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  1. Book ; Online: Hormones and Neural Aging: Lessons From Experimental Models

    Varela-Nieto, Isabel / Chowen, Julie A. / Miguel García-Segura, Luis / Miguel García-Segura, Luis

    2019  

    Keywords Science: general issues ; Neurosciences ; apoptosis ; insulin-like factors ; neurodegeneration ; senescence ; sex hormones
    Size 1 electronic resource (153 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021229855
    ISBN 9782889457083 ; 2889457087
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Neuroprotection in Brain Hypoxia

    Otero-Losada, Matilde / Wandosell, Francisco G. / Miguel Garcia-Segura, Luis / Capani, Francisco

    2019  

    Keywords Science: general issues ; Neurosciences ; neuroprotection ; brain hypoxia ; pathophysioloy ; pharmacology ; genetics
    Size 1 electronic resource (114 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230319
    ISBN 9782889459544 ; 2889459543
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book: Hormones and brain plasticity

    Garcia-Segura, Luis Miguel

    (Oxford series in behavioral neuroendocrinology)

    2009  

    Author's details Luis Miguel Garcia-Segura
    Series title Oxford series in behavioral neuroendocrinology
    Keywords Brain / physiology ; Neuronal Plasticity / physiology ; Brain / growth & development ; Hormones / physiology
    Language English
    Size XIV, 482 S., [4] Bl. : Ill., graph. Darst.
    Publisher Oxford Univ. Press
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT015970419
    ISBN 978-0-19-532661-1 ; 0-19-532661-X
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2009 A 2764 order for loan Magazin

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  4. Article: Editorial: Sex differences in the brain.

    Garcia-Segura, Luis Miguel / DeFelipe, Javier

    Frontiers in neuroanatomy

    2022  Volume 16, Page(s) 1000121

    Language English
    Publishing date 2022-08-10
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2452969-2
    ISSN 1662-5129
    ISSN 1662-5129
    DOI 10.3389/fnana.2022.1000121
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Gonadal hormone deprivation regulates response to tibolone in neurodegenerative pathways.

    McGovern, Andrew J / Arevalo, Maria Angeles / Ciordia, Sergio / Garcia-Segura, Luis Miguel / Barreto, George E

    The Journal of steroid biochemistry and molecular biology

    2024  Volume 241, Page(s) 106520

    Abstract: Gonadal hormone deprivation (GHD) and decline such as menopause and bilateral oophorectomy are associated with an increased risk of neurodegeneration. Yet, hormone therapies (HTs) show varying efficacy, influenced by factors such as sex, drug type, and ... ...

    Abstract Gonadal hormone deprivation (GHD) and decline such as menopause and bilateral oophorectomy are associated with an increased risk of neurodegeneration. Yet, hormone therapies (HTs) show varying efficacy, influenced by factors such as sex, drug type, and timing of treatment relative to hormone decline. We hypothesize that the molecular environment of the brain undergoes a transition following GHD, impacting the effectiveness of HTs. Using a GHD model in mice treated with Tibolone, we conducted proteomic analysis and identified a reprogrammed response to Tibolone, a compound that stimulates estrogenic, progestogenic, and androgenic pathways. Through a comprehensive network pharmacological workflow, we identified a reprogrammed response to Tibolone, particularly within "Pathways of Neurodegeneration", as well as interconnected pathways including "cellular respiration", "carbon metabolism", and "cellular homeostasis". Analysis revealed 23 proteins whose Tibolone response depended on GHD and/or sex, implicating critical processes like oxidative phosphorylation and calcium signalling. Our findings suggest the therapeutic efficacy of HTs may depend on these variables, suggesting a need for greater precision medicine considerations whilst highlighting the need to uncover underlying mechanisms.
    Language English
    Publishing date 2024-04-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 1049188-0
    ISSN 1879-1220 ; 0960-0760
    ISSN (online) 1879-1220
    ISSN 0960-0760
    DOI 10.1016/j.jsbmb.2024.106520
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 708: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Interaction of gonadal hormones, dopaminergic system, and epigenetic regulation in the generation of sex differences in substance use disorders: A systematic review.

    Santos-Toscano, Raquel / Arevalo, Maria Angeles / Garcia-Segura, Luis Miguel / Grassi, Daniela / Lagunas, Natalia

    Frontiers in neuroendocrinology

    2023  Volume 71, Page(s) 101085

    Abstract: Substance use disorder (SUD) is a chronic condition characterized by pathological drug-taking and seeking behaviors. Remarkably different between males and females, suggesting that drug addiction is a sexually differentiated disorder. The neurobiological ...

