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  1. Article: Febuxostat : a viewpoint by N. Lawrence Edwards.

    Edwards, N Lawrence

    Drugs

    2008  Volume 68, Issue 13, Page(s) 1875–1876

    MeSH term(s) Administration, Oral ; Febuxostat ; Gout/blood ; Gout/complications ; Gout/drug therapy ; Gout Suppressants/administration & dosage ; Gout Suppressants/therapeutic use ; Humans ; Hyperuricemia/blood ; Hyperuricemia/complications ; Hyperuricemia/drug therapy ; Thiazoles/administration & dosage ; Thiazoles/therapeutic use ; Uric Acid/blood
    Chemical Substances Gout Suppressants ; Thiazoles ; Febuxostat (101V0R1N2E) ; Uric Acid (268B43MJ25)
    Language English
    Publishing date 2008-08-27
    Publishing country New Zealand
    Document type Comment ; Journal Article
    ZDB-ID 120316-2
    ISSN 1179-1950 ; 0012-6667
    ISSN (online) 1179-1950
    ISSN 0012-6667
    DOI 10.2165/00003495-200868130-00007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Gout management and outcomes during established COVID-19 pandemic in 2020-2021: a cross-sectional Internet survey.

    Singh, Jasvinder A / Edwards, N Lawrence

    Therapeutic advances in musculoskeletal disease

    2022  Volume 14, Page(s) 1759720X221096381

    Abstract: Objective: To assess the management of gout in established COVID-19 pandemic.: Methods: We assessed medication use, health care utilization, gout-specific health-related quality of life (HRQOL), psychological distress using Patient Health ... ...

    Abstract Objective: To assess the management of gout in established COVID-19 pandemic.
    Methods: We assessed medication use, health care utilization, gout-specific health-related quality of life (HRQOL), psychological distress using Patient Health Questionnaire-4 (PHQ-4), resilience, illness perception, and health literacy in people with physician-diagnosed self-reported gout in established COVID-19 pandemic in a cross-sectional Internet survey.
    Results: Among the 130 survey respondents with gout, the mean age was 62.8 years, 65% were male, 83% were White, 59% were prescribed urate-lowering therapy (ULT), and health literacy was adequate in 80%. A third of survey respondents reported more difficulty with their gout management since September 2020. Gout-specific HRQOL deficits were evident. Moderate-severe psychological distress was seen in 22%, and resilience score was 6.5 [standard deviation (SD), 1.9; range, 0-8]. Adjusted for age and sex, compared with no/mild psychological distress, moderate-severe psychological distress was associated with significantly higher odds ratio (OR; 95% confidence interval) of more difficulty with (1) getting health care for gout in clinic, 3.7 (1.0, 13.2); emergency room/urgent care, 8.1 (1.4, 45.0); and in the hospital, 9.8 (1.6, 59.6); (2) getting gout flares treated, 6.6 (1.6, 26.8); (3) avoiding gout complications, 4.5 (1.2, 16.7); and (4) daily activities at home, 4.2 (1.3, 14.1), and performing work, 4.1 (1.2, 13.6).
    Conclusion: Respondents with gout reported health care gaps, low rates of ULT prescription, high psychological distress, and HRQOL deficits during established COVID-19 pandemic. Moderate-severe psychological distress was associated with difficulties in health care access and gout management. Interventions to address these challenges in gout management are needed.
    Language English
    Publishing date 2022-05-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2516075-8
    ISSN 1759-7218 ; 1759-720X
    ISSN (online) 1759-7218
    ISSN 1759-720X
    DOI 10.1177/1759720X221096381
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Gout management and outcomes during the COVID-19 pandemic: a cross-sectional internet survey.

    Singh, Jasvinder A / Edwards, N Lawrence

    Therapeutic advances in musculoskeletal disease

    2020  Volume 12, Page(s) 1759720X20966124

    Abstract: Aim: We aimed to assess the gout management during the COVID-19 pandemic.: Methods: We assessed medication use, healthcare utilization, gout-specific health-related quality of life (HRQoL) on the Gout Impact Scale (GIS), psychological distress using ... ...

