LIVIVO - Search results -

Search results

Result 1 - 10 of total 17

Search options

Article: Microbial Populations of Stony Meteorites: Substrate Controls on First Colonizers.

Tait, Alastair W / Gagen, Emma J / Wilson, Sasha A / Tomkins, Andrew G / Southam, Gordon

2017 Volume 8, Page(s) 1227

Abstract: Finding fresh, sterilized rocks provides ecologists with a clean slate to test ideas about first colonization and the evolution of ... ...

Abstract	Finding fresh, sterilized rocks provides ecologists with a clean slate to test ideas about first colonization and the evolution of soils
Language	English
Publishing date	2017-06-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2017.01227
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Nutrient recovery from water and wastewater

Colston, Robert / Tait, Stephan / Vaneeckhaute, Céline / Cruz, Heidy / Pikaar, Ilje / Seviour, Thomas / Klok, Johannes B.M. / Weijma, Jan / Dijkman, Henk / Buisman, Cees J.N. / Scattergood, Sasha / Robles-Aguilar, Ana A. / Meers, Erik / Béline, Fabrice / Soares, Ana

Resource Recovery from Water ; ISBN: 9781780409566

2022

Keywords	Life Science
Language	English
Publisher	IWA Publishing
Publishing country	nl
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Ammonia stress on a resilient mesophilic anaerobic inoculum: Methane production, microbial community, and putative metabolic pathways

Buhlmann, Christopher H / Bede S. Mickan / Parisa A. Bahri / Sasha N. Jenkins / Stephan Tait / Tharanga K.A. Kahandawala

Bioresource technology. 2019 Mar., v. 275

2019

Abstract: Short term inhibition tests, 16S rRNA tag sequencing and Phylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt), were employed to visualise the effects of increasing total ammoniacal nitrogen (TAN) concentration (3400– ... ...

Abstract	Short term inhibition tests, 16S rRNA tag sequencing and Phylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt), were employed to visualise the effects of increasing total ammoniacal nitrogen (TAN) concentration (3400–10166 ppm TAN) on microbial community structure and metabolic pathways for acetate degradation. The rate of methane production on acetate was significantly reduced by TAN concentrations above 6133 ppm; however, methane continued to be produced, even at 10166 ppm TAN (0.026 ± 0.0003 gCOD.gVS−1inoculum.day−1). Hydrogenotrophic methanogenesis with syntrophic acetate oxidation (SAO) was identified as the dominant pathway for methane production. A shift towards SAO pathways at higher TAN concentrations and a decrease in the number of ‘gene hits’ for key genes in specific methanogenesis pathways was observed. Overall, the results highlighted potential for inhibition activity testing to be used together with PICRUSt, to estimate changes in microbial metabolism and to better understand microbial resilience in industrial AD facilities.
Keywords	acetates ; ammonia ; ammonium nitrogen ; biochemical pathways ; community structure ; genes ; inoculum ; metabolism ; methane ; methane production ; microbial communities ; oxidation ; phylogeny ; ribosomal DNA ; ribosomal RNA
Language	English
Dates of publication	2019-03
Size	p. 70-77.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	1065195-0
ISSN	1873-2976 ; 0960-8524
ISSN (online)	1873-2976
ISSN	0960-8524
DOI	10.1016/j.biortech.2018.12.012
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 3258: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Ammonia stress on a resilient mesophilic anaerobic inoculum: Methane production, microbial community, and putative metabolic pathways.

