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Article ; Online: Whispers in the Blood: Leveraging MicroRNAs for Unveiling Autologous Blood Doping in Athletes.

Hassanpour, Mehdi / Salybekov, Amankeldi A

International journal of molecular sciences

2023 Volume 25, Issue 1

Abstract: The prevalence of autologous blood transfusions (ABTs) presents a formidable challenge in maintaining fair competition in sports, as it significantly enhances hemoglobin mass and oxygen capacity. In recognizing ABT as a prohibited form of doping, the ... ...

Abstract	The prevalence of autologous blood transfusions (ABTs) presents a formidable challenge in maintaining fair competition in sports, as it significantly enhances hemoglobin mass and oxygen capacity. In recognizing ABT as a prohibited form of doping, the World Anti-Doping Agency (WADA) mandates stringent detection methodologies. While current methods effectively identify homologous erythrocyte transfusions, a critical gap persists in detecting autologous transfusions. The gold standard practice of longitudinally monitoring hematological markers exhibits promise but is encumbered by limitations. Despite its potential, instances of blood doping often go undetected due to the absence of definitive verification processes. Moreover, some cases remain unpenalized due to conservative athlete-sanctioning approaches. This gap underscores the imperative need for a more reliable and comprehensive detection method capable of unequivocally differentiating autologous transfusions, addressing the challenges faced in accurately identifying such prohibited practices. The development of an advanced detection methodology is crucial to uphold the integrity of anti-doping measures, effectively identifying and penalizing instances of autologous blood transfusion. This, in turn, safeguards the fairness and equality essential to competitive sports. Our review tackles this critical gap by harnessing the potential of microRNAs in ABT doping detection. We aim to summarize alterations in the total microRNA profiles of erythrocyte concentrates during storage and explore the viability of observing these changes post-transfusion. This innovative approach opens avenues for anti-doping technologies and commercialization, positioning it as a cornerstone in the ongoing fight against doping in sports and beyond. The significance of developing a robust detection method cannot be overstated, as it ensures the credibility of anti-doping efforts and promotes a level playing field for all athletes.
MeSH term(s)	Humans ; MicroRNAs/genetics ; Doping in Sports ; Athletes ; Erythrocytes ; Sports
Chemical Substances	MicroRNAs
Language	English
Publishing date	2023-12-23
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25010249
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Unveiling the Genetic Footprint: Exploring Somatic Mutations in Peripheral Arterial Disease Progression.

Salybekov, Amankeldi A / Hassanpour, Mehdi

Biomedicines

2023 Volume 11, Issue 8

Abstract: Peripheral arterial diseases (PADs) are complex cardiovascular conditions influenced by environmental factors and somatic mutations in multiple genes involved in hematopoiesis and inflammation. While traditional risk factors, such as smoking, ... ...

Abstract	Peripheral arterial diseases (PADs) are complex cardiovascular conditions influenced by environmental factors and somatic mutations in multiple genes involved in hematopoiesis and inflammation. While traditional risk factors, such as smoking, hypercholesterolemia, and hypertension, have been extensively studied, the role of somatic mutations in PAD progression remains underexplored. The present article intends to provide a comprehensive commentary of the molecular mechanisms, genetic landscape, prognostic significance, and clinical implications of somatic mutations in PADs. The expansion of clonal hematopoiesis of indeterminate potential (CHIP) clones in the circulating blood, named clonal hematopoiesis (CH), leads to the infiltration of these clones into atherosclerotic plaques and the production of inflammatory cytokines, increasing the risk of cardiovascular diseases, including PADs. Furthermore, recent experimental evidence has demonstrated the involvement of somatically mutated TP53 genes with a high variant allele frequency (VAF) in PAD development and prognosis. This review delves into the relationship between CH and PADs, elucidating the prevalence, impact, and underlying mechanisms of this association. This understanding paves the way for novel therapeutic approaches targeting CHIP to promote tissue regeneration and improve outcomes in PAD patients. It emphasizes the need for further research to fully unravel the genetic footprint of the disease and highlights potential clinical implications. The findings presented in this article lay the foundation for personalized medicine approaches and open avenues for the development of targeted therapies based on somatic mutation profiling.
Language	English
Publishing date	2023-08-17
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines11082288
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Article ; Online: Whispers in the Blood

