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  1. Article ; Online: Characterization of Hydrophilic α-Helical Hot Spots on the Protein-Protein Interaction Interfaces for the Design of α-Helix Mimetics.

    Wang, Zhen / Ji, Haitao

    Journal of chemical information and modeling

    2022  Volume 62, Issue 8, Page(s) 1873–1890

    Abstract: The cooperativity index, ...

    Abstract The cooperativity index,
    MeSH term(s) Amino Acids/chemistry ; Hydrophobic and Hydrophilic Interactions ; Pilot Projects ; Protein Conformation ; Protein Conformation, alpha-Helical ; Protein Interaction Mapping/methods
    Chemical Substances Amino Acids
    Language English
    Publishing date 2022-04-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 190019-5
    ISSN 1549-960X ; 0095-2338
    ISSN (online) 1549-960X
    ISSN 0095-2338
    DOI 10.1021/acs.jcim.1c01556
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Cobalt-Catalyzed Acceptorless Dehydrogenation of Primary Amines to Nitriles.

    Tian, Haitao / Ding, Cai-Yun / Liao, Rong-Zhen / Li, Man / Tang, Conghui

    Journal of the American Chemical Society

    2024  Volume 146, Issue 17, Page(s) 11801–11810

    Abstract: The direct double dehydrogenation from primary amines to nitriles without an oxidant or hydrogen acceptor is both intriguing and challenging. In this paper, we describe a non-noble metal catalyst capable of realizing such a transformation with high ... ...

    Abstract The direct double dehydrogenation from primary amines to nitriles without an oxidant or hydrogen acceptor is both intriguing and challenging. In this paper, we describe a non-noble metal catalyst capable of realizing such a transformation with high efficiency. A cobalt-centered
    Language English
    Publishing date 2024-04-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.4c00493
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    In stock of ZB MED Bonn / Germany

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  3. Article ; Online: Hierarchical models that address measurement error are needed to evaluate the correlation between treatment effect and control group event rate.

    Murad, M Hassan / Chu, Haitao / Wang, Zhen / Lin, Lifeng

    Journal of clinical epidemiology

    2024  Volume 170, Page(s) 111327

    Abstract: Objectives: To apply a hierarchical model (HM) that addresses measurement error in regression of the treatment effect on the control group event rate (CR). We compare HM to weighted linear regression (WLR) which is subject to measurement error and ... ...

    Abstract Objectives: To apply a hierarchical model (HM) that addresses measurement error in regression of the treatment effect on the control group event rate (CR). We compare HM to weighted linear regression (WLR) which is subject to measurement error and mathematical coupling.
    Study design and setting: We reviewed published HMs that address measurement error and implemented a Bayesian version in open-source code to facilitate adoption by meta-analysts. We compared WLR and HM across a very large convenience sample of meta-analyses published in the Cochrane Database of Systematic Reviews.
    Results: We applied both approaches (WLR and an HM that addresses measurement error) to 3193 meta-analyses that included 33,071 studies (average 10.28 studies per meta-analysis). A statistically significant slope suggesting an association between the treatment effect and CR was demonstrated with both approaches in 568 (17.19%) meta-analyses, with neither approach in 2036 (63.77%) meta-analyses, only with WLS in 229 (7.17%) and only with HM in 360 (11.28%) meta-analyses. The majority of slopes was negative (WLR 85%, HM 83%). In the majority of cases, HM had wider confidence intervals (72.53%) and slopes farther from the null (64.77%).
    Conclusion: Approximately 28% of meta-analyses demonstrate a significant association between the treatment effect and CR when HM is used to address measurement error, which can suggest frequent lack of portability of the relative effect across baseline risks. User-friendly open-source code is provided to meta-analysts interested in exploring this association.
    Language English
    Publishing date 2024-03-18
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 639306-8
    ISSN 1878-5921 ; 0895-4356
    ISSN (online) 1878-5921
    ISSN 0895-4356
    DOI 10.1016/j.jclinepi.2024.111327
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  4. Article ; Online: Modelling and stability analysis of ASFV with swill and the virus in the environment.

    Song, Haitao / Guo, Lirong / Jin, Zhen / Liu, Shengqiang

    Mathematical biosciences and engineering : MBE

    2023  Volume 19, Issue 12, Page(s) 13028–13049

    Abstract: African swine fever (ASF) is an acute, hemorrhagic and severe infectious disease caused by the African swine fever virus (ASFV), and leads to a serious threat to the pig industry in China. Yet the impact of the virus in the environment and contaminated ... ...

