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  1. Article ; Online: Do peripheral and central sites independently contribute to the CO

    Forster, Hubert V / Hodges, Matthew R

    The Journal of physiology

    2023  Volume 602, Issue 1, Page(s) 9–10

    MeSH term(s) Carbon Dioxide ; Respiration ; Carotid Body ; Chemoreceptor Cells
    Chemical Substances Carbon Dioxide (142M471B3J)
    Language English
    Publishing date 2023-12-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/JP285652
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Glenn circulation causes early and progressive shunting in a surgical model of pulmonary arteriovenous malformations.

    Wan, Tina / Rousseau, Henry / Mattern, Carol / Tabor, Madeline / Hodges, Matthew R / Ramchandran, Ramani / Spearman, Andrew D

    bioRxiv : the preprint server for biology

    2024  

    Language English
    Publishing date 2024-04-05
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.04.03.588015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Going to WAR: using a rat model of audiogenic seizure to uncover potential links to ventilatory dysfunction in epilepsy.

    Hodges, Matthew R

    The Journal of physiology

    2017  Volume 595, Issue 3, Page(s) 617–618

    MeSH term(s) Animals ; Epilepsy, Reflex ; Models, Genetic ; Rats ; Seizures
    Language English
    Publishing date 2017-02-16
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/JP273443
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Kir5.1 channels: potential role in epilepsy and seizure disorders.

    Staruschenko, Alexander / Hodges, Matthew R / Palygin, Oleg

    American journal of physiology. Cell physiology

    2022  Volume 323, Issue 3, Page(s) C706–C717

    Abstract: Inwardly rectifying potassium (Kir) channels are broadly expressed in many mammalian organ systems, where they contribute to critical physiological functions. However, the importance and function of the Kir5.1 channel (encoded by ... ...

    Abstract Inwardly rectifying potassium (Kir) channels are broadly expressed in many mammalian organ systems, where they contribute to critical physiological functions. However, the importance and function of the Kir5.1 channel (encoded by the
    MeSH term(s) Animals ; Epilepsy/genetics ; Epilepsy/metabolism ; Humans ; Kidney/metabolism ; Mammals/metabolism ; Mice ; Potassium/metabolism ; Potassium Channels, Inwardly Rectifying/genetics ; Potassium Channels, Inwardly Rectifying/metabolism ; Rats ; Kir5.1 Channel
    Chemical Substances KCNJ16 protein, human ; Kcnj16 protein, mouse ; Potassium Channels, Inwardly Rectifying ; Potassium (RWP5GA015D)
    Language English
    Publishing date 2022-07-18
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 392098-7
    ISSN 1522-1563 ; 0363-6143
    ISSN (online) 1522-1563
    ISSN 0363-6143
    DOI 10.1152/ajpcell.00235.2022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Upcycling of Polybutadiene Facilitated by Selenium-Mediated Allylic Amination.

    Hodges, Mercie N / Elardo, Matthew J / Seo, Jinyoung / Dohoda, Alexander F / Michael, Forrest E / Golder, Matthew R

    Angewandte Chemie (International ed. in English)

    2023  Volume 62, Issue 20, Page(s) e202303115

    Abstract: Accumulation of end-of-life plastics presents ongoing environmental concerns. One strategy to solve this grand challenge is to invent new techniques that modify post-consumer waste and impart new functionality. While promising approaches for the chemical ...

    Abstract Accumulation of end-of-life plastics presents ongoing environmental concerns. One strategy to solve this grand challenge is to invent new techniques that modify post-consumer waste and impart new functionality. While promising approaches for the chemical upcycling of commodity polyolefins and polyaromatics exist, analogous approaches to repurpose unsaturated polymers (e.g., polybutadiene) are scarce. In this work, we propose a method to upcycle polybutadiene, one of the most widely used commercial rubbers, via a mild, metal-free allylic amination reaction. The resulting materials have tunable thermal and surface wetting properties as a function of both sulfonamide identity and grafting density. Importantly, this approach maintains the parent alkene microstructure without evidence of olefin reduction, olefin transposition, and/or chain scission. Based on these findings, we anticipate future applications in the remediation of complex elastomers and vulcanized rubbers.
    Language English
    Publishing date 2023-04-12
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202303115
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  6. Article ; Online: HomeCageScan analysis reveals ongoing pain in Fabry rats.

