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  1. Book ; Online: Regulation of Inflammation in Chronic Disease

    Zhong, Jixin / Shi, Guixiu

    2019  

    Keywords Medicine ; Immunology ; Inflammation ; immune regulation ; chronic disease ; metabolic disease ; cardiovascular disease ; autoimmune ; cancer
    Size 1 electronic resource (580 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230716
    ISBN 9782889459162 ; 2889459160
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Cross Talk Between the Immune System and Metabolism

    Zhong, Jixin / Kong, Wen / Chen, Jie

    2020  

    Keywords Medicine ; Endocrinology ; immune system ; metabolism ; metabolic disease ; chronic inflammation ; metabolic dysregulation
    Size 1 electronic resource (119 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021231316
    ISBN 9782889661701 ; 2889661709
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Immunomodulatory effects of iTr35 cell subpopulation and its research progress.

    Yang, Chenxi / Dong, Lingli / Zhong, Jixin

    Clinical and experimental medicine

    2024  Volume 24, Issue 1, Page(s) 41

    Abstract: The spotlight in recent years has increasingly focused on inducible regulatory T cells 35 (iTr35), a novel subpopulation of regulatory T cells characterized by phenotypic stability, heightened reactivity, and potent immunosuppressive function through the ...

    Abstract The spotlight in recent years has increasingly focused on inducible regulatory T cells 35 (iTr35), a novel subpopulation of regulatory T cells characterized by phenotypic stability, heightened reactivity, and potent immunosuppressive function through the production of IL-35. Despite being in the exploratory phase, research on iTr35 has garnered significant interest. In this review, we aim to consolidate our understanding of the biological characteristics and immunomodulatory mechanisms of iTr35, offering fresh perspectives that may pave the way for its potential applications in disease diagnosis and treatment.
    MeSH term(s) Humans ; T-Lymphocytes, Regulatory ; Immunomodulation ; Immunosuppressive Agents
    Chemical Substances Immunosuppressive Agents
    Language English
    Publishing date 2024-02-22
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 2053018-3
    ISSN 1591-9528 ; 1591-8890
    ISSN (online) 1591-9528
    ISSN 1591-8890
    DOI 10.1007/s10238-024-01303-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Editorial: Rheumatic Diseases and Infection.

    Dong, Lingli / Umehara, Hisanori / Zhong, Jixin

    Frontiers in medicine

    2022  Volume 9, Page(s) 941678

    Language English
    Publishing date 2022-06-01
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2022.941678
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Editorial: Advances in Pathogenesis and Therapies of Gout.

    Duan, Lihua / Zhong, Jixin / Yang, Ye / Zhu, Xiaoxia

    Frontiers in immunology

    2022  Volume 13, Page(s) 890204

    Language English
    Publishing date 2022-04-01
    Publishing country Switzerland
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.890204
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Editorial

    Lingli Dong / Hisanori Umehara / Jixin Zhong

    Frontiers in Medicine, Vol

    Rheumatic Diseases and Infection

    2022  Volume 9

    Keywords infection ; rheumatic disease ; virus ; autoimmune disease (AID) ; inflammatory ; Medicine (General) ; R5-920
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  7. Article ; Online: Regulatory T cells: a new therapeutic link for Sjögren syndrome?

    Ming, Bingxia / Zhu, Yaowu / Zhong, Jixin / Dong, Lingli

    Rheumatology (Oxford, England)

    2023  Volume 62, Issue 9, Page(s) 2963–2970

    Abstract: Great advancements have been made in understanding the pathogenesis of SS, but there remain unmet needs for effective and targeted treatments. Glandular and extraglandular dysfunction in SS is associated with autoimmune lymphocytic infiltration that ... ...

