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  1. Article ; Online: Case Report: A Case of Complicated Typhoid Fever with Rhabdomyolysis and Hemophagocytic Lymphohistiocytosis.

    Selvam, Suresh / Singh, Harpreet / Seth, Sonal / Suri, Vikas / Bhalla, Ashish / Sachdeva, Man Updesh Singh

    The American journal of tropical medicine and hygiene

    2024  Volume 110, Issue 3, Page(s) 501–503

    Abstract: Typhoid fever can have diverse extra-intestinal complications including encephalitis, Guillain-Barré syndrome, endocarditis, myocarditis, osteomyelitis, renal abscess, and splenic abscesses. Secondary hemophagocytic lymphohistiocytosis with ... ...

    Abstract Typhoid fever can have diverse extra-intestinal complications including encephalitis, Guillain-Barré syndrome, endocarditis, myocarditis, osteomyelitis, renal abscess, and splenic abscesses. Secondary hemophagocytic lymphohistiocytosis with rhabdomyolysis is a rare complication of typhoid fever. Here, we present the case of an adolescent with typhoid fever complicated by rhabdomyolysis and hemophagocytic lymphohistiocytosis.
    MeSH term(s) Adolescent ; Humans ; Typhoid Fever/complications ; Typhoid Fever/diagnosis ; Typhoid Fever/drug therapy ; Lymphohistiocytosis, Hemophagocytic/complications ; Splenic Diseases/complications ; Splenic Diseases/diagnostic imaging ; Myocarditis/complications ; Abdominal Abscess ; Rhabdomyolysis/complications
    Language English
    Publishing date 2024-01-30
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2942-7
    ISSN 1476-1645 ; 0002-9637
    ISSN (online) 1476-1645
    ISSN 0002-9637
    DOI 10.4269/ajtmh.23-0580
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Relapsed Multiple Myeloma with Anaplastic Transformation.

    Sundaresan, Durgadevi / Bhagat, Snehvarsha / Sreedharanunni, Sreejesh / Sachdeva, Man Updesh Singh / Malhotra, Pankaj / Sharma, Praveen

    Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion

    2023  Volume 40, Issue 1, Page(s) 179–180

    Language English
    Publishing date 2023-06-03
    Publishing country India
    Document type Journal Article
    ZDB-ID 2422370-0
    ISSN 0974-0449 ; 0971-4502
    ISSN (online) 0974-0449
    ISSN 0971-4502
    DOI 10.1007/s12288-023-01672-z
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  3. Article ; Online: Post-transplant cyclophosphamide pharmacokinetics and haploidentical hematopoietic cell transplantation outcomes: an exploratory study.

    Kasudhan, Kripa Shanker / Patil, Amol N / Jandial, Aditya / Khadwal, Alka / Prakash, Gaurav / Jain, Arihant / Bhurani, Dinesh / Ahmed, Rayaz / Agrawal, Narendra / Singh, Reema / Sachdeva, Man Updesh Singh / Varma, Neelam / Das, Reena / Verma Attri, Savita / Malhotra, Samir / Majhail, Navneet S / Malhotra, Pankaj / Lad, Deepesh P

    Leukemia & lymphoma

    2022  Volume 63, Issue 11, Page(s) 2679–2685

    Abstract: Pharmacokinetics of cyclophosphamide has been explored to optimize conditioning dosing. We hypothesized that post-transplant cyclophosphamide (PTCy) metabolite carboxy-ethyl phosphoramide mustard (CEPM) pharmacokinetics might impact haploidentical ... ...