    Burand, Anthony J / Waltz, Tyler B / Manis, Anna D / Hodges, Matthew R / Stucky, Cheryl L

    Neurobiology of pain (Cambridge, Mass.)

    2023  Volume 13, Page(s) 100113

    Abstract: HomeCageScan (HCS) is an automated behavioral scoring system that can be used to classify and quantify rodent behaviors in the home cage. Although HCS has been used for a number of inducible models of severe pain, little has been done to test this system ...

    Abstract HomeCageScan (HCS) is an automated behavioral scoring system that can be used to classify and quantify rodent behaviors in the home cage. Although HCS has been used for a number of inducible models of severe pain, little has been done to test this system in clinically relevant genetic disease models associated with chronic pain such as Fabry disease. Rats with Fabry disease exhibit mechanical hypersensitivity, however, it is unclear if these rodents also exhibit ongoing non-evoked pain. Therefore, we analyzed HCS data from male and female rats with Fabry disease. Using hierarchical clustering and principal component analysis, we found both sex and genotype differences in several home cage behaviors. Additionally, we used hierarchical clustering to derive behavioral clusters in an unbiased manner. Analysis of these behavioral clusters showed that primarily female Fabry animals moved less, spent less time caring for themselves (e.g., less time spent grooming and drinking), explored less, and slept more; changes that are similar to lifestyle changes observed in patients with long lasting chronic pain. We also show that sniffing, one of the exploratory behaviors that is depressed in Fabry animals, can be partly restored with the analgesic gabapentin, suggesting that depressed sniffing may reflect ongoing pain. Therefore, this approach to HCS data analysis can be used to assess drug efficacy in Fabry disease and potentially other genetic and inducible rodent models associated with persistent pain.
    Language English
    Publishing date 2023-01-05
    Publishing country United States
    Document type Journal Article
    ISSN 2452-073X
    ISSN (online) 2452-073X
    DOI 10.1016/j.ynpai.2022.100113
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Effects of sub-lethal doses of fentanyl on vital physiologic functions and withdrawal-like behaviors in adult goats.

    Neumueller, Suzanne E / Buiter, Nicole / Hilbert, Grace / Grams, Kirstyn / Taylor, Reiauna / Desalvo, John / Hodges, Grace L / Hodges, Madeline M / Pan, Lawrence G / Lewis, Stephen J / Forster, Hubert V / Hodges, Matthew R

    Frontiers in physiology

    2023  Volume 14, Page(s) 1277601

    Abstract: Synthetic opioids like fentanyl have improved the standard of care for many patients in the clinical setting, but their abuse leads to tens of thousands of overdose deaths annually. The current opioid epidemic underscores a critical need for insights ... ...

    Abstract Synthetic opioids like fentanyl have improved the standard of care for many patients in the clinical setting, but their abuse leads to tens of thousands of overdose deaths annually. The current opioid epidemic underscores a critical need for insights into the physiological effects of fentanyl on vital functions. High doses of opioids in small mammals cause opioid-induced respiratory depression (OIRD) leading to hypoventilation, hypoxemia, and hypercapnia. In addition, opioids can also increase the alveolar to arterial oxygen (A-a) gradient and airway dysfunction. However, little is known about the physiologic effects of sub-lethal doses of opioids in large mammals. Here we report the effects of a sub-lethal dose range of fentanyl (25-125 μg/kg; IV) on vital physiologic functions over 90 min (min) and withdrawal-like behaviors over the subsequent 4 h (h) in adult female goats (
    Language English
    Publishing date 2023-10-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2023.1277601
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The serotonergic system and the control of breathing during development.

