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Article: Corrigendum to ‟Repurposing FDA-approved drugs to fight COVID-19 using in silico methods: Targeting SARS-CoV-2 RdRp enzyme and host cell receptors (ACE2, CD147) through virtual screening and molecular dynamic simulationsˮ [Inform. Med. Unlocked 23 (2021) 1-9/100541].

Mahdian, Soodeh / Zarrabi, Mahboobeh / Panahi, Yunes / Dabbagh Sadeghpour, Somayyeh

Informatics in medicine unlocked

2023 , Page(s) 101263

Abstract: This corrects the article DOI: 10.1016/j.imu.2021.100541.]. ...

Abstract	[This corrects the article DOI: 10.1016/j.imu.2021.100541.].
Language	English
Publishing date	2023-05-04
Publishing country	England
Document type	Published Erratum
ISSN	2352-9148
ISSN	2352-9148
DOI	10.1016/j.imu.2023.101263
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Health Crisis in Gaza: The Urgent Need for International Action.

Beiraghdar, Fatemeh / Momeni, Javad / Hosseini, Elham / Panahi, Yunes / Negah, Sajad Sahab

Iranian journal of public health

2024 Volume 52, Issue 12, Page(s) 2478–2483

Abstract: The current and ongoing conflict imposed in Gaza has led to severe environmental challenges in Gaza, resulting in a health crisis that demands immediate attention and intervention. A comprehensive study has evaluated the pressing mental health, water and ...

Abstract	The current and ongoing conflict imposed in Gaza has led to severe environmental challenges in Gaza, resulting in a health crisis that demands immediate attention and intervention. A comprehensive study has evaluated the pressing mental health, water and sanitation, access to healthcare, and infectious disease challenges plaguing the region. Mental health issues, particularly among children and adolescents, have surged in the wake of the conflict, with trauma-related symptoms expected to persist. The water and sanitation crises pose severe public health hazards, with an overwhelming majority of water unfit for consumption and escalating infectious diseases. Shortages of medicines, fuel, and breakdowns have profoundly affected access to healthcare in healthcare facilities, significantly impacting women and girls. The academic society is responsible for conducting research, providing education, and training, and advocating for policy changes. At the same time, the united nation's (UN) role is vital in providing aid, advocating for policy changes, and monitoring human rights and health situations. Urgent action is imperative to stabilize the environmental and health impacts and allow humanitarian aid into Gaza to alleviate the severe health problems. This study underlines the critical need for international support and intervention to address the multifaceted health crises in Gaza and prevent further deterioration.
Language	English
Publishing date	2024-02-26
Publishing country	Iran
Document type	Journal Article
ISSN	2251-6093 ; 0304-4556
ISSN (online)	2251-6093
ISSN	0304-4556
DOI	10.18502/ijph.v52i12.14309
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Evaluation of the efficacy and safety of an innovative flavonoid lotion in patients with haemorrhoid: a randomised clinical trial.

Razdar, Sara / Panahi, Yunes / Mohammadi, Ramtin / Khedmat, Leila / Khedmat, Hossein

BMJ open gastroenterology

2023 Volume 10, Issue 1

Abstract: Objective: Haemorrhoids are one of the most common gastrointestinal and anal diseases. In olive oil and honey propolis, flavonoids have beneficial effects on improving vascular function and decreasing vascular resistance. In this study, we aimed to ... ...

Abstract	Objective: Haemorrhoids are one of the most common gastrointestinal and anal diseases. In olive oil and honey propolis, flavonoids have beneficial effects on improving vascular function and decreasing vascular resistance. In this study, we aimed to produce a combination of these two substances in the form of lotions and assess their healing and side effects in comparison with routine treatment, anti-haemorrhoid ointment (containing hydrocortisone and lidocaine). Design: In this randomised clinical trial study, 86 patients with grade 2 or more haemorrhoid degrees, diagnosed by colonoscopy, were divided into two groups, the case (n=44) and control (n=42). The case group was treated with flavonoid lotion, and the control group was treated with anti-haemorrhoid ointment two times per day for 1 month. Patients were followed weekly with history and physical examination. The data of the two groups were collected before and after the intervention and statistically analysed. Results: Post-treatment reduction in haemorrhoid grade was significant in the case group (p=0.02). This ratio was insignificant in the control group (p=0.139). Flavonoid lotion (p<0.05) significantly reduced the signs and symptoms of haemorrhoids more than anti-haemorrhoid ointment. Conclusion: According to the results, flavonoid lotion can be an excellent alternative to topical chemical drugs, such as anti-haemorrhoid ointment, in treating haemorrhoid disease. Besides its effectiveness and safety, it can be easily manufactured and widely available to patien.
MeSH term(s)	Humans ; Ointments ; Colonoscopy ; Flavonoids/adverse effects
Chemical Substances	Ointments ; Flavonoids
Language	English
Publishing date	2023-08-19
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article
ISSN	2054-4774
ISSN	2054-4774
DOI	10.1136/bmjgast-2023-001158
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Article: Repurposing FDA-approved drugs to fight COVID-19 using

Mahdian, Soodeh / Zarrabi, Mahboobeh / Panahi, Yunes / Dabbagh, Somayyeh

Informatics in medicine unlocked

2021 Volume 23, Page(s) 100541

Abstract: Background: Different approaches have been proved effective for combating the COVID-19 pandemic. Accordingly, : Methods: The study screened the FDA-approved drugs against ACE2, CD147, and RDRP by virtual screening and molecular dynamics (MD) ... ...

Abstract	Background: Different approaches have been proved effective for combating the COVID-19 pandemic. Accordingly, Methods: The study screened the FDA-approved drugs against ACE2, CD147, and RDRP by virtual screening and molecular dynamics (MD) simulation. Results: The results of this study indicated that five drugs with ACE2, four drugs with RDRP, and seven drugs with CD147 achieved the most favorable free binding energy (ΔG < -10). This study selected these drugs for MD simulation investigation whose results demonstrated that ledipasvir with ACE2, estradiol benzoate with CD147, and vancomycin with RDRP represented the most favorable ΔG. Also, paritaprevir and vancomycin have good binding energy with both targets (ACE2 and RdRp). Conclusions: Ledipasvir, estradiol benzoate, and vancomycin and paritaprevir are potentially suitable candidates for further investigation as possible treatments of COVID-19 and novel drug development.
Language	English
Publishing date	2021-02-25
Publishing country	England
Document type	Journal Article
ISSN	2352-9148
ISSN	2352-9148
DOI	10.1016/j.imu.2021.100541
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Repurposing FDA-approved drugs to fight COVID-19 using in silico methods

Soodeh Mahdian / Mahboobeh Zarrabi / Yunes Panahi / Somayyeh Dabbagh

Informatics in Medicine Unlocked, Vol 23, Iss , Pp 100541- (2021)

Targeting SARS-CoV-2 RdRp enzyme and host cell receptors (ACE2, CD147) through virtual screening and molecular dynamic simulations

2021

Abstract: Background: Different approaches have been proved effective for combating the COVID-19 pandemic. Accordingly, in silico drug repurposing strategy, has been highly regarded as an accurate computational tool to achieve fast and reliable results. ... ...

Abstract	Background: Different approaches have been proved effective for combating the COVID-19 pandemic. Accordingly, in silico drug repurposing strategy, has been highly regarded as an accurate computational tool to achieve fast and reliable results. Considering SARS-CoV-2's structural proteins and their interaction the host's cell-specific receptors, this study investigated a drug repurposing strategy aiming to screen compatible inhibitors of FDA-approved drugs against viral entry receptors (ACE2 and CD147) and integral enzyme of the viral polymerase (RdRp). Methods: The study screened the FDA-approved drugs against ACE2, CD147, and RDRP by virtual screening and molecular dynamics (MD) simulation. Results: The results of this study indicated that five drugs with ACE2, four drugs with RDRP, and seven drugs with CD147 achieved the most favorable free binding energy (ΔG < −10). This study selected these drugs for MD simulation investigation whose results demonstrated that ledipasvir with ACE2, estradiol benzoate with CD147, and vancomycin with RDRP represented the most favorable ΔG. Also, paritaprevir and vancomycin have good binding energy with both targets (ACE2 and RdRp). Conclusions: Ledipasvir, estradiol benzoate, and vancomycin and paritaprevir are potentially suitable candidates for further investigation as possible treatments of COVID-19 and novel drug development.
Keywords	COVID-19 ; CD147 ; ACE2 ; RdRp ; Drug repurposing ; Computer applications to medicine. Medical informatics ; R858-859.7
Subject code	572
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: An overview on the treatments and prevention against COVID-19

Panahi, Yunes / Gorabi, Armita Mahdavi / Talaei, Sona / Beiraghdar, Fatemeh / Akbarzadeh, Abolfazl / Tarhriz, Vahideh / Mellatyar, Hassan

Virol J. 2023 Dec., v. 20, no. 1 p.23-23

2023

Abstract: BACKGROUND: The coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to plague the world. While COVID-19 is asymptomatic in most individuals, it can cause symptoms like pneumonia, ARDS ( ... ...

Abstract	BACKGROUND: The coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to plague the world. While COVID-19 is asymptomatic in most individuals, it can cause symptoms like pneumonia, ARDS (acute respiratory distress syndrome), and death in others. Although humans are currently being vaccinated with several COVID-19 candidate vaccines in many countries, however, the world still is relying on hygiene measures, social distancing, and approved drugs. RESULT: There are many potential therapeutic agents to pharmacologically fight COVID-19: antiviral molecules, recombinant soluble angiotensin-converting enzyme 2 (ACE2), monoclonal antibodies, vaccines, corticosteroids, interferon therapies, and herbal agents. By an understanding of the SARS-CoV-2 structure and its infection mechanisms, several vaccine candidates are under development and some are currently in various phases of clinical trials. CONCLUSION: This review describes potential therapeutic agents, including antiviral agents, biologic agents, anti-inflammatory agents, and herbal agents in the treatment of COVID-19 patients. In addition to reviewing the vaccine candidates that entered phases 4, 3, and 2/3 clinical trials, this review also discusses the various platforms that are used to develop the vaccine COVID-19.
Keywords	COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; acute respiratory distress syndrome ; adrenal cortex hormones ; death ; hygiene ; interferons ; peptidyl-dipeptidase A ; pneumonia ; therapeutics ; vaccines
Language	English
Dates of publication	2023-12
Size	p. 23.
Publishing place	BioMed Central
Document type	Article ; Online
ZDB-ID	2160640-7
ISSN	1743-422X
ISSN	1743-422X
DOI	10.1186/s12985-023-01973-9
Database	NAL-Catalogue (AGRICOLA)

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Article: Resveratrol as a Probable Multiheaded Treatment Approach for COVID-19.

Ahmadian, Roohollah / Biganeh, Hossein / Panahi, Yunes / Guest, Paul C / Jamialahmadi, Tannaz / Sahebkar, Amirhossein

Advances in experimental medicine and biology

2022 Volume 1328, Page(s) 441–446

Abstract: The COVID-19 pandemic has plagued the world for more than 1 year now and has resulted in over 77 million cases and 1.7 million related deaths. While we await the rollout of the vaccines, new treatments are urgently needed to reduce the effects of this ... ...

Abstract	The COVID-19 pandemic has plagued the world for more than 1 year now and has resulted in over 77 million cases and 1.7 million related deaths. While we await the rollout of the vaccines, new treatments are urgently needed to reduce the effects of this devastating virus. Here, we describe a number of preclinical studies which show promising effects of the polyphenol resveratrol.
MeSH term(s)	COVID-19 ; Humans ; Pandemics ; Resveratrol/therapeutic use ; SARS-CoV-2
Chemical Substances	Resveratrol (Q369O8926L)
Language	English
Publishing date	2022-01-03
Publishing country	United States
Document type	Journal Article
ISSN	2214-8019 ; 0065-2598
ISSN (online)	2214-8019
ISSN	0065-2598
DOI	10.1007/978-3-030-73234-9_29
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The impact of protein corona on the biological behavior of targeting nanomedicines.

Farshbaf, Masoud / Valizadeh, Hadi / Panahi, Yunes / Fatahi, Yousef / Chen, Meiwan / Zarebkohan, Amir / Gao, Huile

International journal of pharmaceutics

2022 Volume 614, Page(s) 121458

Abstract: For successful translation of targeting nanomedicines from bench to bedside, it is vital to address their most common drawbacks namely rapid clearance and off-target accumulation. These complications evidently originate from a phenomenon called "protein ... ...

Abstract	For successful translation of targeting nanomedicines from bench to bedside, it is vital to address their most common drawbacks namely rapid clearance and off-target accumulation. These complications evidently originate from a phenomenon called "protein corona (PC) formation" around the surface of targeting nanoparticles (NPs) which happens once they encounter the bloodstream and interact with plasma proteins with high collision frequency. This phenomenon endows the targeting nanomedicines with a different biological behavior followed by an unexpected fate, which is usually very different from what we commonly observe in vitro. In addition to the inherent physiochemical properties of NPs, the targeting ligands could also remarkably dictate the amount and type of adsorbed PC. As very limited studies have focused their attention on this particular factor, the present review is tasked to discuss the best simulated environment and latest characterization techniques applied to PC analysis. The effect of PC on the biological behavior of targeting NPs engineered with different targeting moieties is further discussed. Ultimately, the recent progresses in manipulation of nano-bio interfaces to achieve the most favorite therapeutic outcome are highlighted.
MeSH term(s)	Nanomedicine ; Nanoparticles ; Protein Corona
Chemical Substances	Protein Corona
Language	English
Publishing date	2022-01-10
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	428962-6
ISSN	1873-3476 ; 0378-5173
ISSN (online)	1873-3476
ISSN	0378-5173
DOI	10.1016/j.ijpharm.2022.121458
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The effects of N-acetylcysteine administration on metabolic status and serum adiponectin levels in patients with metabolic syndrome: A randomized, double-blind, placebo-controlled trial

