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  1. Article ; Online: Think outside the European box

    Demssie, Yared Nigussie / Wesselink, Renate / Biemans, Harm J.A. / Mulder, Martin / Demssie, Y.N.

    Journal of Cleaner Production

    Identifying sustainability competencies for a base of the pyramid context

    2019  Volume 221

    Abstract: ... we conducted a Delphi study in two rounds in Ethiopia, as a country at the base of the pyramid. Experts (n = 33 ...

    Abstract The complex and global nature of unsustainability requires concerted efforts of sustainability change agents from developed and developing countries all over the world. Various attempts have been made to define competencies needed for change agents to effectively contribute to sustainable development. However, most of the studies on sustainability competencies are Eurocentric in focus. Therefore, it is unclear if a base of the pyramid context would require a different set of competencies. This context is characterized by low per capita income, limited infrastructure, and rural population. To fill this gap, we conducted a Delphi study in two rounds in Ethiopia, as a country at the base of the pyramid. Experts (n = 33) from academia and the industry rated and confirmed seven competencies from the literature as being generally important for sustainable development. Additionally, they identified eight sustainability y competencies specifically important for the Ethiopian context, and thus potentially for other countries with the features of base of the pyramid context. Systems thinking and transdisciplinary competence gained the highest ratings. A subsequent specific literature search revealed that previous studies in contexts other than the base of the pyramid context also identified some of the eight additional sustainability competencies. This is important for future studies regarding the universal nature of certain sustainability competencies. The study brought together three fields of research: sustainability, competence, and base of the pyramid context. Our findings contribute to the theory of professional competence by showing that certain sustainability competencies can be of generic nature, independent of socioeconomic context, whereas others are context-specific. In addition, the sustainability competencies may serve as intended learning outcomes of education and training and development programs for sustainability.
    Keywords Base of the pyramid ; Corporate social responsibility ; Delphi ; Sustainability ; Sustainability competence ; Sustainable development
    Language English
    Publishing country nl
    Document type Article ; Online
    ISSN 0959-6526
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Fostering students’ systems thinking competence for sustainability by using multiple real-world learning approaches

    Demssie, Yared Nigussie / Biemans, Harm J.A. / Wesselink, Renate / Mulder, Martin

    Environmental Education Research

    2023  Volume 29, Issue 2

    Abstract: ... experimental study involving higher education students (n = 36). The study explored the contributions of field ...

    Abstract For a sustainable future, equipping sustainability change agents with relevant sustainability competencies is crucial. Among these competencies is system thinking competence–the understanding of complex interrelationships among the dimensions of sustainable development and the impacts of the interrelationships. Learning approaches relevant to fostering sustainability competencies have been studied. However, research is rare on fostering systems thinking competence by simultaneously using multiple, real-world, and innovative learning approaches. To address this gap, we conducted a pre-test–post-test exploratory experimental study involving higher education students (n = 36). The study explored the contributions of field trips and collaborative learning in combination with mobile learning and paper-and-pencil note taking. The study simultaneously implemented a combined set of learning approaches in a real-world environment. The results suggest that the learning approaches and the real-world environment contribute to fostering the systems thinking competence of participants by exposing them to complex real-world systems and enabling the exchanging of diverse ideas among collaborating participants. As such, our study contributes to social constructivist learning discourses in education for sustainable development by indicating specific combinations of learning approaches and environments that facilitate the meaningful engagement and motivation of learners through self-regulated learning.
    Keywords Education for sustainable development ; collaborative learning ; mobile learning ; real-world learning ; sustainability competencies ; systems thinking
    Subject code 370
    Language English
    Publishing country nl
    Document type Article ; Online
    ZDB-ID 2026134-2
    ISSN 1469-5871 ; 1350-4622
    ISSN (online) 1469-5871
    ISSN 1350-4622
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Hypomagnesaemia: clinical relevance and management.

    Demssie, Yared N / Patel, Leena / Kumar, Mohit / Syed, Akheel A

    British journal of hospital medicine (London, England : 2005)

    2013  Volume 75, Issue 1, Page(s) 39–43

    MeSH term(s) Diabetes Complications/diagnosis ; Diabetes Complications/therapy ; Female ; Homeostasis ; Humans ; Infusions, Intravenous ; Magnesium/administration & dosage ; Magnesium/blood ; Metabolic Diseases/diagnosis ; Metabolic Diseases/etiology ; Metabolic Diseases/therapy ; Middle Aged
    Chemical Substances Magnesium (I38ZP9992A)
    Language English
    Publishing date 2013-12-31
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1750-8460
    ISSN 1750-8460
    DOI 10.12968/hmed.2014.75.1.39
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Tight glycaemic control and cardiovascular disease in type 2 diabetes.

