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Article: PERSONALIZED NEOANTIGEN VACCINE AGAINST CANCER.

Pavelić, Krešimir

2021 Volume 33, Issue Suppl 3, Page(s) S331–S335

Abstract: No significant therapeutic solutions for advanced cancer are available to date. However, an old idea based on usage of tumor-specific antibodies as the basis for a new vaccination form in patients with advanced tumors, has attracted recent research and ... ...

Abstract	No significant therapeutic solutions for advanced cancer are available to date. However, an old idea based on usage of tumor-specific antibodies as the basis for a new vaccination form in patients with advanced tumors, has attracted recent research and is possible due to development of personalized neoantigenic vaccines. Each tumour has indeed, its own mutation content, only a small percentage are shared between patients. Technological advances and the established genome databases, allowed for a rapid mapping of mutations in the genome. The latter allows for a rational selection of targets for personalized vaccines and on-demand production of customized therapy according to the patient's individual tumour properties. This article accordingly, summarizes basic principles of vaccines for personalized neoantigens, translational research and clinical studies related to these vaccines. Finally, the future of such therapy with personalized vaccines is discussed.
MeSH term(s)	Antigens, Neoplasm ; Cancer Vaccines ; Humans ; Immunotherapy ; Neoplasms/genetics ; Neoplasms/therapy ; Precision Medicine
Chemical Substances	Antigens, Neoplasm ; Cancer Vaccines
Language	English
Publishing date	2021-05-18
Publishing country	Croatia
Document type	Journal Article
ZDB-ID	1067580-2
ISSN	0353-5053
ISSN	0353-5053
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Zs.A 3158: Show issues

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Article ; Online: Enhancing the bioavailability and activity of natural antioxidants with nanobubbles and nanoparticles.

Čolić, Miroslav / Kraljević Pavelić, Sandra / Peršurić, Željka / Agaj, Andrea / Bulog, Aleksandar / Pavelić, Krešimir

Redox report : communications in free radical research

2024 Volume 29, Issue 1, Page(s) 2333619

Abstract: KEY POLICY HIGHLIGHTSNanobubbles and nanoparticles may enhance the polyphenols' bioavailabilityNanobubbles may stimulate the activation of Nrf2 and detox enzymesArmoured oxygen nanobubbles may enhance radiotherapy or chemotherapy effects. ...

Abstract	KEY POLICY HIGHLIGHTSNanobubbles and nanoparticles may enhance the polyphenols' bioavailabilityNanobubbles may stimulate the activation of Nrf2 and detox enzymesArmoured oxygen nanobubbles may enhance radiotherapy or chemotherapy effects.
MeSH term(s)	Antioxidants/therapeutic use ; Biological Availability ; Nanoparticles ; Polyphenols ; Oxygen
Chemical Substances	Antioxidants ; Polyphenols ; Oxygen (S88TT14065)
Language	English
Publishing date	2024-04-05
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1305290-1
ISSN	1743-2928 ; 1351-0002
ISSN (online)	1743-2928
ISSN	1351-0002
DOI	10.1080/13510002.2024.2333619
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Zs.A 4584: Show issues

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Article: Antimicrobial and Mechanical Effects of Zeolite Use in Dental Materials: A Systematic Review.

Hao, Jessica / Lang, Spencer / Mante, Francis / Pavelić, Kresimir / Ozer, Fusun

Acta stomatologica Croatica

2021 Volume 55, Issue 1, Page(s) 76–89

Abstract: Objective: Ion-incorporated zeolite is a widely used antimicrobial material studied for various dental applications. At present, there is no other systematic review that evaluates the effectiveness of zeolite in all dental materials. The purpose of this ...

Abstract	Objective: Ion-incorporated zeolite is a widely used antimicrobial material studied for various dental applications. At present, there is no other systematic review that evaluates the effectiveness of zeolite in all dental materials. The purpose of this study was to review all available literature that analyzed the antimicrobial effects and/or mechanical properties of zeolite as a restorative material in dentistry. Material and methods: Following PRISMA guidelines, an exhaustive search of PubMed, Ovid Medline, Scopus, Embase, and the Dentistry & Oral Sciences Source was conducted. No language or time restrictions were used and the study was conducted from June 1, 2020 to August 17, 2020. Only full text articles were selected that pertained to the usage of zeolite in dental materials including composite resin, bonding agents, cements, restorative root material, cavity base material, prosthesis, implants, and endodontics. Results: At the beginning of the study, 1534 studies were identified, of which 687 duplicate records were excluded. After screening for the title, abstract, and full texts, 35 articles remained and were included in the qualitative synthesis. An Inter-Rater Reliability (IRR) test, which included a percent user agreement and reliability percent, was conducted for each of the 35 articles chosen. Conclusion: Although ion-incorporated zeolite may enhance the antimicrobial properties of dental materials, the mechanical properties of some materials, such as MTA and acrylic resin, may be compromised. Therefore, since the decrease in mechanical properties depends on zeolite concentration in the restorative material, it is generally recommended to add 0.2-2% zeolite by weight.
Language	English
Publishing date	2021-01-20
Publishing country	Croatia
Document type	Journal Article ; Review
ZDB-ID	603047-6
ISSN	0001-7019
ISSN	0001-7019
DOI	10.15644/asc55/1/9
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Article ; Online: The effect of zeolite incorporation on the physical properties of silver-reinforced glass ionomer cement.

