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  1. Article ; Online: Does the Use of Viscoelastic Hemostatic Assays for Periprocedural Hemostasis Management in Liver Disease Improve Clinical Outcomes?

    Maynard, Suzanne / Marrinan, Elizabeth / Roberts, Lara / Stanworth, Simon

    Transfusion medicine reviews

    2024  , Page(s) 150823

    Abstract: Routine hemostasis parameters such as prothrombin time and fibrinogen are frequently abnormal in patients with chronic liver disease and have been demonstrated to be poor predictors for periprocedural bleeding. Alterations in procoagulant and ... ...

    Abstract Routine hemostasis parameters such as prothrombin time and fibrinogen are frequently abnormal in patients with chronic liver disease and have been demonstrated to be poor predictors for periprocedural bleeding. Alterations in procoagulant and anticoagulant factors in this population result in a state of rebalanced hemostasis, which is not reflected by routine hemostatic measures. Viscoelastic hemostatic assays (VHA) present a point of care measure of global hemostasis with an emerging role in guiding transfusion in the liver transplant setting. The potential role for VHA in guiding periprocedural transfusion is unknown. Here we critically appraise the available limited evidence on the use of VHA to guide prophylactic treatment in patients with cirrhosis undergoing procedures. We assess whether the impact of a VHA-guided approach improves clinical outcomes. Suggested areas for future research with a focus on clinically relevant outcomes, particularly periprocedural bleeding, are highlighted.
    Language English
    Publishing date 2024-03-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639107-2
    ISSN 1532-9496 ; 0887-7963
    ISSN (online) 1532-9496
    ISSN 0887-7963
    DOI 10.1016/j.tmrv.2024.150823
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2239: Show issues Location:
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  2. Article ; Online: Acute myeloid leukaemia presenting with Sweet syndrome.

    Atkins, Oscar / Mirvis, Eitan / Maynard, Suzanne / Katsomitrou, Vaitsa

    British journal of haematology

    2022  Volume 199, Issue 5, Page(s) 637

    MeSH term(s) Humans ; Sweet Syndrome/diagnosis ; Sweet Syndrome/etiology ; Leukemia, Myeloid, Acute/complications ; Leukemia, Myeloid, Acute/diagnosis ; Myelodysplastic Syndromes
    Language English
    Publishing date 2022-09-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.18439
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  3. Article ; Online: Machine learning in transfusion medicine: A scoping review.

    Maynard, Suzanne / Farrington, Joseph / Alimam, Samah / Evans, Hayley / Li, Kezhi / Wong, Wai Keong / Stanworth, Simon J

    Transfusion

    2023  Volume 64, Issue 1, Page(s) 162–184

    MeSH term(s) Humans ; Transfusion Medicine ; Machine Learning
    Language English
    Publishing date 2023-11-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 208417-x
    ISSN 1537-2995 ; 0041-1132
    ISSN (online) 1537-2995
    ISSN 0041-1132
    DOI 10.1111/trf.17582
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    Zs.A 284: Show issues Location:
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  4. Article ; Online: Commentary on Nuyts et al. (2018): Education is the key to preventing growing inequalities in smoking prevalence.

    Maynard, Olivia M / Gage, Suzanne H

    Addiction (Abingdon, England)

    2018  Volume 113, Issue 3, Page(s) 533–534

    MeSH term(s) Netherlands ; Prevalence ; Smoking ; Socioeconomic Factors ; Tobacco Smoking
    Language English
    Publishing date 2018-02-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1141051-6
    ISSN 1360-0443 ; 0965-2140
    ISSN (online) 1360-0443
    ISSN 0965-2140
    DOI 10.1111/add.14115
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    Zs.B 551: Show issues Location:
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  5. Article ; Online: Smoke-free policies in psychiatric hospitals need resources.

    Gage, Suzanne H / Maynard, Olivia M

    The lancet. Psychiatry

    2017  Volume 4, Issue 7, Page(s) 509–510

    MeSH term(s) Hospitals, Psychiatric ; Inpatients ; Interrupted Time Series Analysis ; Physical Abuse ; Smoke-Free Policy ; Smoking Prevention
    Language English
    Publishing date 2017-06-15
    Publishing country England
    Document type Journal Article ; Comment
    ISSN 2215-0374
    ISSN (online) 2215-0374
    DOI 10.1016/S2215-0366(17)30241-9
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  6. Article ; Online: A pulsed-dose study evaluating chronic toxicity of chlorothalonil to fish: A case study for environmental risk assessment.

    Hamer, Mick / Maynard, Samuel K / Schneider, Suzanne

    Environmental toxicology and chemistry

    2019  Volume 38, Issue 7, Page(s) 1549–1559

    Abstract: Chlorothalonil is a fungicide which is highly toxic to aquatic organisms. However, in natural aquatic environments, it is very rapidly degraded, with a half-life typically in hours, reducing exposure of aquatic organisms and the potential for effects. In ...

