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Article: Editorial: Epigenetic and Transcriptional Dysregulations in Cancer and Therapeutic Opportunities.

Ansari, Rais A / Abbas, Ata

2022 Volume 13, Page(s) 857380

Language	English
Publishing date	2022-02-22
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2022.857380
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Features of biochemical changes in patients with localized scleroderмa

Mohamed Abbas Ata

ScienceRise: Medical Science, Vol 0, Iss 1 (28), Pp 20-

2019 Volume 24

Abstract: The aim of the study was to determine the characteristics of biochemical changes in localized scleroderma based on the analysis and evaluation of dysmetabolic disorders of homeostasis from the standpoint of the individual characteristics of patients. ... ...

Abstract	The aim of the study was to determine the characteristics of biochemical changes in localized scleroderma based on the analysis and evaluation of dysmetabolic disorders of homeostasis from the standpoint of the individual characteristics of patients. Materials and methods. Under our supervision there were 107 patients with localized scleroderma in the acute stage who were hospitalized in the Department of Dermatology of the State Institution “Institute of Dermatology and Venereology of the National Academy of Medical Sciences of Ukraine” from 2014 to 2018. All patients were randomly assigned to 3 groups comparable in all parameters — the main group and two comparison groups. The main group consisted of 33 (34.01 %) localized scleroderma patients who received complex treatment; in the І group - 34 (35.05 %) patients who received only traditional therapy; in group II - 30 (30.92 %) patients who received treatment according to the scheme, which included traditional therapy with the addition of thiotriazoline. The study of the concentration of C-reactive protein (CRP) was performed by quantitative immunoturbidimetry according to OP. Shevchenko (1997); serum protein fractions - by electrophoresis on agarose gel plates by the method of S.S. Chernecky, V.J. Berger (2008); total lipids - by V.N. Titovu, M.G. Tvorogova (1992); high-density lipoproteins, triglycerides, beta-lipoproteins - by S.E. Severin (1977);cholesterol concentration - according to D. Vaidya (2005); the atherogenic coefficient was calculated by the formula: CA = (total cholesterol - HDL) / HDL); determination of serum magnesium and chlorine using colorimetric analysis (A.Sh. Byshevsky, OA Tersenov, 1994). Results. In the studied groups of patients with OSD and in healthy donors, a study was made of the level of C-reactive protein (CRP., The concentration of which in patients with OSD in the exacerbation stage reached 44 g / l before treatment, after conducting a course of appropriate drug therapy in each study group amounted to: in group II, the ...
Keywords	обмежена склеродермія ; біохімічні дослідження ; терапія ; магній ; хлор ; с-реактивний білок ; білкові фракції ; Medicine ; R
Subject code	616
Language	English
Publishing date	2019-01-01T00:00:00Z
Publisher	PC Technology Center
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A macrocyclic peptide inhibitor traps MRP1 in a catalytically incompetent conformation.

Pietz, Harlan L / Abbas, Ata / Johnson, Zachary Lee / Oldham, Michael L / Suga, Hiroaki / Chen, Jue

Proceedings of the National Academy of Sciences of the United States of America

2023 Volume 120, Issue 11, Page(s) e2220012120

Abstract: Adenosine triphosphate-binding cassette (ABC) transporters, such as multidrug resistance protein 1 (MRP1), protect against cellular toxicity by exporting xenobiotic compounds across the plasma membrane. However, constitutive MRP1 function hinders drug ... ...

