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  1. Book ; Thesis: Regulation von Oncostatin M in humanen M1-Makrophagen durch Histamin

    Hüer, Marius / Werfel, Thomas

    2022  

    Institution Medizinische Hochschule Hannover
    Klinik für Dermatologie, Allergologie und Venerologie / Abteilung für Immundermatologie und Experimentelle Allergologie
    Author's details vorgelegt von Marius Hüer ; aus der Klinik für Dermatologie, Allergologie und Venerologie, Abteilung Immundermatologie und experimentelle Allergologie der Medizinischen Hochschule Hannover ; Betreuer/in der Arbeit: Prof. Dr. med. Thomas Werfel
    Language German
    Size 82 Blätter, Illustrationen, Diagramme
    Publishing place Hannover
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Medizinische Hochschule Hannover, 2022
    HBZ-ID HT021733256
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2023 E 318 order for loan Magazin

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  2. Book: Dupilumab bei atopischer Dermatitis

    Werfel, Thomas

    erstes Biologikum bei Erwachsenen mit schwerer atopischer Dermatitis

    (Drug report ; 12. Jahrgang, Heft 5 (Mai 2018))

    2018  

    Author's details Autor Prof. Dr. med. Thomas Werfel
    Series title Drug report ; 12. Jahrgang, Heft 5 (Mai 2018)
    Collection
    Language German
    Size 11 Seiten, Illustrationen, Diagramme
    Publisher Thieme
    Publishing place Stuttgart
    Publishing country Germany
    Document type Book
    HBZ-ID HT019710254
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 6601 -12,5- verfügbar in Königswinter Königswinter

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  3. Book ; Thesis: Stimulation des Histamin-H4-Rezeptors moduliert den Differenzierungsprozess und die Chemokin-Freisetzung von humanen Makrophagen und Untersuchungen zur genetischen Variation (SNPs) in der Promotorregion des Histamin-H4-Rezeptor-Gens

    Lonnemann, Lisanne Zoe / Werfel, Thomas

    2022  

    Institution Medizinische Hochschule Hannover
    Klinik für Dermatologie, Allergologie und Venerologie / Abteilung für Immundermatologie und Experimentelle Allergologie
    Author's details vorgelegt von Lisanne Zoe Lonnemann ; Betreuer der Arbeit: Prof. Dr. med. Thomas Werfel
    Language German
    Size 138 Seiten, Illustrationen, Diagramme
    Publishing place Hannover
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Medizinische Hochschule Hannover, 2023
    HBZ-ID HT030666813
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2024 E 446 order for loan Magazin

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  4. Book ; Conference proceedings ; Thesis: Einfluss von Histamin auf alternativ-aktivierte M2-Makrophagen in kutanen Entzündungsprozessen bei atopischer Dermatitis

    Schaper, Judith Tabea / Werfel, Thomas

    2020  

    Institution Medizinische Hochschule Hannover
    Event/congress Klinik für Dermatologie, Allergologie und Venerologie
    Author's details vorgelegt von Judith Tabea Schaper ; aus der Klinik für Dermatologie, Allergologie und Venerologie der Medizinischen Hochschule Hannover ; Betreuer der Arbeit: Prof. Dr. med. Thomas Werfel
    Language German
    Size XII, 112 Seiten, Illustrationen, Diagramme, 30 cm
    Publishing place Hannover
    Publishing country Germany
    Document type Book ; Conference proceedings ; Thesis
    Thesis / German Habilitation thesis Dissertation, Medizinische Hochschule Hannover, 2021
    HBZ-ID HT021061639
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    2021 E 1138 order for loan Magazin

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  5. Book ; Online ; E-Book: Allergic diseases - from basic mechanisms to comprehensive management and prevention

    Traidl-Hoffmann, Claudia / Zuberbier, Torsten / Werfel, Thomas

    (Handbook of experimental pharmacology ; 268)

    2022  

    Author's details Claudia Traidl-Hoffmann, Torsten Zuberbier, Thomas Werfel editors
    Series title Handbook of experimental pharmacology ; 268
    Collection
    Keywords Pharmacology
    Subject code 615
    Language English
    Size 1 Online-Ressource (xi, 500 Seiten), Illustrationen, Diagramme
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT021292335
    ISBN 978-3-030-84048-8 ; 9783030840471 ; 3-030-84048-4 ; 3030840476
    DOI 10.1007/978-3-030-84048-8
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  6. Book ; Online ; E-Book: Weißbuch Allergie in Deutschland

    Klimek, Ludger / Vogelberg, Christian / Werfel, Thomas

    2019  

    Author's details Ludger Klimek (AeDA), Christian Vogelberg (GPA), Thomas Werfel (DGAKI) (Hrsg.)
    Keywords Internal medicine ; Dermatology ; Allergy ; Family medicine ; Emergency medicine
    Language German
    Size 1 Online-Ressource (x, 416 Seiten), Illustrationen
    Edition 4., überarbeitete und erweiterte Auflage
    Publisher Springer Medizin
    Publishing place Berlin
    Publishing country Germany
    Document type Book ; Online ; E-Book
    Note Auf dem Umschlag: "Mit Extra-Kapitel "Zentrale Forderungen : für die Deutsche AllergieLiga"
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019930353
    ISBN 978-3-89935-313-6 ; 9783899353129 ; 3-89935-313-7 ; 3899353129
    DOI 10.1007/978-3-89935-313-6
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  7. Book ; Thesis: Verteilung von Polymorphismen des LILRA2 und LILRB3 bei Autoimmunerkrankungen und Beschreibung einer neuen Gruppe dendritischer Zellen bei der rheumatoiden Arthritis

    Holz, Anna / Witte, Torsten / Werfel, Thomas

    2018  

    Institution Medizinische Hochschule Hannover
    Klinik für Immunologie und Rheumatologie
    Author's details vorgelegt von Anna Holz
    Language German
    Size 69 Blätter, Illustrationen, Diagramme, 30 cm
    Publishing place Hannover
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Medizinische Hochschule Hannover, 2018
    HBZ-ID HT019725246
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2018 E 751 order for loan Magazin

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  8. Article ; Online: Assessment of the Immune Response to Tumor Cell Apoptosis and Efferocytosis.

