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  1. Article: Obstructive Sleep Apnea Treatment with Oral Appliance in a Myotonic Dystrophy Type I Subject: A Case Report.

    Guimarães, Maria de Lourdes Rabelo / Ribeiro, Milena Carvalho Tourino / Barbosa, Thiago Antunes da Silva / Costa, Laila Gabriela de Figueiredo / Bastos, Patricia Souza

    Sleep science (Sao Paulo, Brazil)

    2023  Volume 16, Issue 3, Page(s) e375–e380

    Abstract: ... ...

    Abstract Objective
    Language English
    Publishing date 2023-09-11
    Publishing country Germany
    Document type Case Reports
    ZDB-ID 2697016-8
    ISSN 1984-0063 ; 1984-0659
    ISSN (online) 1984-0063
    ISSN 1984-0659
    DOI 10.1055/s-0043-1772817
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Antimicrobial and wound healing potential of naphthoquinones encapsulated in nanochitosan.

    Freitas, Cyntia Silva / Pereira, Patricia Ribeiro / Cardoso, Raiane Vieira / Pauli, Fernanda Petzold / Ribeiro, Ruan Carlos Busquet / Da Silva, Fernando De Carvalho / Ferreira, Vitor Francisco / Paschoalin, Vania Margaret Flosi

    Frontiers in bioengineering and biotechnology

    2024  Volume 11, Page(s) 1284630

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2024-01-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2023.1284630
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Influence of genetics on the occurrence of enamel hypomineralization affecting permanent and primary teeth: A scoping review.

    Teixeira, Thamires Pereira de Souza / Pereira, Patricia Soares Araújo / Carvalho, Felipe de Assis Ribeiro / Soviero, Vera Mendes

    International journal of paediatric dentistry

    2023  

    Abstract: Background: Molar incisor hypomineralization (MIH) is prevalent worldwide and is a challenge for clinicians who provide oral care to children. Molar incisor hypomineralization has been considered a multifactorial disturbance that results from a ... ...

    Abstract Background: Molar incisor hypomineralization (MIH) is prevalent worldwide and is a challenge for clinicians who provide oral care to children. Molar incisor hypomineralization has been considered a multifactorial disturbance that results from a combination of environmental and genetic factors.
    Aim: This scoping review followed the Joanna Briggs Institute protocol and aimed to identify the available evidence of the genetic influence on the etiology of MIH.
    Design: The search strategy was conducted in multiple databases, including PubMed, BVS, Embase, Web of Science, and Scopus. Two trained reviewers, requiring a third reviewer in case of disagreements, collected evidence.
    Results: Of 563 retrieved studies, 17 were included in the review. From 14 studies performed in humans, 10 investigated DNA polymorphisms, one analyzed DNA methylation, one aimed model of inheritance, and two focused on the phenotype in twins or in the family. Three animal studies were based on the null expression of genes.
    Conclusion: This scoping review, based on the studies that used different methodologies, reinforces the hypothesis of a genetic contribution to the multifactorial etiology of MIH. The available data are limited in terms of size and origin of the samples. Hence, further genetic studies are still required.
    Language English
    Publishing date 2023-10-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 1070942-3
    ISSN 1365-263X ; 0960-7439
    ISSN (online) 1365-263X
    ISSN 0960-7439
    DOI 10.1111/ipd.13129
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: The history of families at-risk for hereditary breast and ovarian cancer: what are the impacts of genetic counseling and testing?

    Campacci, Natalia / Grasel, Rebeca Silveira / Galvão, Henrique de Campos Reis / Garcia, Lucas França / Ribeiro, Paula Carvalho / Pereira, Kercy Fram de Jesus de Sena / Goldim, José Roberto / Ashton-Prolla, Patricia / Palmero, Edenir Inêz

    Frontiers in psychology

    2024  Volume 15, Page(s) 1306388

    Abstract: Introduction: Cancer Genetic Counseling (CGC) and genetic testing (GT) assume a paramount role for hereditary cancer predisposition syndrome families. We assessed the effects of CGC and GT on women affected by cancer who are at risk for hereditary ... ...