    Abstract Substance use disorder (SUD) is a chronic condition characterized by pathological drug-taking and seeking behaviors. Remarkably different between males and females, suggesting that drug addiction is a sexually differentiated disorder. The neurobiological bases of sex differences in SUD include sex-specific reward system activation, influenced by interactions between gonadal hormone level changes, dopaminergic reward circuits, and epigenetic modifications of key reward system genes. This systematic review, adhering to PICOS and PRISMA-P 2015 guidelines, highlights the sex-dependent roles of estrogens, progesterone, and testosterone in SUD. In particular, estradiol elevates and progesterone reduces dopaminergic activity in SUD females, whilst testosterone and progesterone augment SUD behavior in males. Finally, SUD is associated with a sex-specific increase in the rate of opioid and monoaminergic gene methylation. The study reveals the need for detailed research on gonadal hormone levels, dopaminergic or reward system activity, and epigenetic landscapes in both sexes for efficient SUD therapy development.
    MeSH term(s) Female ; Humans ; Male ; Dopamine/physiology ; Epigenesis, Genetic ; Gonadal Steroid Hormones ; Meta-Analysis as Topic ; Progesterone ; Sex Characteristics ; Substance-Related Disorders/genetics ; Systematic Reviews as Topic ; Testosterone
    Chemical Substances Dopamine (VTD58H1Z2X) ; Gonadal Steroid Hormones ; Progesterone (4G7DS2Q64Y) ; Testosterone (3XMK78S47O)
    Language English
    Publishing date 2023-08-04
    Publishing country United States
    Document type Journal Article ; Review ; Systematic Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 390985-2
    ISSN 1095-6808 ; 0532-7466 ; 0091-3022
    ISSN (online) 1095-6808
    ISSN 0532-7466 ; 0091-3022
    DOI 10.1016/j.yfrne.2023.101085
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3423: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 443: Show issues

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  7. Article ; Online: Corrigendum to "Tibolone protects T98G cells from glucose deprivation" [J. Steroid Biochem. Mol. Biol. 144 (2014) 294-303].

    Rodriguez, Marco Ávila / Garcia-Segura, Luis Miguel / Cabezas, Ricardo / Torrente, Daniel / Capani, Francisco / Gonzalez, Janneth / Barreto, George

    The Journal of steroid biochemistry and molecular biology

    2023  Volume 232, Page(s) 106292

    Language English
    Publishing date 2023-03-23
    Publishing country England
    Document type Published Erratum
    ZDB-ID 1049188-0
    ISSN 1879-1220 ; 0960-0760
    ISSN (online) 1879-1220
    ISSN 0960-0760
    DOI 10.1016/j.jsbmb.2023.106292
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    Zs.A 708: Show issues Location:
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  8. Article ; Online: Respirasome Proteins Are Regulated by Sex-Hormone Interactions in the Brain.

    McGovern, Andrew J / Arevalo, Maria Angeles / Ciordia, Sergio / Garcia-Segura, Luis Miguel / Barreto, George E

    International journal of molecular sciences

    2022  Volume 23, Issue 23

    Abstract: The existence of sex differences in disease incidence is attributed, in part, to sex differences in metabolism. Uncovering the precise mechanism driving these differences is an extraordinarily complex process influenced by genetics, endogenous hormones, ... ...

    Abstract The existence of sex differences in disease incidence is attributed, in part, to sex differences in metabolism. Uncovering the precise mechanism driving these differences is an extraordinarily complex process influenced by genetics, endogenous hormones, sex-specific lifetime events, individual differences and external environmental/social factors. In fact, such differences may be subtle, but across a life span, increase susceptibility to a pathology. Whilst research persists in the hope of discovering an elegant biological mechanism to underpin sex differences in disease, here, we show, for the first time, that such a mechanism may be subtle in nature but influenced by multiple sex-specific factors. A proteomic dataset was generated from a gonadectomized mouse model treated with Tibolone, a menopausal hormone therapy. Following functional enrichment analysis, we identified that Alzheimer's disease and the electron transport chain-associated pathways were regulated by sex-hormone interactions. Specifically, we identified that the expression of three respirasome proteins, NDUFA2, NDUFA7 and UQCR10, is significantly altered by compounding factors that contribute to sex differences. These proteins function in bioenergetics and produce reactive oxygen species, which are each dysregulated in many diseases with sex differences in incidence. We show sex-specific reprogrammed responses to Tibolone following gonadectomy, which primarily influence the expression of proteins contributing to metabolic pathways. This further infers that metabolic differences may underpin the observed sex differences in disease, but also that hormone therapy research now has potential in exploring sex-specific interventions to produce an effective method of prevention or treatment.
    Language English
    Publishing date 2022-11-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms232314754
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Genetics and Epigenetics of the X and Y Chromosomes in the Sexual Differentiation of the Brain.