    Abstract African swine fever (ASF) is an acute, hemorrhagic and severe infectious disease caused by the African swine fever virus (ASFV), and leads to a serious threat to the pig industry in China. Yet the impact of the virus in the environment and contaminated swill on the ASFV transmission is unclear in China. Then we build the ASFV transmission model with the virus in the environment and swill. We compute the basic reproduction number, and prove that the disease-free equilibrium is globally asymptotically stable when $ R_0 < 1 $ and the unique endemic equilibrium is globally asymptotically stable when $ R_0 > 1 $. Using the public information, parameter values are evaluated. PRCCs and eFAST sensitivity analysis reveal that the release rate of ASFV from asymptomatic and symptomatic infectious pigs and the proportion of pig products from infectious pigs to swill have a significant impact on the ASFV transmission. Our findings suggest that the virus in the environment and contaminated swill contribute to the ASFV transmission. Our results may help animal health to prevent and control the ASFV transmission.
    MeSH term(s) Swine ; Animals ; African Swine Fever Virus ; African Swine Fever/epidemiology ; China/epidemiology
    Language English
    Publishing date 2023-01-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2265126-3
    ISSN 1551-0018 ; 1551-0018
    ISSN (online) 1551-0018
    ISSN 1551-0018
    DOI 10.3934/mbe.2022608
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Mechanochemical synthesis of microscale zero-valent iron/N-doped graphene-like biochar composite for degradation of tetracycline via molecular O

    Zhang, Xueyi / Sun, Wenshuang / Wang, Yue / Li, Zhen / Huang, Xianqiang / Li, Tielong / Wang, Haitao

    Journal of colloid and interface science

    2024  Volume 659, Page(s) 1015–1028

    Abstract: In this study, we prepared a micron zero-valent iron/N-doped graphene-like biochar (mZVI/NGB) composite using a mechanochemical method for tetracycline (TC) degradation through ... ...

    Abstract In this study, we prepared a micron zero-valent iron/N-doped graphene-like biochar (mZVI/NGB) composite using a mechanochemical method for tetracycline (TC) degradation through O
    MeSH term(s) Iron/chemistry ; Graphite ; Hydrogen Peroxide ; Anti-Bacterial Agents ; Tetracycline/chemistry ; Water Pollutants, Chemical/chemistry ; Charcoal
    Chemical Substances Iron (E1UOL152H7) ; biochar ; Graphite (7782-42-5) ; Hydrogen Peroxide (BBX060AN9V) ; Anti-Bacterial Agents ; Tetracycline (F8VB5M810T) ; Water Pollutants, Chemical ; Charcoal (16291-96-6)
    Language English
    Publishing date 2024-01-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241597-5
    ISSN 1095-7103 ; 0021-9797
    ISSN (online) 1095-7103
    ISSN 0021-9797
    DOI 10.1016/j.jcis.2024.01.061
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    Z 71/707: Show issues

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  6. Article ; Online: Identification of key autophagy-related genes and pathways in spinal cord injury.

    Shang, Zhen / Shi, Weipeng / Fu, Haitao / Zhang, Yingze / Yu, Tengbo

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 6553

    Abstract: Spinal cord injury (SCI) can cause a range of functional impairments, and patients with SCI have limited potential for functional recovery. Previous studies have demonstrated that autophagy plays a role in the pathological process of SCI, but the ... ...

    Abstract Spinal cord injury (SCI) can cause a range of functional impairments, and patients with SCI have limited potential for functional recovery. Previous studies have demonstrated that autophagy plays a role in the pathological process of SCI, but the specific mechanism of autophagy in this context remains unclear. Therefore, we explored the role of autophagy in SCI by identifying key autophagy-related genes and pathways. This study utilized the GSE132242 expression profile dataset, which consists of four control samples and four SCI samples; autophagy-related genes were sourced from GeneCards. R software was used to screen differentially expressed genes (DEGs) in the GSE132242 dataset, which were then intersected with autophagy-related genes to identify autophagy-related DEGs in SCI. Subsequently, the expression levels of these genes were confirmed and analyzed with gene ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG). A protein-protein interaction (PPI) analysis was conducted to identify interaction genes, and the resulting network was visualized with Cytoscape. The MCODE plug-in was used to build gene cluster modules, and the cytoHubba plug-in was applied to screen for hub genes. Finally, the GSE5296 dataset was used to verify the reliability of the hub genes. We screened 129 autophagy-related DEGs, including 126 up-regulated and 3 down-regulated genes. GO and KEGG pathway enrichment analysis showed that these 129 genes were mainly involved in the process of cell apoptosis, angiogenesis, IL-1 production, and inflammatory reactions, the TNF signaling pathway and the p53 signaling pathway. PPI identified 10 hub genes, including CCL2, TGFB1, PTGS2, FN1, HGF, MYC, IGF1, CD44, CXCR4, and SERPINEL1. The GSE5296 dataset revealed that the control group exhibited lower expression levels than the SCI group, although only CD44 and TGFB1 showed significant differences. This study identified 129 autophagy-related genes that might play a role in SCI. CD44 and TGFB1 were identified as potentially important genes in the autophagy process after SCI. These findings provide new targets for future research and offer new perspectives on the pathogenesis of SCI.
    MeSH term(s) Humans ; Gene Expression Profiling/methods ; Protein Interaction Maps/genetics ; Reproducibility of Results ; Spinal Cord Injuries/genetics ; Spinal Cord Injuries/metabolism ; Autophagy/genetics ; Computational Biology/methods
    Language English
    Publishing date 2024-03-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-56683-1
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  7. Article: Common Structural Features of Hydrophobic α-Helical Hot Spots: Insights for the Design of Novel α-Helix Mimetics.

