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  1. Article ; Online: New regulators of systemic iron homeostasis.

    Ganz, Tomas

    Signal transduction and targeted therapy

    2021  Volume 6, Issue 1, Page(s) 280

    MeSH term(s) Homeostasis ; Iron
    Chemical Substances Iron (E1UOL152H7)
    Language English
    Publishing date 2021-07-21
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2886872-9
    ISSN 2059-3635 ; 2095-9907
    ISSN (online) 2059-3635
    ISSN 2095-9907
    DOI 10.1038/s41392-021-00696-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: New regulators of systemic iron homeostasis

    Tomas Ganz

    Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-

    2021  Volume 2

    Keywords Medicine ; R ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2021-07-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Drugging erythroferrone to treat anemias.

    Ganz, Tomas

    Blood

    2020  Volume 135, Issue 8, Page(s) 516–518

    MeSH term(s) Animals ; Hepcidins ; Mice ; Thalassemia
    Chemical Substances Hepcidins
    Language English
    Publishing date 2020-11-30
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2019004678
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.140: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 364: Show issues

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  4. Article ; Online: The role of hepcidin in fetal iron homeostasis.

    Ganz, Tomas

    Blood

    2020  Volume 136, Issue 13, Page(s) 1474–1475

    MeSH term(s) Female ; Ferritins ; Hepcidins/metabolism ; Homeostasis ; Humans ; Iron/metabolism ; Liver/metabolism ; Pregnancy
    Chemical Substances Hepcidins ; Ferritins (9007-73-2) ; Iron (E1UOL152H7)
    Language English
    Publishing date 2020-09-24
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2020007382
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.140: Show issues Location:
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  5. Article ; Online: Pathogenic Mechanisms in Thalassemia II: Iron Overload.

    Ganz, Tomas / Nemeth, Elizabeta

    Hematology/oncology clinics of North America

    2023  Volume 37, Issue 2, Page(s) 353–363

    Abstract: Iron overload remains a lethal complication of β-thalassemia and other anemias caused by ineffective erythropoiesis. This review discusses the pathogenetic mechanisms of iron overload in thalassemia, at organismal, cellular, and molecular levels. ...

    Abstract Iron overload remains a lethal complication of β-thalassemia and other anemias caused by ineffective erythropoiesis. This review discusses the pathogenetic mechanisms of iron overload in thalassemia, at organismal, cellular, and molecular levels.
    MeSH term(s) Humans ; Hepcidins ; Erythropoiesis ; Thalassemia/complications ; Iron Overload/etiology ; beta-Thalassemia
    Chemical Substances Hepcidins
    Language English
    Publishing date 2023-03-11
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 93115-9
    ISSN 1558-1977 ; 0889-8588
    ISSN (online) 1558-1977
    ISSN 0889-8588
    DOI 10.1016/j.hoc.2022.12.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Se 1077: Show issues Location:
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  6. Article ; Online: Hypoferremia of inflammation: Innate host defense against infections.

    Ganz, Tomas / Nemeth, Elizabeta

    Blood cells, molecules & diseases

    2023  Volume 104, Page(s) 102777

    Abstract: Iron is an essential nutrient for microbes, plants and animals. Multicellular organisms have evolved multiple strategies to control invading microbes by restricting microbial access to iron. Hypoferremia of inflammation is a rapidly-acting organismal ... ...

    Abstract Iron is an essential nutrient for microbes, plants and animals. Multicellular organisms have evolved multiple strategies to control invading microbes by restricting microbial access to iron. Hypoferremia of inflammation is a rapidly-acting organismal response that prevents the formation of iron species that would be readily accessible to microbes. This review takes an evolutionary perspective to explore the mechanisms and host defense function of hypoferremia of inflammation and its clinical implications.
    MeSH term(s) Animals ; Hepcidins ; Inflammation ; Iron
    Chemical Substances Hepcidins ; Iron (E1UOL152H7)
    Language English
    Publishing date 2023-06-21
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1237083-6
    ISSN 1096-0961 ; 1079-9796
    ISSN (online) 1096-0961
    ISSN 1079-9796
    DOI 10.1016/j.bcmd.2023.102777
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1138: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  7. Article ; Online: Exploring the relationship between hyperlactatemia and anemia.