Mehdi Hassanpour / Amankeldi A. Salybekov

International Journal of Molecular Sciences, Vol 25, Iss 1, p

Leveraging MicroRNAs for Unveiling Autologous Blood Doping in Athletes

2023 Volume 249

Abstract	The prevalence of autologous blood transfusions (ABTs) presents a formidable challenge in maintaining fair competition in sports, as it significantly enhances hemoglobin mass and oxygen capacity. In recognizing ABT as a prohibited form of doping, the World Anti-Doping Agency (WADA) mandates stringent detection methodologies. While current methods effectively identify homologous erythrocyte transfusions, a critical gap persists in detecting autologous transfusions. The gold standard practice of longitudinally monitoring hematological markers exhibits promise but is encumbered by limitations. Despite its potential, instances of blood doping often go undetected due to the absence of definitive verification processes. Moreover, some cases remain unpenalized due to conservative athlete-sanctioning approaches. This gap underscores the imperative need for a more reliable and comprehensive detection method capable of unequivocally differentiating autologous transfusions, addressing the challenges faced in accurately identifying such prohibited practices. The development of an advanced detection methodology is crucial to uphold the integrity of anti-doping measures, effectively identifying and penalizing instances of autologous blood transfusion. This, in turn, safeguards the fairness and equality essential to competitive sports. Our review tackles this critical gap by harnessing the potential of microRNAs in ABT doping detection. We aim to summarize alterations in the total microRNA profiles of erythrocyte concentrates during storage and explore the viability of observing these changes post-transfusion. This innovative approach opens avenues for anti-doping technologies and commercialization, positioning it as a cornerstone in the ongoing fight against doping in sports and beyond. The significance of developing a robust detection method cannot be overstated, as it ensures the credibility of anti-doping efforts and promotes a level playing field for all athletes.
Keywords	autologous blood doping ; biomarker detection ; extracellular vesicles ; microRNAs ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	290 ; 796
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Late-Onset Haze and Severe Corneal Flattening after Combined Corneal Collagen Cross-Linking and Photorefractive Keratectomy (CXL Plus): A Case Report.

Mazouchi, Marjan / Hassanpour, Kiana / Esfandiari, Hamed / Sadoughi, Mohammad-Mehdi

Case reports in ophthalmology

2024 Volume 15, Issue 1, Page(s) 56–62

Abstract: Introduction: Significant corneal flattening and haze are important complications that can occur after combined corneal collagen cross-linking (CXL) and photorefractive keratectomy (PRK) procedures (CXL Plus).: Case presentation: We present a 24-year- ...

Abstract	Introduction: Significant corneal flattening and haze are important complications that can occur after combined corneal collagen cross-linking (CXL) and photorefractive keratectomy (PRK) procedures (CXL Plus). Case presentation: We present a 24-year-old man who underwent combined standard CXL and PRK. The patient experienced satisfactory vision for approximately 4 years after the surgery. However, after this period, he began to complain of visual blurring. Subsequent examination revealed significant corneal haze, excessive flattening in both eyes, and thinning (thinnest point 227 μm in the right eye, 244 μm in the left eye) 4 years postoperatively. Upon presentation, the corrected distance visual acuity (CDVA) was 20/200 in the right eye and 20/400 in the left eye. The presenting refraction was +2.50 sph, -3.50 cyl 114 in the right eye and +11.5 sph, -9.75 cyl 81 in the left eye. With rigid gas permeable contact lenses, the corrected visual acuity was 20/50 in both eyes. Before the CXL Plus surgery, initial refraction and CDVA were 20/50 in the right eye (-5.50 sph, -3.00 cyl 175) and 20/30 in the left eye (-5.50 sph, -2.75 cyl 175). The patient was treated by penetrating keratoplasty. The CDVA reached 20/30 at the final follow-up. Conclusion: Our report highlights significant corneal haze and flattening that occurred 4 years after combined CXL and PRK treatment. These findings suggest that this procedure might not be safe in suspected patients of keratoconus. Further long-term follow-up research is necessary to evaluate the safety of combined CXL and PRK procedures.
Language	English
Publishing date	2024-01-17
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2577666-6
ISSN	1663-2699
ISSN	1663-2699
DOI	10.1159/000535987
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Article: CD34 positive cells as endothelial progenitor cells in biology and medicine.

