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  1. Article ; Online: Do benzodiazepines reduce the efficacy of transcranial magnetic stimulation?

    Tran, Lana / Hahn, Lisa / Gill, Shane / Ng, Felicity / Clarke, Patrick / Paterson, Tom / Galletly, Cherrie

    Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists

    2024  , Page(s) 10398562241229623

    Abstract: Objective: To investigate the effect of concomitant use of benzodiazepines on the efficacy of repetitive transcranial magnetic stimulation (rTMS) in patients with treatment-resistant major depressive disorder (TR-MDD).: Methods: This is a ... ...

    Abstract Objective: To investigate the effect of concomitant use of benzodiazepines on the efficacy of repetitive transcranial magnetic stimulation (rTMS) in patients with treatment-resistant major depressive disorder (TR-MDD).
    Methods: This is a retrospective study comparing rTMS treatment outcomes between patients taking benzodiazepines (
    Results: Patients taking benzodiazepines during rTMS treatment did not show any difference in partial response, response or remission rates compared to patients not treated with benzodiazepines. There was a significant decrease (
    Conclusions: Concomitant benzodiazepine treatment had no effect on the efficacy of rTMS treatment of TRD, contrary to previous research.
    Language English
    Publishing date 2024-02-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2213198-X
    ISSN 1440-1665 ; 1039-8562
    ISSN (online) 1440-1665
    ISSN 1039-8562
    DOI 10.1177/10398562241229623
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Small habitat matrix: How does it work?

    Ng, Casey Keat-Chuan / Payne, John / Oram, Felicity

    Ambio. 2021 Mar., v. 50, no. 3

    2021  

    Abstract: We present herein our perspective of a novel Small Habitats Matrix (SHM) concept showing how small habitats on private lands are untapped but can be valuable for mitigating ecological degradation. Grounded by the realities in Sabah, Malaysian Borneo, we ... ...

    Abstract We present herein our perspective of a novel Small Habitats Matrix (SHM) concept showing how small habitats on private lands are untapped but can be valuable for mitigating ecological degradation. Grounded by the realities in Sabah, Malaysian Borneo, we model a discontinuous “stepping stones” linkage that includes both terrestrial and aquatic habitats to illustrate exactly how the SHM can be deployed. Taken together, the SHM is expected to optimize the meta-population vitality in monoculture landscapes for aerial, arboreal, terrestrial and aquatic wildlife communities. We also provide the tangible cost estimates and discuss how such a concept is both economically affordable and plausible to complement global conservation initiatives. By proposing a practical approach to conservation in the rapidly developing tropics, we present a perspective from “ground zero” that reaches out to fellow scientists, funders, activists and pro-environmental land owners who often ask, “What more can we do?”
    Keywords Borneo ; environmental degradation ; wildlife
    Language English
    Dates of publication 2021-03
    Size p. 601-614.
    Publishing place Springer Netherlands
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 120759-3
    ISSN 1654-7209 ; 0044-7447
    ISSN (online) 1654-7209
    ISSN 0044-7447
    DOI 10.1007/s13280-020-01384-y
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Small habitat matrix: How does it work?

    Ng, Casey Keat-Chuan / Payne, John / Oram, Felicity

    Ambio

    2020  Volume 50, Issue 3, Page(s) 601–614

    Abstract: We present herein our perspective of a novel Small Habitats Matrix (SHM) concept showing how small habitats on private lands are untapped but can be valuable for mitigating ecological degradation. Grounded by the realities in Sabah, Malaysian Borneo, we ... ...