Lang, Spencer / Hao, Jessica / Mante, Francis / Pavelic, Kresimir / Ozer, Fusun

Journal of materials science. Materials in medicine

2022 Volume 33, Issue 4, Page(s) 38

Abstract: Zeolite can impart antibacterial properties to dental materials in the long-term when incorporated with inorganic cations. However, due to its porosity, it may jeopardize the mechanical integrity of the dental material. The aim of this project was to ... ...

Abstract	Zeolite can impart antibacterial properties to dental materials in the long-term when incorporated with inorganic cations. However, due to its porosity, it may jeopardize the mechanical integrity of the dental material. The aim of this project was to determine the effect on physical properties when zeolite is added to commercially available Ag-reinforced Glass Ionomer Cement (GIC). Sample groups were prepared according to the percentage of zeolite-clinoptilolite (0% - control, 0.5%, 1%, 2%, and 4% wt) added to Ag-GIC. Water sorption, solubility, Vickers hardness, and flexural strength were determined. Specifically, 10 × 2 mm circular disks were fabricated for the Vickers hardness, water sorption, and water solubility tests and 25 × 5 × 2 mm bars were created for the flexural strength test. The results from the surface hardness, water sorption, and flexural strength tests suggested that adding 0.5-4% wt of zeolite to Ag-reinforced GIC did not diminish its physical properties. However, the water solubility results showed that higher concentrations (2-4% wt) of zeolite had a statistically significant increase in water solubility compared to the control. Up to 4% wt zeolite can be incorporated into Ag-reinforced GIC without compromising mechanical properties. Incorporation of 0.5-1% wt zeolite to Ag-reinforced GIC will maintain an adequate surface hardness, water sorption, and flexural strength without compromising water solubility. Further research is needed to determine the effects of higher water solubility on clinical efficacy of zeolite modified Ag-GIC. Graphical abstract.
MeSH term(s)	Glass Ionomer Cements ; Materials Testing ; Silver ; Surface Properties ; Water ; Zeolites
Chemical Substances	Glass Ionomer Cements ; Water (059QF0KO0R) ; Zeolites (1318-02-1) ; Silver (3M4G523W1G)
Language	English
Publishing date	2022-04-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	1031752-1
ISSN	1573-4838 ; 0957-4530
ISSN (online)	1573-4838
ISSN	0957-4530
DOI	10.1007/s10856-022-06659-2
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Zs.A 3040: Show issues

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Article ; Online: Recent Advances in Modern Anticancer Research.

Marković, Dean / Pavelić, Krešimir

Current medicinal chemistry

2020 Volume 27, Issue 8, Page(s) 1172–1173

MeSH term(s)	Antineoplastic Agents/therapeutic use ; Biomedical Research/trends ; Humans ; Neoplasms/therapy
Chemical Substances	Antineoplastic Agents
Language	English
Publishing date	2020-04-02
Publishing country	United Arab Emirates
Document type	Editorial ; Introductory Journal Article
ZDB-ID	1319315-6
ISSN	1875-533X ; 0929-8673
ISSN (online)	1875-533X
ISSN	0929-8673
DOI	10.2174/092986732708200326173257
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Zs.A 4432: Show issues

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Article: A Perspective on COVID-19 Management.

Pavelić, Krešimir / Kraljević Pavelić, Sandra / Brix, Bianca / Goswami, Nandu

Journal of clinical medicine

2021 Volume 10, Issue 8

Abstract: A novel coronavirus-Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2)-outbreak correlated with the global coronavirus disease 2019 (COVID-19) pandemic was declared by the WHO in March 2020, resulting in numerous counted cases attributed to ... ...