Buhlmann, Christopher H / Mickan, Bede S / Jenkins, Sasha N / Tait, Stephan / Kahandawala, Tharanga K A / Bahri, Parisa A

Bioresource technology

2018 Volume 275, Page(s) 70–77

Abstract	Short term inhibition tests, 16S rRNA tag sequencing and Phylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt), were employed to visualise the effects of increasing total ammoniacal nitrogen (TAN) concentration (3400-10166 ppm TAN) on microbial community structure and metabolic pathways for acetate degradation. The rate of methane production on acetate was significantly reduced by TAN concentrations above 6133 ppm; however, methane continued to be produced, even at 10166 ppm TAN (0.026 ± 0.0003 gCOD.gVS
MeSH term(s)	Acetic Acid/metabolism ; Ammonia/metabolism ; Anaerobiosis ; Metabolic Networks and Pathways ; Methane/biosynthesis ; Microbiota ; Oxidation-Reduction ; Stress, Physiological
Chemical Substances	Ammonia (7664-41-7) ; Methane (OP0UW79H66) ; Acetic Acid (Q40Q9N063P)
Language	English
Publishing date	2018-12-07
Publishing country	England
Document type	Journal Article
ZDB-ID	1065195-0
ISSN	1873-2976 ; 0960-8524
ISSN (online)	1873-2976
ISSN	0960-8524
DOI	10.1016/j.biortech.2018.12.012
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Bonn / Germany

Z 3258: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Biochemical methane potential of dairy manure residues and separated fractions: An Australia-wide study of the impact of production and cleaning systems.

Grell, Torben / Harris, Peter W / Marchuk, Serhiy / Jenkins, Sasha / McCabe, Bernadette K / Tait, Stephan

Bioresource technology

2023 Volume 391, Issue Pt A, Page(s) 129903

Abstract: This study investigated biochemical methane potential ( ... ...

Abstract	This study investigated biochemical methane potential (B
MeSH term(s)	Manure ; Methane ; Anaerobiosis ; Australia ; Biofuels
Chemical Substances	Manure ; Methane (OP0UW79H66) ; Biofuels
Language	English
Publishing date	2023-10-24
Publishing country	England
Document type	Journal Article
ZDB-ID	1065195-0
ISSN	1873-2976 ; 0960-8524
ISSN (online)	1873-2976
ISSN	0960-8524
DOI	10.1016/j.biortech.2023.129903
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Bonn / Germany

Z 3258: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Designing a Child-, Family-, and Healthcare Provider-Centered Procedure Room in a Tertiary Care Children's Hospital.

Litwin, Sasha / Clarke, Lindsay / Copeland, Jocelyne / Tyrrell, Jennifer / Tait, Caleb / Mohabir, Vina / Campbell, Fiona

HERD

2023 Volume 16, Issue 3, Page(s) 195–209

Abstract: Aim: The study aim was to co-design new pediatric procedure room prototypes with children, caregivers, and healthcare providers (HCPs).: Background: Medical procedures can cause pain and anxiety for children and their families. If spaces are not ... ...

Abstract	Aim: The study aim was to co-design new pediatric procedure room prototypes with children, caregivers, and healthcare providers (HCPs). Background: Medical procedures can cause pain and anxiety for children and their families. If spaces are not designed for patients' needs, procedures may take longer, require sedation, and result in an inferior care experience. Involving HCPs in co-designing optimal spaces can result in more efficient and safer environments. co-designing spaces with patients and their families can inform psychologically safer and less traumatic environments. Methods: We followed human-centered design methodology. Data were collected via semi-structured interviews, field observations, and two multidisciplinary design workshops with patients, caregivers, and HCPs. Themes from the data were extracted using a content analysis and used to make evidence-informed recommendations for design features. Results: The study took place from October 2021 to February 2022. Patients, families, and HCPs reported similar needs: (1) control over the environment, including the ability to adjust lighting, temperature, and sound; (2) space that supports patient privacy; (3) the use of evidence-based pain reduction and distraction methods; (4) attention to the sensory environment, including visual (light, color), tactile (textures of furniture and equipment), auditory, and olfactory stimuli; (5) human factors organization of the space and equipment; (6) accessible and equitable spatial design; and (7) the significance of the journey leading up to and after the procedure. Conclusions: It is feasible to co-design procedure rooms that support evidence-based psychological, physical, and pharmacological interventions that are known to minimize pain for children.
MeSH term(s)	Humans ; Tertiary Healthcare ; Caregivers ; Anxiety ; Hospitals ; Pain ; Family
Language	English
Publishing date	2023-04-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2525547-2
ISSN	2167-5112 ; 1937-5867
ISSN (online)	2167-5112
ISSN	1937-5867
DOI	10.1177/19375867231161097
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: The role of glucocorticoids and progestins in inflammatory, autoimmune, and infectious disease.