    Abstract Introduction: Cancer Genetic Counseling (CGC) and genetic testing (GT) assume a paramount role for hereditary cancer predisposition syndrome families. We assessed the effects of CGC and GT on women affected by cancer who are at risk for hereditary breast and ovarian cancer predisposition syndrome (HBOC).
    Methods: This study encompasses four time points: before the CGC session, after the CGC session when blood is drawn for GT, after disclosure of GT results, and six months following disclosure of GT results. The impacts of CGC and GT were assessed using psychosocial questionnaires. Additionally, a pedigree, genogram, and ecomap were constructed through a semistructured interview.
    Results: A total of sixty women were included in the study. Most participants considered their perception of cancer risk to be equivalent to that of the general population, even among those with pathogenic variants. An increased perception of breast and ovarian cancer risks was associated with a heightened inclination toward religious engagement as a coping mechanism. Patients carrying variants of uncertain significance expressed greater concerns about developing another cancer compared to those who had
    Discussion: These findings can assist healthcare professionals considering a personalized approaches in clinical practice.
    Language English
    Publishing date 2024-03-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2024.1306388
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Exploring the Antimicrobial and Antitumoral Activities of Naphthoquinone-Grafted Chitosans.

    Pauli, Fernanda Petzold / Freitas, Cyntia Silva / Pereira, Patricia Ribeiro / Magalhães, Alviclér / de Carvalho da Silva, Fernando / Paschoalin, Vania M F / Ferreira, Vitor Francisco

    Polymers

    2023  Volume 15, Issue 6

    Abstract: Biopolymers obtained from natural macromolecules are noteworthy among materials presenting high biocompatibility and adequate biodegradability, as is the case of chitosan (CS), making this biopolymeric compound a suitable drug delivery system. Herein, ... ...

    Abstract Biopolymers obtained from natural macromolecules are noteworthy among materials presenting high biocompatibility and adequate biodegradability, as is the case of chitosan (CS), making this biopolymeric compound a suitable drug delivery system. Herein, chemically-modified CS were synthetized using 2,3-dichloro-1,4-naphthoquinone (1,4-NQ) and the sodium salt of 1,2-naphthoquinone-4-sulfonic acid (1,2-NQ), producing 1,4-NQ-CS and 1,2-NQ-CS by three different methods, employing an ethanol and water mixture (EtOH:H
    Language English
    Publishing date 2023-03-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym15061430
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: 1,2-Naphthoquinone-4-sulfonic acid salts in organic synthesis.

    Ribeiro, Ruan Carlos B / Ferreira, Patricia G / Borges, Amanda de A / Forezi, Luana da S M / da Silva, Fernando de Carvalho / Ferreira, Vitor F

    Beilstein journal of organic chemistry

    2022  Volume 18, Page(s) 53–69

    Abstract: Several low molecular weight naphthoquinones are very useful in organic synthesis. These compounds have given rise to thousands of other naphthoquinones that have been tested against various microorganisms and pharmacological targets, including being ... ...

    Abstract Several low molecular weight naphthoquinones are very useful in organic synthesis. These compounds have given rise to thousands of other naphthoquinones that have been tested against various microorganisms and pharmacological targets, including being used in the preparation of several drugs that are on the pharmaceutical market. Among these naphthoquinones, the series of compounds prepared from 1,2-naphthoquinone-4-sulfonic acid salts (β-NQS) stands out. In addition to being used in organic synthesis, they are excellent analytical derivatization reagents to spectrophotometrically determine drugs containing primary and secondary amino groups. This review summarizes the literature involving β-NQS.
    Language English
    Publishing date 2022-01-05
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2192461-2
    ISSN 1860-5397
    ISSN 1860-5397
    DOI 10.3762/bjoc.18.5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Obstructive Sleep Apnea Treatment with Oral Appliance in a Myotonic Dystrophy Type I Subject: A Case Report

    Guimarães, Maria de Lourdes Rabelo / Ribeiro, Milena Carvalho Tourino / Barbosa, Thiago Antunes da Silva / Costa, Laila Gabriela de Figueiredo / Bastos, Patricia Souza

    Sleep Science

    2023  Volume 16, Issue 03, Page(s) e375–e380

    Abstract: Objective: to report a myotonic dystrophy type 1 (MD1) subject with obstructive sleep apnea syndrome treated with oral appliance.: Methods: A review of individual's history and records, associated with a photographic register of all diagnostic ... ...