    Abstract Aim: We aimed to assess the gout management during the COVID-19 pandemic.
    Methods: We assessed medication use, healthcare utilization, gout-specific health-related quality of life (HRQoL) on the Gout Impact Scale (GIS), psychological distress using the patient health questionnaire-4 (PHQ-4), and resilience in people with self-reported physician-diagnosed gout during the COVID-19 pandemic in a cross-sectional Internet survey.
    Results: Among the 122 survey respondents with physician-diagnosed gout, 82% were prescribed urate-lowering therapy (ULT) and 66% were taking ULT daily; mean age was 54.2 years [standard deviation (SD), 13.8], 65% were male, and 79% were White. More regular use of gout medication was reported during the COVID-19 pandemic: allopurinol, 44%; colchicine, 37%; non-steroidal anti-inflammatory drugs, 36%. Gout flares were common: 63% had ⩾1 gout flare monthly; 11% went to emergency room/urgent care; and 2% were hospitalized with gout flares. Between 41% and 56% of respondents reported more difficulty with gout management and related functional status related to COVID-19; 17-37% had difficulty with healthcare access for gout. HRQOL deficits were evident for gout concern overall, 79.4 (SD, 25); unmet gout treatment need, 64.5 (SD, 27.1); and gout concern during flare, 67.3 (SD, 27.1); but less so for gout medication side effects, 48.9 (SD, 27.4). Psychological distress was moderate in 19% and severe in 15% (mild, 22%; normal, 45%). Resilience score on Connor-Davidson Resilience Scale (CD-RISC2) was 5.6 (SD, 1.8; range 0-8). Compared with no/mild psychological distress, moderate-severe psychological distress during the COVID-19 pandemic was significantly associated with more difficulty getting gout medication filled (
    Conclusion: Healthcare gaps, psychological distress, and HRQoL deficits were commonly reported by people with gout during the COVID-19 pandemic. Interventions to address these challenges for people with gout during the COVID-19 pandemic are needed.
    Keywords covid19
    Language English
    Publishing date 2020-10-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2516075-8
    ISSN 1759-7218 ; 1759-720X
    ISSN (online) 1759-7218
    ISSN 1759-720X
    DOI 10.1177/1759720X20966124
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Patient Perceptions of Gout Management Goals: A Cross-sectional Internet Survey.

    Singh, Jasvinder A / Edwards, N Lawrence

    Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases

    2020  Volume 26, Issue 4, Page(s) 129–133

    Abstract: Objective: To assess patient perceptions of gout management goals.: Methods: We conducted a cross-sectional Internet survey of people who visited the Gout and Uric Acid Education Society's website to assess patient/respondent perception of gout ... ...

    Abstract Objective: To assess patient perceptions of gout management goals.
    Methods: We conducted a cross-sectional Internet survey of people who visited the Gout and Uric Acid Education Society's website to assess patient/respondent perception of gout management goals. We used chi-square test for categorical or t-test for continuous variables.
    Results: Among the 320 survey respondents with physician-diagnosed gout, mean age was 57 (SD, 13.4) years, 72% were male, 77% White; mean gout duration was 7.6 years (SD, 11), gout flares in the last year were 5.2 (SD, 6.1), and medical comorbidities were common, 2.7 (SD, 2.6). Two-thirds respondents each reported very severe or severe symptoms from gout and that gout ranked among the top two health conditions with a negative impact on quality of life. During a clinic visit, only one-third of respondents' physicians spent 50% of more of the time discussing gout treatment. Only 54% respondents were prescribed ULT by their healthcare provider. By patient preference, the best life-long gout treatment strategies were the lowering of the serum urate level and the control of gout symptoms (62%) followed by serum urate lowering (32%). Respondents considered the following as the most important things for making gout treatment satisfactory: (1) patient education; (2) effective physician-patient communication; (3) diet and lifestyle modification; (4) serum urate monitoring and target achievement; (5) pain management and flare prevention; and (6) medication management.
    Conclusions: Patient identification of gout symptom control and serum urate level monitoring as the most important treatment goals is informative for clinicians and guideline developers.
    MeSH term(s) Attitude to Health ; Cross-Sectional Studies ; Disease Management ; Drug Monitoring/methods ; Drug Monitoring/psychology ; Female ; Gout/blood ; Gout/psychology ; Gout/therapy ; Gout Suppressants/therapeutic use ; Humans ; Male ; Middle Aged ; Patient Education as Topic/methods ; Patient Education as Topic/standards ; Physician-Patient Relations ; Quality of Life ; Risk Reduction Behavior ; Social Perception ; Symptom Assessment ; Uric Acid/blood
    Chemical Substances Gout Suppressants ; Uric Acid (268B43MJ25)
    Language English
    Publishing date 2020-05-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1283266-2
    ISSN 1536-7355 ; 1076-1608
    ISSN (online) 1536-7355
    ISSN 1076-1608
    DOI 10.1097/RHU.0000000000000981
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: EULAR gout treatment guidelines by Richette

    Singh, Jasvinder A / Edwards, N Lawrence

    Annals of the rheumatic diseases

    2017  Volume 77, Issue 4, Page(s) e20

    MeSH term(s) Gout ; Gout Suppressants ; Humans ; Uric Acid
    Chemical Substances Gout Suppressants ; Uric Acid (268B43MJ25)
    Language English
    Publishing date 2017-03-27
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/annrheumdis-2017-211418
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Social Listening in Gout: Impact of Proactive vs. Reactive Management on Self-Reported Emotional States.