Abstract	Adenosine triphosphate-binding cassette (ABC) transporters, such as multidrug resistance protein 1 (MRP1), protect against cellular toxicity by exporting xenobiotic compounds across the plasma membrane. However, constitutive MRP1 function hinders drug delivery across the blood-brain barrier, and MRP1 overexpression in certain cancers leads to acquired multidrug resistance and chemotherapy failure. Small-molecule inhibitors have the potential to block substrate transport, but few show specificity for MRP1. Here we identify a macrocyclic peptide, named CPI1, which inhibits MRP1 with nanomolar potency but shows minimal inhibition of a related multidrug transporter P-glycoprotein. A cryoelectron microscopy (cryo-EM) structure at 3.27 Å resolution shows that CPI1 binds MRP1 at the same location as the physiological substrate leukotriene C4 (LTC
MeSH term(s)	Adenosine Triphosphate/metabolism ; ATP Binding Cassette Transporter, Subfamily B/metabolism ; ATP Binding Cassette Transporter, Subfamily B, Member 1/chemistry ; ATP-Binding Cassette Transporters/metabolism ; Biological Transport ; Cryoelectron Microscopy ; Leukotriene C4/metabolism ; Multidrug Resistance-Associated Proteins/metabolism ; Peptides/metabolism ; Peptides, Cyclic/pharmacology
Chemical Substances	Adenosine Triphosphate (8L70Q75FXE) ; ATP Binding Cassette Transporter, Subfamily B ; ATP Binding Cassette Transporter, Subfamily B, Member 1 ; ATP-Binding Cassette Transporters ; Leukotriene C4 (2CU6TT9V48) ; multidrug resistance-associated protein 1 (Y49M64GZ4Q) ; Multidrug Resistance-Associated Proteins ; Peptides ; Peptides, Cyclic
Language	English
Publishing date	2023-03-09
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2220012120
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Article: Asthma exacerbations and body mass index in children and adolescents: experience from a tertiary care center.

Aziz, Danish Abdul / Bajwa, Rameen Ata / Viquar, Werdah / Siddiqui, Fatima / Abbas, Aiza

Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace

2023

Abstract: The prevalence and incidence of asthma continue to rise globally. Obesity has been identified as a potential risk factor for asthma exacerbations. The association between body mass index (BMI) and asthma is not well studied in some regions. This study ... ...

Abstract	The prevalence and incidence of asthma continue to rise globally. Obesity has been identified as a potential risk factor for asthma exacerbations. The association between body mass index (BMI) and asthma is not well studied in some regions. This study aims to investigate the impact of BMI in pediatric asthmatic patients. This retrospective study was conducted at the Aga Khan University Hospital from 2019 to 2022. Children and adolescents with asthma exacerbation were included. The patients were classified into four groups based on their BMI: underweight, healthy weight, overweight, and obese. The demographic characteristics, medications used, predicted FEV1 measurements, asthma exacerbations per year, length of stay per admission, and the number of patients requiring High Dependency Unit (HDU) care were recorded and analyzed. Our results demonstrated that patients in the healthy weight category had the highest percentage of FEV1 (91.46±8.58) and FEV1/FVC (85.75±9.23) (p<0.001). The study found a significant difference in the average number of asthma exacerbations per year between the four groups. Obese patients had the highest number of episodes (3.22±0.94), followed by the underweight group (2.42±0.59) (p<0.01). The length of stay per admission was significantly shorter for patients with a healthy weight (2.0±0.81), and there was a statistically significant difference observed in the number of patients requiring HDU care among the four groups, as well as in the average length of stay at the HDU (p<0.001). Elevated BMI is related to an increased number of annual asthma exacerbations, a low FEV1 and FEV1/FVC, increased length of stay at admission, and increased stay in the HDU.
Language	English
Publishing date	2023-06-27
Publishing country	Italy
Document type	Journal Article
ZDB-ID	1160940-0
ISSN	1122-0643 ; 1120-0391
ISSN	1122-0643 ; 1120-0391
DOI	10.4081/monaldi.2023.2581
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Article ; Online: Asthma exacerbations and body mass index in children and adolescents

Danish Abdul Aziz / Rameen Ata Bajwa / Werdah Viquar / Fatima Siddiqui / Aiza Abbas