    Abstract Pharmacokinetics of cyclophosphamide has been explored to optimize conditioning dosing. We hypothesized that post-transplant cyclophosphamide (PTCy) metabolite carboxy-ethyl phosphoramide mustard (CEPM) pharmacokinetics might impact haploidentical transplantation (haplo-HCT) outcomes. CEPM area under the curve (AUC<sub>0-48</sub>) was determined by eleven sampling timepoints on day +3/+4 using LC-MS/MS. The median CEPM AUC<sub>0-48</sub> in a cohort of 30 patients was 14.2 (14) mg·hr/L. The incidence of severe chronic graft-versus-host disease (GVHD) (73% vs. 11%, p = 0.02), and GVHD-/relapse-free survival (GRFS) was significantly inferior in the CEPM AUC<sub>0-48</sub> < 14 mg·hr/L group (54 days vs. 344 days, p = 0.02). There was, however, no difference in grade III-IV acute GVHD (38% vs. 14%, p = 0.12) and overall survival (295 days vs. not reached, p = 0.2). CEPM AUC<sub>0-48,</sub> is associated with severe chronic GVHD and GRFS post-haplo-HCT in this exploratory study. There is scope for personalizing day + 4 PTCy dose based on day + 3 CEPM AUC<sub>0-8</sub>.
    MeSH term(s) Humans ; Graft vs Host Disease/etiology ; Graft vs Host Disease/prevention & control ; Transplantation Conditioning/adverse effects ; Chromatography, Liquid ; Neoplasm Recurrence, Local ; Tandem Mass Spectrometry ; Hematopoietic Stem Cell Transplantation/adverse effects ; Cyclophosphamide/adverse effects ; Retrospective Studies
    Chemical Substances Cyclophosphamide (8N3DW7272P)
    Language English
    Publishing date 2022-06-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1042374-6
    ISSN 1029-2403 ; 1042-8194
    ISSN (online) 1029-2403
    ISSN 1042-8194
    DOI 10.1080/10428194.2022.2087067
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2997: Show issues Location:
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  4. Article: Bone Marrow Metastasis in a Suspected Case of Angiosarcoma Unravelled by Immunohistochemistry.

    Sharma, Saniya / Sachdeva, Man Updesh Singh / Rastogi, Pulkit / Prabhakar, Nidhi

    Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion

    2021  Volume 38, Issue 2, Page(s) 432–433

    Abstract: A 40-year-old female presented with progressive fatigue and left upper abdominal discomfort for 1 month. CT scan revealed ill-defined hypervascular lesions in the liver and diffuse enlargement of the spleen. She had severe anemia with leukoerythroblastic ...

    Abstract A 40-year-old female presented with progressive fatigue and left upper abdominal discomfort for 1 month. CT scan revealed ill-defined hypervascular lesions in the liver and diffuse enlargement of the spleen. She had severe anemia with leukoerythroblastic reaction. Bone marrow smears revealed clusters and discrete spindle cells, few plump and round cells. Trephine biopsy revealed an infiltrative spindle-cell neoplasm replacing the marrow with the focal presence of epithelioid cell clusters. On immunostaining, the tumor cells were positive for CD34, CD31, Friend Leukemia Virus Integration-1 (FLI1), and vimentin, consistent with metastatic angiosarcoma. There were multiple small aggregates of 5-10 MIB-1 positive tumor cells (overall positivity < 1%). She succumbed to her illness before initiation of any therapy. Bone marrow metastasis of angiosarcoma is extremely rare. The aggressive clinical course and judicious use of immunohistochemical markers are required for definitive diagnosis.
    Language English
    Publishing date 2021-10-27
    Publishing country India
    Document type Journal Article
    ZDB-ID 2422370-0
    ISSN 0974-0449 ; 0971-4502
    ISSN (online) 0974-0449
    ISSN 0971-4502
    DOI 10.1007/s12288-021-01501-1
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  5. Article: An alternative approach to confirm mixed lineage involvement in acute leukemia with

    Ray, Debadrita / Sreedharanunni, Sreejesh / Balakrishnan, Anand / Sharma, Praveen / Mallik, Nabhajit / Peyam, Srinivasan / Sachdeva, Man Updesh Singh

    Blood research

    2023  Volume 58, Issue 2, Page(s) 120–123

    Language English
    Publishing date 2023-06-26
    Publishing country Korea (South)
    Document type Letter
    ZDB-ID 2711910-5
    ISSN 2288-0011 ; 2287-979X
    ISSN (online) 2288-0011
    ISSN 2287-979X
    DOI 10.5045/br.2023.2023084
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  6. Article: Autopsy findings of acute erythroid leukemia.

    Parkhi, Mayur / Mallik, Nabhajit / Lad, Deepesh / Sachdeva, Man Updesh Singh / Bal, Amanjit / Malhotra, Pankaj / Mitra, Suvradeep

    Autopsy & case reports

    2023  Volume 13, Page(s) e2023429

    Abstract: ... myeloblasts. We describe an autopsy case of this rare entity in a 62-year-old man with co-morbidities ...