Tait, A Sasha / Butts, Cherie L / Sternberg, Esther M

Journal of leukocyte biology

2008 Volume 84, Issue 4, Page(s) 924–931

Abstract: A bidirectional communication exists between the CNS and the immune system. The autonomic nervous system, through neurotransmitters and neuropeptides, works in parallel with the hypothalamic-pituitary-adrenal axis through the actions of glucocorticoids ... ...

Abstract	A bidirectional communication exists between the CNS and the immune system. The autonomic nervous system, through neurotransmitters and neuropeptides, works in parallel with the hypothalamic-pituitary-adrenal axis through the actions of glucocorticoids to modulate inflammatory events. The immune system, through the action of cytokines and other factors, in turn, activates the CNS to orchestrate negative-feedback mechanisms that keep the immune response in check. Disruption of these interactions has been associated with a number of syndromes including inflammatory, autoimmune, and cardiovascular diseases, metabolic and psychiatric disorders, and the development of shock. The hypothalamic-pituitary-gonadal axis also plays an important part in regulating immunity through the secretion of sex hormones. Although numerous studies have established a role for immunomodulation by estrogen and testosterone, the role of progesterone is less well understood. Progesterone is crucial for reproductive organ development and maintenance of pregnancy, and more recent studies have clearly shown its role as an important immune regulator. The main focus of this review will be about the role of steroid hormones, specifically glucocorticoids and progesterone, in inflammatory responses and infectious diseases and how dysregulation of their actions may contribute to development of autoimmune and inflammatory disease.
MeSH term(s)	Autoimmune Diseases/physiopathology ; Disease Progression ; Disease Susceptibility ; Glucocorticoids/immunology ; Glucocorticoids/physiology ; Humans ; Infections/immunology ; Infections/physiopathology ; Inflammation/immunology ; Inflammation/physiopathology ; Lupus Erythematosus, Systemic/immunology ; Lupus Erythematosus, Systemic/physiopathology ; Polymorphism, Genetic ; Progestins/immunology ; Progestins/physiology ; Receptors, Glucocorticoid/genetics ; Receptors, Glucocorticoid/immunology ; Receptors, Glucocorticoid/physiology
Chemical Substances	Glucocorticoids ; Progestins ; Receptors, Glucocorticoid
Language	English
Publishing date	2008-07-29
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	605722-6
ISSN	1938-3673 ; 0741-5400
ISSN (online)	1938-3673
ISSN	0741-5400
DOI	10.1189/jlb.0208104
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 603: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Cetuximab in Patients with Breast Cancer, Non-Small Cell Lung Cancer, and Ovarian Cancer Without KRAS, NRAS, or BRAF Mutations: Results from the Targeted Agent and Profiling Utilization Registry (TAPUR) Study.

Fisher, Julie G / Tait, David / Garrett-Mayer, Elizabeth / Halabi, Susan / Mangat, Pam K / Schink, Julian C / Alvarez, Ricardo H / Veljovich, Dan / Cannon, Timothy L / Crilley, Pamela A / Pollock, Theodore / Calfa, Carmen J / Al Baghdadi, Tareq / Thota, Ramya / Fleming, Nicole / Cotta, Jared A / Rygiel, Andrew L / Warren, Sasha L / Schilsky, Richard L

Targeted oncology

2020 Volume 15, Issue 6, Page(s) 733–741

Abstract: Background: The Targeted Agent and Profiling Utilization Registry (TAPUR) Study, a phase II basket study, evaluates anti-tumor activity of commercially available targeted agents in patients with advanced cancers harboring genomic alterations known as ... ...

