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  1. Article ; Online: Also the parents of children with type 1 diabetes need psychological support.

    Ludvigsson, Johnny

    Acta paediatrica (Oslo, Norway : 1992)

    2024  

    Language English
    Publishing date 2024-03-03
    Publishing country Norway
    Document type Editorial
    ZDB-ID 203487-6
    ISSN 1651-2227 ; 0365-1436 ; 0803-5253
    ISSN (online) 1651-2227
    ISSN 0365-1436 ; 0803-5253
    DOI 10.1111/apa.17188
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  2. Article ; Online: Immune Interventions at Onset of Type 1 Diabetes - Finally, a Bit of Hope.

    Ludvigsson, Johnny

    The New England journal of medicine

    2023  Volume 389, Issue 23, Page(s) 2199–2201

    MeSH term(s) Humans ; Diabetes Mellitus, Type 1/drug therapy ; Immunotherapy/methods ; Hope ; Time Factors
    Language English
    Publishing date 2023-12-06
    Publishing country United States
    Document type Editorial
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMe2312091
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  3. Article ; Online: Determination of autoantibodies in type 2 diabetes: one simple way to improve classification.

    Ludvigsson, Johnny

    Diabetologia

    2023  Volume 66, Issue 5, Page(s) 955–957

    Abstract: This letter aims to increase interest in better classification of type 2 diabetes. This can be done in a simple and cheap way via determination of autoantibodies. Autoantibody analysis can be used to detect the 7-12% of people with diabetes that is ... ...

    Abstract This letter aims to increase interest in better classification of type 2 diabetes. This can be done in a simple and cheap way via determination of autoantibodies. Autoantibody analysis can be used to detect the 7-12% of people with diabetes that is phenotypic of type 2 diabetes but is, in fact, latent autoimmune diabetes in adults (LADA), which may be regarded as a variant of type 1 diabetes. This may help to explain why some individuals with type 2 diabetes do not go into remission after reducing their weight, while others do, and why remission sometimes ends earlier than expected. Improved classification of diabetes may play an important role in determining adequate therapy.
    MeSH term(s) Adult ; Humans ; Diabetes Mellitus, Type 2/diagnosis ; Autoantibodies ; Diabetes Mellitus, Type 1 ; Latent Autoimmune Diabetes in Adults ; Glutamate Decarboxylase
    Chemical Substances Autoantibodies ; Glutamate Decarboxylase (EC 4.1.1.15)
    Language English
    Publishing date 2023-01-11
    Publishing country Germany
    Document type Letter
    ZDB-ID 1694-9
    ISSN 1432-0428 ; 0012-186X
    ISSN (online) 1432-0428
    ISSN 0012-186X
    DOI 10.1007/s00125-022-05858-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Glutamic acid decarboxylase immunotherapy for type 1 diabetes.

    Ludvigsson, Johnny

    Current opinion in endocrinology, diabetes, and obesity

    2022  Volume 29, Issue 4, Page(s) 361–369

    Abstract: Purpose of review: To describe recent development of an autoantigen (GAD) treatment towards well tolerated and efficacious precision medicine in type 1 diabetes.: Recent findings: Although subcutaneous GAD-alum treatment failed to reach primary ... ...

    Abstract Purpose of review: To describe recent development of an autoantigen (GAD) treatment towards well tolerated and efficacious precision medicine in type 1 diabetes.
    Recent findings: Although subcutaneous GAD-alum treatment failed to reach primary endpoint in a phase III trial, metanalyses showed a 97% probability of efficacy, and clear efficacy in patients carrying Hyman Leucoycte Antigen (HLA) DR3DQ2. Efforts have been made to improve efficacy by trying combination therapies with vitamin D + Ibuprofen resp vitamin D + Etanercept (TNF-α inhibition), without any breakthrough until the administration of GAD-alum was changed from subcutaneous to intralymphatic. With a very small dose of GAD-alum (4 μg) given into an inguinal lymph three times with 1 month interval, the efficacy in patients with HLADR3DQ2 has been impressive, with significantly better beta cell preservation than patients who got placebo in a double-blind randomized trial, and clinical efficacy with more patients in partial remission (IDAA1c < 9) and larger proportion of patients with CGM-measured blood glucose Time In Range (TIR), significantly correlated to the C-peptide values. The treatment has been easy for patients and healthcare without treatment-related risk or adverse events.
    Summary: Intralymphatic GAD-alum treatment in type 1 diabetes patients carrying HLA DR3DQ2 seems to be an attractive immune intervention.
    MeSH term(s) Autoantigens ; Diabetes Mellitus, Type 1 ; Glutamate Decarboxylase/therapeutic use ; Humans ; Immunotherapy ; Randomized Controlled Trials as Topic ; Vitamin D/therapeutic use
    Chemical Substances Autoantigens ; Vitamin D (1406-16-2) ; Glutamate Decarboxylase (EC 4.1.1.15)
    Language English
    Publishing date 2022-07-02
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2272017-0
    ISSN 1752-2978 ; 1752-296X
    ISSN (online) 1752-2978
    ISSN 1752-296X
    DOI 10.1097/MED.0000000000000748
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Time spent outdoors in childhood related to myopia among young adults in the Swedish ABIS cohort.

