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  1. Article ; Online: Time to Introduce Nerve Density in Cancer Histopathologic Assessment.

    Hondermarck, Hubert / Jiang, Chen Chen

    Clinical cancer research : an official journal of the American Association for Cancer Research

    2023  Volume 29, Issue 13, Page(s) 2342–2344

    Abstract: The density of nerves in the tumor microenvironment is increasingly reported to be associated with worse clinical outcome in various cancers. Therefore, it is time to consider the assessment of nerve density in clinical cancer pathology, and ... ...

    Abstract The density of nerves in the tumor microenvironment is increasingly reported to be associated with worse clinical outcome in various cancers. Therefore, it is time to consider the assessment of nerve density in clinical cancer pathology, and interestingly, the development of artificial intelligence may facilitate this clinical translation. See related article by Perez-Pacheco et al., p. 2501.
    MeSH term(s) Humans ; Artificial Intelligence ; Mouth Neoplasms ; Nerve Tissue ; Tumor Microenvironment/physiology
    Language English
    Publishing date 2023-05-30
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1225457-5
    ISSN 1557-3265 ; 1078-0432
    ISSN (online) 1557-3265
    ISSN 1078-0432
    DOI 10.1158/1078-0432.CCR-23-0736
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book: Proteomics: biomedical and pharmaceutical applications

    Hondermarck, Hubert

    2004  

    Title variant Proteomics
    Author's details ed. by Hubert Hondermarck
    Language English
    Size XII, 396 S. : Ill., graph. Darst.
    Publisher Kluwer
    Publishing place Dordrecht u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT014115913
    ISBN 1-4020-2322-7 ; 978-1-4020-2322-4
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2004 A 4247 order for loan Magazin

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  3. Article ; Online: Cancer Omics: Adding Understanding to Knowledge.

    Hondermarck, Hubert

    Proteomics

    2019  Volume 19, Issue 21-22, Page(s) e1800393

    MeSH term(s) Genomics/methods ; Humans ; Metabolomics/methods ; Neoplasms/genetics ; Neoplasms/metabolism ; Neoplasms/therapy ; Proteomics/methods
    Language English
    Publishing date 2019-10-06
    Publishing country Germany
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2032093-0
    ISSN 1615-9861 ; 1615-9853
    ISSN (online) 1615-9861
    ISSN 1615-9853
    DOI 10.1002/pmic.201800393
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The neural addiction of cancer.

    Magnon, Claire / Hondermarck, Hubert

    Nature reviews. Cancer

    2023  Volume 23, Issue 5, Page(s) 317–334

    Abstract: The recently uncovered key role of the peripheral and central nervous systems in controlling tumorigenesis and metastasis has opened a new area of research to identify innovative approaches against cancer. Although the 'neural addiction' of cancer is ... ...

    Abstract The recently uncovered key role of the peripheral and central nervous systems in controlling tumorigenesis and metastasis has opened a new area of research to identify innovative approaches against cancer. Although the 'neural addiction' of cancer is only partially understood, in this Perspective we discuss the current knowledge and perspectives on peripheral and central nerve circuitries and brain areas that can support tumorigenesis and metastasis and the possible reciprocal influence that the brain and peripheral tumours exert on one another. Tumours can build up local autonomic and sensory nerve networks and are able to develop a long-distance relationship with the brain through circulating adipokines, inflammatory cytokines, neurotrophic factors or afferent nerve inputs, to promote cancer initiation, growth and dissemination. In turn, the central nervous system can affect tumour development and metastasis through the activation or dysregulation of specific central neural areas or circuits, as well as neuroendocrine, neuroimmune or neurovascular systems. Studying neural circuitries in the brain and tumours, as well as understanding how the brain communicates with the tumour or how intratumour nerves interplay with the tumour microenvironment, can reveal unrecognized mechanisms that promote cancer development and progression and open up opportunities for the development of novel therapeutic strategies. Targeting the dysregulated peripheral and central nervous systems might represent a novel strategy for next-generation cancer treatment that could, in part, be achieved through the repurposing of neuropsychiatric drugs in oncology.
    MeSH term(s) Humans ; Neoplasms ; Brain/metabolism ; Cytokines/metabolism ; Carcinogenesis ; Tumor Microenvironment
    Chemical Substances Cytokines
    Language English
    Publishing date 2023-04-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2062767-1
    ISSN 1474-1768 ; 1474-175X
    ISSN (online) 1474-1768
    ISSN 1474-175X
    DOI 10.1038/s41568-023-00556-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Nerves and availability of mesodermal cells are essential for the function of the segment addition zone (SAZ) during segment regeneration in polychaete annelids.

