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Article ; Online: Effects of soy containing diet and isoflavones on cytochrome P450 enzyme expression and activity.

Ronis, Martin J J

2016 Volume 48, Issue 3, Page(s) 331–341

Abstract: Cytochromes P450 (CYPs) play an important role in metabolism and clearance of most clinically utilized drugs and other xenobiotics. They are important in metabolism of endogenous compounds including fatty acids, sterols, steroids and lipid-soluble ... ...

Abstract	Cytochromes P450 (CYPs) play an important role in metabolism and clearance of most clinically utilized drugs and other xenobiotics. They are important in metabolism of endogenous compounds including fatty acids, sterols, steroids and lipid-soluble vitamins. Dietary factors such as phytochemicals are capable of affecting CYP expression and activity, which may be important in diet-drug interactions and in the development of fatty liver disease, cardiovascular disease and cancer. One important diet-CYP interaction is with diets containing plant proteins, particularly soy protein. Soy diets are traditionally consumed in Asian countries and are linked to lower incidence of several cancers and of cardiovascular disease in Asian populations. Soy is also an important protein source in vegetarian and vegan diets and the sole protein source in soy infant formulas. Recent studies suggest that consumption of soy can inhibit induction of CY1 enzymes by polycyclic aromatic hydrocarbons (PAHs) which may contribute to cancer prevention. In addition, there are data to suggest that soy components promiscuously activate several nuclear receptors including PXR, PPAR and LXR resulting in increased expression of CYP3As, CYP4As and CYPs involved in metabolism of cholesterol to bile acids. Such soy-CYP interactions may alter drug pharmacokinetics and therapeutic efficacy and are associated with improved lipid homeostasis and reduced risk of cardiovascular disease. The current review summarizes results from in vitro; in vivo and clinical studies of soy-CYP interactions and examines the evidence linking the effects of soy diets on CYP expression to isoflavone phytoestrogens, particularly, genistein and daidzein that are associated with soy protein.
MeSH term(s)	Animals ; Cytochrome P-450 Enzyme System/biosynthesis ; Cytochrome P-450 Enzyme System/genetics ; Cytochrome P-450 Enzyme System/metabolism ; Diet ; Gene Expression Regulation, Enzymologic/drug effects ; Genistein/pharmacology ; Humans ; Isoflavones/pharmacology ; Soybean Proteins/pharmacology
Chemical Substances	Isoflavones ; Soybean Proteins ; daidzein (6287WC5J2L) ; Cytochrome P-450 Enzyme System (9035-51-2) ; Genistein (DH2M523P0H)
Language	English
Publishing date	2016-07-20
Publishing country	England
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural
ZDB-ID	184967-0
ISSN	1097-9883 ; 0360-2532 ; 0012-6594
ISSN (online)	1097-9883
ISSN	0360-2532 ; 0012-6594
DOI	10.1080/03602532.2016.1206562
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Improved method for isolating high-quality RNA from mouse bone with RNA

Pedersen, Kim B / Williams, Ashlee / Watt, James / Ronis, Martin J

Bone reports

2019 Volume 11, Page(s) 100211

Abstract: Accurate gene expression analysis of bone requires the ability to isolate RNA of good quality. Isolation of intact RNA from frozen bone tissue is problematic since RNA rapidly becomes degraded after thawing. Since we are interested in assessing gene ... ...

Abstract	Accurate gene expression analysis of bone requires the ability to isolate RNA of good quality. Isolation of intact RNA from frozen bone tissue is problematic since RNA rapidly becomes degraded after thawing. Since we are interested in assessing gene expression from both bone marrow and mineralized bone, we aimed to develop improved simple, robust and statistically validated methods providing high-quality RNA from both mouse femur shaft and femur marrow. RNA integrity was quantified by the RNA Integrity Number (RIN) measured on a TapeStation. While the RNA stabilization reagent RNA
Language	English
Publishing date	2019-05-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	2821774-3
ISSN	2352-1872
ISSN	2352-1872
DOI	10.1016/j.bonr.2019.100211
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Adverse Effects of Nutraceuticals and Dietary Supplements.

Ronis, Martin J J / Pedersen, Kim B / Watt, James

Annual review of pharmacology and toxicology

2017 Volume 58, Page(s) 583–601

Abstract: Over 70% of Americans take some form of dietary supplement every day, and the supplement industry is currently big business, with a gross of over $28 billion. However, unlike either foods or drugs, supplements do not need to be registered or approved by ... ...