Hassanpour, Mehdi / Salybekov, Amankeldi A / Kobayashi, Shuzo / Asahara, Takayuki

Frontiers in cell and developmental biology

2023 Volume 11, Page(s) 1128134

Abstract: CD34 is a cell surface antigen expressed in numerous stem/progenitor cells including hematopoietic stem cells (HSCs) and endothelial progenitor cells (EPCs), which are known to be rich sources of EPCs. Therefore, regenerative therapy using ... ...

Abstract	CD34 is a cell surface antigen expressed in numerous stem/progenitor cells including hematopoietic stem cells (HSCs) and endothelial progenitor cells (EPCs), which are known to be rich sources of EPCs. Therefore, regenerative therapy using CD34
Language	English
Publishing date	2023-04-17
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2023.1128134
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Article ; Online: The application of graphene/h-BN metamaterial in medical linear accelerators for reducing neutron leakage in the treatment room.

Hassanpour, Mehdi / Hassanpour, Marzieh / Rezaie, Mohammadreza / Khezripour, Saeedeh / Faruque, Mohammad Rashed Iqbal / Khandaker, Mayeen Uddin

Physical and engineering sciences in medicine

2023 Volume 46, Issue 3, Page(s) 1023–1032

Abstract: Neutrons can be generated in medical linear accelerators (Linac) due to the interaction of high-energy photons (> 10 MeV) with the components of the accelerator head. The generated photoneutrons may penetrate the treatment room if a suitable neutron ... ...

Abstract	Neutrons can be generated in medical linear accelerators (Linac) due to the interaction of high-energy photons (> 10 MeV) with the components of the accelerator head. The generated photoneutrons may penetrate the treatment room if a suitable neutron shield is not used. This causes a biological risk to the patient and occupational workers. The use of appropriate materials in the barriers surrounding the bunker may be effective in preventing the transmission of neutrons from the treatment room to the outside. In addition, neutrons are present in the treatment room due to leakage in the Linac's head. This study aims to reduce the transmission of neutrons from the treatment room by using graphene/hexagonal boron nitride (h-BN) metamaterial as a neutron shielding material. MCNPX code was used to model three layers of graphene/h-BN metamaterial around the target and other components of the linac, and to investigate its effect on the photon spectrum and photoneutrons. Results indicate that the first layer of a graphene/h-BN metamaterial shield around the target improves photon spectrum quality at low energies, whereas the second and third layers have no significant effect. Regarding neutrons, three layers of the metamaterial results in a 50% reduction in the number of neutrons in the air within the treatment room.
MeSH term(s)	Humans ; Graphite ; Monte Carlo Method ; Neutrons ; Particle Accelerators
Chemical Substances	boron nitride (2U4T60A6YD) ; Graphite (7782-42-5)
Language	English
Publishing date	2023-05-23
Publishing country	Switzerland
Document type	Journal Article
ISSN	2662-4737
ISSN (online)	2662-4737
DOI	10.1007/s13246-023-01269-w
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Article ; Online: Therapeutic application of regeneration-associated cells: a novel source of regenerative medicine.

Salybekov, Amankeldi A / Hassanpour, Mehdi / Kobayashi, Shuzo / Asahara, Takayuki

Stem cell research & therapy

2023 Volume 14, Issue 1, Page(s) 191

Abstract: Chronic diseases with comorbidities or associated risk factors may impair the function of regenerative cells and the regenerative microenvironment. Following this consideration, the vasculogenic conditioning culture (VCC) method was developed to boost ... ...

Abstract	Chronic diseases with comorbidities or associated risk factors may impair the function of regenerative cells and the regenerative microenvironment. Following this consideration, the vasculogenic conditioning culture (VCC) method was developed to boost the regenerative microenvironment to achieve regeneration-associated cells (RACs), which contain vasculogenic endothelial progenitor cells (EPCs) and anti-inflammatory/anti-immunity cells. Preclinical and clinical studies demonstrate that RAC transplantation is a safe and convenient cell population for promoting ischemic tissue recovery based on its strong vasculogenicity and functionality. The outputs of the scientific reports reviewed in the present study shed light on the fact that RAC transplantation is efficient in curing various diseases. Here, we compactly highlight the universal features of RACs and the latest progress in their translation toward clinics.
MeSH term(s)	Regenerative Medicine/methods ; Endothelial Progenitor Cells ; Stem Cell Transplantation ; Cell Differentiation
Language	English
Publishing date	2023-08-02
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2548671-8
ISSN	1757-6512 ; 1757-6512
ISSN (online)	1757-6512
ISSN	1757-6512
DOI	10.1186/s13287-023-03428-y
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Article ; Online: Engineered extracellular vesicles: A novel platform for cancer combination therapy and cancer immunotherapy.