    Boilly, Benoni / Hondermarck, Hubert / Aguado, M Teresa

    Development genes and evolution

    2024  

    Abstract: Most of annelids grow all over their asexual life through the continuous addition of segments from a special zone called "segment addition zone" (SAZ) adjacent to the posterior extremity called pygidium. Amputation of posterior segments leads to ... ...

    Abstract Most of annelids grow all over their asexual life through the continuous addition of segments from a special zone called "segment addition zone" (SAZ) adjacent to the posterior extremity called pygidium. Amputation of posterior segments leads to regeneration (posterior regeneration-PR) of the pygidium and a new SAZ, as well as new segments issued from this new SAZ. Amputation of anterior segments leads some species to regeneration (anterior regeneration-AR) of the prostomium and a SAZ which produces new segments postero-anteriorly as during PR. During the 1960s and 1970s decades, experimental methods on different species (Syllidae, Nereidae, Aricidae) showed that the function of SAZ depends on the presence and number of mesodermal regeneration cells. Selective destruction of mesodermal regeneration cells in AR had no effect on the regeneration of the prostomium, but as for PR, it inhibited segment regeneration. Thus, worms deprived of mesodermal regeneration cells are always able to regenerate the pygidium or the prostomium, but they are unable to regenerate segments, a result which indicates that the SAZ functions only if these regeneration cells are present during PR or AR. Additionally, during AR, nerve fibres regenerate from the cut nerve cord toward the newformed brain, a situation which deprives the SAZ of local regenerating nerve fibres and their secreted growth factors. In contrast, during PR, nerve fibres regenerate both during the entire regeneration phase and then in normal growth. This review summarizes the experimental evidence for mesoderm cell involvement in segment regeneration, and the differential impact of the digestive tube and the regenerated nerve cord during PR vs AR.
    Language English
    Publishing date 2024-02-10
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1327962-2
    ISSN 1432-041X ; 0949-944X
    ISSN (online) 1432-041X
    ISSN 0949-944X
    DOI 10.1007/s00427-024-00713-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Proteogenomics Gets onto the Regulation of mRNA Decoding and Translation into Protein.

    Hondermarck, Hubert

    Proteomics

    2017  Volume 17, Issue 21

    Abstract: Proteogenomics, the integrative analysis of the proteome and the genome, increasingly provides protein-level insights about the regulation of gene expression and protein translation. Armengaud et al. (Proteomics 2017, 17, 1700211) nicely illustrate this ... ...

    Abstract Proteogenomics, the integrative analysis of the proteome and the genome, increasingly provides protein-level insights about the regulation of gene expression and protein translation. Armengaud et al. (Proteomics 2017, 17, 1700211) nicely illustrate this trend with the first in-depth proteomic analysis of the eukaryotic and unicellular intestinal parasite Blastocystis sp. Not only this work constitutes an important milestone toward the proteogenomics profile of this human pathogen, but also it demonstrates at the protein level the occurrence of a specific mechanism of mRNA decoding. GU-rich motifs located downstream of mRNA polyadenylation sites create termination codons that ultimately result in the synthesis of proteins with lower molecular weight than predicted from gene sequence. Thus, the scope of proteogenomics now extends to the regulation of mRNA translation into proteins, providing a proof of concept for future studies in multicellular eukaryotes such as humans and plants.
    Language English
    Publishing date 2017-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2032093-0
    ISSN 1615-9861 ; 1615-9853
    ISSN (online) 1615-9861
    ISSN 1615-9853
    DOI 10.1002/pmic.201700315
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Neural regulation of body polarities in nereid worm regeneration.

    Boilly, Benoni / Hondermarck, Hubert / Boilly-Marer, Yolande

    FASEB bioAdvances

    2022  Volume 4, Issue 1, Page(s) 22–28

    Abstract: Nerve dependence in regeneration has been established more than 200 years ago but the mechanisms by which nerves are necessary to regeneration remain to be fully elucidated. Aside from their direct impact in stimulating cellular growth, nerves also have ... ...

    Abstract Nerve dependence in regeneration has been established more than 200 years ago but the mechanisms by which nerves are necessary to regeneration remain to be fully elucidated. Aside from their direct impact in stimulating cellular growth, nerves also have a role on the establishment of body polarities (antero-posterior and dorso-ventral patterns) and this has been particularly well studied in nereid annelid worms. Nereids can regenerate appendages (parapodia) and the tail (body segments). In both parapodia and tail regeneration, the presence of the nerve cord is necessary to the establishment of body polarities. In this review, we will detail the experimental procedures which have been conducted in nereids to elucidate the role of the nerve cord in the establishment of the antero-posterior and dorso-ventral polarities. Most of the studies reported here were published several decades ago and based on anatomical and histological analyses; this review should constitute a knowledgebase and an inspiration for needed modern-time explorations at the molecular levels to elucidate the impact of the nervous system in the acquisition of body polarities.
    Language English
    Publishing date 2022-01-04
    Publishing country United States
    Document type Journal Article
    ISSN 2573-9832
    ISSN (online) 2573-9832
    DOI 10.1096/fba.2021-00116
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The nervous system: Orchestra conductor in cancer, regeneration, inflammation and immunity.