Abstract	Over 70% of Americans take some form of dietary supplement every day, and the supplement industry is currently big business, with a gross of over $28 billion. However, unlike either foods or drugs, supplements do not need to be registered or approved by the US Food and Drug Administration (FDA) prior to production or sales. Under the Dietary Supplement Health and Education Act of 1994, the FDA is restricted to adverse report monitoring postmarketing. Despite widespread consumption, there is limited evidence of health benefits related to nutraceutical or supplement use in well-nourished adults. In contrast, a small number of these products have the potential to produce significant toxicity. In addition, patients often do not disclose supplement use to their physicians. Therefore, the risk of adverse drug-supplement interactions is significant. An overview of the major supplement and nutraceutical classes is presented here, together with known toxic effects and the potential for drug interactions.
MeSH term(s)	Animals ; Dietary Supplements/adverse effects ; Drug Interactions/physiology ; Drug-Related Side Effects and Adverse Reactions/etiology ; Humans ; United States ; United States Food and Drug Administration
Language	English
Publishing date	2017-10-06
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	196587-6
ISSN	1545-4304 ; 0362-1642
ISSN (online)	1545-4304
ISSN	0362-1642
DOI	10.1146/annurev-pharmtox-010617-052844
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Estradiol and NADPH oxidase crosstalk regulates responses to high fat feeding in female mice.

Ronis, Martin J / Blackburn, Michael L / Shankar, Kartik / Ferguson, Matthew / Cleves, Mario A / Badger, Thomas M

Experimental biology and medicine (Maywood, N.J.)

2019 Volume 244, Issue 10, Page(s) 834–845

MeSH term(s)	Adiponectin/blood ; Adipose Tissue/metabolism ; Animals ; Diet, High-Fat ; Estradiol/metabolism ; Estradiol/physiology ; Female ; Leptin/blood ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; NADPH Oxidases/metabolism ; NADPH Oxidases/physiology ; Receptor Cross-Talk ; Signal Transduction
Chemical Substances	Adiponectin ; Leptin ; Estradiol (4TI98Z838E) ; NADPH Oxidases (EC 1.6.3.-)
Language	English
Publishing date	2019-06-04
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	4015-0
ISSN	1535-3699 ; 1525-1373 ; 0037-9727
ISSN (online)	1535-3699 ; 1525-1373
ISSN	0037-9727
DOI	10.1177/1535370219853563
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Article ; Online: Nox4 expression in osteo-progenitors controls bone development in mice during early life.

Chen, Jin-Ran / Lazarenko, Oxana P / Blackburn, Michael L / Chen, Jennifer F / Randolph, Christopher E / Zabaleta, Jovanny / Schroder, Katrin / Pedersen, Kim B / Ronis, Martin J J

Communications biology

2022 Volume 5, Issue 1, Page(s) 583

Abstract: Tightly regulated and cell-specific NADPH-oxidases (Nox) represent one of the major sources of reactive oxygen species (ROS) signaling molecules that are involved in tissue development and stem cell self-renewal. We have characterized the role of Nox4 in ...

Abstract	Tightly regulated and cell-specific NADPH-oxidases (Nox) represent one of the major sources of reactive oxygen species (ROS) signaling molecules that are involved in tissue development and stem cell self-renewal. We have characterized the role of Nox4 in osteo-progenitors during postnatal bone development. Nox4 expression in bone and ROS generation were increased during early osteoblast differentiation and bone development. Stromal osteoblastic cell self-renewal, proliferation and ROS production were significantly lower in samples from whole-body Nox4 knockout mice (Nox4
MeSH term(s)	Animals ; Bone Development/physiology ; Female ; Male ; Mice ; Mice, Knockout ; NADPH Oxidase 4/biosynthesis ; NADPH Oxidase 4/genetics ; NADPH Oxidase 4/metabolism ; Osteogenesis/physiology ; Reactive Oxygen Species/metabolism
Chemical Substances	Reactive Oxygen Species ; NADPH Oxidase 4 (EC 1.6.3.-) ; Nox4 protein, mouse (EC 1.6.3.-)
Language	English
Publishing date	2022-06-14
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ISSN	2399-3642
ISSN (online)	2399-3642
DOI	10.1038/s42003-022-03544-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Soy Formula Is Not Estrogenic and Does Not Result in Reproductive Toxicity in Male Piglets: Results from a Controlled Feeding Study.

Ronis, Martin J J / Gomez-Acevedo, Horacio / Shankar, Kartik / Hennings, Leah / Sharma, Neha / Blackburn, Michael L / Miousse, Isabelle / Dawson, Harry / Chen, Celine / Mercer, Kelly E / Badger, Thomas M

Nutrients

2022 Volume 14, Issue 5

Abstract: Soy infant formula which is fed to over half a million infants per year contains isoflavones such as genistein, which have been shown to be estrogenic at high concentrations. The developing testis is sensitive to estrogens, raising concern that the use ... ...