Ahmadi, Mahdi / Hassanpour, Mehdi / Rezaie, Jafar

Life sciences

2022 Volume 308, Page(s) 120935

Abstract: Extracellular vesicles (EVs), phospholipid membrane-bound vesicles, produced by most cells, contribute to cell-cell communication. They transfer several proteins, lipids, and nucleic acids between cells both locally and systemically. Owing to the ... ...

Abstract	Extracellular vesicles (EVs), phospholipid membrane-bound vesicles, produced by most cells, contribute to cell-cell communication. They transfer several proteins, lipids, and nucleic acids between cells both locally and systemically. Owing to the biocompatibility and immune activity of EVs, therapeutic approaches using these vesicles as drug delivery systems are being developed. Different methods are used to design more effective engineered EVs, which can serve as smart tools in cancer therapy and immunotherapy. Recent progress in the field of targeted-cancer therapy has led to the gradual use of engineered EVs in combinational therapy to combat heterogeneous tumor cells and multifaceted tumor microenvironments. The high plasticity, loading ability, and genetic manipulation capability of engineered EVs have made them the ideal platforms to realize numerous combinations of cancer therapy approaches. From the combination therapy view, engineered EVs can co-deliver chemotherapy with various therapeutic agents to target tumor cells effectively, further taking part in immunotherapy-related cancer combination therapy. However, a greater number of studies were done in pre-clinical platforms and the clinical translation of these studies needs further scrutiny because some challenges are associated with the application of engineered EVs. Given the many therapeutic potentials of engineered EVs, this review discusses their function in various cancer combination therapy and immunotherapy-related cancer combination therapy. In addition, this review describes the opportunities and challenges associated with the clinical application of engineered EVs.
MeSH term(s)	Drug Delivery Systems/methods ; Extracellular Vesicles/metabolism ; Humans ; Immunotherapy ; Neoplasms/drug therapy ; Nucleic Acids/metabolism ; Nucleic Acids/therapeutic use ; Phospholipids/metabolism ; Tumor Microenvironment
Chemical Substances	Nucleic Acids ; Phospholipids
Language	English
Publishing date	2022-09-06
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2022.120935
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Article: Autophagy stimulation delayed biological aging and decreased cardiac differentiation in rabbit mesenchymal stem cells.

Hassanpour, Mehdi / Cheraghi, Omid / Rahbarghazi, Reza / Nouri, Mohammad

Journal of cardiovascular and thoracic research

2021 Volume 13, Issue 3, Page(s) 234–240

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2021-08-25
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2654729-6
ISSN	2008-6830 ; 2008-5117
ISSN (online)	2008-6830
ISSN	2008-5117
DOI	10.34172/jcvtr.2021.43
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Article ; Online: CD34 positive cells as endothelial progenitor cells in biology and medicine

Mehdi Hassanpour / Amankeldi A. Salybekov / Shuzo Kobayashi / Takayuki Asahara

Frontiers in Cell and Developmental Biology, Vol

2023 Volume 11

Abstract	CD34 is a cell surface antigen expressed in numerous stem/progenitor cells including hematopoietic stem cells (HSCs) and endothelial progenitor cells (EPCs), which are known to be rich sources of EPCs. Therefore, regenerative therapy using CD34+ cells has attracted interest for application in patients with various vascular, ischemic, and inflammatory diseases. CD34+ cells have recently been reported to improve therapeutic angiogenesis in a variety of diseases. Mechanistically, CD34+ cells are involved in both direct incorporation into the expanding vasculature and paracrine activity through angiogenesis, anti-inflammatory, immunomodulatory, and anti-apoptosis/fibrosis roles, which support the developing microvasculature. Preclinical, pilot, and clinical trials have well documented a track record of safety, practicality, and validity of CD34+ cell therapy in various diseases. However, the clinical application of CD34+ cell therapy has triggered scientific debates and controversies in last decade. This review covers all preexisting scientific literature and prepares an overview of the comprehensive biology of CD34+ cells as well as the preclinical/clinical details of CD34+ cell therapy for regenerative medicine.
Keywords	CD34 positive cells ; endothelial progenitor cells ; vasculogenesis ; exosome ; regenerative medicine ; Biology (General) ; QH301-705.5
Subject code	610
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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