    Abstract We present herein our perspective of a novel Small Habitats Matrix (SHM) concept showing how small habitats on private lands are untapped but can be valuable for mitigating ecological degradation. Grounded by the realities in Sabah, Malaysian Borneo, we model a discontinuous "stepping stones" linkage that includes both terrestrial and aquatic habitats to illustrate exactly how the SHM can be deployed. Taken together, the SHM is expected to optimize the meta-population vitality in monoculture landscapes for aerial, arboreal, terrestrial and aquatic wildlife communities. We also provide the tangible cost estimates and discuss how such a concept is both economically affordable and plausible to complement global conservation initiatives. By proposing a practical approach to conservation in the rapidly developing tropics, we present a perspective from "ground zero" that reaches out to fellow scientists, funders, activists and pro-environmental land owners who often ask, "What more can we do?"
    MeSH term(s) Animals ; Animals, Wild ; Biodiversity ; Borneo ; Conservation of Natural Resources ; Ecosystem
    Language English
    Publishing date 2020-09-11
    Publishing country Sweden
    Document type Journal Article
    ZDB-ID 120759-3
    ISSN 1654-7209 ; 0044-7447
    ISSN (online) 1654-7209
    ISSN 0044-7447
    DOI 10.1007/s13280-020-01384-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Pituitary abscess: a case report and systematic review of 488 cases.

    Stringer, Felicity / Foong, Yi Chao / Tan, Alanna / Hayman, Sarah / Zajac, Jeffrey D / Grossmann, Mathis / Zane, Justin Ng Yau / Zhu, Jasmine / Ayyappan, Sujith

    Orphanet journal of rare diseases

    2023  Volume 18, Issue 1, Page(s) 165

    Abstract: Background: Pituitary abscess (PA) is a rare condition and not well understood. We aimed to describe a case and perform a comprehensive systematic review to explore presenting symptoms, radiological findings, endocrine abnormalities and mortality.: ... ...

    Abstract Background: Pituitary abscess (PA) is a rare condition and not well understood. We aimed to describe a case and perform a comprehensive systematic review to explore presenting symptoms, radiological findings, endocrine abnormalities and mortality.
    Aim: To identify presenting symptoms, radiological findings, endocrinological abnormalities and predictors of mortality for PA.
    Methods: We systematically reviewed the literature to identify all case reports of PA. Data regarding presentation, mortality, radiological findings, endocrinological abnormalities and treatment was extracted.
    Results: We identified 488 patients from 218 articles meeting the inclusion criteria. Mortality was 5.1%, with days to presentation (OR 1.0005, 95% CI 1.0001-1.0008, p < 0.01) being the only identified independent predictor of mortality. Mortality rates have decreased over time, with cases published prior to 2000 having higher mortality rates (OR 6.92, 95% CI 2.80-17.90, p < 0.001). The most common symptom was headache (76.2%), followed by visual field defects (47.3%). Classical signs of infection were only present in 43%. The most common imaging feature on magnetic resonance imaging (MRI) was high T2 and low T1 signal of the pituitary gland with peripheral contrast enhancement. Over half (54.8%) were culture negative, with the most common bacterial organism being staphylococcus aureus (7.8%) and fungal organism being aspergillus (8.8%). The most common endocrine abnormality was hypopituitarism (41.1%), followed by diabetes insipidus (24.8%). Whilst symptoms resolved in most patients, persistent endocrine abnormalities were present in over half of patients (61.0%).
    Conclusion: PA is associated with significant mortality, with delayed presentation increasing risk of mortality. Ongoing endocrinological abnormalities are common. Given the non-specific clinical presentation, the appearance of high T2, low T1 and peripheral contrast enhancement of the pituitary on MRI should prompt consideration of this rare disease.
    MeSH term(s) Humans ; Abscess/complications ; Pituitary Diseases/complications ; Pituitary Diseases/diagnosis ; Pituitary Diseases/microbiology ; Hypopituitarism/complications ; Pituitary Neoplasms/complications ; Magnetic Resonance Imaging
    Language English
    Publishing date 2023-06-26
    Publishing country England
    Document type Systematic Review ; Case Reports ; Journal Article
    ZDB-ID 2225857-7
    ISSN 1750-1172 ; 1750-1172
    ISSN (online) 1750-1172
    ISSN 1750-1172
    DOI 10.1186/s13023-023-02788-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Is mental illness migratory?