Monaldi Archives for Chest Disease (2023)

experience from a tertiary care center

2023

Abstract	The prevalence and incidence of asthma continue to rise globally. Obesity has been identified as a potential risk factor for asthma exacerbations. The association between body mass index (BMI) and asthma is not well studied in some regions. This study aims to investigate the impact of BMI in pediatric asthmatic patients. This retrospective study was conducted at the Aga Khan University Hospital from 2019 to 2022. Children and adolescents with asthma exacerbation were included. The patients were classified into four groups based on their BMI: underweight, healthy weight, overweight, and obese. The demographic characteristics, medications used, predicted FEV1 measurements, asthma exacerbations per year, length of stay per admission, and the number of patients requiring High Dependency Unit (HDU) care were recorded and analyzed. Our results demonstrated that patients in the healthy weight category had the highest percentage of FEV1 (91.46±8.58) and FEV1/FVC (85.75±9.23) (p<0.001). The study found a significant difference in the average number of asthma exacerbations per year between the four groups. Obese patients had the highest number of episodes (3.22±0.94), followed by the underweight group (2.42±0.59) (p<0.01). The length of stay per admission was significantly shorter for patients with a healthy weight (2.0±0.81), and there was a statistically significant difference observed in the number of patients requiring HDU care among the four groups, as well as in the average length of stay at the HDU (p<0.001). Elevated BMI is related to an increased number of annual asthma exacerbations, a low FEV1 and FEV1/FVC, increased length of stay at admission, and increased stay in the HDU.
Keywords	Body Mass Index ; Asthma Exacerbation ; Lung Volumes ; obesity ; Medicine ; R
Subject code	610
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	PAGEPress Publications
Document type	Article ; Online
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Article ; Online: Fuzzy-Based Efficient Healthcare Data Collection and Analysis Mechanism Using Edge Nodes in the IoMT.

Khan, Muhammad Nafees Ulfat / Tang, Zhiling / Cao, Weiping / Abid, Yawar Abbas / Pan, Wanghua / Ullah, Ata

Sensors (Basel, Switzerland)

2023 Volume 23, Issue 18

Abstract: The Internet of Things (IoT) is an advanced technology that comprises numerous devices with carrying sensors to collect, send, and receive data. Due to its vast popularity and efficiency, it is employed in collecting crucial data for the health sector. ... ...

Abstract	The Internet of Things (IoT) is an advanced technology that comprises numerous devices with carrying sensors to collect, send, and receive data. Due to its vast popularity and efficiency, it is employed in collecting crucial data for the health sector. As the sensors generate huge amounts of data, it is better for the data to be aggregated before being transmitting the data further. These sensors generate redundant data frequently and transmit the same values again and again unless there is no variation in the data. The base scheme has no mechanism to comprehend duplicate data. This problem has a negative effect on the performance of heterogeneous networks.It increases energy consumption; and requires high control overhead, and additional transmission slots are required to send data. To address the above-mentioned challenges posed by duplicate data in the IoT-based health sector, this paper presents a fuzzy data aggregation system (FDAS) that aggregates data proficiently and reduces the same range of normal data sizes to increase network performance and decrease energy consumption. The appropriate parent node is selected by implementing fuzzy logic, considering important input parameters that are crucial from the parent node selection perspective and share Boolean digit 0 for the redundant values to store in a repository for future use. This increases the network lifespan by reducing the energy consumption of sensors in heterogeneous environments. Therefore, when the complexity of the environment surges, the efficiency of FDAS remains stable. The performance of the proposed scheme has been validated using the network simulator and compared with base schemes. According to the findings, the proposed technique (FDAS) dominates in terms of reducing energy consumption in both phases, achieves better aggregation, reduces control overhead, and requires the fewest transmission slots.
Language	English
Publishing date	2023-09-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s23187799
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Article ; Online: Metabolic stress regulates genome-wide transcription in a PTEN-dependent manner.

