitals scored better. Regarding accessibility, cost, and equity of healthcare services, public hospitals fared better. Conclusion: The report emphasizes the necessity of focused initiatives to improve quality management procedures in both public and commercial institutions. Collaboration between the two sectors can make it easier to deploy evidence-based tactics and share best practices to raise overall healthcare quality in the Visakhapatnam area.
Language	English
Publishing date	2024-02-29
Publishing country	India
Document type	Journal Article
ZDB-ID	2573569-X
ISSN	0975-7406 ; 0976-4879
ISSN (online)	0975-7406
ISSN	0976-4879
DOI	10.4103/jpbs.jpbs_882_23
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online: A Model-free Deep Reinforcement Learning Approach To Maneuver A Quadrotor Despite Single Rotor Failure

Sharma, Paras / Poddar, Prithvi / Sujit, P. B.

2021

Abstract: Ability to recover from faults and continue mission is desirable for many quadrotor applications. The quadrotor's rotor may fail while performing a mission and it is essential to develop recovery strategies so that the vehicle is not damaged. In this ... ...

Abstract	Ability to recover from faults and continue mission is desirable for many quadrotor applications. The quadrotor's rotor may fail while performing a mission and it is essential to develop recovery strategies so that the vehicle is not damaged. In this paper, we develop a model-free deep reinforcement learning approach for a quadrotor to recover from a single rotor failure. The approach is based on Soft-actor-critic that enables the vehicle to hover, land, and perform complex maneuvers. Simulation results are presented to validate the proposed approach using a custom simulator. The results show that the proposed approach achieves hover, landing, and path following in 2D and 3D. We also show that the proposed approach is robust to wind disturbances.
Keywords	Computer Science - Robotics
Publishing date	2021-09-21
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Metal–Organic Framework-Based Selective Sensing of Biothiols via Chemidosimetric Approach in Water

Shivani Sharma / Sujit K. Ghosh

ACS Omega, Vol 3, Iss 1, Pp 254-

2018 Volume 258

Keywords	Chemistry ; QD1-999
Language	English
Publishing date	2018-01-01T00:00:00Z
Publisher	American Chemical Society
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Self-assembled 3D-microstructured dual carbon black filled polymer nanocomposite-coated fabric for tunable electromagnetic interference shielding

Sarkar, Kajal / Khanra, Sipra / Sharma, Sujit / Ghorai, Sanjoy Kumar / Chattopadhyay, Santanu

The Journal of The Textile Institute. 2023 Feb. 1, v. 114, no. 2 p.207-216

2023

Abstract: Dual carbon black (CB) was used to create self-assembled three-dimensional (3D)-microstructured polymer nanocomposite by a simple solution mixing process. A mechanical stirrer was employed for uniform dispersion and minimizing CB aggregates sizes in the ... ...

Abstract	Dual carbon black (CB) was used to create self-assembled three-dimensional (3D)-microstructured polymer nanocomposite by a simple solution mixing process. A mechanical stirrer was employed for uniform dispersion and minimizing CB aggregates sizes in the viscous blended medium of hydrolyzed polyvinyl alcohol (PVA) and natural rubber latex (NRL). A stable 3D-microstructural architecture was obtained when an extremely high volume fraction (0.54) of dual CB was used. 3D-microstructured polymer nanocomposite was then applied on the cotton fabric and characterized for the final performance of electromagnetic interference (EMI) shielding effectiveness. The morphological and microstructural analysis revealed that dual CB at a particular ratio of 10:90 (smaller:larger) could provide excellent electrical conductivity (>1.5 S/cm) as well as EMI shielding when assessed against a frequency range of 8.2–12.4 GHz. A durable ultra-thin layer (100 µm) of nanocomposite was sufficient to achieve tunable >31 dB shielding effectiveness.
Keywords	cotton fabric ; electrical conductivity ; electromagnetic interference ; hydrolysis ; latex ; polymer nanocomposites ; polyvinyl alcohol ; rubber ; soot ; Polymer nanocomposite ; microstructure ; coated fabric ; electrical properties ; EMI shielding
Language	English
Dates of publication	2023-0201
Size	p. 207-216.
Publishing place	Taylor & Francis
Document type	Article ; Online
ISSN	1754-2340
DOI	10.1080/00405000.2022.2026577
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Current insights into epigenetics, noncoding RNA interactome and clinical pharmacokinetics of dietary polyphenols in cancer chemoprevention

Shah, Deepa / Gandhi, Manav / Kumar, Arun / Cruz-Martins, Natália / Sharma, Rohit / Nair, Sujit

Critical Reviews in Food Science and Nutrition. 2023 May 7, v. 63, no. 12 p.1755-1791

2023

Abstract: Several studies have reported the health-beneficial effects of dietary phytochemicals, namely polyphenols, to prevent various diseases, including cancer. Polyphenols, like (−)-epigallocatechin-3-gallate (EGCG) from green tea, curcumin from turmeric, and ... ...

