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Book: Occupational lung disorders

Mapp, C. E.

(European respiratory monograph ; 11)

1999

Author's details	ed. by C. E. Mapp
Series title	European respiratory monograph ; 11
Collection
Language	English
Size	355 S. : graph. Darst.
Publisher	European Respiratory Soc. Journals
Publishing place	Sheffield, UK
Publishing country	Great Britain
Document type	Book
HBZ-ID	HT010911697
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Legal Needs, Health, and Health Care Utilization Among Patients Participating in the Delaware Medical Legal Partnership.

Mapp, Alexandra M / Moore, Christopher / Booker, Erin / Santiago, Cindy / Baker, Dawn / Salvatore, Alicia L

Journal of public health management and practice : JPHMP

2022 Volume 28, Issue 6, Page(s) E815–E824

Abstract: ... iHELP legal domains are income and insurance (i), housing and utilities (H), education and employment (E ...

Abstract	Context: Unmet legal needs can exacerbate health disparities and contribute to a lack of adherence to treatment plans and medical recommendations for care. Medical legal partnerships (MLPs) are integrated health care and legal aid interventions offered by many health systems in the United States. Although much research has been published regarding the success of MLPs with specific patient groups, there is a gap in literature regarding the nature of MLPs in a more general, at-risk patient population. Objective: We aimed to better understand specific patient characteristics and health outcomes associated with different iHELP legal needs. Design: This is a cross-sectional study of patients who were enrolled in the Delaware MLP (DMLP) from November 2018 to June 2020 (N = 212). Setting: The DMLP is a collaboration between ChristianaCare, a Mid-Atlantic health system, and the Community Legal Aid Society, Inc (CLASI). Participants: Patients must be adults (ie, 18 years or older), below 200% of the federal poverty level (eg, ≤$53 000 for a household of 4 as of 2021), have at least one qualifying legal need, and live in the state. Intervention: The DMLP is designed to address unmet legal needs that fall under a framework called iHELP. iHELP legal domains are income and insurance (i), housing and utilities (H), education and employment (E), legal status (L), and personal and family stability (P). Main outcome measures: Outcomes of interest were iHELP legal needs, patient demographics, perceived stress and mental and physical health-related quality of life, comorbidities, and health care utilization. Results: Housing and utilities (46.2%) and income support (41.5%) were the highest reported legal needs. Perceived stress scores were significantly higher for those with income needs (P = .01) as well as those with housing and utilities needs (P = .01). Conclusions: MLP programs offer a value-added service that can address unmet legal needs in vulnerable, at-risk patients.
MeSH term(s)	Adult ; Cross-Sectional Studies ; Delaware ; Delivery of Health Care ; Humans ; Patient Acceptance of Health Care ; Quality of Life ; United States
Language	English
Publishing date	2022-08-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	2027860-3
ISSN	1550-5022 ; 1078-4659
ISSN (online)	1550-5022
ISSN	1078-4659
DOI	10.1097/PHH.0000000000001597
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Article ; Online: What is the role of genetics in occupational asthma?

Mapp, C E

The European respiratory journal

2009 Volume 33, Issue 3, Page(s) 459–460

MeSH term(s)	Asthma/genetics ; Environment ; Humans ; Immunoglobulin E/metabolism ; Inflammation ; Occupational Diseases/genetics ; Occupational Exposure ; Public Health
Chemical Substances	Immunoglobulin E (37341-29-0)
Language	English
Publishing date	2009-03
Publishing country	England
Document type	Editorial ; Research Support, Non-U.S. Gov't
ZDB-ID	639359-7
ISSN	1399-3003 ; 0903-1936
ISSN (online)	1399-3003
ISSN	0903-1936
DOI	10.1183/09031936.00183508
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Article ; Online: Garcinolic Acid Distinguishes Between GACKIX Domains and Modulates Interaction Networks.

Breen, Meghan E / Joy, Stephen T / Baruti, Omari J / Beyersdorf, Matthew S / Henley, Madeleine J / De Salle, Samantha N / Ycas, Peter D / Croskey, Ayza / Cierpicki, Tomasz / Pomerantz, William C K / Mapp, Anna K

Chembiochem : a European journal of chemical biology

2023 Volume 24, Issue 21, Page(s) e202300439

Abstract: Natural products are often uniquely suited to modulate protein-protein interactions (PPIs) due to their architectural and functional group complexity relative to synthetic molecules. Here we demonstrate that the natural product garcinolic acid ... ...

Abstract	Natural products are often uniquely suited to modulate protein-protein interactions (PPIs) due to their architectural and functional group complexity relative to synthetic molecules. Here we demonstrate that the natural product garcinolic acid allosterically blocks the CBP/p300 KIX PPI network and displays excellent selectivity over related GACKIX motifs. It does so via a strong interaction (K
MeSH term(s)	Protein Structure, Tertiary ; Protein Domains ; Binding Sites ; Protein Binding ; CREB-Binding Protein/chemistry
Chemical Substances	CREB-Binding Protein (EC 2.3.1.48)
Language	English
Publishing date	2023-09-07
Publishing country	Germany
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
ZDB-ID	2020469-3
ISSN	1439-7633 ; 1439-4227
ISSN (online)	1439-7633
ISSN	1439-4227
DOI	10.1002/cbic.202300439
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Article ; Online: Correction: HDAC7 is an actionable driver of therapeutic antibody resistance by macrophages from CLL patients.

Burgess, M / Chen, Y C E / Mapp, S / Blumenthal, A / Mollee, P / Gill, D / Saunders, N A

Oncogene

2020 Volume 40, Issue 6, Page(s) 1203

Language	English
Publishing date	2020-12-19
Publishing country	England
Document type	Published Erratum
ZDB-ID	639046-8
ISSN	1476-5594 ; 0950-9232
ISSN (online)	1476-5594
ISSN	0950-9232
DOI	10.1038/s41388-020-01619-y
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Article: Direct and Propagated Effects of Small Molecules on Protein-Protein Interaction Networks.

Cesa, Laura C / Mapp, Anna K / Gestwicki, Jason E

Frontiers in bioengineering and biotechnology

2015 Volume 3, Page(s) 119

Abstract: Networks of protein-protein interactions (PPIs) link all aspects of cellular biology. Dysfunction in the assembly or dynamics of PPI networks is a hallmark of human disease, and as such, there is growing interest in the discovery of small molecules that ... ...

Abstract	Networks of protein-protein interactions (PPIs) link all aspects of cellular biology. Dysfunction in the assembly or dynamics of PPI networks is a hallmark of human disease, and as such, there is growing interest in the discovery of small molecules that either promote or inhibit PPIs. PPIs were once considered undruggable because of their relatively large buried surface areas and difficult topologies. Despite these challenges, recent advances in chemical screening methodologies, combined with improvements in structural and computational biology have made some of these targets more tractable. In this review, we highlight developments that have opened the door to potent chemical modulators. We focus on how allostery is being used to produce surprisingly robust changes in PPIs, even for the most challenging targets. We also discuss how interfering with one PPI can propagate changes through the broader web of interactions. Through this analysis, it is becoming clear that a combination of direct and propagated effects on PPI networks is ultimately how small molecules re-shape biology.
Language	English
Publishing date	2015-08-24
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2719493-0
ISSN	2296-4185
ISSN	2296-4185
DOI	10.3389/fbioe.2015.00119
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Article ; Online: HDAC7 is an actionable driver of therapeutic antibody resistance by macrophages from CLL patients.

Burgess, M / Chen, Y C E / Mapp, S / Blumenthal, A / Mollee, P / Gill, D / Saunders, N A

Oncogene

2020 Volume 39, Issue 35, Page(s) 5756–5767

Abstract: ... E. coli within 30 min of treatment. The enhanced response is phenocopied by knockdown of the Class ...

Abstract	Resistance, to therapeutic antibodies used to treat chronic lymphocytic leukemia (CLL) patients is common. Monocyte-derived macrophages (MDMs) are a major effector of antitumour responses to therapeutic antibodies and we have previously reported that resistance to therapeutic antibodies, by MDMs, increases as CLL disease progresses. In this study, we examine the effect of a Class IIa-selective HDAC inhibitor (TMP195) on the phagocytic response to opsonised tumor cells or non-opsonised targets by MDMs derived from CLL patients. We report that TMP195 enhances phagocytic responses to antibody-opsonised CLL cells and E. coli within 30 min of treatment. The enhanced response is phenocopied by knockdown of the Class IIa HDAC, HDAC7, or by low concentrations of the pan-HDAC inhibitor, vorinostat. HDAC7 knockdown and inhibition induces hyperacetylation and hyperphosphorylation of Bruton's tyrosine kinase (BTK). Moreover, BTK inhibitors abrogated the enhanced response to HDAC7 inhibition. Our data show that HDAC7 is an actionable driver of resistance to therapeutic antibodies by MDMs derived from CLL patients.
MeSH term(s)	Drug Resistance, Neoplasm/drug effects ; Histone Deacetylases/metabolism ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy ; Macrophages/metabolism
Chemical Substances	HDAC7 protein, human (EC 3.5.1.98) ; Histone Deacetylases (EC 3.5.1.98)
Language	English
Publishing date	2020-07-24
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639046-8
ISSN	1476-5594 ; 0950-9232
ISSN (online)	1476-5594
ISSN	0950-9232
DOI	10.1038/s41388-020-01394-w
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Article: The role of genetic factors in occupational asthma.

Mapp, C E

The European respiratory journal

2003 Volume 22, Issue 1, Page(s) 173–178

Abstract: This article explores the influence of genetic factors on the development of sensitisation and occupational asthma (OA). First, several types of studies aimed at examining the role of genes, as well as the role of gene-environment interactions in asthma, ...

Abstract	This article explores the influence of genetic factors on the development of sensitisation and occupational asthma (OA). First, several types of studies aimed at examining the role of genes, as well as the role of gene-environment interactions in asthma, including the available data for OA specifically, were reviewed. Genetic approaches include linkage and allele-sharing analysis and segregation analysis. Secondly, deoxyribonucleic acid banking for epidemiological studies was focused upon, highlighting the factors to be considered in choosing the appropriate specimens for genotyping. OA, like asthma, is a multifactorial condition and, to date, no ideal genetic study has been described to examine complex gene-environment interactions. Most studies in OA have examined human leukocyte antigen-associated polymorphisms with some nonreproducible results. The search for genes in occupational asthma is still in progress, and much of the information obtained has been based on small sample sizes, using different strategies for the recruitment of subjects. The best methodological approach still needs to be determined and the results of genetic identification need to be confirmed in different samples.
MeSH term(s)	Animals ; Asthma/genetics ; Cytokines/physiology ; Genetic Linkage ; Genetic Predisposition to Disease ; Humans ; Occupational Diseases/genetics ; Oxidative Stress
Chemical Substances	Cytokines
Language	English
Publishing date	2003-06-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	639359-7
ISSN	1399-3003 ; 0903-1936
ISSN (online)	1399-3003
ISSN	0903-1936
DOI	10.1183/09031936.03.00011003
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Zs.MO 292: Show issues

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Article ; Online: Analysis of blood type for SARS-CoV-2 and correlation for disease acquisition in various sociodemographic groups including women of childbearing age.

Vacca, Maria L / Vyas, Nikunj / Banks, Joshua / Joyce, Elaine / Hou, Cindy / Leiby, Benjamin E / DeAngelo, Stefanie / Levin, Todd P / Shingler-Nace, Autum / Mapp, Marilyn / Hiester, Ashlee / Coughenour, Jonathan H

American journal of infection control

2022 Volume 50, Issue 6, Page(s) 598–601

Abstract: Background: Multiple studies have occurred to determine if a patient's blood type, Rhesus factor (Rh), and sociodemographic attributes contribute to contracting SARS-CoV-2. True association remains unknown.: Methods: Inclusion criteria included in- ... ...