    Kell, Shelby R / Wang, Zhen / Ji, Haitao

    ACS medicinal chemistry letters

    2022  Volume 13, Issue 10, Page(s) 1670–1677

    Abstract: The binding conformations of α-helical hydrophobic hot spots are convergent into two spatial areas in protein-protein complex structures. The physical basis for convergence was disclosed, which allows the development of pharmacophore models ... ...

    Abstract The binding conformations of α-helical hydrophobic hot spots are convergent into two spatial areas in protein-protein complex structures. The physical basis for convergence was disclosed, which allows the development of pharmacophore models for
    Language English
    Publishing date 2022-09-14
    Publishing country United States
    Document type Journal Article
    ISSN 1948-5875
    ISSN 1948-5875
    DOI 10.1021/acsmedchemlett.2c00296
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  8. Article ; Online: Ginsenoside RG1-induced mesenchymal stem cells alleviate diabetic cardiomyopathy through secreting exosomal circNOTCH1 to promote macrophage M2 polarization.

    Zhen, Juan / Bai, Jinping / Liu, Jia / Men, Hongbo / Yu, Haitao

    Phytotherapy research : PTR

    2023  Volume 38, Issue 4, Page(s) 1745–1760

    Abstract: Diabetic cardiomyopathy (DCM) is a cardiac complication resulting from long-term uncontrolled diabetes, characterized by myocardial fibrosis and abnormal cardiac function. This study aimed at investigating the potential of ginsenoside RG1 (RG1)-induced ... ...

    Abstract Diabetic cardiomyopathy (DCM) is a cardiac complication resulting from long-term uncontrolled diabetes, characterized by myocardial fibrosis and abnormal cardiac function. This study aimed at investigating the potential of ginsenoside RG1 (RG1)-induced mesenchymal stem cells (MSCs) in alleviating DCM. A DCM mouse model was constructed, and the effects of RG1-induced MSCs on myocardial function and fibrosis in diabetic mice were evaluated. RG1-induced MSCs were cocultured with high glucose-treated fibroblasts for subsequent functional and mechanism assays. It was discovered that RG1-induced MSCs secrete exosomes that induce macrophage M2 polarization. Mechanistically, exosomes derived from RG1-induced MSCs transferred circNOTCH1 into macrophages, activating the NOTCH signaling pathway. A competing endogenous RNA (ceRNA) regulatory axis consisting of circNOTCH1, miR-495-3p, and NOTCH1 was found to contribute to DCM alleviation.. This study unveiled that exosomal circNOTCH1 secreted by RG1-induced MSCs can alleviate DCM by activating the NOTCH signaling pathway to induce macrophage M2 polarization. This finding may contribute to the development of new therapeutic approaches for DCM.
    MeSH term(s) Mice ; Animals ; Diabetic Cardiomyopathies/drug therapy ; Diabetes Mellitus, Experimental/metabolism ; Mesenchymal Stem Cells ; Macrophages/metabolism ; MicroRNAs/genetics ; Ginsenosides
    Chemical Substances ginsenoside Rg1 (PJ788634QY) ; MicroRNAs ; Ginsenosides
    Language English
    Publishing date 2023-09-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 639136-9
    ISSN 1099-1573 ; 0951-418X
    ISSN (online) 1099-1573
    ISSN 0951-418X
    DOI 10.1002/ptr.8018
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    Zs.B 3092: Show issues Location:
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  9. Article: Role of microencapsulated

    Cui, Yaoming / Huang, Peiyu / Duan, Haitao / Song, Shijia / Gan, Liping / Liu, Zhen / Lin, Qiaohan / Wang, Jinrong / Qi, Gunghai / Guan, Junjun

    Frontiers in microbiology

    2023  Volume 14, Page(s) 1287899

    Abstract: The alleviating effects ... ...

    Abstract The alleviating effects of
    Language English
    Publishing date 2023-11-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2023.1287899
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  10. Article ; Online: Retraction notice to "miR-367 regulation of DOC-2/DAB2 interactive protein promotes proliferation, migration and invasion of osteosarcoma cells" [Biomed. Pharmacother. 95 (2017) 120-128].

    Cai, Wei / Jiang, Haitao / Yu, Yifan / Xu, Yong / Zuo, Wenshan / Wang, Shouguo / Su, Zhen

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2023  Volume 160, Page(s) 114282

    Language English
    Publishing date 2023-01-31
    Publishing country France
    Document type Journal Article ; Retraction of Publication
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2023.114282
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    Ud II Zs.198: Show issues Location:
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