    Abstract Acute erythroid leukemia (AEL) is an exceedingly uncommon but distinct hematological malignancy that shows neoplastic proliferation of erythroid precursors with maturation arrest and no significant myeloblasts. We describe an autopsy case of this rare entity in a 62-year-old man with co-morbidities. He underwent a bone marrow (BM) examination for pancytopenia during the first outpatient department visit, which revealed an increased number of erythroid precursors with dysmegakaryopoiesis suggesting the possibility of Myelodysplastic syndromes (MDS). Thereafter, his cytopenia got worsened, warranting blood and platelet transfusions. Four weeks later on the second BM examination, AEL was diagnosed based on morphology and immunophenotyping. Targeted resequencing for myeloid mutations revealed TP53 and DNMT3A mutations. He was initially managed along febrile neutropenia with the stepwise escalation of antibiotics. He developed hypoxia attributed to anemic heart failure. Subsequently, he had hypotension and respiratory fatigue pre-terminally and succumbed to his Illness. A complete autopsy showed infiltration of various organs by AEL and leukostasis. Besides, there was extramedullary hematopoiesis, arterionephrosclerosis, diabetic nephropathy (ISN-RPS class II), mixed dust pneumoconiosis, and pulmonary arteriopathy. The histomorphology of AEL was challenging, and the differential diagnoses were many. Thus, this case highlights the autopsy pathology of AEL, an uncommon entity with a strict definition, and its relevant differentials.
    Language English
    Publishing date 2023-05-08
    Publishing country Brazil
    Document type Case Reports
    ZDB-ID 2815488-5
    ISSN 2236-1960
    ISSN 2236-1960
    DOI 10.4322/acr.2023.429
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  7. Article ; Online: The frequency and clinical outcome of mono-hit and multi-hit TP53 aberrations in newly diagnosed multiple myeloma.

    Sreedharanunni, Sreejesh / Singla, Shelly / Balakrishnan, Anand / Singh, Archana / Jamwal, Manu / Singh, Namrata / Singh, Charanpreet / Jandial, Aditya / Lad, Deepesh / Sharma, Praveen / Sachdeva, Man Updesh Singh / Malhotra, Pankaj / Das, Reena

    Pathology

    2024  

    Abstract: We investigated the frequency and outcome of mono-hit and multi-hit TP53 aberrations [biallelic or ≥1 TP53 mutations (TP53mut) or TP53mut with variant allele frequency (VAF) ≥55%] in an Indian cohort of newly diagnosed multiple myeloma (NDMM) patients. ... ...

    Abstract We investigated the frequency and outcome of mono-hit and multi-hit TP53 aberrations [biallelic or ≥1 TP53 mutations (TP53mut) or TP53mut with variant allele frequency (VAF) ≥55%] in an Indian cohort of newly diagnosed multiple myeloma (NDMM) patients. We employed fluorescence insitu hybridisation (FISH; n=457) and targeted next-generation sequencing (NGS; n=244) on plasma cell-enriched samples. We also studied the impact of TP53mut in cases with and without TP53 deletions (TP53del). In our cohort with a median age of 60 years, TP53del and TP53mut were seen in 12.9% (n=59/457; 14-95% cells) and 10.2% (n=25/244; 30 variants; VAF 3.4-98.2%; median 38.2%) respectively. Mono-hit and multi-hit-TP53 aberrations were observed in 10.2% and 7.8%, respectively. Compared to TP53-wild-type (TP53wt), mono-hit and multi-hit TP53 aberrations were associated with significantly poorer progression-free survival (PFS) (22.6 vs 12.1 vs 9.5 months; p=0.004) and overall survival (OS) [not reached (NR) vs 13.1 vs 15.6 months respectively; p=0.024]. However, multi-hit TP53 did not significantly differ in OS/PFS compared to mono-hit cases. Compared to TP53wt, PFS and OS were significantly poorer in patients with TP53mut only (9.5 vs 22.6 months and 12.1 months vs NR, respectively; p=0.020/0.004). TP53mut retained its significance even in the presence of any Revised International Staging System (HR 2.1; 95% CI 1.1-3.8; p=0.015) for OS. The detection of additional cases with TP53 aberrations, as well as poor survival associated with the presence of mutation alone, supports TP53mut testing in NDMM at least in patients without TP53del and other high-risk cytogenetic abnormalities.
    Language English
    Publishing date 2024-02-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 7085-3
    ISSN 1465-3931 ; 0031-3025
    ISSN (online) 1465-3931
    ISSN 0031-3025
    DOI 10.1016/j.pathol.2023.12.415
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 723: Show issues Location:
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  8. Article: Chromosome 7q31 Amplification in Fluorescence