    Abstract Objective: to report a myotonic dystrophy type 1 (MD1) subject with obstructive sleep apnea syndrome treated with oral appliance.
    Methods: A review of individual's history and records, associated with a photographic register of all diagnostic methods and literature research about the topic were done.
    Final Statements: This case depicts the therapeutical choices disposable to treat subjects with obstructive sleep apnea and DM1. Although considered an uncommon treatment, the oral appliances, if well indicated in adequately selected cases, can satisfactorily improve respiratory parameters, symptoms and quality of life.
    Keywords myotonic dystrophy type 1 ; sleep apnea syndromes ; sleepiness ; oral appliance ; biomarker ; therapeutics
    Language English
    Publishing date 2023-09-01
    Publisher Thieme Revinter Publicações Ltda.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2697016-8
    ISSN 1984-0063 ; 1984-0659 ; 1984-0063
    ISSN (online) 1984-0063
    ISSN 1984-0659 ; 1984-0063
    DOI 10.1055/s-0043-1772817
    Database Thieme publisher's database

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  8. Article ; Online: Blood biochemical, hormonal, and hematological responses of native sheep submitted to different environmental conditions.

    Rodrigues, Raimundo Calixto Martins / Furtado, Dermeval Araújo / Ribeiro, Neila Lidiany / de Sousa Silva, Ricardo / da Costa Silva, José Antônio Pires / da Silva, Maycon Rodrigues / Mascarenhas, Nágela Maria Henrique / Cavalcanti, Cácio Ribeiro / Ayres, Gypson Dutra Junqueira / Dornelas, Karoline Carvalho / Lima, Patricia Rodriguesde / de Figueiredo, Caio Franklin Vieira

    Research in veterinary science

    2023  Volume 165, Page(s) 105067

    Abstract: The aim of this study was to evaluate the biochemical, hormonal, and hematological blood responses of native sheep subjected to five temperatures (20°, 24°, 28°, 32°, and 36 °C), using 24 sheep of the following breeds: Santa Inês (SI), Morada Nova (MN), ... ...

    Abstract The aim of this study was to evaluate the biochemical, hormonal, and hematological blood responses of native sheep subjected to five temperatures (20°, 24°, 28°, 32°, and 36 °C), using 24 sheep of the following breeds: Santa Inês (SI), Morada Nova (MN), Soinga (SO) and no defined racial pattern (NDRP), kept in collective pens inside the climatic chamber. The experimental design was completely randomized, in a 5 × 4 factorial scheme (5 temperatures and 4 breeds) with 6 animals of each breed at each temperature. There was interaction for urea (P < .0001), glucose (P < .0001), cholesterol (P < .0001), and magnesium (P < .0001) as a function of breed and air temperature. Urea (P = .001), glucose (P < .0001), triglycerides (P = .033), cholesterol (P = .004), and magnesium (P < .0001) showed differences according to breed. It was observed that T4 (P < .0001) and cortisol (P < .0001) showed an interaction between breed and temperature, while T4 (P = .001) and cortisol (P = .001) an effect of breed. The highest magnesium concentration was observed in MN, and the lowest was in NDRP, SO, and SI, which are statistically similar, and SI and NDRP are statistically similar. The hormones showed a significant effect (P < .0001) for temperature, where cortisol increased, and thyroid hormones decreased with increasing temperature. Temperatures of 32° and 36 °C contribute to changes in blood, hormone, and hematological biochemical responses of native sheep.
    MeSH term(s) Sheep ; Animals ; Hydrocortisone ; Magnesium ; Cholesterol ; Glucose ; Urea
    Chemical Substances Hydrocortisone (WI4X0X7BPJ) ; Magnesium (I38ZP9992A) ; Cholesterol (97C5T2UQ7J) ; Glucose (IY9XDZ35W2) ; Urea (8W8T17847W)
    Language English
    Publishing date 2023-10-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 840961-4
    ISSN 1532-2661 ; 0034-5288
    ISSN (online) 1532-2661
    ISSN 0034-5288
    DOI 10.1016/j.rvsc.2023.105067
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 673: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  9. Article ; Online: Correlation between symptoms of depression, attitude, and self-care in elderly with type 2 diabetes.

    Frazão, Maria Cristina Lins Oliveira / Viana, Lia Raquel de Carvalho / Ferreira, Gerlania Rodrigues Salviano / Pimenta, Cláudia Jeane Lopes / Silva, Cleane Rosa Ribeiro da / Madruga, Kaisy Martins de Albuquerque / Batista, Patrícia Serpa de Souza / Costa, Kátia Neyla de Freitas Macedo

    Revista brasileira de enfermagem

    2023  Volume 76, Issue 3, Page(s) e20220741

    Abstract: ... the Geriatric Depression Scale (15 items), the Questionário de Atitudes Psicológicas do Diabetes [Psychological ...