    Hondermarck, Hubert / Huang, Pearl S / Wagner, John A

    FASEB bioAdvances

    2021  Volume 3, Issue 11, Page(s) 944–952

    Abstract: Although the role of nerves in stimulating cellular growth and dissemination has long been described in tissue regeneration studies, until recently a similar trophic role of nerves in disease was not well recognized. However, recent studies in oncology ... ...

    Abstract Although the role of nerves in stimulating cellular growth and dissemination has long been described in tissue regeneration studies, until recently a similar trophic role of nerves in disease was not well recognized. However, recent studies in oncology have demonstrated that the growth and dissemination of cancers also requires the infiltration of nerves in the tumor microenvironment. Nerves generate various neurosignaling pathways, which orchestrate cancer initiation, progression, and metastases. Similarly, nerves are increasingly implicated for their regulatory functions in immunity and inflammation. This orchestrator role of nerves in cellular and molecular interactions during regeneration, cancer, immunity, and inflammation offers new possibilities for targeting or enhancing neurosignaling in human health and diseases.
    Language English
    Publishing date 2021-08-27
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2573-9832
    ISSN (online) 2573-9832
    DOI 10.1096/fba.2021-00080
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Neural regulation of body polarities in nereid worm regeneration

    Benoni Boilly / Hubert Hondermarck / Yolande Boilly‐Marer

    FASEB BioAdvances, Vol 4, Iss 1, Pp 22-

    2022  Volume 28

    Abstract: Abstract Nerve dependence in regeneration has been established more than 200 years ago but the mechanisms by which nerves are necessary to regeneration remain to be fully elucidated. Aside from their direct impact in stimulating cellular growth, nerves ... ...

    Abstract Abstract Nerve dependence in regeneration has been established more than 200 years ago but the mechanisms by which nerves are necessary to regeneration remain to be fully elucidated. Aside from their direct impact in stimulating cellular growth, nerves also have a role on the establishment of body polarities (antero‐posterior and dorso‐ventral patterns) and this has been particularly well studied in nereid annelid worms. Nereids can regenerate appendages (parapodia) and the tail (body segments). In both parapodia and tail regeneration, the presence of the nerve cord is necessary to the establishment of body polarities. In this review, we will detail the experimental procedures which have been conducted in nereids to elucidate the role of the nerve cord in the establishment of the antero‐posterior and dorso‐ventral polarities. Most of the studies reported here were published several decades ago and based on anatomical and histological analyses; this review should constitute a knowledgebase and an inspiration for needed modern‐time explorations at the molecular levels to elucidate the impact of the nervous system in the acquisition of body polarities.
    Keywords annelids ; body polarity ; nerve ; positional information ; regeneration ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  10. Article ; Online: Neurotrophins and their receptors in breast cancer.

    Hondermarck, Hubert

    Cytokine & growth factor reviews

    2012  Volume 23, Issue 6, Page(s) 357–365

    Abstract: Growth factors of the neurotrophin family and their receptors have been mainly studied in the nervous system, but they are also expressed in carcinomas, and in breast cancer they significantly impact tumor cell growth and metastasis through various ... ...

    Abstract Growth factors of the neurotrophin family and their receptors have been mainly studied in the nervous system, but they are also expressed in carcinomas, and in breast cancer they significantly impact tumor cell growth and metastasis through various signaling pathways. Nerve growth factor and its precursor proNGF, brain-derived neurotrophic factor and neurotrophin-4/5 stimulate breast cancer cells through an autocrine loop involving the tyrosine kinase receptors TrkA, TrkB as well as its truncated form TrkB.T1 and the p75(NTR) death receptor. Preclinical studies have shown that targeting neurotrophins and their receptors induce an inhibition of breast cancer cell survival, proliferation and invasion. Furthermore, targeting neurotrophins may also decrease tumor-induced cancer pain and this additional effect further strengthens their clinical relevance.
    MeSH term(s) Breast Neoplasms/metabolism ; Female ; Humans ; Nerve Growth Factors/metabolism ; Receptors, Nerve Growth Factor/metabolism
    Chemical Substances Nerve Growth Factors ; Receptors, Nerve Growth Factor
    Language English
    Publishing date 2012-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1330534-7
    ISSN 1879-0305 ; 1359-6101
    ISSN (online) 1879-0305
    ISSN 1359-6101
    DOI 10.1016/j.cytogfr.2012.06.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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