Abbas, Ata / Padmanabhan, Roshan / Eng, Charis

Human molecular genetics

2020 Volume 29, Issue 16, Page(s) 2736–2745

Abstract: PTEN is implicated in a wide variety of pathophysiological conditions and traditionally studied in the context of the PIK3-AKT-mTOR axis. Recent studies from our group and others have reported a novel role of PTEN in the regulation of transcription at ... ...

Abstract	PTEN is implicated in a wide variety of pathophysiological conditions and traditionally studied in the context of the PIK3-AKT-mTOR axis. Recent studies from our group and others have reported a novel role of PTEN in the regulation of transcription at the genome-wide scale. This emerging role of PTEN on global transcriptional regulation is providing a better understanding of various diseases, including cancer. Because cancer progression is an energy-demanding process and PTEN is known to regulate metabolic processes, we sought to understand the role of PTEN in transcriptional regulation under metabolic stress, a condition often developing in the tumor microenvironment. In the present study, we demonstrate that PTEN modulates genome-wide RNA Polymerase II occupancy in cells undergoing glucose deprivation. The glucose-deprived PTEN null cells were found to continue global gene transcription, which may activate a survival mode. However, cells with constitutive PTEN expression slow transcription, an evolutionary mechanism that may save cellular energy and activate programmed cell death pathways, in the absence of glucose. Interestingly, alternative exon usage by PTEN null cells is increased under metabolic stress in contrast to PTEN-expressing cells. Overall, our study demonstrates distinct mechanisms involved in PTEN-dependent genome-wide transcriptional control under metabolic stress. Our findings provide a new insight in understanding tumor pathology and how PTEN loss of function, whether by genetic or non-genetic mechanisms, can contribute to a favorable transcriptional program employed by tumor cells to escape apoptosis, hence developing more aggressive and metastatic phenotypes.
MeSH term(s)	Apoptosis/genetics ; Cell Line, Tumor ; Genome, Human/genetics ; Glucose/metabolism ; Humans ; Neoplasms/genetics ; Neoplasms/metabolism ; Neoplasms/pathology ; PTEN Phosphohydrolase/genetics ; Phosphatidylinositol 3-Kinases/genetics ; Proto-Oncogene Proteins c-akt/genetics ; RNA Polymerase II/genetics ; Stress, Physiological/genetics ; TOR Serine-Threonine Kinases/genetics ; Transcription, Genetic/genetics
Chemical Substances	TOR Serine-Threonine Kinases (EC 2.7.1.1) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; RNA Polymerase II (EC 2.7.7.-) ; PTEN Phosphohydrolase (EC 3.1.3.67) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2020-08-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1108742-0
ISSN	1460-2083 ; 0964-6906
ISSN (online)	1460-2083
ISSN	0964-6906
DOI	10.1093/hmg/ddaa168
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Zs.A 3469: Show issues

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Article ; Online: PTEN interacts with RNA polymerase II to dephosphorylate polymerase II C-terminal domain.

Abbas, Ata / Romigh, Todd / Eng, Charis

Oncotarget

2019 Volume 10, Issue 48, Page(s) 4951–4959

Abstract: Gene transcription is a highly complex and strictly regulated process. RNA polymerase II (Pol II) C-terminal domain (CTD) undergoes massive cycles of phosphorylation and dephosphorylation during the process of gene transcription. These post-translational ...

Abstract	Gene transcription is a highly complex and strictly regulated process. RNA polymerase II (Pol II) C-terminal domain (CTD) undergoes massive cycles of phosphorylation and dephosphorylation during the process of gene transcription. These post-translational modifications of CTD provide an interactive platform for various factors required for transcription initiation, elongation, termination, and co-transcriptional RNA processing. Pol II CTD kinases and phosphatases are key regulators and any deviation may cause genome-wide transcriptional dysregulation leading to various pathological conditions including cancer. PTEN, a well known tumor suppressor, is one of the most commonly somatically altered in diverse malignancies. When mutated in the germline,
Language	English
Publishing date	2019-08-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2560162-3
ISSN	1949-2553 ; 1949-2553
ISSN (online)	1949-2553
ISSN	1949-2553
DOI	10.18632/oncotarget.27128
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Article ; Online: Two-factor higher-order model of perfectionism in Iranian general and clinical samples.