    Demssie, Yared N / Soran, Handrean / Younis, Naveed

    British journal of hospital medicine (London, England : 2005)

    2009  Volume 70, Issue 1, Page(s) 31–2, 34

    Abstract: The role of tight glycaemic control in reducing cardiovascular events and mortality in type 2 diabetes has not yet been firmly established. Recent clinical trials have yielded unexpected outcomes. This review summarizes the background and outcome of ... ...

    Abstract The role of tight glycaemic control in reducing cardiovascular events and mortality in type 2 diabetes has not yet been firmly established. Recent clinical trials have yielded unexpected outcomes. This review summarizes the background and outcome of these trials and the implications for management of glycaemia in type 2 diabetes.
    MeSH term(s) Adult ; Aged ; Clinical Trials as Topic ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/mortality ; Diabetic Angiopathies/mortality ; Diabetic Angiopathies/prevention & control ; Glycated Hemoglobin A/drug effects ; Humans ; Hypoglycemic Agents/therapeutic use ; Middle Aged ; Risk Factors ; Treatment Outcome
    Chemical Substances Glycated Hemoglobin A ; Hypoglycemic Agents ; hemoglobin A1c protein, human
    Language English
    Publishing date 2009-01
    Publishing country England
    Document type Journal Article ; Review
    ISSN 1750-8460
    ISSN 1750-8460
    DOI 10.12968/hmed.2009.70.1.37692
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Hyperprolactinaemia.

    Demssie, Yared N / Davis, Julian R E

    Clinical medicine (London, England)

    2008  Volume 8, Issue 2, Page(s) 216–219

    MeSH term(s) Dopamine Agonists/adverse effects ; Dopamine Agonists/therapeutic use ; Female ; Humans ; Hyperprolactinemia/diagnosis ; Hyperprolactinemia/physiopathology ; Hyperprolactinemia/therapy ; Magnetic Resonance Imaging ; Male ; Pregnancy
    Chemical Substances Dopamine Agonists
    Language English
    Publishing date 2008-04-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2048646-7
    ISSN 1473-4893 ; 1470-2118
    ISSN (online) 1473-4893
    ISSN 1470-2118
    DOI 10.7861/clinmedicine.8-2-216
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The role of insulin detemir in overweight type 2 diabetes management.

    Demssie, Yared N / Younis, Naveed / Soran, Handrean

    Vascular health and risk management

    2009  Volume 5, Issue 3, Page(s) 553–560

    Abstract: The recent evidence-based shift towards an algorithm of early initiation and aggressive titration of insulin therapy in the management of type 2 diabetes requires the use of an effective insulin formulation that is both safe and acceptable to patients ... ...

    Abstract The recent evidence-based shift towards an algorithm of early initiation and aggressive titration of insulin therapy in the management of type 2 diabetes requires the use of an effective insulin formulation that is both safe and acceptable to patients and physicians alike. The advent of the long-acting insulin analogues, insulin detemir and glargine, in the last decade has revolutionized insulin therapy in type 2 diabetes. Their unique pharmacokinetic and pharmacodynamic properties have offered tangible advantage over the conventional intermediate and long-acting insulin preparations in terms of improving glucose control as well as reducing risk of hypoglycemia and weight gain. This review focuses on the pharmacodynamic properties of the long-acting insulin analogue detemir, the outcome of studies on its relative efficacy and safety as well as its proposed place in the management of type 2 diabetes.
    MeSH term(s) Blood Glucose/drug effects ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Glycated Hemoglobin A/metabolism ; Humans ; Hypoglycemia/chemically induced ; Hypoglycemic Agents/adverse effects ; Hypoglycemic Agents/pharmacokinetics ; Hypoglycemic Agents/therapeutic use ; Insulin/adverse effects ; Insulin/analogs & derivatives ; Insulin/pharmacokinetics ; Insulin/therapeutic use ; Insulin Detemir ; Insulin, Long-Acting ; Overweight/blood ; Overweight/complications ; Treatment Outcome ; Weight Gain/drug effects
    Chemical Substances Blood Glucose ; Glycated Hemoglobin A ; Hypoglycemic Agents ; Insulin ; Insulin, Long-Acting ; hemoglobin A1c protein, human ; Insulin Detemir (4FT78T86XV)
    Language English
    Publishing date 2009-06-29
    Publishing country New Zealand
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2186568-1
    ISSN 1178-2048 ; 1176-6344
    ISSN (online) 1178-2048
    ISSN 1176-6344
    DOI 10.2147/vhrm.s4326
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The role of insulin detemir in overweight type 2 diabetes management

    Yared N Demssie / Naveed Younis / Handrean Soran

    Vascular Health and Risk Management, Vol 2009, Iss default, Pp 553-

    2009  Volume 560

    Abstract: Yared N Demssie1, Naveed Younis2, Handrean Soran31Department of Diabetes and Endocrinology, Salford ...