Abstract	A novel coronavirus-Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2)-outbreak correlated with the global coronavirus disease 2019 (COVID-19) pandemic was declared by the WHO in March 2020, resulting in numerous counted cases attributed to SARS-CoV-2 worldwide. Herein, we discuss current knowledge on the available therapy options for patients diagnosed with COVID-19. Based on available scientific data, we present an overview of solutions in COVID-19 management by use of drugs, vaccines and antibodies. Many questions with non-conclusive answers on the measures for the management of the COVID-19 pandemic and its impact on health still exist-i.e., the actual infection percentage of the population, updated precise mortality data, variability in response to infection by the population, the nature of immunity and its duration, vaccine development issues, a fear that science might end up with excessive promises in response to COVID-19-and were raised among scientists. Indeed, science may or may not deliver results in real time. In the presented paper we discuss some consequences of disease, its detection and serological tests, some solutions to disease prevention and management, pitfalls and obstacles, including vaccination. The presented ideas and data herein are meant to contribute to the ongoing debate on COVID-19 without pre-selection of available information.
Language	English
Publishing date	2021-04-09
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm10081586
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Article: Clinical Parameters in Osteoporosis Patients Supplemented With PMA-Zeolite at the End of 5-Year Double-Blinded Clinical Trial.

Kraljević Pavelić, Sandra / Krpan, Dalibor / Žuvić, Marta / Eisenwagen, Sandra / Pavelić, Krešimir

Frontiers in medicine

2022 Volume 9, Page(s) 870962

Abstract: Osteoporosis is among the most common pathologies. Associated complications in osteoporotic patients, in particular hip fractures and vertebral fractures, cause disabilities and significant quality of life deterioration. Standard treatment of ... ...

Abstract	Osteoporosis is among the most common pathologies. Associated complications in osteoporotic patients, in particular hip fractures and vertebral fractures, cause disabilities and significant quality of life deterioration. Standard treatment of osteoporosis, based on pharmacotherapy does still not yield adequate results, and the problem of osteoporosis remains incompletely solved. Additionally, adverse drug events and fractures after long-termed pharmacotherapy pose additional challenges within designing a proper therapy regimen. Improved clinical approach and new synergistic treatment modalities are consequently still needed. The rationale of the presented study was accordingly, to expand our preclinical animal study on human patients with osteoporosis, based on positive effects on bones observed in animals with osteopenia treated with PMA-zeolite. We specifically monitored effects of PMA-zeolite on the bone quality parameters, fracture risk and quality of life in a cohort of initially recruited 100 osteoporosis patients during a follow-up period of 5 years within a randomized, placebo-controlled and double blinded clinical study (TOP study). Obtained results provide evidence on the PMA-zeolite positive effects on the bone strength of osteoporotic patients as the risk of fractures was significantly decreased in PMA-zeolite-treated patients with respect to time before entering the study (
Language	English
Publishing date	2022-06-27
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2022.870962
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Article ; Online: Nanoparticles in Medicine: Current Status in Cancer Treatment.

Pavelić, Krešimir / Kraljević Pavelić, Sandra / Bulog, Aleksandar / Agaj, Andrea / Rojnić, Barbara / Čolić, Miroslav / Trivanović, Dragan

International journal of molecular sciences

2023 Volume 24, Issue 16

Abstract: Cancer is still a leading cause of deaths worldwide, especially due to those cases diagnosed at late stages with metastases that are still considered untreatable and are managed in such a way that a lengthy chronic state is achieved. Nanotechnology has ... ...

Abstract	Cancer is still a leading cause of deaths worldwide, especially due to those cases diagnosed at late stages with metastases that are still considered untreatable and are managed in such a way that a lengthy chronic state is achieved. Nanotechnology has been acknowledged as one possible solution to improve existing cancer treatments, but also as an innovative approach to developing new therapeutic solutions that will lower systemic toxicity and increase targeted action on tumors and metastatic tumor cells. In particular, the nanoparticles studied in the context of cancer treatment include organic and inorganic particles whose role may often be expanded into diagnostic applications. Some of the best studied nanoparticles include metallic gold and silver nanoparticles, quantum dots, polymeric nanoparticles, carbon nanotubes and graphene, with diverse mechanisms of action such as, for example, the increased induction of reactive oxygen species, increased cellular uptake and functionalization properties for improved targeted delivery. Recently, novel nanoparticles for improved cancer cell targeting also include nanobubbles, which have already demonstrated increased localization of anticancer molecules in tumor tissues. In this review, we will accordingly present and discuss state-of-the-art nanoparticles and nano-formulations for cancer treatment and limitations for their application in a clinical setting.
MeSH term(s)	Metal Nanoparticles/therapeutic use ; Nanotubes, Carbon ; Silver ; Medicine ; Gold ; Neoplasms/drug therapy
Chemical Substances	Nanotubes, Carbon ; Silver (3M4G523W1G) ; Gold (7440-57-5)
Language	English
Publishing date	2023-08-15
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms241612827
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Article ; Online: Study of zeolite clinoptilolite d-glucose adsorption properties in vitro and in vivo.