    Flurie, Maurice / Converse, Monica / Wassman, E Robert / LaMoreaux, Brian / Edwards, N Lawrence / Flowers, Colton / Hernandez, Daniel / Hernandez, Helen W / Ho, Gary / Parker, Christopher / DeFelice, Christopher / Picone, Maria

    Rheumatology and therapy

    2024  Volume 11, Issue 2, Page(s) 301–311

    Abstract: Introduction: This study aimed to characterize patient-reported outcomes from social media conversations in the gout community. The impact of management strategy differences on the community's emotional states was explored.: Methods: We analyzed two ... ...

    Abstract Introduction: This study aimed to characterize patient-reported outcomes from social media conversations in the gout community. The impact of management strategy differences on the community's emotional states was explored.
    Methods: We analyzed two social media sources using a variety of natural language processing techniques. We isolated conversations with a high probability of discussing disease management (score > 0.99). These conversations were stratified by management type: proactive or reactive. The polarity (positivity/negativity) of language and emotions conveyed in statements shared by community members was assessed by management type.
    Results: Among the statements related to management, reactive management (e.g., urgent care) was mentioned in 0.5% of statements, and proactive management (e.g., primary care) was mentioned in 0.6% of statements. Reactive management statements had a significantly larger proportion of negative words (59%) than did proactive management statements (44%); "fear" occurred more frequently with reactive statements, whereas "trust" predominated in proactive statements. Allopurinol was the most common medication in proactive management statements, whereas reactive management had significantly higher counts of prednisone/steroid mentions.
    Conclusions: A unique aspect of examining gout-related social media conversations is the ability to better understand the intersection of clinical management and emotional impacts in the gout community. The effect of social media statements was significantly stratified by management type for gout community members, where proactive management statements were characterized by more positive language than reactive management statements. These results suggest that proactive disease management may result in more positive mental and emotional experiences in patients with gout.
    Language English
    Publishing date 2024-01-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2783278-8
    ISSN 2198-6584 ; 2198-6576
    ISSN (online) 2198-6584
    ISSN 2198-6576
    DOI 10.1007/s40744-023-00637-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Adaptive optics imaging in inherited retinal diseases: A scoping review of the clinical literature.

    Britten-Jones, Alexis Ceecee / Thai, Lawrence / Flanagan, Jeremy P M / Bedggood, Phillip A / Edwards, Thomas L / Metha, Andrew B / Ayton, Lauren N

    Survey of ophthalmology

    2023  Volume 69, Issue 1, Page(s) 51–66

    Abstract: Adaptive optics (AO) imaging enables direct, objective assessments of retinal cells. Applications of AO show great promise in advancing our understanding of the etiology of inherited retinal disease (IRDs) and discovering new imaging biomarkers. This ... ...

    Abstract Adaptive optics (AO) imaging enables direct, objective assessments of retinal cells. Applications of AO show great promise in advancing our understanding of the etiology of inherited retinal disease (IRDs) and discovering new imaging biomarkers. This scoping review systematically identifies and summarizes clinical studies evaluating AO imaging in IRDs. Ovid MEDLINE and EMBASE were searched on February 6, 2023. Studies describing AO imaging in monogenic IRDs were included. Study screening and data extraction were performed by 2 reviewers independently. This review presents (1) a broad overview of the dominant areas of research; (2) a summary of IRD characteristics revealed by AO imaging; and (3) a discussion of methodological considerations relating to AO imaging in IRDs. From 140 studies with AO outcomes, including 2 following subretinal gene therapy treatments, 75% included fewer than 10 participants with AO imaging data. Of 100 studies that included participants' genetic diagnoses, the most common IRD genes with AO outcomes are CNGA3, CNGB3, CHM, USH2A, and ABCA4. Confocal reflectance AO scanning laser ophthalmoscopy was the most reported imaging modality, followed by flood-illuminated AO and split-detector AO. The most common outcome was cone density, reported quantitatively in 56% of studies. Future research areas include guidelines to reduce variability in the reporting of AO methodology and a focus on functional AO techniques to guide the development of therapeutic interventions.
    MeSH term(s) Humans ; Retina/diagnostic imaging ; Retinal Diseases/diagnostic imaging ; Retinal Diseases/genetics ; Retinal Cone Photoreceptor Cells ; Ophthalmoscopy/methods ; Usher Syndromes ; ATP-Binding Cassette Transporters
    Chemical Substances ABCA4 protein, human ; ATP-Binding Cassette Transporters
    Language English
    Publishing date 2023-09-29
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 391346-6
    ISSN 1879-3304 ; 0039-6257
    ISSN (online) 1879-3304
    ISSN 0039-6257
    DOI 10.1016/j.survophthal.2023.09.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Releasing and tracking the distribution of adventive Trissolcus japonicus (Hymenoptera: Scelionidae) in Virginia.