    Bro, Tomas / Ludvigsson, Johnny

    Acta ophthalmologica

    2024  

    Abstract: Purpose: Elucidate the prevalence of myopia among young adults from a birth cohort of Swedish children and its relationship to possible risk factors during their childhood.: Methods: Five thousand two hundred young adults, mean 23.4 years and 58% ... ...

    Abstract Purpose: Elucidate the prevalence of myopia among young adults from a birth cohort of Swedish children and its relationship to possible risk factors during their childhood.
    Methods: Five thousand two hundred young adults, mean 23.4 years and 58% females, participating in the prospective birth cohort All Babies in Southeast Sweden (ABIS) answered a questionnaire including questions regarding health and physical activity, spectacle use, myopia and age at first optical correction. Questionnaires at previous follow-ups at ages 2-3, 5-6 and 8 years included information on type of housing, time outdoors, screen time and hours of reading. Myopia prevalence and associations with potential risk factors were analysed in univariate and multivariate regression models with Bonferroni's correction of p-values.
    Results: In the ABIS Swedish birth cohort of young adults, the prevalence of myopia was 29%. A univariate logistic regression showed a higher odds ratio for myopia with female gender (OR 1.59; p < 0.05) and a completed and started university education (OR 1.52; p < 0.05). Significantly lower odds ratios were found for hours spent outdoors at 8 years of age (OR 0.82; p < 0.05). Multivariate logistic regression showed a higher odds ratio for myopia in females (OR 1.52-1.57; p < 0.05) and completed and started university education (OR 1.34-1.49; p < 0.05) in all models. In a model including accommodative effort, measured in diopter hours at 8 years of age, hours spent outdoors were associated with a lower odds ratio for myopia (OR 0.86; p < 0.05). No association could be detected between myopia and the type of housing or near work.
    Conclusion: The prevalence of myopia among young adults in a Swedish birth cohort was lower or unchanged compared to previous data. Female gender, higher education and less time spent outdoors in childhood were associated with an increased risk of developing myopia. Recommendations from child health services and schools should be given to stimulate children to spend enough time outdoors.
    Language English
    Publishing date 2024-04-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2408333-1
    ISSN 1755-3768 ; 1755-375X
    ISSN (online) 1755-3768
    ISSN 1755-375X
    DOI 10.1111/aos.16688
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  6. Article ; Online: Effect of COVID-19 pandemic on treatment of Type 1 diabetes in children.

    Ludvigsson, Johnny

    Acta paediatrica (Oslo, Norway : 1992)

    2020  Volume 110, Issue 3, Page(s) 933–934

    MeSH term(s) Adolescent ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19/transmission ; Child ; Child, Preschool ; Diabetes Mellitus, Type 1/blood ; Diabetes Mellitus, Type 1/therapy ; Glycated Hemoglobin A/metabolism ; Humans ; Physical Distancing ; Sweden ; Telemedicine/organization & administration
    Chemical Substances Glycated Hemoglobin A
    Keywords covid19
    Language English
    Publishing date 2020-10-29
    Publishing country Norway
    Document type Journal Article
    ZDB-ID 203487-6
    ISSN 1651-2227 ; 0365-1436 ; 0803-5253
    ISSN (online) 1651-2227
    ISSN 0365-1436 ; 0803-5253
    DOI 10.1111/apa.15627
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  7. Article ; Online: Fixeringen vid antal döda med covid-19 är vilseledande.

    Ludvigsson, Johnny

    Lakartidningen

    2020  Volume 117

    Abstract: Misleading obsession to number of deaths with Covid-19. ...

    Title translation Misleading obsession to number of deaths with Covid-19.
    Abstract Misleading obsession to number of deaths with Covid-19.
    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/mortality ; Humans ; Pandemics ; Pneumonia, Viral/mortality ; SARS-CoV-2
    Keywords covid19
    Language Swedish
    Publishing date 2020-08-28
    Publishing country Sweden
    Document type Journal Article
    ZDB-ID 391010-6
    ISSN 1652-7518 ; 0023-7205
    ISSN (online) 1652-7518
    ISSN 0023-7205
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  8. Article: Insulin Adverse Events.

    Ludvigsson, Johnny

    Pediatric endocrinology reviews : PER

    2020  Volume 17, Issue Suppl 1, Page(s) 183–190

    Abstract: The negative consequencies of diabetes treatment are traditionally regarded as caused by a disastrous treatment rather than adverse events of the insulin preparations. However, hypoglycemia, changes at the injection site (lipatrophy, lipoma), insulin ... ...

    Abstract The negative consequencies of diabetes treatment are traditionally regarded as caused by a disastrous treatment rather than adverse events of the insulin preparations. However, hypoglycemia, changes at the injection site (lipatrophy, lipoma), insulin allergy, obesity and increased risk of certain forms of cancer can easily be regarded as adverse events of the drug, and needle-phobia, psychological problems, increased risk of suicide are adverse events related to insulin and its administration. Also macroangiopathy and even microangiopathy to some extent can be regarded as adverse events as the most crucial part of the treatment of Type 1 diabetes is the insulin treatment. There is still room for improvments of insulin as a drug. We need insulins with more predictable absorption and kinetics, leading to more stable near-normal blood glucose, less risk of hypoglycemia, less effect in periphery and more effect on the liver, and less risk of vascular complications, obesity, cancer.
    MeSH term(s) Blood Glucose ; Diabetes Mellitus, Type 2 ; Humans ; Hypoglycemia ; Hypoglycemic Agents ; Insulin/therapeutic use
    Chemical Substances Blood Glucose ; Hypoglycemic Agents ; Insulin
    Language English
    Publishing date 2020-03-21
    Publishing country Israel
    Document type Journal Article
    ZDB-ID 2434390-0
    ISSN 1565-4753
    ISSN 1565-4753
    DOI 10.17458/per.vol17.2020.l.insulinadverseevents
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  9. Article ; Online: Autoantigen Treatment in Type 1 Diabetes: Unsolved Questions on How to Select Autoantigen and Administration Route.

    Ludvigsson, Johnny

    International journal of molecular sciences

    2020  Volume 21, Issue 5

    Abstract: Autoantigen treatment has been tried for the prevention of type 1 diabetes (T1D) and to preserve residual beta-cell function in patients with a recent onset of the disease. In experimental animal models, efficacy was good, but was insufficient in human ... ...

    Abstract Autoantigen treatment has been tried for the prevention of type 1 diabetes (T1D) and to preserve residual beta-cell function in patients with a recent onset of the disease. In experimental animal models, efficacy was good, but was insufficient in human subjects. Besides the possible minor efficacy of peroral insulin in high-risk individuals to prevent T1D, autoantigen prevention trials have failed. Other studies on autoantigen prevention and intervention at diagnosis are ongoing. One problem is to select autoantigen/s; others are dose and route. Oral administration may be improved by using different vehicles. Proinsulin peptide therapy in patients with T1D has shown possible minor efficacy. In patients with newly diagnosed T1D, subcutaneous injection of glutamic acid decarboxylase (GAD) bound to alum hydroxide (GAD-alum) can likely preserve beta-cell function, but the therapeutic effect needs to be improved. Intra-lymphatic administration may be a better alternative than subcutaneous administration, and combination therapy might improve efficacy. This review elucidates some actual problems of autoantigen therapy in the prevention and/or early intervention of type 1 diabetes.
    MeSH term(s) Administration, Oral ; Animals ; Autoantigens/administration & dosage ; Autoantigens/immunology ; Autoantigens/therapeutic use ; Chemotherapy, Adjuvant ; Diabetes Mellitus, Type 1/drug therapy ; Diabetes Mellitus, Type 1/immunology ; Drug Therapy, Combination ; Glutamate Decarboxylase/therapeutic use ; Humans ; Injections, Intralymphatic ; Injections, Subcutaneous ; Insulin/metabolism ; Proinsulin/therapeutic use ; Vitamin D/therapeutic use
    Chemical Substances Autoantigens ; Insulin ; Vitamin D (1406-16-2) ; Proinsulin (9035-68-1) ; Glutamate Decarboxylase (EC 4.1.1.15)
    Language English
    Publishing date 2020-02-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21051598
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  10. Article ; Online: Population-based birth cohort studies, a powerful design to identify childhood environmental risk factors for inflammatory bowel disease.

    Lerchova, Tereza / Mårild, Karl / Ludvigsson, Johnny

    United European gastroenterology journal

    2024  Volume 12, Issue 1, Page(s) 157–158

    MeSH term(s) Humans ; Child ; Inflammatory Bowel Diseases/epidemiology ; Inflammatory Bowel Diseases/etiology ; Colitis, Ulcerative/complications ; Cohort Studies ; Risk Factors
    Language English
    Publishing date 2024-01-04
    Publishing country England
    Document type Letter
    ZDB-ID 2728585-6
    ISSN 2050-6414 ; 2050-6406
    ISSN (online) 2050-6414
    ISSN 2050-6406
    DOI 10.1002/ueg2.12522
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