    Abstract Yared N Demssie1, Naveed Younis2, Handrean Soran31Department of Diabetes and Endocrinology, Salford Royal Foundation NHS Trust, Salford, UK; 2Department of Medicine, University Hospital South Manchester Foundation NHS Trust, Wythenshawe, Manchester, UK; 3University Department of Medicine, Central Manchester and Manchester Children’s NHS Foundation Trust, Manchester, UKAbstract: The recent evidence-based shift towards an algorithm of early initiation and aggressive titration of insulin therapy in the management of type 2 diabetes requires the use of an effective insulin formulation that is both safe and acceptable to patients and physicians alike. The advent of the long-acting insulin analogues, insulin detemir and glargine, in the last decade has revolutionized insulin therapy in type 2 diabetes. Their unique pharmacokinetic and pharmacodynamic properties have offered tangible advantage over the conventional intermediate and long-acting insulin preparations in terms of improving glucose control as well as reducing risk of hypoglycemia and weight gain. This review focuses on the pharmacodynamic properties of the long-acting insulin analogue detemir, the outcome of studies on its relative efficacy and safety as well as its proposed place in the management of type 2 diabetes.Keywords: insulin detemir, type 2 diabetes, overweight
    Keywords Diseases of the circulatory (Cardiovascular) system ; RC666-701 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Cardiovascular ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Subject code 571
    Language English
    Publishing date 2009-06-01T00:00:00Z
    Publisher Dove Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Metabolic outcomes 1 year after gastric bypass surgery in obese people with type 2 diabetes.

    Demssie, Yared N / Jawaheer, Jhalini / Farook, Seleena / New, John P / Syed, Akheel A

    Medical principles and practice : international journal of the Kuwait University, Health Science Centre

    2012  Volume 21, Issue 2, Page(s) 125–128

    Abstract: Objective: To assess metabolic outcomes in obese people with type 2 diabetes (T2D) in the first year following gastric bypass surgery.: Subjects and methods: Forty-nine obese patients with T2D who had undergone gastric bypass surgery 12 or more ... ...

    Abstract Objective: To assess metabolic outcomes in obese people with type 2 diabetes (T2D) in the first year following gastric bypass surgery.
    Subjects and methods: Forty-nine obese patients with T2D who had undergone gastric bypass surgery 12 or more months previously were identified. Body weight and glycosylated haemoglobin (HbA(1c)) pre-operatively and 3, 6 and 12 months postoperatively, changes to glucose-lowering therapies, and blood pressure (BP) and total and high-density lipoprotein (HDL) cholesterol pre-operatively and 12 months postoperatively were recorded. The primary outcome measure was change in HbA(1c); secondary outcomes included changes in BP and lipid profile.
    Results: The mean pre-operative body weight was 141.4 kg, the body mass index 49.4 and HbA(1c) 8.1%. The mean postoperative percentage of excess body weight loss at 3, 6 and 12 months was 39.0, 53.9 and 71.1 with reduction in HbA(1c) to 6.6, 6.2 and 5.8%, respectively (p < 0.0001). Remission of diabetes (HbA(1c) <6.5%) occurred in 12 of 18 patients (67%) at 3 months, 20 of 27 (74%) at 6 months and 21 of 25 (84%) at 12 months; of 41 patients under glucose-lowering treatment, 26 (63%) achieved complete withdrawal of treatment and 7 (17%) had their doses reduced. The mean of differences between baseline and 12-month measurements of systolic BP was 10.5 mm Hg (p = 0.021) and the total-to-HDL cholesterol ratio 0.9 (p < 0.002).
    Conclusion: Our study confirmed the finding of previous studies that gastric bypass surgery in obese people with T2D results in significant weight loss, and improved glycaemic, BP and lipid profiles. Bariatric surgery should be regarded as an effective therapeutic intervention in this patient population.
    MeSH term(s) Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/metabolism ; Female ; Gastric Bypass ; Glycated Hemoglobin A/analysis ; Humans ; Hypoglycemic Agents/therapeutic use ; Male ; Middle Aged ; Obesity/complications ; Obesity/surgery ; Weight Loss
    Chemical Substances Glycated Hemoglobin A ; Hypoglycemic Agents
    Language English
    Publishing date 2012
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 645108-1
    ISSN 1423-0151 ; 1011-7571
    ISSN (online) 1423-0151
    ISSN 1011-7571
    DOI 10.1159/000331793
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Think outside the European box: Identifying sustainability competencies for a base of the pyramid context