    Werfel, Thomas A

    Methods in molecular biology (Clifton, N.J.)

    2022  Volume 2543, Page(s) 45–55

    Abstract: Apoptotic cells are cleared from the body principally through recognition and engulfment by neighboring phagocytes, a process known as efferocytosis. During efferocytosis, phagocytes are recruited to the site/activated by "find me" signals released from ... ...

    Abstract Apoptotic cells are cleared from the body principally through recognition and engulfment by neighboring phagocytes, a process known as efferocytosis. During efferocytosis, phagocytes are recruited to the site/activated by "find me" signals released from apoptotic cells, precisely identify apoptotic cells by the recognition of "eat me" signals on the apoptotic cell surface, and engulf the apoptotic cells to prevent secondary necrosis and inflammation. Thus, efferocytosis is critical for tissue homeostasis in normal physiology. However, efferocytosis of apoptotic tumor cells-performed by tumor-associated macrophages-suppresses immunity within the tumor microenvironment and limits the antitumor response. This phenomenon is further exacerbated in tumor residual disease because of the high apoptotic cell burden generated by cytotoxic therapies. Blocking efferocytosis could be a powerful approach to boost tumor immunogenicity, particularly as a combination approach with cytotoxic therapies that produce many apoptotic cells, but little is currently known about the immune response to efferocytosis. Moreover, there is a dearth of in vivo models available to study the immunologic and therapeutic consequences of blocking efferocytosis in tumor residual disease.Here, we describe a model that enables in vivo studies of tumor immunology in the aftermath of cytotoxic therapy with an emphasis on the impact of efferocytosis. Orthotopic HER2+ mammary tumors are established in immune-competent mice, followed by a single administration of lapatinib, a receptor tyrosine kinase inhibitor of HER2, to the mice that induces widespread, transient apoptosis in the tumor microenvironment. In the days following lapatinib treatment, agents that block efferocytosis such as BMS-777607 are administered. Tissue is collected from cohorts of mice at day 2 (after lapatinib treatment only) to assess apoptosis, day 8 (after lapatinib treatment followed by blockade of efferocytosis) to assess the immune response to apoptosis and efferocytosis, and day 28 (after 4 consecutive weeks of treatment) to assess therapeutic efficacy. This model enables mechanistic studies of tumor immunology in residual disease as well as therapeutic efficacy studies of targeted agents that disrupt efferocytosis.
    MeSH term(s) Animals ; Apoptosis/physiology ; Lapatinib/pharmacology ; Macrophages/metabolism ; Mice ; Necrosis/pathology ; Neoplasms/pathology ; Phagocytosis ; Tumor Microenvironment
    Chemical Substances Lapatinib (0VUA21238F)
    Language English
    Publishing date 2022-09-10
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2553-8_5
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  9. Book ; Conference proceedings ; Thesis: Bedeutung genetischer Varianten im C3a-Rezeptor, in der RNase 7 und im HRH4 sowie in den flankierenden Genabschnitten für den Phänotyp bei atopischer Dermatitis

    Runde, Lisa-Marie / Werfel, Thomas / Mommert, Susanne

    2021  

    Institution Medizinische Hochschule Hannover
    Event/congress Klinik für Dermatologie, Allergologie und Venerologie
    Author's details vorgelegt von Lisa-Marie Runde ; aus der Klinik für Dermatologie, Allergologie und Venerologie, Abteilung Immundermatologie und experimentelle Allergologie der Medizinischen Hochschule Hannover ; Betreuer/Betreuerin der Arbeit: Prof. Dr. med. Thomas Werfel, Ko-Betreuer/-in der Arbeit: Dr. rer. nat. Susanne Mommert
    Language German
    Publishing place Hannover
    Publishing country Germany
    Document type Book ; Conference proceedings ; Thesis
    Thesis / German Habilitation thesis Dissertation, Medizinische Hochschule Hannover, 2021
    HBZ-ID HT021284268
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2022 E 344 order for loan Magazin

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  10. Book: Neurodermitis S2-Leitlinie

    Werfel, Thomas

    Gültigkeitsdauer: 3 Jahre

    (Journal der Deutschen Dermatologischen Gesellschaft ; 7, Suppl. 1)

    2009  

    Author's details Autoren Thomas Werfel
    Series title Journal der Deutschen Dermatologischen Gesellschaft ; 7, Suppl. 1
    Collection
    Language German
    Size IV, S64 S.
    Edition Version 8.4.2008
    Publisher Blackwell
    Publishing place Berlin
    Publishing country Germany
    Document type Book
    HBZ-ID HT015824096
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 6148 -7,Suppl.1- verfügbar in Königswinter Königswinter

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