Abstract	Soy infant formula which is fed to over half a million infants per year contains isoflavones such as genistein, which have been shown to be estrogenic at high concentrations. The developing testis is sensitive to estrogens, raising concern that the use of soy formulas may result in male reproductive toxicity. In the current study, male White-Dutch Landrace piglets received either sow milk (Sow), or were provided milk formula (Milk), soy formula (Soy), milk formula supplemented with 17-beta-estradiol (2 mg/kg/d) (M + E2) or supplemented with genistein (84 mg/L of diet; (M + G) from postnatal day 2 until day 21. E2 treatment reduced testis weight (p < 0.05) as percentage of body weight, significantly suppressed serum androgen concentrations, increased tubule area, Germ cell and Sertoli cell numbers (p < 0.05) relative to those of Sow or Milk groups. Soy formula had no such effects relative to Sow or Milk groups. mRNAseq revealed 103 differentially expressed genes in the M + E2 group compared to the Milk group related to endocrine/metabolic disorders. However, little overlap was observed between the other treatment groups. These data suggest soy formula is not estrogenic in the male neonatal piglet and that soy formula does not significantly alter male reproductive development.
MeSH term(s)	Animals ; Genistein/toxicity ; Infant Formula ; Isoflavones/analysis ; Male ; Milk/chemistry ; Reproduction ; Swine
Chemical Substances	Isoflavones ; Genistein (DH2M523P0H)
Language	English
Publishing date	2022-03-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14051126
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Article ; Online: Impact of Alcohol on Bone Health in People Living With HIV: Integrating Clinical Data From Serum Bone Markers With Morphometric Analysis in a Non-Human Primate Model.

Denys, Alexandra / Norman, Allison / Perrien, Daniel S / Suva, Larry J / Simon, Liz / McDaniel, Lee S / Ferguson, Tekeda / Pedersen, Kim / Welsh, David / Molina, Patricia E / Ronis, Martin Jj

JBMR plus

2022 Volume 7, Issue 1, Page(s) e10703

Abstract: People living with HIV (PLWH) represent a vulnerable population to adverse musculoskeletal outcomes due to HIV infection, antiretroviral therapy (ART), and at-risk alcohol use. Developing measures to prevent skeletal degeneration in this group requires a ...

Abstract	People living with HIV (PLWH) represent a vulnerable population to adverse musculoskeletal outcomes due to HIV infection, antiretroviral therapy (ART), and at-risk alcohol use. Developing measures to prevent skeletal degeneration in this group requires a grasp of the relationship between alcohol use and low bone mass in both the PLWH population and its constituents as defined by sex, age, and race. We examined the association of alcohol use with serum biochemical markers of bone health in a diverse cohort of PLWH enrolled in the New Orleans Alcohol Use in HIV (NOAH) study. To explore the effects of alcohol on bone in the context of HIV and ART and the role of estrogen, we conducted a parallel, translational study using simian immunodeficiency virus (SIV)
Language	English
Publishing date	2022-11-28
Publishing country	England
Document type	Journal Article
ISSN	2473-4039
ISSN (online)	2473-4039
DOI	10.1002/jbm4.10703
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: N-Acetylcysteine prevents the decreases in cardiac collagen I/III ratio and systolic function in neonatal mice with prenatal alcohol exposure.

Ninh, Van K / El Hajj, Elia C / Ronis, Martin J / Gardner, Jason D

Toxicology letters

2019 Volume 315, Page(s) 87–95

Abstract: Prenatal alcohol exposure (PAE) is often associated with congenital heart defects, most commonly septal, valvular, and great vessel defects. However, there have been no known studies on whether PAE affects the resulting fibroblast population after ... ...