    Abstract Chlorothalonil is a fungicide which is highly toxic to aquatic organisms. However, in natural aquatic environments, it is very rapidly degraded, with a half-life typically in hours, reducing exposure of aquatic organisms and the potential for effects. In standard regulatory studies looking at the chronic toxicity of chlorothalonil to fathead minnow, the most sensitive endpoint was fecundity. A standard fish full-life cycle study, where chlorothalonil concentrations were maintained constant throughout, resulted in a no-observed-effect concentration (NOEC) of 1.4 µg/L. Comparing peak modeled exposure concentrations to this NOEC can result in the chronic risk to fish being considered unacceptable. The present study investigated the effect on fecundity in fathead minnow using a fish short-term reproduction assay. Five different exposure profiles were employed with time-varying concentrations based on realistic worst-case modeled environmental exposure profiles, multiplied by an assessment factor of 10, which resulted in maximum measured concentrations up to 15.5 µg/L. There were no effects on fecundity from any of the exposure profiles tested. Therefore, based on these more realistic exposure profiles, the chronic risk to fish could be considered acceptable if these exposures were deemed to be representative of the worst case. Environ Toxicol Chem 2019;38:1549-1559. © 2019 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals, Inc. on behalf of SETAC.
    MeSH term(s) Animals ; Cyprinidae/growth & development ; Cyprinidae/physiology ; Female ; Fungicides, Industrial/chemistry ; Fungicides, Industrial/toxicity ; Hydrogen-Ion Concentration ; Nitriles/chemistry ; Nitriles/toxicity ; Ovum/drug effects ; Ovum/growth & development ; Ovum/metabolism ; Reproduction/drug effects ; Risk Assessment ; Temperature ; Water Pollutants, Chemical/chemistry ; Water Pollutants, Chemical/toxicity
    Chemical Substances Fungicides, Industrial ; Nitriles ; Water Pollutants, Chemical ; tetrachloroisophthalonitrile (J718M71A7A)
    Language English
    Publishing date 2019-06-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 46234-2
    ISSN 1552-8618 ; 0730-7268
    ISSN (online) 1552-8618
    ISSN 0730-7268
    DOI 10.1002/etc.4421
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    Zs.A 2312: Show issues Location:
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  7. Article: "Capgras" Delusions Involving Belongings, Not People, and Evolving Visual Hallucinations Associated with Occipital Lobe Seizures.

    Lilly, Brandon / Maynard, Erika / Melvin, Kelly / Holroyd, Suzanne

    Case reports in psychiatry

    2018  Volume 2018, Page(s) 1459869

    Abstract: Capgras syndrome is characterized by the delusional belief that a familiar person has been replaced by a visually similar imposter or replica. Rarely, the delusional focus may be objects rather than people. Numerous etiologies have been described for ... ...

    Abstract Capgras syndrome is characterized by the delusional belief that a familiar person has been replaced by a visually similar imposter or replica. Rarely, the delusional focus may be objects rather than people. Numerous etiologies have been described for Capgras to include seizures. Similarly, visual hallucinations, both simple and complex, can occur secondary to seizure activity. We present, to our knowledge, the first reported case of visual hallucinations and Capgras delusions for objects that developed secondary to new onset occipital lobe epilepsy. We then discuss the possible underlying neurologic mechanisms responsible for the symptomatology.
    Language English
    Publishing date 2018-03-07
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2629914-8
    ISSN 2090-6838 ; 2090-682X
    ISSN (online) 2090-6838
    ISSN 2090-682X
    DOI 10.1155/2018/1459869
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  8. Article ; Online: Seizures after initiation of rewarming in cooled infants with hypoxic ischaemic encephalopathy.

    Battin, Malcolm R / Davis, Suzanne L / Gardner, Marisa / Joe, Priscilla / Rasmussen, Maynard / Haas, Richard / Sharpe, Cynthia

    Pediatric research

    2023  Volume 95, Issue 3, Page(s) 752–757

    Abstract: Background: Seizures after initiation of rewarming from therapeutic hypothermia for neonatal encephalopathy are well recognised but not easy to predict.: Methods: A secondary analysis was performed of NEOLEV2 trial data, a multicentre randomised ... ...