Abstract	Background: The Targeted Agent and Profiling Utilization Registry (TAPUR) Study, a phase II basket study, evaluates anti-tumor activity of commercially available targeted agents in patients with advanced cancers harboring genomic alterations known as drug targets. Objective: With no known genomic targets predictive of sensitivity to cetuximab, cetuximab was evaluated in patients with breast cancer (BC), non-small cell lung cancer (NSCLC), and ovarian cancer (OC), without KRAS, NRAS, or BRAF mutations. Patients and methods: Eligible patients with advanced BC, NSCLC, and OC received a cetuximab loading dose, then weekly infusions (250 mg/m Results: Patients with BC (n = 10), NSCLC (n = 10), and OC (n = 29) were enrolled between June 2016 and September 2018. No objective responses or stable disease for at least 16 weeks were observed in the BC and NSCLC cohorts. No objective responses and four patients with stable disease for at least 16 weeks were observed in the OC cohort. Six of 49 patients reported grade 3 or higher adverse events or serious adverse events at least possibly related to cetuximab. Conclusions: Cetuximab does not have clinical activity in patients with advanced BC, NSCLC, and OC without KRAS, NRAS, or BRAF mutations. Clinical trial registration: NCT02693535 (26 February, 2016).
MeSH term(s)	Aged ; Antineoplastic Agents, Immunological/pharmacology ; Antineoplastic Agents, Immunological/therapeutic use ; Breast Neoplasms/drug therapy ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Ovarian Epithelial/drug therapy ; Cetuximab/pharmacology ; Cetuximab/therapeutic use ; Female ; Humans ; Lung Neoplasms/drug therapy ; Male ; Middle Aged ; Proto-Oncogene Proteins B-raf/genetics ; Registries
Chemical Substances	Antineoplastic Agents, Immunological ; Proto-Oncogene Proteins B-raf (EC 2.7.11.1) ; Cetuximab (PQX0D8J21J)
Language	English
Publishing date	2020-10-22
Publishing country	France
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2222136-0
ISSN	1776-260X ; 1776-2596
ISSN (online)	1776-260X
ISSN	1776-2596
DOI	10.1007/s11523-020-00753-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Details ▾
- Full text online
- Order with fees

Article: High-throughput clonal selection of recombinant CHO cells using a dominant selectable and amplifiable metallothionein-GFP fusion protein.

Bailey, Charles G / Tait, A Sasha / Sunstrom, Noelle-Ann

Biotechnology and bioengineering

2002 Volume 80, Issue 6, Page(s) 670–676

Abstract: Transfected mammalian cells can be used for the production of fully processed recombinant proteins for medical and industrial purposes. However, the isolation of high-producing clones is traditionally time-consuming. Therefore, we developed a high- ... ...

Abstract	Transfected mammalian cells can be used for the production of fully processed recombinant proteins for medical and industrial purposes. However, the isolation of high-producing clones is traditionally time-consuming. Therefore, we developed a high-throughput screening method to reduce the time and effort required to isolate high-producing cells. This involved the construction of an expression vector containing the amplifiable gene metallothionein (MT), fused in-frame to green fluorescent protein (GFP). The fusion gene (MTGFP) confers metal resistance similar to that of the wild-type metallothionein and expression can be monitored using either flow cytometry or a fluorometer to measure green fluorescence. Expression of MTGFP acted as a dominant selectable marker allowing rapid and more efficient selection of clones at defined metal concentrations than with the antibiotic G418. Cells harboring MTGFP responded to increasing metal concentrations with a corresponding increase in fluorescence. There was also a corresponding increase in recombinant protein production, indicating that MTGFP could be used as a selectable and amplifiable gene for the coexpression of foreign genes. Using our expression vector encoding MTGFP, we demonstrate a high-throughput clonal selection protocol for the rapid isolation of high-producing clones from transfected CHO cells. We were able to isolate cell lines reaching specific productivities of >10 microg hGH/10(6) cells/day within 4 weeks of transfection. The advantage of this method is that it can be easily adapted for automated procedures using robotic handling systems.
MeSH term(s)	Animals ; CHO Cells/physiology ; Cloning, Molecular/methods ; Cricetinae ; Gene Expression Regulation ; Genes, Dominant ; Green Fluorescent Proteins ; Luminescent Proteins ; Metallothionein/analysis ; Metallothionein/genetics ; Nucleic Acid Amplification Techniques/methods ; Quality Control ; Recombinant Fusion Proteins/biosynthesis ; Recombinant Fusion Proteins/metabolism ; Selection, Genetic ; Sensitivity and Specificity ; Species Specificity ; Statistics as Topic ; Transfection/methods
Chemical Substances	Luminescent Proteins ; Recombinant Fusion Proteins ; Green Fluorescent Proteins (147336-22-9) ; Metallothionein (9038-94-2)
Language	English
Publishing date	2002-12-20
Publishing country	United States
Document type	Comparative Study ; Evaluation Studies ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	280318-5
ISSN	1097-0290 ; 0006-3592
ISSN (online)	1097-0290
ISSN	0006-3592
DOI	10.1002/bit.10424
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.B 960: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: Reversible inactivation of HIF-1 prolyl hydroxylases allows cell metabolism to control basal HIF-1.