    Cabrera Zapata, Lucas E / Garcia-Segura, Luis Miguel / Cambiasso, María Julia / Arevalo, Maria Angeles

    International journal of molecular sciences

    2022  Volume 23, Issue 20

    Abstract: For many decades to date, neuroendocrinologists have delved into the key contribution of gonadal hormones to the generation of sex differences in the developing brain and the expression of sex-specific physiological and behavioral phenotypes in adulthood. ...

    Abstract For many decades to date, neuroendocrinologists have delved into the key contribution of gonadal hormones to the generation of sex differences in the developing brain and the expression of sex-specific physiological and behavioral phenotypes in adulthood. However, it was not until recent years that the role of sex chromosomes in the matter started to be seriously explored and unveiled beyond gonadal determination. Now we know that the divergent evolutionary process suffered by X and Y chromosomes has determined that they now encode mostly dissimilar genetic information and are subject to different epigenetic regulations, characteristics that together contribute to generate sex differences between XX and XY cells/individuals from the zygote throughout life. Here we will review and discuss relevant data showing how particular X- and Y-linked genes and epigenetic mechanisms controlling their expression and inheritance are involved, along with or independently of gonadal hormones, in the generation of sex differences in the brain.
    MeSH term(s) Female ; Male ; Animals ; Sex Differentiation/genetics ; Y Chromosome ; Sex Chromosomes/genetics ; Sex Chromosomes/metabolism ; Sex Characteristics ; Gonadal Hormones/metabolism ; Brain/metabolism ; Epigenesis, Genetic ; X Chromosome
    Chemical Substances Gonadal Hormones
    Language English
    Publishing date 2022-10-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms232012288
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Sex chromosome complement interacts with gonadal hormones in determining regional-specific neuroactive steroid levels in plasma, hippocampus, and hypothalamus. A study using the four core genotype mouse model.

    Cioffi, Lucia / Grassi, Daniela / Diviccaro, Silvia / Caruso, Donatella / Pinto-Benito, Daniel / Arevalo, Maria-Angeles / Garcia-Segura, Luis Miguel / Melcangi, Roberto Cosimo / Giatti, Silvia

    The Journal of steroid biochemistry and molecular biology

    2024  Volume 241, Page(s) 106514

    Abstract: An important aspect of the neuromodulatory and neuroprotective actions exerted by neuroactive steroids is that they are sex-specific, as determined by the sexually dimorphic levels of these molecules in plasma and the nervous tissue. Thus, the ... ...

    Abstract An important aspect of the neuromodulatory and neuroprotective actions exerted by neuroactive steroids is that they are sex-specific, as determined by the sexually dimorphic levels of these molecules in plasma and the nervous tissue. Thus, the identification of the factors that generate the sex-dimorphic levels of neuroactive steroids may be crucial from a neuroprotectant perspective. The main driver for sex determination in mammals is the SRY gene and the subsequent presence of a specific gonad: testes for males and ovaries for females, thus producing hormonal compounds, primarily androgens and estrogens, respectively. Nowadays, it is well established that despite the relevance of gonads, other factors control sexual features, and, among them, sex chromosome complement is highly relevant. In this study, neuroactive steroids were evaluated by liquid chromatography-tandem mass spectrometry in the hypothalamus, the hippocampus, and plasma of the four core genotype mouse model, to determine the relative contribution of sex chromosome complement and gonads in determining their sex dimorphic levels. The data obtained reveal that although gonads are the main contributing factor for sex differences in neuroactive steroid levels, the levels of some neuroactive steroids, including testosterone, are also influenced in brain and plasma by tissue-specific actions of sex chromosomes. The data presented here adds a new piece to the puzzle of steroid level regulation, which may be useful in designing sex-specific neuroprotective approaches to pathological conditions affecting the nervous system.
    Language English
    Publishing date 2024-03-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 1049188-0
    ISSN 1879-1220 ; 0960-0760
    ISSN (online) 1879-1220
    ISSN 0960-0760
    DOI 10.1016/j.jsbmb.2024.106514
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 708: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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