    Abstract Great advancements have been made in understanding the pathogenesis of SS, but there remain unmet needs for effective and targeted treatments. Glandular and extraglandular dysfunction in SS is associated with autoimmune lymphocytic infiltration that invades the epithelial structures of affected organs. Regulatory T (Treg) cells are a subset of CD4+ T lymphocytes that maintain self-tolerance during physiological conditions. Besides inhibiting excessive inflammation and autoimmune response by targeting various immune cell subsets and tissues, Treg cells have also been shown to promote tissue repair and regeneration in pathogenic milieus. The changes of quantity and function of Treg cells in various autoimmune and chronic inflammatory disorders have been reported, owing to their effects on immune regulation. Here we summarize the recent findings from murine models and clinical data about the dysfunction of Treg cells in SS pathogenesis and discuss the therapeutic strategies of direct or indirect targeting of Treg cells in SS. Understanding the current knowledge of Treg cells in the development of SS will be important to elucidate disease pathogenesis and may guide research for successful therapeutic intervention in this disease.
    MeSH term(s) Humans ; Animals ; Mice ; T-Lymphocytes, Regulatory ; Sjogren's Syndrome ; CD4-Positive T-Lymphocytes ; Inflammation/pathology ; Immune Tolerance
    Language English
    Publishing date 2023-02-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/kead070
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Precision Medicine in Rheumatic Diseases: Unlocking the Potential of Antibody-Drug Conjugates.

    Huang, Zhiwen / Braunstein, Zachary / Chen, Jun / Wei, Yingying / Rao, Xiaoquan / Dong, Lingli / Zhong, Jixin

    Pharmacological reviews

    2024  

    Abstract: In the era of precision medicine, Antibody-Drug Conjugates (ADCs) have emerged as a cutting-edge therapeutic strategy. These innovative compounds combine the precision of monoclonal antibodies with the potent cell-killing or immune-modulating abilities ... ...

    Abstract In the era of precision medicine, Antibody-Drug Conjugates (ADCs) have emerged as a cutting-edge therapeutic strategy. These innovative compounds combine the precision of monoclonal antibodies with the potent cell-killing or immune-modulating abilities of attached drug payloads. This unique strategy not only reduces off-target toxicity but also enhances the therapeutic effectiveness of drugs. Beyond their well-established role in oncology, ADCs are now showing promising potential in addressing the unmet needs in the therapeutics of rheumatic diseases. Rheumatic diseases, a diverse group of chronic autoimmune diseases with varying etiologies, clinical presentations, and prognoses, often demand prolonged pharmacological interventions, creating a pressing need for novel, efficient and low-risk treatment options. ADCs, with their ability to precisely target the immune components, have emerged as a novel therapeutic strategy in this context. This review will provide an overview of the core components and mechanisms behind ADCs, a summary of the latest clinical trials of ADCs for the treatment if rheumatic diseases, as well as a discussion on the challenges and future prospects faced by the development of next-generation ADCs.
    Language English
    Publishing date 2024-04-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209898-2
    ISSN 1521-0081 ; 0031-6997
    ISSN (online) 1521-0081
    ISSN 0031-6997
    DOI 10.1124/pharmrev.123.001084
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Response to: 'Clinical features of patients with rheumatic diseases and COVID-19 infection in Sarawak, Malaysia' by Wan

    Zhong, Jixin / Dong, Lingli

    Annals of the rheumatic diseases

    2020  Volume 81, Issue 8, Page(s) e149

    MeSH term(s) COVID-19 ; Humans ; Malaysia/epidemiology ; Rheumatic Diseases/complications
    Keywords covid19
    Language English
    Publishing date 2020-07-24
    Publishing country England
    Document type Research Support, Non-U.S. Gov't ; Letter ; Comment
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/annrheumdis-2020-218441
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Editorial: Regulation of Inflammation in Chronic Disease.

    Zhong, Jixin / Shi, Guixiu

    Frontiers in immunology

    2019  Volume 10, Page(s) 737

    MeSH term(s) Chronic Disease ; Disease Susceptibility ; Humans ; Inflammation/complications ; Inflammation/etiology ; Inflammation/metabolism
    Language English
    Publishing date 2019-04-12
    Publishing country Switzerland
    Document type Editorial ; Introductory Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2019.00737
    Database MEDical Literature Analysis and Retrieval System OnLINE

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