    Abstract Background: Seizures after initiation of rewarming from therapeutic hypothermia for neonatal encephalopathy are well recognised but not easy to predict.
    Methods: A secondary analysis was performed of NEOLEV2 trial data, a multicentre randomised trial of levetiracetam versus phenobarbital for neonatal seizures. Enrolled infants underwent continuous video EEG (cEEG) monitoring. The trial data were reviewed for 42 infants with seizures during therapeutic hypothermia and 118 infants who received therapeutic hypothermia but had no seizures on cEEG.
    Results: Overall, 112 of 160 (70%) had cEEG monitoring continued until rewarming was completed. Of the 42 infants with prior seizures, there were 30 infants with valid cEEG available and seizures occurred following the initiation of rewarming in 8 (26.6%). For the 118 seizure-naive infants, 82 (69.5%) continued cEEG until either rewarming was completed or 90 h of age and none had documented seizures.
    Conclusion: Overall, just over a quarter of infants with prior seizures had cEEG evidence of at least one seizure in the 24 h after initiation of rewarming but no seizure-naive infant had cEEG evidence of seizure(s) on rewarming. Critically, by reporting the two groups separately, the data can provide guidance on the duration of EEG monitoring.
    Impact: Infants with hypoxic ischaemic encephalopathy who have cEEG evidence of seizures during therapeutic hypothermia have a significant risk of further seizures on rewarming. For infants with hypoxic ischaemic encephalopathy but no cEEG evidence of seizures during therapeutic hypothermia, there is very little risk of de novo seizures. Ongoing work utilising large cohorts may generate EEG criteria that refine estimates of risk for rewarming seizures. Based on current experience, if seizures have occurred during therapeutic hypothermia for hypoxic ischaemic encephalopathy, the EEG monitoring should be continued during rewarming and for 12 h thereafter to minimise the risk of missing an event.
    MeSH term(s) Infant, Newborn ; Humans ; Rewarming ; Hypoxia-Ischemia, Brain/complications ; Hypoxia-Ischemia, Brain/therapy ; Seizures/drug therapy ; Electroencephalography ; Hypothermia, Induced/adverse effects
    Language English
    Publishing date 2023-11-01
    Publishing country United States
    Document type Randomized Controlled Trial ; Multicenter Study ; Journal Article
    ZDB-ID 4411-8
    ISSN 1530-0447 ; 0031-3998
    ISSN (online) 1530-0447
    ISSN 0031-3998
    DOI 10.1038/s41390-023-02863-0
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    Zs.A 564: Show issues Location:
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    Zs.MO 373: Show issues

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  9. Article: A pulsed‐dose study evaluating chronic toxicity of chlorothalonil to fish: A case study for environmental risk assessment

    Hamer, Mick / Maynard, Samuel K / Schneider, Suzanne

    Environmental toxicology and chemistry. 2019 July, v. 38, no. 7

    2019  

    Abstract: Chlorothalonil is a fungicide which is highly toxic to aquatic organisms. However, in natural aquatic environments, it is very rapidly degraded, with a half‐life typically in hours, reducing exposure of aquatic organisms and the potential for effects. In ...

    Abstract Chlorothalonil is a fungicide which is highly toxic to aquatic organisms. However, in natural aquatic environments, it is very rapidly degraded, with a half‐life typically in hours, reducing exposure of aquatic organisms and the potential for effects. In standard regulatory studies looking at the chronic toxicity of chlorothalonil to fathead minnow, the most sensitive endpoint was fecundity. A standard fish full–life cycle study, where chlorothalonil concentrations were maintained constant throughout, resulted in a no‐observed‐effect concentration (NOEC) of 1.4 μg/L. Comparing peak modeled exposure concentrations to this NOEC can result in the chronic risk to fish being considered unacceptable. The present study investigated the effect on fecundity in fathead minnow using a fish short‐term reproduction assay. Five different exposure profiles were employed with time‐varying concentrations based on realistic worst‐case modeled environmental exposure profiles, multiplied by an assessment factor of 10, which resulted in maximum measured concentrations up to 15.5 μg/L. There were no effects on fecundity from any of the exposure profiles tested. Therefore, based on these more realistic exposure profiles, the chronic risk to fish could be considered acceptable if these exposures were deemed to be representative of the worst case. Environ Toxicol Chem 2019;38:1549–1559. © 2019 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals, Inc. on behalf of SETAC.
    Keywords Pimephales promelas ; aquatic environment ; case studies ; chlorothalonil ; chronic toxicity ; environmental assessment ; environmental exposure ; exposure profile ; fecundity ; fish ; half life ; risk
    Language English
    Dates of publication 2019-07
    Size p. 1549-1559.
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 46234-2
    ISSN 1552-8618 ; 0730-7268
    ISSN (online) 1552-8618
    ISSN 0730-7268
    DOI 10.1002/etc.4421
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Are waterpipe users tobacco-dependent?

    Maynard, Olivia M / Gage, Suzanne H / Munafò, Marcus R

    Addiction (Abingdon, England)

    2013  Volume 108, Issue 11, Page(s) 1886–1887

    MeSH term(s) Female ; Humans ; Male ; Smoking
    Language English
    Publishing date 2013-10-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1141051-6
    ISSN 1360-0443 ; 0965-2140
    ISSN (online) 1360-0443
    ISSN 0965-2140
    DOI 10.1111/add.12317
    Database MEDical Literature Analysis and Retrieval System OnLINE

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