Abstract	Several studies have reported the health-beneficial effects of dietary phytochemicals, namely polyphenols, to prevent various diseases, including cancer. Polyphenols, like (−)-epigallocatechin-3-gallate (EGCG) from green tea, curcumin from turmeric, and ellagic acid from pomegranate are known to act by modulating antioxidant, anti-inflammatory and apoptotic signal transduction pathways in the tumor milieu. The evolving literature underscores the role of epigenetic regulation of genes associated with cancer by these polyphenols, primarily via non-coding RNAs (ncRNAs), such as microRNAs (miRNA) and long noncoding RNA (lncRNA). However, there is little clarity on the exact role(s) played by these ncRNAs and their interactions with other ncRNAs, or with their protein targets, in response to modulation by these dietary polyphenols. Here, we review ncRNA interactions and functional networks of the complex ncRNA interactome with their targets in preclinical studies along with the role of epigenetics as well as key aspects of pharmacokinetics and phytochemistry of dietary polyphenols. We also summarize the current state of clinical trials with these dietary polyphenols. Taken together, this synthetic review provides insights into the molecular aspects underlying the anticancer chemopreventive effects of dietary polyphenols as well as summarizes data on novel biomarkers modulated by these polyphenols for preventive or therapeutic purposes in various types of cancer.
Keywords	antioxidants ; apoptosis ; biomarkers ; chemoprevention ; curcumin ; ellagic acid ; epigallocatechin gallate ; epigenetics ; food science ; green tea ; microRNA ; neoplasms ; non-coding RNA ; nutrition ; pharmacokinetics ; polyphenols ; pomegranates ; signal transduction ; therapeutics ; turmeric
Language	English
Dates of publication	2023-0507
Size	p. 1755-1791.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	1037504-1
ISSN	1549-7852 ; 1040-8398
ISSN (online)	1549-7852
ISSN	1040-8398
DOI	10.1080/10408398.2021.1968786
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Metal-Organic Framework-Based Selective Sensing of Biothiols via Chemidosimetric Approach in Water.

Sharma, Shivani / Ghosh, Sujit K

ACS omega

2018 Volume 3, Issue 1, Page(s) 254–258

Abstract: Selective detection of biothiols holds prime importance owing to the role of varied concentrations of biothiols in various diseases, thus demanding extensive research for developing materials toward selective sensing. In this study, we targeted ... ...

Abstract	Selective detection of biothiols holds prime importance owing to the role of varied concentrations of biothiols in various diseases, thus demanding extensive research for developing materials toward selective sensing. In this study, we targeted postsynthetic modification (PSM) approach for imparting desired functionality to chemically stable UiO-66-NH
Language	English
Publishing date	2018-01-10
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.7b01891
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Rhodium-based half-Heusler alloys as thermoelectric materials.

Jaishi, Dhurba R / Bati, Sujit / Sharma, Nileema / Karki, Bishnu / Belbase, Bishnu P / Ghimire, Madhav Prasad

Physical chemistry chemical physics : PCCP

2022 Volume 24, Issue 33, Page(s) 19844–19852

Abstract: Thermoelectric phenomena provide an alternative for power generation and refrigeration, which could be the best solution to the energy crisis by utilizing waste heat energy in the near future. In this study, we have investigated the structural, elastic, ... ...

Abstract	Thermoelectric phenomena provide an alternative for power generation and refrigeration, which could be the best solution to the energy crisis by utilizing waste heat energy in the near future. In this study, we have investigated the structural, elastic, electronic, and thermoelectric properties of 18-valence electron count rhodium-based half-Heusler alloys focusing on RhTiP, RhTiAs, RhTiSb, and RhTiBi. The non-existence of imaginary frequencies in the phonon dispersion curve for these systems verifies that they are structurally stable. RhTiP is ductile, while others are brittle. The alloys are semiconducting with indirect band gaps ranging from 0.94 to 1.01 eV. While considering thermoelectricity, we discovered that p-type doping is more favorable in improving the thermoelectric properties. The calculated power factor values with p-type doping are comparable to some of the reported half-Heusler materials. The optimum figure of merit
Language	English
Publishing date	2022-08-24
Publishing country	England
Document type	Journal Article
ZDB-ID	1476244-4
ISSN	1463-9084 ; 1463-9076
ISSN (online)	1463-9084
ISSN	1463-9076
DOI	10.1039/d2cp02504c
Database	MEDical Literature Analysis and Retrieval System OnLINE

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