    Ng, Felicity

    Acta neuropsychiatrica

    2006  Volume 18, Issue 3-4, Page(s) 128–129

    Language English
    Publishing date 2006-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 1154361-9
    ISSN 1601-5215 ; 0924-2708
    ISSN (online) 1601-5215
    ISSN 0924-2708
    DOI 10.1111/j.1601-5215.2006.00146.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Long-term renal outcome post-multimodal computed tomography in stroke evaluation.

    Lim, Julia / Goh, Ian / Gwini, Stella-May / Stringer, Felicity / Ng, Zun Niang / Dohrmann, Sara / Smith, Heather / Clissold, Benjamin

    Internal medicine journal

    2022  Volume 52, Issue 1, Page(s) 134–138

    Abstract: Recent studies have demonstrated the risk of contrast-associated acute kidney injury (CA-AKI) is low post-multimodal computed tomography (MMCT) in the evaluation of acute stroke. We provide a complementary study with long-term renal follow up. A ... ...

    Abstract Recent studies have demonstrated the risk of contrast-associated acute kidney injury (CA-AKI) is low post-multimodal computed tomography (MMCT) in the evaluation of acute stroke. We provide a complementary study with long-term renal follow up. A retrospective analysis was performed on all suspected strokes from January 2019 to June 2020 for those who had undergone computed tomography angiography, computed tomography perfusion or both. We identified 776 cases, of which 538 were excluded. The incidence of CA-AKI was 7.6% (n/N = 18/238; 95% confidence interval = 4.2-11.0). All CA-AKI cases had renal confounders. No AKI at >30 days was found in 60.5% (n = 144) of all cases studied. The long-term renal outcome post-MMCT in stroke evaluation is favourable at >30 days.
    MeSH term(s) Acute Kidney Injury/chemically induced ; Acute Kidney Injury/diagnostic imaging ; Acute Kidney Injury/epidemiology ; Contrast Media ; Humans ; Retrospective Studies ; Stroke/complications ; Stroke/diagnostic imaging ; Tomography, X-Ray Computed/methods
    Chemical Substances Contrast Media
    Language English
    Publishing date 2022-01-21
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2045436-3
    ISSN 1445-5994 ; 1444-0903
    ISSN (online) 1445-5994
    ISSN 1444-0903
    DOI 10.1111/imj.15643
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: The interface between religion and psychosis.

    Ng, Felicity

    Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists

    2007  Volume 15, Issue 1, Page(s) 62–66

    Abstract: Objective: This paper aims to explore the interface between religion and psychosis, and to comment on its relevance in clinical practice.: Method: The context of religious psychotic phenomena is briefly discussed, leading to an examination of the ... ...

    Abstract Objective: This paper aims to explore the interface between religion and psychosis, and to comment on its relevance in clinical practice.
    Method: The context of religious psychotic phenomena is briefly discussed, leading to an examination of the biological substrates of religious experiences, the hypothesized process of religious psychotic symptom formation, and the clinical implications when assessing religious delusions. A PubMED search was conducted to identify original research and review articles of relevance to the discussion.
    Results: Religion is an enduring theme in psychosis, the understanding of which can be assisted by distinguishing between religion as a culture and religiosity as pathology. There are strong arguments for the involvement of temporolimbic instability in the generation of religious psychotic symptoms.
    Conclusions: Psychosis can be conceptualized as the manifestation of aberrant perceptual and/or integrative processes. The prevalence of religion as a psychotic theme may be explained by its central cultural role, the implication of temporolimbic overactivity in the pathogenesis of some cases of psychosis, and the tendency to interpret intense or discrepant perceptual events as spiritual. In the clinical setting, the determination of religious delusions can be challenging at times. In addition to seeking advice on unfamiliar religions, a thorough assessment of the dimensions of religious beliefs and symptoms of neurocognitive dysfunction can be useful.
    MeSH term(s) Cognition Disorders/epidemiology ; Cognition Disorders/physiopathology ; Culture ; Humans ; Limbic System/physiopathology ; Psychotic Disorders/epidemiology ; Psychotic Disorders/psychology ; Religion and Psychology ; Temporal Lobe/physiopathology
    Language English
    Publishing date 2007-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2213198-X
    ISSN 1440-1665 ; 1039-8562
    ISSN (online) 1440-1665
    ISSN 1039-8562
    DOI 10.1080/10398560601083118
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Pituitary abscess

    Felicity Stringer / Yi Chao Foong / Alanna Tan / Sarah Hayman / Jeffrey D. Zajac / Mathis Grossmann / Justin Ng Yau Zane / Jasmine Zhu / Sujith Ayyappan

    Orphanet Journal of Rare Diseases, Vol 18, Iss 1, Pp 1-

    a case report and systematic review of 488 cases

    2023  Volume 15

    Abstract: Abstract Background Pituitary abscess (PA) is a rare condition and not well understood. We aimed to describe a case and perform a comprehensive systematic review to explore presenting symptoms, radiological findings, endocrine abnormalities and mortality. ...

    Abstract Abstract Background Pituitary abscess (PA) is a rare condition and not well understood. We aimed to describe a case and perform a comprehensive systematic review to explore presenting symptoms, radiological findings, endocrine abnormalities and mortality. Aim To identify presenting symptoms, radiological findings, endocrinological abnormalities and predictors of mortality for PA. Methods We systematically reviewed the literature to identify all case reports of PA. Data regarding presentation, mortality, radiological findings, endocrinological abnormalities and treatment was extracted. Results We identified 488 patients from 218 articles meeting the inclusion criteria. Mortality was 5.1%, with days to presentation (OR 1.0005, 95% CI 1.0001–1.0008, p < 0.01) being the only identified independent predictor of mortality. Mortality rates have decreased over time, with cases published prior to 2000 having higher mortality rates (OR 6.92, 95% CI 2.80–17.90, p < 0.001). The most common symptom was headache (76.2%), followed by visual field defects (47.3%). Classical signs of infection were only present in 43%. The most common imaging feature on magnetic resonance imaging (MRI) was high T2 and low T1 signal of the pituitary gland with peripheral contrast enhancement. Over half (54.8%) were culture negative, with the most common bacterial organism being staphylococcus aureus (7.8%) and fungal organism being aspergillus (8.8%). The most common endocrine abnormality was hypopituitarism (41.1%), followed by diabetes insipidus (24.8%). Whilst symptoms resolved in most patients, persistent endocrine abnormalities were present in over half of patients (61.0%). Conclusion PA is associated with significant mortality, with delayed presentation increasing risk of mortality. Ongoing endocrinological abnormalities are common. Given the non-specific clinical presentation, the appearance of high T2, low T1 and peripheral contrast enhancement of the pituitary on MRI should prompt consideration of this rare disease.
    Keywords Pituitary ; Abscess ; Hypopituitarism ; Rathke’s cleft cyst ; Systematic review ; Medicine ; R
    Subject code 310
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Palliative medicine specialists' causal explanations for depression in the palliative care setting: a qualitative in-depth interview study.

    Ng, Felicity / Crawford, Gregory B / Chur-Hansen, Anna

    BMJ supportive & palliative care

    2016  Volume 6, Issue 2, Page(s) 178–185

    Abstract: Objective: Medical practitioners have different causal explanations for depression, and may have greater difficulty in explaining causality of depression in the palliative care setting. The objective of this study was to investigate and describe the ... ...