    Abstract Objectives: to correlate depressive symptoms, attitude, and self-care of elderly people with type 2 diabetes.
    Methods: study developed with 144 elderly people with diabetes; carried out in Family Health Units. A semi-structured instrument was used to obtain data on the sociodemographic profile; the Geriatric Depression Scale (15 items), the Questionário de Atitudes Psicológicas do Diabetes [Psychological Attitudes of Diabetes Questionnaire], and the Diabetes Self-Care Activities Questionnaire (DSCA) were also used.
    Results: it was identified that 24.3% of the participants presented depressive symptoms, and 93.8% presented negative attitudes of coping. A greater adherence to self-care activities related to the practice of medication was observed. In the correlation between the scales, a negative and inversely proportional correspondence was noted between depressive symptomatology and physical activity (p=0.010) and foot care (p=0.006), likewise between attitude and foot care (p=0.009).
    Conclusions: self-care in elderly people with diabetes mellitus is influenced by depressive symptoms and negative coping attitudes.
    MeSH term(s) Humans ; Aged ; Diabetes Mellitus, Type 2/therapy ; Diabetes Mellitus, Type 2/drug therapy ; Depression/etiology ; Depression/psychology ; Self Care ; Attitude ; Adaptation, Psychological
    Language Portuguese
    Publishing date 2023-07-10
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 731983-6
    ISSN 1984-0446 ; 0034-7167
    ISSN (online) 1984-0446
    ISSN 0034-7167
    DOI 10.1590/0034-7167-2022-0741
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3392: Show issues Location:
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  10. Article ; Online: Novel naphthoquinone-1H-1,2,3-triazole hybrids: Design, synthesis and evaluation as inductors of ROS-mediated apoptosis in the MCF-7 cells.

    de Souza, Acácio S / Dias, Deborah S / Ribeiro, Ruan C B / Costa, Dora C S / de Moraes, Matheus G / Pinho, David R / Masset, Maria E G / Marins, Laís M / Valle, Sandy P / de Carvalho, Cláudio J C / de Carvalho, Gustavo S G / Mello, Angélica Lauria N / Sola-Penna, Mauro / Palmeira-Mello, Marcos V / Conceição, Raissa A / Rodrigues, Carlos R / Souza, Alessandra M T / Forezi, Luana da S M / Zancan, Patricia /
    Ferreira, Vitor F / da Silva, Fernando de C

    Bioorganic & medicinal chemistry

    2024  Volume 102, Page(s) 117671

    Abstract: The search for novel anticancer drugs is essential to expand treatment options, overcome drug resistance, reduce toxicity, promote innovation, and tackle the economic impact. The importance of these studies lies in their contribution to advancing cancer ... ...

    Abstract The search for novel anticancer drugs is essential to expand treatment options, overcome drug resistance, reduce toxicity, promote innovation, and tackle the economic impact. The importance of these studies lies in their contribution to advancing cancer research and enhancing patient outcomes in the battle against cancer. Here, we developed new asymmetric hybrids containing two different naphthoquinones linked by a 1,2,3-1H-triazole nucleus, which are potential new drugs for cancer treatment. The antitumor activity of the novel compounds was tested using the breast cancer cell lines MCF-7 and MDA-MB-231, using the non-cancer cell line MCF10A as control. Our results showed that two out of twenty-two substances tested presented potential antitumor activity against the breast cancer cell lines. These potential drugs, named here 12g and 12h were effective in reducing cell viability and promoting cell death of the tumor cell lines, exhibiting minimal effects on the control cell line. The mechanism of action of the novel drugs was assessed revealing that both drugs increased reactive oxygen species production with consequent activation of the AMPK pathway. Therefore, we concluded that 12g and 12h are novel AMPK activators presenting selective antitumor effects.
    MeSH term(s) Humans ; Female ; MCF-7 Cells ; Reactive Oxygen Species/metabolism ; Triazoles/pharmacology ; Naphthoquinones/pharmacology ; AMP-Activated Protein Kinases ; Cell Proliferation ; Apoptosis ; Cell Line, Tumor ; Antineoplastic Agents/pharmacology ; Breast Neoplasms/drug therapy ; Drug Screening Assays, Antitumor
    Chemical Substances Reactive Oxygen Species ; Triazoles ; Naphthoquinones ; AMP-Activated Protein Kinases (EC 2.7.11.31) ; Antineoplastic Agents
    Language English
    Publishing date 2024-03-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 1161284-8
    ISSN 1464-3391 ; 0968-0896
    ISSN (online) 1464-3391
    ISSN 0968-0896
    DOI 10.1016/j.bmc.2024.117671
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3815: Show issues Location:
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