Abstract	Prenatal alcohol exposure (PAE) is often associated with congenital heart defects, most commonly septal, valvular, and great vessel defects. However, there have been no known studies on whether PAE affects the resulting fibroblast population after development, and whether this has any consequences in the postnatal period. Our previous study focused on the effects of PAE on the postnatal fibroblast population, which translated into changes in cardiac extracellular matrix (ECM) composition and cardiac function in the neonatal heart. Moreover, our lab has previously demonstrated that alcohol-induced fibrosis is mediated by oxidative stress mechanisms in adult rat hearts following chronic alcohol exposure. Thus, we hypothesize that PAE alters cardiac ECM composition that persists into the postnatal period, leading to cardiac dysfunction, and these effects are prevented by antioxidant treatment. To investigate these effects, pregnant mice were intraperitoneally injected with 2.9 g EtOH/kg body weight on gestation days 6.75 and 7.25. Controls were injected with vehicle saline. Randomly selected dams in both groups were then treated with 100 mg/kg body weight of the antioxidant N-acetylcysteine (NAC) immediately after EtOH or vehicle administration. Left ventricular (LV) chamber dimension and function were assessed in sedated animals on neonatal day 5 using echocardiography. Ejection fraction decreased in the PAE group. NAC treatment prevented this depression of systolic function in PAE neonates. Hearts were analyzed for expression of fibroblast activation markers. Alpha smooth muscle actin (α-SMA) increased in PAE neonatal hearts, and this increase was prevented by NAC treatment. In PAE pups, collagen I decreased, but collagen III expression increased compared to saline animals; the overall collagen I/III ratio significantly decreased. When PAE mice were treated with NAC, collagen I/III ratio did not change. Overall, our data demonstrate that prenatal alcohol exposure produces changes in collagen subtype in neonatal cardiac ECM and a decline in systolic function, and these adverse effects were prevented by NAC treatment.
MeSH term(s)	Acetylcysteine/pharmacology ; Alcoholism/physiopathology ; Animals ; Animals, Newborn ; Cell Proliferation/drug effects ; Collagen Type I/metabolism ; Coronary Vessels/chemistry ; Disease Models, Animal ; Ethanol/toxicity ; Female ; Fibroblasts/drug effects ; Mice ; Pregnancy ; Prenatal Exposure Delayed Effects/chemically induced
Chemical Substances	Collagen Type I ; Ethanol (3K9958V90M) ; Acetylcysteine (WYQ7N0BPYC)
Language	English
Publishing date	2019-08-16
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	433788-8
ISSN	1879-3169 ; 0378-4274
ISSN (online)	1879-3169
ISSN	0378-4274
DOI	10.1016/j.toxlet.2019.08.010
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Article ; Online: Nox4 Expression Is Not Required for OVX-Induced Osteoblast Senescence and Bone Loss in Mice.

Chen, Jin-Ran / Lazarenko, Oxana P / Zhao, Haijun / Wankhade, Umesh D / Pedersen, Kim / Watt, James / Ronis, Martin J J

JBMR plus

2020 Volume 4, Issue 8, Page(s) e10376

Abstract: Estrogen deficiency and aging play critical roles in the pathophysiology of bone as a result of increased oxidative stress. It has been suggested that prevention of NADPH oxidase- (Nox-) dependent accumulation of ROS may be an approach to potentially ... ...

Abstract	Estrogen deficiency and aging play critical roles in the pathophysiology of bone as a result of increased oxidative stress. It has been suggested that prevention of NADPH oxidase- (Nox-) dependent accumulation of ROS may be an approach to potentially minimize bone loss caused by these conditions. Using ovariectomized (OVX) and Nox4 gene-deletion mouse models, we investigated the role of Nox4 in OVX-induced bone loss and osteoblast senescence signaling. Six-month-old WT C57Bl6 mice were allocated to a sham control group, OVX, and OVX plus E2 treatment group for 8 weeks. Decreased bone mass including BMD and BMC were found in the OVX group compared with the sham control (
Language	English
Publishing date	2020-07-23
Publishing country	England
Document type	Journal Article
ISSN	2473-4039
ISSN (online)	2473-4039
DOI	10.1002/jbm4.10376
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Soy Formula Is Not Estrogenic and Does Not Result in Reproductive Toxicity in Male Piglets: Results from a Controlled Feeding Study

Ronis, Martin J. J. / Dawson, Harry D. / Gomez-Acevedo, Horacio / Shankar, Kartik / Hennings, Leah / Sharma, Neha / Blackburn, Michael L. / Miousse, Isabelle / Dawson, Harry / Chen, Celine / Mercer, Kelly E. / Badger, Thomas M.

Nutrients. 2022 Mar. 07, v. 14, no. 5

2022

Abstract	Soy infant formula which is fed to over half a million infants per year contains isoflavones such as genistein, which have been shown to be estrogenic at high concentrations. The developing testis is sensitive to estrogens, raising concern that the use of soy formulas may result in male reproductive toxicity. In the current study, male White-Dutch Landrace piglets received either sow milk (Sow), or were provided milk formula (Milk), soy formula (Soy), milk formula supplemented with 17-beta-estradiol (2 mg/kg/d) (M + E2) or supplemented with genistein (84 mg/L of diet; (M + G) from postnatal day 2 until day 21. E2 treatment reduced testis weight (p < 0.05) as percentage of body weight, significantly suppressed serum androgen concentrations, increased tubule area, Germ cell and Sertoli cell numbers (p < 0.05) relative to those of Sow or Milk groups. Soy formula had no such effects relative to Sow or Milk groups. mRNAseq revealed 103 differentially expressed genes in the M + E2 group compared to the Milk group related to endocrine/metabolic disorders. However, little overlap was observed between the other treatment groups. These data suggest soy formula is not estrogenic in the male neonatal piglet and that soy formula does not significantly alter male reproductive development.
Keywords	Sertoli cells ; androgens ; blood serum ; body weight ; diet ; gene expression regulation ; genistein ; germ cells ; infant formulas ; landraces ; males ; milk ; piglets ; reproductive toxicology ; sow milk
Language	English
Dates of publication	2022-0307
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14051126
Database	NAL-Catalogue (AGRICOLA)

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