    Cummings, Kevin J / Hodges, Matthew R

    Respiratory physiology & neurobiology

    2019  Volume 270, Page(s) 103255

    Abstract: Serotonin (5-hydroxytryptamine 5-HT) was first discovered in the late 1940's as an endogenous bioactive amine capable of inducing vasoconstriction, and in the mid-1950's was found in the brain. It was in these early years that some of the first ... ...

    Abstract Serotonin (5-hydroxytryptamine 5-HT) was first discovered in the late 1940's as an endogenous bioactive amine capable of inducing vasoconstriction, and in the mid-1950's was found in the brain. It was in these early years that some of the first demonstrations were made regarding a role for brain 5-HT in neurological function and behavior, including data implicating reduced brain levels of 5-HT in clinical depression. Since that time, advances in molecular biology and physiological approaches in basic science research have intensely focused on 5-HT in the brain, and the many facets of its role during embryonic development, post-natal maturation, and neural function in adulthood continues to be established. This review focuses on what is known about the developmental roles for the 5-HT system, which we define as the neurons producing 5-HT along with pre-and post-synaptic receptors, in a vital homeostatic motor behavior - the control of breathing. We will cover what is known about the embryonic origins and fate specification of 5-HT neurons, and how the 5-HT system influences pre- and post-natal maturation of the ventilatory control system. In addition, we will focus on the role of the 5-HT system in specific respiratory behaviors during fetal, neonatal and postnatal development, and the relevance of dysfunction in this system in respiratory-related human pathologies including Sudden Infant Death Syndrome (SIDS).
    MeSH term(s) Animals ; Humans ; Respiration ; Respiratory Physiological Phenomena ; Respiratory System/growth & development ; Respiratory System/innervation ; Serotonergic Neurons/physiology ; Serotonin/physiology
    Chemical Substances Serotonin (333DO1RDJY)
    Language English
    Publishing date 2019-07-27
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2077867-3
    ISSN 1878-1519 ; 1569-9048
    ISSN (online) 1878-1519
    ISSN 1569-9048
    DOI 10.1016/j.resp.2019.103255
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  9. Article ; Online: The central role of serotonin.

    Mouradian, Gary C / Hodges, Matthew R

    eLife

    2018  Volume 7

    Abstract: The neurotransmitter serotonin helps to co-ordinate the respiratory and cardiovascular responses of newborns to oxygen deprivation. ...

    Abstract The neurotransmitter serotonin helps to co-ordinate the respiratory and cardiovascular responses of newborns to oxygen deprivation.
    MeSH term(s) Humans ; Infant, Newborn ; Serotonin
    Chemical Substances Serotonin (333DO1RDJY)
    Language English
    Publishing date 2018-10-23
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.42291
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  10. Article: GillesPy2: A Biochemical Modeling Framework for Simulation Driven Biological Discovery.

    Matthew, Sean / Carter, Fin / Cooper, Joshua / Dippel, Matthew / Green, Ethan / Hodges, Samuel / Kidwell, Mason / Nickerson, Dalton / Rumsey, Bryan / Reeve, Jesse / Petzold, Linda R / Sanft, Kevin R / Drawert, Brian

    Letters in biomathematics

    2023  Volume 10, Issue 1, Page(s) 87–103

    Abstract: Stochastic modeling has become an essential tool for studying biochemical reaction networks. There is a growing need for user-friendly and feature-complete software for model design and simulation. To address this need, we present GillesPy2, an open- ... ...

    Abstract Stochastic modeling has become an essential tool for studying biochemical reaction networks. There is a growing need for user-friendly and feature-complete software for model design and simulation. To address this need, we present GillesPy2, an open-source framework for building and simulating mathematical and biochemical models. GillesPy2, a major upgrade from the original GillesPy package, is now a stand-alone Python 3 package. GillesPy2 offers an intuitive interface for robust and reproducible model creation, facilitating rapid and iterative development. In addition to expediting the model creation process, GillesPy2 offers efficient algorithms to simulate stochastic, deterministic, and hybrid stochastic-deterministic models.
    Language English
    Publishing date 2023-05-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2837332-7
    ISSN 2373-7867
    ISSN 2373-7867
    Database MEDical Literature Analysis and Retrieval System OnLINE

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