    Abstract Objective: Medical practitioners have different causal explanations for depression, and may have greater difficulty in explaining causality of depression in the palliative care setting. The objective of this study was to investigate and describe the causal explanations of depression in the palliative care setting, from the perspective of palliative medicine specialists.
    Methods: Palliative medicine specialists practising in Australia were recruited and purposively sampled. Individual semistructured, in-depth interviews were conducted to explore their explanatory models of depression, including a focus on causal explanations. Nine participants were interviewed to reach data saturation. Interview transcripts were analysed for themes.
    Results: Six themes for causal explanations of depression were identified: (1) Depression is inexplicable; (2) Biological explanations-primarily neurotransmitter depletion; (3) Psychological explanations-including reaction to circumstances, inability to accept illness and dying, diminished self, and coping mechanisms; (4) Social explanations-including inadequate social support, and contribution from modern medicine and societal norms; (5) Interrelationships between causal factors-mainly multifactoriality; (6) Different explanation for de novo and pre-existing depressions. Participants also articulated a link between causal explanations and clinical interventions.
    Conclusions: Palliative medicine specialists hold causal explanations of depression that align with the biopsychosocial and vulnerability-stress models. They use multiple individual explanations with diverse theoretical underpinnings, and largely view depression as multifactorial in causality. Given that causal explanations are linked to clinical interventions, these findings have implications for clinical practice and medical education.
    MeSH term(s) Attitude of Health Personnel ; Australia ; Causality ; Depressive Disorder/epidemiology ; Female ; Humans ; Male ; Models, Neurological ; Models, Psychological ; Palliative Care/psychology ; Palliative Medicine ; Qualitative Research
    Language English
    Publishing date 2016-06
    Publishing country England
    Document type Journal Article
    ISSN 2045-4368
    ISSN (online) 2045-4368
    DOI 10.1136/bmjspcare-2013-000626
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Treatment approaches of palliative medicine specialists for depression in the palliative care setting: findings from a qualitative, in-depth interview study.

    Ng, Felicity / Crawford, Gregory B / Chur-Hansen, Anna

    BMJ supportive & palliative care

    2016  Volume 6, Issue 2, Page(s) 186–193

    Abstract: Background: Treatment of depression in the palliative care setting is complicated by varied treatment preferences, a small body of research, and unique challenges associated with the end-of-life. Little is known about the treatment practices of medical ... ...

    Abstract Background: Treatment of depression in the palliative care setting is complicated by varied treatment preferences, a small body of research, and unique challenges associated with the end-of-life. Little is known about the treatment practices of medical practitioners in this setting.
    Objective: This study aimed to investigate and characterise the treatment approaches of palliative medicine specialists for depression.
    Design: Semistructured, in-depth interviews were conducted to explore explanatory models of depression from palliative medicine specialists, including a focus on treatment. Verbatim interview transcripts were analysed for themes.
    Setting/participants: Palliative medicine specialists practising in Australia were recruited and purposively sampled. Nine participants were interviewed to reach data saturation.
    Results: Five themes were identified in relation to treatment of depression: (1) guiding principles of treatment; (2) treatment approaches; (3) factors underpinning treatment decisions; (4) difficulties arising in treatment; and (5) interdisciplinary roles. Participants described five distinct treatment approaches, consisting of biological orientation, psychosocial orientation, combination approach, undifferentiated approach and ambivalence. Treatment decisions were contingent on patient, depression, clinician and sociocultural factors. Difficulties included discomfort with treating depression, being inadequately equipped and confronting therapeutic limitations. Treating depression was considered to require multidisciplinary team effort.
    Conclusions: Palliative medicine specialists' treatment approaches are linked to their concepts of and causal explanations for depression. Future treatment guidelines could aim to consider specific varieties of depression, be more differentiated in treatment modality and type, and consider decision-shaping factors. Continuing mental health education and the incorporation of psychiatry and psychology into palliative care services may have enduring benefits.
    MeSH term(s) Depression/diagnosis ; Depression/therapy ; Depressive Disorder/diagnosis ; Depressive Disorder/therapy ; Female ; Humans ; Male ; Palliative Care/methods ; Palliative Medicine/methods ; Qualitative Research
    Language English
    Publishing date 2016-06
    Publishing country England
    Document type Journal Article
    ISSN 2045-4368
    ISSN (online) 2045-4368
    DOI 10.1136/bmjspcare-2014-000719
    Database MEDical Literature Analysis and Retrieval System OnLINE

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