    Demssie, Yared Nigussie / Wesselink, Renate / Biemans, Harm J.A / Mulder, Martin

    Journal of cleaner production. 2019 June 01, v. 221

    2019  

    Abstract: ... we conducted a Delphi study in two rounds in Ethiopia, as a country at the base of the pyramid. Experts (n = 33 ...

    Abstract The complex and global nature of unsustainability requires concerted efforts of sustainability change agents from developed and developing countries all over the world. Various attempts have been made to define competencies needed for change agents to effectively contribute to sustainable development. However, most of the studies on sustainability competencies are Eurocentric in focus. Therefore, it is unclear if a base of the pyramid context would require a different set of competencies. This context is characterized by low per capita income, limited infrastructure, and rural population. To fill this gap, we conducted a Delphi study in two rounds in Ethiopia, as a country at the base of the pyramid. Experts (n = 33) from academia and the industry rated and confirmed seven competencies from the literature as being generally important for sustainable development. Additionally, they identified eight sustainability y competencies specifically important for the Ethiopian context, and thus potentially for other countries with the features of base of the pyramid context. Systems thinking and transdisciplinary competence gained the highest ratings. A subsequent specific literature search revealed that previous studies in contexts other than the base of the pyramid context also identified some of the eight additional sustainability competencies. This is important for future studies regarding the universal nature of certain sustainability competencies. The study brought together three fields of research: sustainability, competence, and base of the pyramid context. Our findings contribute to the theory of professional competence by showing that certain sustainability competencies can be of generic nature, independent of socioeconomic context, whereas others are context-specific. In addition, the sustainability competencies may serve as intended learning outcomes of education and training and development programs for sustainability.
    Keywords developing countries ; education ; experts ; industry ; infrastructure ; learning ; per-capita income ; rural population ; sustainable development ; Ethiopia
    Language English
    Dates of publication 2019-0601
    Size p. 828-838.
    Publishing place Elsevier Ltd
    Document type Article
    ISSN 0959-6526
    DOI 10.1016/j.jclepro.2019.02.255
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Recurrent spindle cell oncocytoma of the pituitary, a case report and review of literature.

    Demssie, Yared N / Joseph, Jacob / Dawson, Timothy / Roberts, Gareth / de Carpentier, John / Howell, Simon

    Pituitary

    2009  Volume 14, Issue 4, Page(s) 367–370

    Abstract: Spindle cell oncocytoma (SCO) is a rare non-functioning tumour of the pituitary which has just been formally recognized as a distinct entity by the 2007 WHO classification of brain tumours. We report a case of SCO who presented with symptoms of visual ... ...

    Abstract Spindle cell oncocytoma (SCO) is a rare non-functioning tumour of the pituitary which has just been formally recognized as a distinct entity by the 2007 WHO classification of brain tumours. We report a case of SCO who presented with symptoms of visual blurring, weight loss, intermittent vomiting and excessive tiredness of several months duration. Investigations revealed a bitemporal visual field defect, a panhypopituitary hormonal profile and a large pituitary tumour with suprasellar extension. He underwent a successful trans-sphenoidal resection of the pituitary tumour but it subsequently recurred twice at 9 months interval which required further two debulking procedures. A diagnosis of SCO was made based on its unique histologic and staining properties. To date there are only ten reported cases of SCO in total with only two of these cases being recurrent. Our case displayed the most aggressive clinical course despite having a low Ki-67 index contrary to the previously reported cases of recurrent SCO.
    MeSH term(s) Adenoma, Oxyphilic/diagnosis ; Adenoma, Oxyphilic/pathology ; Adenoma, Oxyphilic/surgery ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neoplasm Recurrence, Local/diagnosis ; Pituitary Neoplasms/diagnosis ; Pituitary Neoplasms/pathology ; Pituitary Neoplasms/surgery ; Review Literature as Topic
    Language English
    Publishing date 2009-02-25
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 1385151-2
    ISSN 1573-7403 ; 1386-341X
    ISSN (online) 1573-7403
    ISSN 1386-341X
    DOI 10.1007/s11102-009-0170-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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