    Kapadia, Alpeshkumar Bipinbhai / Naseem, Shano / Sachdeva, Man Updesh Singh / Sreedharanunni, Sreejesh

    Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion

    2020  Volume 37, Issue 3, Page(s) 514–516

    Language English
    Publishing date 2020-11-13
    Publishing country India
    Document type Journal Article
    ZDB-ID 2422370-0
    ISSN 0974-0449 ; 0971-4502
    ISSN (online) 0974-0449
    ISSN 0971-4502
    DOI 10.1007/s12288-020-01380-y
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  9. Article ; Online: Mantle cell lymphoma with diminished expression of B-cell antigens: an unusual presentation.

    Virk, Harpreet / Sreedharanunni, Sreejesh / Sachdeva, Man Updesh Singh / Das, Ashim

    BMJ case reports

    2020  Volume 13, Issue 7

    MeSH term(s) Antigens, CD/analysis ; Biopsy ; Bone Marrow/pathology ; Cyclin D1/genetics ; Genes, bcl-1 ; Humans ; In Situ Hybridization, Fluorescence ; Kidney/pathology ; Lymphoma, Mantle-Cell/blood ; Lymphoma, Mantle-Cell/genetics ; Lymphoma, Mantle-Cell/immunology ; Lymphoma, Mantle-Cell/pathology ; Male ; Middle Aged ; Translocation, Genetic
    Chemical Substances Antigens, CD ; CCND1 protein, human ; Cyclin D1 (136601-57-5)
    Language English
    Publishing date 2020-07-16
    Publishing country England
    Document type Case Reports
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2020-235561
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  10. Article ; Online: Monocyte platelet aggregates in children with Kawasaki disease- a preliminary study from a tertiary care centre in North-West India.

    Vignesh, Pandiarajan / Rawat, Amit / Shandilya, Jitendra Kumar / Singh Sachdeva, Man Updesh / Ahluwalia, Jasmina / Singh, Surjit

    Pediatric rheumatology online journal

    2021  Volume 19, Issue 1, Page(s) 25

    Abstract: Background: Platelet activation is an integral part of pathogenesis of Kawasaki disease (KD). However, there is paucity of literature on flow-cytometry based assessment of platelet activation in KD. We aimed to analyse monocyte-platelet aggregates (MPAs) ...

    Abstract Background: Platelet activation is an integral part of pathogenesis of Kawasaki disease (KD). However, there is paucity of literature on flow-cytometry based assessment of platelet activation in KD. We aimed to analyse monocyte-platelet aggregates (MPAs), one of the sensitive markers for platelet activation, by flow cytometry in children with KD.
    Findings: In this single-centre prospective study, we have enrolled 14 children with KD and results were compared with age-matched febrile (n = 15) and healthy (n = 13) controls. After gating monocytes in side-scatter plot, MPAs were identified based on CD14 and CD41 expression. Two (2) ml of blood samples for children with KD were collected at 3 phases of illness- acute stage before start of intravenous immunoglobulin or aspirin, 24 h after completion of IVIg infusion, and 3 months after acute episode of KD. Children with KD had a significantly higher MPA% values [Median (IQR)- 41.3% (26.6, 52.7)] when compared with febrile [Median (IQR)- 5.98% (2.98-9.72)] and normal [Median (IQR)- 4.48% (2.57-5.59)] controls, p<0.01. On follow-up, the MPA% showed a gradual decline in children with KD, but even at 3 months, the value [Median (IQR)- 7.55% (4.15-14.6)] was higher compared to healthy controls [Median (IQR)- 4.48% (2.57-5.59)].
    Conclusions: Our results suggest that MPA% was significantly elevated in acute stages in children with KD and activated platelets may continue to persist even after systemic inflammation has subsided. Future studies are warranted whether objective evidence of platelet activation may guide the use of immunomodulatory and anti-platelet therapy in KD.
    MeSH term(s) Blood Platelets ; Cell Aggregation ; Child ; Child, Preschool ; Female ; Humans ; India ; Male ; Monocytes ; Mucocutaneous Lymph Node Syndrome/blood ; Platelet Activation ; Prospective Studies ; Tertiary Care Centers
    Language English
    Publishing date 2021-03-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2279468-2
    ISSN 1546-0096 ; 1546-0096
    ISSN (online) 1546-0096
    ISSN 1546-0096
    DOI 10.1186/s12969-021-00515-3
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