Moloodi, Reza / Pourshahbaz, Abbas / Mohammadkhani, Parvaneh / Fata, Ladan / Ghaderi, Ata

BMC psychology

2021 Volume 9, Issue 1, Page(s) 30

Abstract: Background: Studies in Western cultures have shown that perfectionism is conceptualized by two-factor higher-order model including perfectionistic strivings and perfectionistic concerns. However, little is known about the construct of perfectionism in ... ...

Abstract	Background: Studies in Western cultures have shown that perfectionism is conceptualized by two-factor higher-order model including perfectionistic strivings and perfectionistic concerns. However, little is known about the construct of perfectionism in Eastern societies. Thus, we examined the two-factor higher-order model of perfectionism in Iranian general and clinical samples. Methods: We recruited a general population sample (n = 384) and patients with major depressive disorder, obsessive compulsive disorder, social anxiety disorder, and eating disorders (n = 152) from Tehran, Iran from September 2016 to December 2017. They completed the Clinical Perfectionism Questionnaire, Perfectionism Inventory, and Depression, Anxiety, Stress Scale-21. Results: The two-factor higher-order model of perfectionism showed adequate fit with data for females from the general population and clinical sample. Data for males were only available from the general population, and the model showed adequate fit with the data first after removing the Rumination scale of the perfectionistic concerns. The perfectionistic strivings dimension showed no or negative association with depression, anxiety, and stress symptoms, but perfectionistic concerns dimension showed positive correlation with these indices in all samples for both males and females. Conclusions: The results support the two-factor higher-order model of perfectionism in samples of Iranian females from the general population and clinical sample. However, the results were different for males from the general population. In other words, the modified two-factor higher-order model showed acceptable fit with the data for males from the general population only after removing the Rumination scale from perfectionistic concerns. These differences among males and females were discussed.
MeSH term(s)	Anxiety/epidemiology ; Depressive Disorder, Major ; Feeding and Eating Disorders ; Female ; Humans ; Iran ; Male ; Perfectionism
Language	English
Publishing date	2021-02-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2705921-2
ISSN	2050-7283 ; 2050-7283
ISSN (online)	2050-7283
ISSN	2050-7283
DOI	10.1186/s40359-021-00529-2
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Article ; Online: Surfactin-Conjugated Silver Nanoparticles as an Antibacterial and Antibiofilm Agent against

Rahman, Lutfur / Sarwar, Yasra / Khaliq, Shazia / Inayatullah / Abbas, Wasim / Mobeen, Ameena / Ullah, Ata / Hussain, Syed Zajif / Khan, Waheed S / Kyriazi, Maria-Eleni / Hussain, Irshad / Kanaras, Antonios G / Rehman, Asma

ACS applied materials & interfaces

2023 Volume 15, Issue 37, Page(s) 43321–43331

Abstract: The emergence of antimicrobial resistance is an alarming global health concern and has stimulated the development of novel functional nanomaterials to combat multi-drug-resistant (MDR) bacteria. In this work, we demonstrate for the first time the ... ...

Abstract	The emergence of antimicrobial resistance is an alarming global health concern and has stimulated the development of novel functional nanomaterials to combat multi-drug-resistant (MDR) bacteria. In this work, we demonstrate for the first time the synthesis and application of surfactin-coated silver nanoparticles as an efficient antibacterial and antibiofilm agent against the drug-resistant bacteria
MeSH term(s)	Metal Nanoparticles ; Pseudomonas aeruginosa ; Silver/pharmacology ; Anti-Bacterial Agents/pharmacology ; Biofilms
Chemical Substances	Silver (3M4G523W1G) ; Anti-Bacterial Agents
Language	English
Publishing date	2023-09-05
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.3c07071
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