Panahi, Yunes / Ostadmohammadi, Vahidreza / Raygan, Fariba / Sharif, Mohammad Reza / Sahebkar, Amirhossein

Journal of Functional Foods. 2022 Dec., v. 99 p.105299-

2022

Abstract: This study examined the impact of N-acetylcysteine (NAC) administration on metabolic parameters and serum adiponectin levels in individuals with metabolic syndrome (MetS). This randomized clinical trial included 76 people with MetS, aged 25-75 years. ... ...

Abstract	This study examined the impact of N-acetylcysteine (NAC) administration on metabolic parameters and serum adiponectin levels in individuals with metabolic syndrome (MetS). This randomized clinical trial included 76 people with MetS, aged 25-75 years. Participants were randomly assigned to receive either 1800 mg/day NAC (n = 38) or matched placebo (n = 38) for 12 weeks. Fasting blood samples were collected at the onset and at the end of 12-week intervention to quantify metabolic parameters. NAC significantly reduced fasting plasma glucose (P = 0.02), fasting serum insulin (P = 0.006), insulin resistance index (P = 0.005), and serum C-reactive protein (P = 0.003), and increased serum HDL-cholesterol (P = 0.001) and plasma total glutathione (P < 0.001) versus the placebo group. NAC administration did not alter adiponectin, blood pressure, other lipid indices, malondialdehyde, and total antioxidant capacity. Overall, 1800 mg/day NAC consumption for 12 weeks in MetS subjects had positive impacts on the parameters of glycemic homeostasis, HDL-cholesterol, inflammatory status, and body antioxidative defense system. NAC prescription may be a new strategy for the amelioration of metabolic parameters in individuals with MetS. Clinical Trial Registration: This clinical trial was prospectively registered in the Iranian website for registration of clinical trials (https://www.irct.ir/trial/44284).
Keywords	C-reactive protein ; acetylcysteine ; adiponectin ; antioxidant activity ; blood glucose ; blood pressure ; blood serum ; clinical trials ; glutathione ; high density lipoprotein cholesterol ; homeostasis ; insulin ; insulin resistance ; malondialdehyde ; metabolic syndrome ; people ; placebos ; N-acetylcysteine ; Metabolic status ; Oxidative stress ; Inflammation
Language	English
Dates of publication	2022-12
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Use and reproduction
ZDB-ID	2511964-3
ISSN	1756-4646
ISSN	1756-4646
DOI	10.1016/j.jff.2022.105299
Database	NAL-Catalogue (AGRICOLA)

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Article: Effects of Iranian herbal Zofa

Ghazvini, Ali / Vahedian-Azimi, Amir / Abdoli, Morteza / Rahimibashar, Farshid / Panahi, Yunes / Sathyapalan, Thozhukat / Sahebkar, Amirhossein

Avicenna journal of phytomedicine

2023 Volume 13, Issue 5, Page(s) 500–512

Abstract: Objective: The objective of this study was to determine the role of Iranian herbal Zofa: Materials and methods: This randomized clinical trial was conducted on 105 patients with COVID-19. Patients were randomly assigned to the intervention (n=35) ... ...

Abstract	Objective: The objective of this study was to determine the role of Iranian herbal Zofa Materials and methods: This randomized clinical trial was conducted on 105 patients with COVID-19. Patients were randomly assigned to the intervention (n=35) group (received 10 ml of Zofa Results: The groups were comparable regarding age (p=0.980), gender (p=0.584), comorbidities (p=0.318), or drug history (p=0.771). There was no difference between patients' recovery status at the time of discharge (p=0.327) or two weeks post-discharge (p=0.165) in the intervention and control groups. No patient was hospitalized to the intensive care unit (ICU) for supplemental oxygen therapy and no patient died in the intervention group. However, in the control group, three (4.5%) patients were transferred to the ICU, and two (3.03%) patients died. Conclusion: Considering the better recovery status of the patients at the time of discharge and the absence of patient deaths in the intervention group, more additional studies are needed to confirm these findings and elucidate the role of Zofa
Language	English
Publishing date	2023-12-06
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2658672-1
ISSN	2228-7949 ; 2228-7930
ISSN (online)	2228-7949
ISSN	2228-7930
DOI	10.22038/AJP.2023.21909
Database	MEDical Literature Analysis and Retrieval System OnLINE

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