Lu, Huasheng / Dalgard, Clifton L / Mohyeldin, Ahmed / McFate, Thomas / Tait, A Sasha / Verma, Ajay

The Journal of biological chemistry

2005 Volume 280, Issue 51, Page(s) 41928–41939

Abstract: Continuous hydroxylation of the HIF-1 transcription factor alpha subunit by oxygen and 2-oxoglutarate-dependent dioxygenases promotes decay of this protein and thus prevents the transcriptional activation of many genes involved in energy metabolism, ... ...

Abstract	Continuous hydroxylation of the HIF-1 transcription factor alpha subunit by oxygen and 2-oxoglutarate-dependent dioxygenases promotes decay of this protein and thus prevents the transcriptional activation of many genes involved in energy metabolism, angiogenesis, cell survival, and matrix modification. Hypoxia blocks HIF-1alpha hydroxylation and thus activates HIF-1alpha-mediated gene expression. Several nonhypoxic stimuli can also activate HIF-1, although the mechanisms involved are not well known. Here we show that the glucose metabolites pyruvate and oxaloacetate inactivate HIF-1alpha decay in a manner selectively reversible by ascorbate, cysteine, histidine, and ferrous iron but not by 2-oxoglutarate or oxygen. Pyruvate and oxaloacetate bind to the 2-oxoglutarate site of HIF-1alpha prolyl hydroxylases, but their effects on HIF-1 are not mimicked by other Krebs cycle intermediates, including succinate and fumarate. We show that inactivation of HIF-1 hydroxylation by glucose-derived 2-oxoacids underlies the prominent basal HIF-1 activity commonly seen in many highly glycolytic cancer cells. Since HIF-1 itself promotes glycolytic metabolism, enhancement of HIF-1 by glucose metabolites may constitute a novel feed-forward signaling mechanism involved in malignant progression.
MeSH term(s)	Ascorbic Acid/pharmacology ; Base Sequence ; Cell Line ; Cysteine/pharmacology ; DNA Primers ; Glutathione/pharmacology ; Glycolysis ; Histidine/pharmacology ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/antagonists & inhibitors ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Oxaloacetic Acid/pharmacology ; Procollagen-Proline Dioxygenase/antagonists & inhibitors ; Procollagen-Proline Dioxygenase/metabolism ; Pyruvic Acid/pharmacology
Chemical Substances	DNA Primers ; HIF1A protein, human ; Hypoxia-Inducible Factor 1, alpha Subunit ; Oxaloacetic Acid (2F399MM81J) ; Histidine (4QD397987E) ; Pyruvic Acid (8558G7RUTR) ; Procollagen-Proline Dioxygenase (EC 1.14.11.2) ; Glutathione (GAN16C9B8O) ; Cysteine (K848JZ4886) ; Ascorbic Acid (PQ6CK8PD0R)
Language	English
Publishing date	2005-10-13
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1074/jbc.M508718200
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uc I Zs.108: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito