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Article ; Online: The importance of patient-centred drug development for amyotrophic lateral sclerosis.

Kiernan, Matthew C / Halliday, Glenda M / Rowe, Dominic B / Tan, Rachel H

2023 Volume 49, Issue 6, Page(s) e12944

MeSH term(s)	Humans ; Amyotrophic Lateral Sclerosis/drug therapy ; Drug Development
Language	English
Publishing date	2023-12-26
Publishing country	England
Document type	Letter
ZDB-ID	80371-6
ISSN	1365-2990 ; 0305-1846
ISSN (online)	1365-2990
ISSN	0305-1846
DOI	10.1111/nan.12944
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Zs.A 1241: Show issues

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Article: Physician Management and CT Ordering in the Emergency Department for Primary Headaches.

Krebs, Lynette D / Villa-Roel, Cristina / Yang, Esther H / Couperthwaite, Stephanie / Ospina, Maria B / Holroyd, Brian R / Rowe, Brian H

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques

2024 , Page(s) 1–7

Abstract: Objective: Management of primary headache (PHA) varies across emergency departments (ED), yet there is widespread agreement that computed tomography (CT) scans are overused. This study assessed emergency physicians' (EPs) PHA management and their ... ...

Abstract	Objective: Management of primary headache (PHA) varies across emergency departments (ED), yet there is widespread agreement that computed tomography (CT) scans are overused. This study assessed emergency physicians' (EPs) PHA management and their attitudes towards head CT ordering. Methods: A cross-sectional study was undertaken with EPs from one Canadian center. Drivers of physicians' perceptions regarding the appropriateness of CT ordering for patients with PHA were explored. Results: A total of 73 EPs (70% males; 48% with <10 years of practice) participated in the study. Most EPs (88%) did not order investigations for moderate-severe primary headaches; however, CT was the common investigation (47%) for headaches that did not improve. Computed tomography ordering was frequently motivated by the need for specialist consultation (64%) or admission (64%). A small proportion (27%) believed patients usually/frequently expected a scan. Nearly half of EPs (48%) identified patient imaging expectations/requests as a barrier to reducing CT ordering. Emergency physicians with CCFP (EM) certification were less likely to perceive CT ordering for patients with PHA as appropriate. Conversely, those who identified the possibility of missing a condition as a major barrier to limiting their CT use were more likely to perceive CT ordering for patients with PHA as appropriate. Conclusions: Emergency physicians reported consistency and evidence-based medical management. They highlighted the complexities of limiting CT ordering and both their level of training and their perceived barriers for limiting CT ordering seem to be influencing their attitudes. Further studies could elucidate these and other factors influencing their practice.
Language	English
Publishing date	2024-01-18
Publishing country	England
Document type	Journal Article
ZDB-ID	197622-9
ISSN	0317-1671
ISSN	0317-1671
DOI	10.1017/cjn.2024.6
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Zs.A 1203: Show issues

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Article ; Online: Differential interferon responses to influenza A and B viruses in primary ferret respiratory epithelial cells.

Rowe, Thomas / Davis, William / Wentworth, David E / Ross, Ted

Journal of virology

2024 Volume 98, Issue 2, Page(s) e0149423

Abstract: ... and H3N2 subtypes) or IBV (B/Victoria and B/Yamagata lineages) and assessed for 72 h. Cells were ... Influenza B viruses (IBV) cocirculate with influenza A viruses (IAV) and cause periodic ...

Abstract	Influenza B viruses (IBV) cocirculate with influenza A viruses (IAV) and cause periodic epidemics of disease, yet antibody and cellular responses following IBV infection are less well understood. Using the ferret model for antisera generation for influenza surveillance purposes, IAV resulted in robust antibody responses following infection, whereas IBV required an additional booster dose, over 85% of the time, to generate equivalent antibody titers. In this study, we utilized primary differentiated ferret nasal epithelial cells (FNECs) which were inoculated with IAV and IBV to study differences in innate immune responses which may result in differences in adaptive immune responses in the host. FNECs were inoculated with IAV (H1N1pdm09 and H3N2 subtypes) or IBV (B/Victoria and B/Yamagata lineages) and assessed for 72 h. Cells were analyzed for gene expression by quantitative real-time PCR, and apical and basolateral supernatants were assessed for virus kinetics and interferon (IFN), respectively. Similar virus kinetics were observed with IAV and IBV in FNECs. A comparison of gene expression and protein secretion profiles demonstrated that IBV-inoculated FNEC expressed delayed type-I/II IFN responses and reduced type-III IFN secretion compared to IAV-inoculated cells. Concurrently, gene expression of Thymic Stromal Lymphopoietin (
MeSH term(s)	Animals ; Child ; Humans ; Adaptive Immunity ; Antibodies, Viral/analysis ; Antibodies, Viral/biosynthesis ; Antibodies, Viral/immunology ; Disease Models, Animal ; Epithelial Cells/cytology ; Epithelial Cells/immunology ; Epithelial Cells/virology ; Ferrets/immunology ; Ferrets/virology ; Immunity, Innate ; Influenza A virus/classification ; Influenza A virus/growth & development ; Influenza A virus/immunology ; Influenza A Virus, H1N1 Subtype/immunology ; Influenza A Virus, H3N2 Subtype/immunology ; Influenza B virus/classification ; Influenza B virus/growth & development ; Influenza B virus/immunology ; Influenza Vaccines ; Influenza, Human/virology ; Interferons/immunology ; Nasal Mucosa/cytology ; Nasal Mucosa/immunology ; Nasal Mucosa/virology ; Thymic Stromal Lymphopoietin/genetics ; Thymic Stromal Lymphopoietin/immunology ; Cells, Cultured
Chemical Substances	Antibodies, Viral ; Influenza Vaccines ; Interferons (9008-11-1) ; Thymic Stromal Lymphopoietin (GT0IL38SP4)
Language	English
Publishing date	2024-01-31
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	80174-4
ISSN	1098-5514 ; 0022-538X
ISSN (online)	1098-5514
ISSN	0022-538X
DOI	10.1128/jvi.01494-23
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Zs.A 609: Show issues

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Article ; Online: A framework for evaluation of on-farm mastitis diagnostics in Australia.

Zadoks, R N / Scholz, E / Rowe, S M / Norris, J M / Pooley, H B / House, J

Australian veterinary journal

2023 Volume 101, Issue 4, Page(s) 142–152

Abstract: Numerous culture-based diagnostics are available on the Australian and international markets for on-farm detection of bacterial pathogens in milk. Use of such diagnostics may provide an opportunity to improve the prudent use of antimicrobials in udder ... ...

Abstract	Numerous culture-based diagnostics are available on the Australian and international markets for on-farm detection of bacterial pathogens in milk. Use of such diagnostics may provide an opportunity to improve the prudent use of antimicrobials in udder health management. Farms are low-resource settings in terms of diagnostic microbiology capacity. The World Health Organisation has identified criteria for the evaluation of diagnostic tests in low resource settings based on Accuracy, Sensitivity, Specificity, User-friendliness, being Rapid or Robust, Equipment-free and being Deliverable (ASSURED). Here, we review how those criteria can be interpreted in the context of microbiological diagnosis of mastitis pathogens, and how on-farm diagnostics that are currently available in Australia perform relative to ASSURED criteria. This evaluation identifies multiple trade-offs, both with regard to scientific criteria and with regards to convenience criteria. More importantly, the purpose of testing may differ between farms, and test performance should be evaluated relative to its intended use. The ability of on-farm mastitis diagnostics to inform mastitis treatment decision-making in a timely and cost-effective manner depends not just on test characteristics but also on farm-specific pathogen prevalence, and on the farm enterprise's priorities and the farm manager's potential courses of action. With most assay evaluations to date conducted in professional laboratories, there is a surprising dearth of information on how well any of the diagnostic tests perform on-farm and, indeed, of the on-farm decision-making processes that they aim to inform.
MeSH term(s)	Cattle ; Female ; Animals ; Farms ; Mastitis, Bovine/diagnosis ; Australia ; Anti-Infective Agents ; Milk/microbiology ; Dairying ; Cattle Diseases
Chemical Substances	Anti-Infective Agents
Language	English
Publishing date	2023-01-12
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	41542-x
ISSN	1751-0813 ; 0005-0423
ISSN (online)	1751-0813
ISSN	0005-0423
DOI	10.1111/avj.13228
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Zs.B 550: Show issues

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Article ; Online: The predictive value of a positive phase 2 ASH abstract for peer-reviewed publication and progression to phase 3.

Cucchi, David G J / Polak, Tobias B / Ossenkoppele, Gert J / Rowe, Jacob M / Estey, Elihu H

Blood

2022 Volume 139, Issue 12, Page(s) 1920–1923

MeSH term(s)	Publishing ; Societies, Medical
Language	English
Publishing date	2022-01-12
Publishing country	United States
Document type	Clinical Trial, Phase II ; Journal Article
ZDB-ID	80069-7
ISSN	1528-0020 ; 0006-4971
ISSN (online)	1528-0020
ISSN	0006-4971
DOI	10.1182/blood.2021013988
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Uh III Zs.140: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 364: Show issues

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Article ; Online: Insulin-mediated endothelin signaling is antiviral during West Nile virus infection.

Trammell, Chasity E / Rowe, Evelyn H / Char, Aditya B / Jones, Brianne J / Fawcett, Stephen / Ahlers, Laura R H / Goodman, Alan G

Journal of virology

2023 Volume 97, Issue 10, Page(s) e0111223

Abstract: Importance: Arboviruses, particularly those transmitted by mosquitoes, pose a significant threat to humans and are an increasing concern because of climate change, human activity, and expanding vector-competent populations. West Nile virus is of ... ...

Abstract	Importance: Arboviruses, particularly those transmitted by mosquitoes, pose a significant threat to humans and are an increasing concern because of climate change, human activity, and expanding vector-competent populations. West Nile virus is of significant concern as the most frequent mosquito-borne disease transmitted annually within the continental United States. Here, we identify a previously uncharacterized signaling pathway that impacts West Nile virus infection, namely endothelin signaling. Additionally, we demonstrate that we can successfully translate results obtained from
MeSH term(s)	Animals ; Humans ; Drosophila melanogaster/immunology ; Drosophila melanogaster/metabolism ; Drosophila melanogaster/virology ; Insulin/metabolism ; Signal Transduction ; West Nile Fever/immunology ; West Nile Fever/metabolism ; West Nile Fever/virology ; West Nile virus/immunology ; West Nile virus/physiology ; Endothelins/immunology ; Endothelins/metabolism
Chemical Substances	Insulin ; Endothelins
Language	English
Publishing date	2023-10-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	80174-4
ISSN	1098-5514 ; 0022-538X
ISSN (online)	1098-5514
ISSN	0022-538X
DOI	10.1128/jvi.01112-23
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Zs.A 609: Show issues

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Article: Insulin-mediated endothelin signaling is antiviral during West Nile virus infection.

Trammell, Chasity E / Rowe, Evelyn H / Jones, Brianne J / Char, Aditya B / Fawcett, Stephen / Ahlers, Laura R H / Goodman, Alan G

bioRxiv : the preprint server for biology

2023

Abstract: West Nile virus (WNV) is the most prevalent mosquito-borne virus in the United States with approximately 2,000 cases each year. There are currently no approved human vaccines and a lack of prophylactic and therapeutic treatments. Understanding host ... ...

Abstract	West Nile virus (WNV) is the most prevalent mosquito-borne virus in the United States with approximately 2,000 cases each year. There are currently no approved human vaccines and a lack of prophylactic and therapeutic treatments. Understanding host responses to infection may reveal potential intervention targets to reduce virus replication and disease progression. The use of Importance: Arboviruses, particularly those transmitted by mosquitoes, pose a significant threat to humans and are an increasing concern because of climate change, human activity, and expanding vector-competent populations. West Nile virus is of significant concern as the most frequent mosquito-borne disease transmitted annually within the continental United States. Here, we identify a previously uncharacterized signaling pathway that impacts West Nile virus infection, namely endothelin signaling. Additionally, we demonstrate that we can successfully translate results obtained from
Language	English
Publishing date	2023-01-18
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.01.17.524426
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Article ; Online: 18

Marcus, Charles / Tajmir, Shahein H / Rowe, Steven P / Sheikhbahaei, Sara / Solnes, Lilja B

Seminars in nuclear medicine

2022 Volume 52, Issue 6, Page(s) 662–672

Abstract: Treatment response assessment in lung cancer is crucial in the management strategy and outcome of patients. Accurate treatment response assessment can guide the treating physicians and improve patient survival. Anatomic and metabolic tumor response ... ...

Abstract	Treatment response assessment in lung cancer is crucial in the management strategy and outcome of patients. Accurate treatment response assessment can guide the treating physicians and improve patient survival. Anatomic and metabolic tumor response assessments have been evaluated extensively, showing a positive impact in the management of these patients.
MeSH term(s)	Humans ; Fluorodeoxyglucose F18 ; Positron Emission Tomography Computed Tomography/methods ; Artificial Intelligence ; Treatment Outcome ; Lung Neoplasms/diagnostic imaging ; Radiopharmaceuticals
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Radiopharmaceuticals
Language	English
Publishing date	2022-05-29
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	120248-0
ISSN	1558-4623 ; 0001-2998
ISSN (online)	1558-4623
ISSN	0001-2998
DOI	10.1053/j.semnuclmed.2022.04.001
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Zs.A 763: Show issues

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Article ; Online: Alien limb syndrome: A Bayesian account of unwanted actions.

Wolpe, Noham / Hezemans, Frank H / Rowe, James B

Cortex; a journal devoted to the study of the nervous system and behavior

2020 Volume 127, Page(s) 29–41

Abstract: An alien limb is a debilitating disorder of volitional control. The core feature of alien limb is the performance of simple or complex semi-purposeful movements which the patient reports to be unintentional or unwanted, or occasionally in opposition to ... ...

Abstract	An alien limb is a debilitating disorder of volitional control. The core feature of alien limb is the performance of simple or complex semi-purposeful movements which the patient reports to be unintentional or unwanted, or occasionally in opposition to their intentions. Theories of the mechanism of alien limb phenomena have emphasised the role of disinhibition in the brain, and exaggerated action 'affordances'. However, despite advances in cognitive neuroscience research and a large public and media interest, there has been no unifying computational and anatomical account of the cause of alien limb movements. Here, we extend Bayesian brain principles to propose that alien limb is a disorder of 'predictive processing' in hierarchical sensorimotor brain networks. Specifically, we suggest that alien limb results from predictions about action outcomes that are afforded unduly high precision. The principal mechanism for this abnormally high precision is an impairment in the relay of input from medial regions, predominantly the supplementary motor area (SMA), which modulate the precision of lateral brain regions encoding the predicted action outcomes. We discuss potential implications of this model for future research and treatment of alien limb.
MeSH term(s)	Alien Hand Syndrome ; Bayes Theorem ; Brain ; Humans ; Movement
Language	English
Publishing date	2020-02-18
Publishing country	Italy
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	280622-8
ISSN	1973-8102 ; 0010-9452
ISSN (online)	1973-8102
ISSN	0010-9452
DOI	10.1016/j.cortex.2020.02.002
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Zs.A 687: Show issues

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Article ; Online: Apathy is associated with reduced precision of prior beliefs about action outcomes.

Hezemans, Frank H / Wolpe, Noham / Rowe, James B

Journal of experimental psychology. General

2020 Volume 149, Issue 9, Page(s) 1767–1777

Abstract: Apathy is a debilitating syndrome that is associated with reduced goal-directed behavior. Although apathy is common and detrimental to prognosis in many neuropsychiatric diseases, its underlying mechanisms remain controversial. We propose a new model of ... ...

Abstract	Apathy is a debilitating syndrome that is associated with reduced goal-directed behavior. Although apathy is common and detrimental to prognosis in many neuropsychiatric diseases, its underlying mechanisms remain controversial. We propose a new model of apathy, in the context of Bayesian theories of brain function, whereby actions require predictions of their outcomes to be held with sufficient precision for "explaining away" differences in sensory inputs. In the active inference model, apathy results from reduced precision of prior beliefs about action outcomes. We tested this hypothesis using a visuomotor task in healthy adults (N = 47), with experimental manipulation of physical effort and financial reward. Bayesian modeling of performance and participants' perception of their performance was used to infer the precision of their priors. We confirmed that the perception of performance was biased toward the target, which was accounted for by relatively precise prior beliefs about action outcomes. These priors were consistently more precise than the corresponding performance distribution, and were scaled to effort and reward. Crucially, prior precision was negatively associated with trait apathy, suggesting that apathetic individuals had less precise prior beliefs about action outcomes. The results support a Bayesian account of apathy that could inform future studies of clinical populations. (PsycInfo Database Record (c) 2020 APA, all rights reserved).
MeSH term(s)	Adolescent ; Adult ; Apathy/physiology ; Bayes Theorem ; Female ; Humans ; Male ; Psychomotor Performance/physiology ; Reward ; Young Adult
Language	English
Publishing date	2020-02-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	189732-9
ISSN	1939-2222 ; 0096-3445
ISSN (online)	1939-2222
ISSN	0096-3445
DOI	10.1037/xge0000739
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Zs.A 2255: Show issues

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