Abstract	Background: Multiple studies have occurred to determine if a patient's blood type, Rhesus factor (Rh), and sociodemographic attributes contribute to contracting SARS-CoV-2. True association remains unknown. Methods: Inclusion criteria included in-patients who were tested for SARS-CoV-2 with blood type assessed. Study endpoints combined ABO, Rh and all-cause inpatient mortality (ACIM) with testing positivity. Pregnancy status was one of several secondary endpoints evaluated. A logistic regression analysis was used to estimate association. Results: Of the 27,662 patients who met inclusion criteria, Type A blood was associated with increased positivity [1.01 (1.0-1.21), P = .03]. Type B [1.10 (0.99-1.23), P = .08] and AB [0.98 (0.81-1.19), P = .84] showed no association. When evaluating ACIM, type A [1.18 (0.91-1.52), P = .22], B [1.13 (0.82- 1.56), P = .480], and AB [1.06 (0.62-1.81), P = .839] were not associated with increased mortality. The female subgroup was less likely to test positive [0.88 (0.82-0.986), P = .002]. Black patients demonstrated a higher likelihood of positivity when compared to White [1.96 (1.79-2.14), P < .001]. Non-pregnant women exhibited a 2.5 times greater likelihood of testing positive [2.49 (2.04-3.04), P < .001]. Conclusions: This study confirms results of previous research which showed SARS-Co-V-2 positivity related to blood type. It also confirms more recent research demonstrating inequities related to acquisition of SARS-CoV-2 for certain sociodemographic groups. Larger studies are warranted to confirm and further explore novel pregnancy findings.
MeSH term(s)	COVID-19/epidemiology ; Female ; Humans ; Pregnancy ; SARS-CoV-2
Language	English
Publishing date	2022-03-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	392362-9
ISSN	1527-3296 ; 0196-6553
ISSN (online)	1527-3296
ISSN	0196-6553
DOI	10.1016/j.ajic.2022.03.012
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Article ; Online: Peppermint Oil: Evaluating Efficacy on Nausea in Patients Receiving Chemotherapy in the Ambulatory Setting.

Mapp, Curlissa P / Hostetler, Darlene / Sable, Jill F / Parker, Catherine / Gouge, Elizabeth / Masterson, Margaret / Willis-Styles, Michelle / Fortner, Claudine / Higgins, Melinda

Clinical journal of oncology nursing

2020 Volume 24, Issue 2, Page(s) 160–164

Abstract: Background: Nausea is one of the most commonly reported side effects in patients receiving chemotherapy. Patients who experience nausea during chemotherapy may also experience depression, metabolic imbalances, dehydration, decreased ability to function, ...

Abstract	Background: Nausea is one of the most commonly reported side effects in patients receiving chemotherapy. Patients who experience nausea during chemotherapy may also experience depression, metabolic imbalances, dehydration, decreased ability to function, and treatment delays, which can ultimately affect outcomes. Objectives: This study aimed to determine the efficacy of a cool damp washcloth with peppermint essential oil versus a cool damp washcloth alone on the self-reported intensity of nausea in patients receiving chemotherapy in the outpatient ambulatory setting. Methods: 79 adult patients receiving chemotherapy were recruited from an outpatient ambulatory infusion center in the southeastern United States. Patients were separated into two groups (no scent and peppermint) and asked to rate the intensity of their chemotherapy-induced nausea at pre- and postintervention using the Baxter Retching Faces pictorial scale. Findings: The results demonstrated that the use of peppermint oil was effective in decreasing the intensity of nausea experienced by patients compared to a cool washcloth alone.
MeSH term(s)	Adult ; Aged ; Antiemetics ; Aromatherapy ; Female ; Humans ; Male ; Middle Aged ; Nausea/drug therapy ; Plant Oils/therapeutic use ; Southeastern United States
Chemical Substances	Antiemetics ; Plant Oils ; peppermint oil (AV092KU4JH)
Language	English
Publishing date	2020-03-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2014665-6
ISSN	1538-067X ; 1092-1095
ISSN (online)	1538-067X
ISSN	1092-1095
DOI	10.1188/20.CJON.160-164
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Zs.MO 390: Show issues

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