    Bergh, J Christopher / Talamas, Elijah J / Brandt, Samuel N / Edwards, Ashley / MacRae, Lucinda / Monger, Grace / Bowen, Jason / Lawrence, Katherine / Reed, Kathleen / Pottorff, Steve

    Environmental entomology

    2023  Volume 52, Issue 4, Page(s) 583–592

    Abstract: Adventive populations of Trissolcus japonicus (Ashmead), an egg parasitoid of the invasive agricultural pest, brown marmorated stink bug, Halyomorpha halys (Stål) (Hemiptera: Pentatomidae), have been detected in the United States since 2014. Given its ... ...

    Abstract Adventive populations of Trissolcus japonicus (Ashmead), an egg parasitoid of the invasive agricultural pest, brown marmorated stink bug, Halyomorpha halys (Stål) (Hemiptera: Pentatomidae), have been detected in the United States since 2014. Given its importance as an H. halys biocontrol agent, efforts to redistribute T. japonicus began within some US states. Our surveillance for T. japonicus in northwestern Virginia in 2016-2017 yielded annual detections only in 1 county. Thus, to promote its broader establishment, releases of H. halys egg masses parasitized by T. japonicus from Virginia occurred in 2018 (2 releases) and 2020 (1 release) at 9 sites throughout Virginia's tree fruit production regions. Monitoring of T. japonicus and H. halys, using yellow sticky cards deployed in H. halys host trees and pheromone-baited sticky traps, respectively, was conducted from 2018 to 2022. Annual captures of H. halys adults and nymphs appeared to reflect adequate populations to support T. japonicus establishment across most or all sites. Prerelease monitoring yielded a single T. japonicus at 1 site. By 2022, T. japonicus was detected at or near 7 of the remaining 8 release sites, with first detections varying between 1 and 2 yr from the releases in 2018 and 2020. Captures at most sites were very low, but establishment at several locations was indicated by detections in 2-4 seasons. In 2022, T. japonicus surveillance at 11 additional sites in northwestern Virginia yielded detections at all locations, including those at which it had not been detected in 2016-2017, providing evidence for its range expansion.
    MeSH term(s) Animals ; Hymenoptera ; Virginia ; Heteroptera ; Seasons ; Trees
    Language English
    Publishing date 2023-06-10
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
    ZDB-ID 120799-4
    ISSN 1938-2936 ; 0046-2268 ; 0046-225X
    ISSN (online) 1938-2936
    ISSN 0046-2268 ; 0046-225X
    DOI 10.1093/ee/nvad048
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Gout management and outcomes during the COVID-19 pandemic

    Singh, Jasvinder A. / Edwards, N. Lawrence

    Therapeutic Advances in Musculoskeletal Disease

    a cross-sectional internet survey

    2020  Volume 12, Page(s) 1759720X2096612

    Abstract: Aim: We aimed to assess the gout management during the COVID-19 pandemic. Methods: We assessed medication use, healthcare utilization, gout-specific health-related quality of life (HRQoL) on the Gout Impact Scale (GIS), psychological distress using the ... ...

    Abstract Aim: We aimed to assess the gout management during the COVID-19 pandemic. Methods: We assessed medication use, healthcare utilization, gout-specific health-related quality of life (HRQoL) on the Gout Impact Scale (GIS), psychological distress using the patient health questionnaire-4 (PHQ-4), and resilience in people with self-reported physician-diagnosed gout during the COVID-19 pandemic in a cross-sectional Internet survey. Results: Among the 122 survey respondents with physician-diagnosed gout, 82% were prescribed urate-lowering therapy (ULT) and 66% were taking ULT daily; mean age was 54.2 years [standard deviation (SD), 13.8], 65% were male, and 79% were White. More regular use of gout medication was reported during the COVID-19 pandemic: allopurinol, 44%; colchicine, 37%; non-steroidal anti-inflammatory drugs, 36%. Gout flares were common: 63% had ⩾1 gout flare monthly; 11% went to emergency room/urgent care; and 2% were hospitalized with gout flares. Between 41% and 56% of respondents reported more difficulty with gout management and related functional status related to COVID-19; 17–37% had difficulty with healthcare access for gout. HRQOL deficits were evident for gout concern overall, 79.4 (SD, 25); unmet gout treatment need, 64.5 (SD, 27.1); and gout concern during flare, 67.3 (SD, 27.1); but less so for gout medication side effects, 48.9 (SD, 27.4). Psychological distress was moderate in 19% and severe in 15% (mild, 22%; normal, 45%). Resilience score on Connor–Davidson Resilience Scale (CD-RISC2) was 5.6 (SD, 1.8; range 0–8). Compared with no/mild psychological distress, moderate–severe psychological distress during the COVID-19 pandemic was significantly associated with more difficulty getting gout medication filled ( p = 0.02), flares treated ( p = 0.005), and receiving gout education ( p = 0.001). Conclusion: Healthcare gaps, psychological distress, and HRQoL deficits were commonly reported by people with gout during the COVID-19 pandemic. Interventions to address these challenges for people with gout during the COVID-19 pandemic are needed.
    Keywords Orthopedics and Sports Medicine ; covid19
    Language English
    Publisher SAGE Publications
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2516075-8
    ISSN 1759-7218 ; 1759-720X
    ISSN (online) 1759-7218
    ISSN 1759-720X
    DOI 10.1177/1759720x20966124
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: PTHrP intracrine actions divergently influence breast cancer growth through p27 and LIFR.

    Edwards, Courtney M / Kane, Jeremy F / Smith, Jailyn A / Grant, Déja M / Johnson, Jasmine A / Diaz, Maria A Hernandez / Vecchi, Lawrence A / Bracey, Kai M / Omokehinde, Tolu N / Fontana, Joseph R / Karno, Breelyn A / Scott, Halee T / Vogel, Carolina J / Lowery, Jonathan W / Martin, T John / Johnson, Rachelle W

    Breast cancer research : BCR

    2024  Volume 26, Issue 1, Page(s) 34

    Abstract: The role of parathyroid hormone (PTH)-related protein (PTHrP) in breast cancer remains controversial, with reports of PTHrP inhibiting or promoting primary tumor growth in preclinical studies. Here, we provide insight into these conflicting findings by ... ...

    Abstract The role of parathyroid hormone (PTH)-related protein (PTHrP) in breast cancer remains controversial, with reports of PTHrP inhibiting or promoting primary tumor growth in preclinical studies. Here, we provide insight into these conflicting findings by assessing the role of specific biological domains of PTHrP in tumor progression through stable expression of PTHrP (-36-139aa) or truncated forms with deletion of the nuclear localization sequence (NLS) alone or in combination with the C-terminus. Although the full-length PTHrP molecule (-36-139aa) did not alter tumorigenesis, PTHrP lacking the NLS alone accelerated primary tumor growth by downregulating p27, while PTHrP lacking the NLS and C-terminus repressed tumor growth through p27 induction driven by the tumor suppressor leukemia inhibitory factor receptor (LIFR). Induction of p27 by PTHrP lacking the NLS and C-terminus persisted in bone disseminated cells, but did not prevent metastatic outgrowth, in contrast to the primary tumor site. These data suggest that the PTHrP NLS functions as a tumor suppressor, while the PTHrP C-terminus may act as an oncogenic switch to promote tumor progression through differential regulation of p27 signaling.
    MeSH term(s) Humans ; Female ; Parathyroid Hormone-Related Protein/genetics ; Parathyroid Hormone-Related Protein/metabolism ; Breast Neoplasms/pathology ; Receptors, OSM-LIF ; Nuclear Localization Signals ; Cell Proliferation/genetics ; Leukemia Inhibitory Factor Receptor alpha Subunit
    Chemical Substances Parathyroid Hormone-Related Protein ; Receptors, OSM-LIF ; Nuclear Localization Signals ; LIFR protein, human ; Leukemia Inhibitory Factor Receptor alpha Subunit
    Language English
    Publishing date 2024-02-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2015059-3
    ISSN 1465-542X ; 1465-5411
    ISSN (online) 1465-542X
    ISSN 1465-5411
    DOI 10.1186/s13058-024-01791-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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