    Zhang, Shuping / Liu, Wei / Ganz, Tomas / Liu, Sijin

    Trends in endocrinology and metabolism: TEM

    2024  Volume 35, Issue 4, Page(s) 300–307

    Abstract: Hyperlactatemia and anemia commonly coexist and their crosstalk is a longstanding mystery with elusive mechanisms involved in physical activities, infections, cancers, and genetic disorders. For instance, hyperlactatemia leads to iron restriction by ... ...

    Abstract Hyperlactatemia and anemia commonly coexist and their crosstalk is a longstanding mystery with elusive mechanisms involved in physical activities, infections, cancers, and genetic disorders. For instance, hyperlactatemia leads to iron restriction by upregulating hepatic hepcidin expression. Increasing evidence also points to lactate as a crucial signaling molecule rather than merely a metabolic byproduct. Here, we discuss the mutual influence between anemia and hyperlactatemia. This opinion calls for a reconsideration of the multifaceted roles of lactate and lactylation in anemia and emphasizes the need to fill knowledge gaps, including the dose dependence of lactate's effects, its sources, and its subcellular localization.
    MeSH term(s) Humans ; Hyperlactatemia ; Acidosis, Lactic ; Lactic Acid ; Anemia
    Chemical Substances Lactic Acid (33X04XA5AT)
    Language English
    Publishing date 2024-01-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1042384-9
    ISSN 1879-3061 ; 1043-2760
    ISSN (online) 1879-3061
    ISSN 1043-2760
    DOI 10.1016/j.tem.2023.12.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2999: Show issues Location:
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  8. Article ; Online: Anemia of Inflammation.

    Ganz, Tomas

    The New England journal of medicine

    2019  Volume 381, Issue 12, Page(s) 1148–1157

    MeSH term(s) Anemia/diagnosis ; Anemia/etiology ; Biomarkers/blood ; Hemoglobins/analysis ; Humans ; Inflammation/complications ; Inflammation/metabolism ; Iron/metabolism
    Chemical Substances Biomarkers ; Hemoglobins ; Iron (E1UOL152H7)
    Language English
    Publishing date 2019-09-18
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMra1804281
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The Discovery of the Iron-Regulatory Hormone Hepcidin.

    Ganz, Tomas

    Clinical chemistry

    2019  Volume 65, Issue 10, Page(s) 1330–1331

    MeSH term(s) Animals ; Hepcidins/genetics ; Hepcidins/metabolism ; Humans ; Iron/blood ; Iron/metabolism ; Iron Metabolism Disorders/genetics ; Iron Metabolism Disorders/metabolism ; Mice, Knockout ; Upstream Stimulatory Factors/genetics
    Chemical Substances HAMP protein, human ; Hepcidins ; Upstream Stimulatory Factors ; Usf2 protein, mouse ; Iron (E1UOL152H7)
    Language English
    Publishing date 2019-06-24
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80102-1
    ISSN 1530-8561 ; 0009-9147
    ISSN (online) 1530-8561
    ISSN 0009-9147
    DOI 10.1373/clinchem.2019.306407
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ud II Zs.171: Show issues Location:
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  10. Article ; Online: Erythrocytes and erythroblasts give up iron.

    Ganz, Tomas

    Blood

    2018  Volume 132, Issue 19, Page(s) 2004–2005

    MeSH term(s) Anemia, Iron-Deficiency ; Cation Transport Proteins ; Erythroblasts ; Erythrocytes ; Hemolysis ; Humans ; Iron ; Oxidative Stress
    Chemical Substances Cation Transport Proteins ; metal transporting protein 1 ; Iron (E1UOL152H7)
    Language English
    Publishing date 2018-11-07
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2018-09-876102
    Database MEDical Literature Analysis and Retrieval System OnLINE

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