Markoska, Rumenka / Stojković, Ranko / Filipović, Marko / Jurin, Mladenka / Špada, Vedrana / Kavre Piltaver, Ivna / Pavelić, Krešimir / Marković, Dean / Kraljević Pavelić, Sandra

Chemico-biological interactions

2023 Volume 382, Page(s) 110641

Abstract: Beneficial effects of a natural zeolite clinoptilolite in vivo on mammals, including humans, have been empirically observed and documented in literature. The positive biological activities have been associated to its detoxifying and antioxidative ... ...

Abstract	Beneficial effects of a natural zeolite clinoptilolite in vivo on mammals, including humans, have been empirically observed and documented in literature. The positive biological activities have been associated to its detoxifying and antioxidative properties, and its immunostimulative and adsorption properties. Herein, we present the in vitro and in vivo study of clinoptilolite zeolite materials adsorption properties for d-glucose. In particular, we present data on the interaction of d-glucose on the tested zeolites' surface obtained by scanning electron microscope (SEM) and Energy-dispersive X-ray spectroscopy (EDS) and quantification by ultra high-performance liquid chromatography (UHPLC). We also present results on the reduction of blood glucose levels in mice pre-treated with clinoptilolite in vivo upon feeding with d-glucose. In vivo results were in line with the in vitro adsorption and/or interaction properties of tested zeolite materials for d-glucose and were quantified by UHPLC as well (11.34% for TMAZ; 10.82% for PMA and 8.76% for PMAO2). In vivo experiments in mice showed that PMA zeolite reduces blood glucose levels upon 15 min for 13% (at p < 0.05) up to 19.11% upon 120 min (without statistical significance) in clinoptilolite pre-treated mice fed by addition of d-glucose. Due to lack of explicit mechanistic knowledge on zeolite clinoptilolite interactions or adsorption with sugars in vitro and in vivo, presented study provides novel insights into these aspects for researchers in the field. The presented data merit further investigations as the material clearly shows a potential in management of hyperglycemia, such as for example in obese people, people with diabetes and people with metabolic syndrome where it could help regulate blood glucose levels.
MeSH term(s)	Humans ; Animals ; Mice ; Zeolites/pharmacology ; Zeolites/chemistry ; Adsorption ; Glucose ; Blood Glucose ; Mammals
Chemical Substances	clinoptilolite (12173-10-3) ; Zeolites (1318-02-1) ; Glucose (IY9XDZ35W2) ; Blood Glucose
Language	English
Publishing date	2023-07-22
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	218799-1
ISSN	1872-7786 ; 0009-2797
ISSN (online)	1872-7786
ISSN	0009-2797
DOI	10.1016/j.cbi.2023.110641
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Zs.A 686: Show issues

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Article ; Online: Fighting Cancer with Bacteria and Their Toxins.

Trivanović, Dragan / Pavelić, Krešimir / Peršurić, Željka

International journal of molecular sciences

2021 Volume 22, Issue 23

Abstract: Cancer is one of the most important global health problems that continues to demand new treatment strategies. Many bacteria that cause persistent infections play a role in carcinogenesis. However, since bacteria are well studied in terms of molecular ... ...

Abstract	Cancer is one of the most important global health problems that continues to demand new treatment strategies. Many bacteria that cause persistent infections play a role in carcinogenesis. However, since bacteria are well studied in terms of molecular mechanisms, they have been proposed as an interesting solution to treat cancer. In this review, we present the use of bacteria, and particularly bacterial toxins, in cancer therapy, highlighting the advantages and limitations of bacterial toxins. Proteomics, as one of the omics disciplines, is essential for the study of bacterial toxins. Advances in proteomics have contributed to better characterization of bacterial toxins, but also to the development of anticancer drugs based on bacterial toxins. In addition, we highlight the current state of knowledge in the rapidly developing field of bacterial extracellular vesicles, with a focus on their recent application as immunotherapeutic agents.
MeSH term(s)	Antineoplastic Agents/pharmacology ; Bacteria/metabolism ; Bacterial Outer Membrane/metabolism ; Bacterial Toxins/pharmacology ; Extracellular Vesicles/metabolism ; Female ; Humans ; Lung Neoplasms/pathology ; Lung Neoplasms/therapy ; Male ; Proteomics
Chemical Substances	Antineoplastic Agents ; Bacterial Toxins
Language	English
Publishing date	2021-11-30
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms222312980
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