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Article ; Online: Acute effect of low-load resistance exercise with blood flow restriction on oxidative stress biomarkers: A systematic review and meta-analysis.

Ferlito, João Vitor / Rolnick, Nicholas / Ferlito, Marcos Vinicius / De Marchi, Thiago / Deminice, Rafael / Salvador, Mirian

PloS one

2023 Volume 18, Issue 4, Page(s) e0283237

Abstract: Background: The purpose of this review was to analyze the acute effects of low-load resistance exercise with blood flow restriction (LLE-BFR) on oxidative stress markers in healthy individuals in comparison with LLE or high-load resistance exercise ( ... ...

Abstract	Background: The purpose of this review was to analyze the acute effects of low-load resistance exercise with blood flow restriction (LLE-BFR) on oxidative stress markers in healthy individuals in comparison with LLE or high-load resistance exercise (HLRE) without BFR. Materials and methods: A systematic review was performed in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. These searches were performed in CENTRAL, SPORTDiscus, EMBASE, PubMed, CINAHL and Virtual Health Library- VHL, which includes Lilacs, Medline and SciELO. The risk of bias and quality of evidence were assessed through the PEDro scale and GRADE system, respectively. Results: Thirteen randomized clinical trials were included in this review (total n = 158 subjects). Results showed lower post-exercise damage to lipids (SMD = -0.95 CI 95%: -1.49 to -0. 40, I2 = 0%, p = 0.0007), proteins (SMD = -1.39 CI 95%: -2.11 to -0.68, I2 = 51%, p = 0.0001) and redox imbalance (SMD = -0.96 CI 95%: -1.65 to -0.28, I2 = 0%, p = 0.006) in favor of LLRE-BFR compared to HLRE. HLRE presents higher post-exercise superoxide dismutase activity but in the other biomarkers and time points, no significant differences between conditions were observed. For LLRE-BFR and LLRE, we found no difference between the comparisons performed at any time point. Conclusions: Based on the available evidence from randomized trials, providing very low or low certainty of evidence, this review demonstrates that LLRE-BFR promotes less oxidative stress when compared to HLRE but no difference in levels of oxidative damage biomarkers and endogenous antioxidants between LLRE. Trial registration: Register number: PROSPERO number: CRD42020183204.
MeSH term(s)	Humans ; Resistance Training/methods ; Exercise ; Hemodynamics ; Oxidative Stress ; Biomarkers
Chemical Substances	Biomarkers
Language	English
Publishing date	2023-04-21
Publishing country	United States
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0283237
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Evaluating possible maternal effect lethality and genetic background effects in

Lyon, Gholson J / Longo, Joseph / Garcia, Andrew / Inusa, Fatima / Marchi, Elaine / Shi, Daniel / Dörfel, Max / Arnesen, Thomas / Aldabe, Rafael / Lyons, Scott / Nashat, Melissa A / Bolton, David

bioRxiv : the preprint server for biology

2024

Abstract: Amino-terminal (Nt-) acetylation (NTA) is a common protein modification, affecting approximately 80% of all human proteins. The human essential X-linked gene, ...

Abstract	Amino-terminal (Nt-) acetylation (NTA) is a common protein modification, affecting approximately 80% of all human proteins. The human essential X-linked gene,
Language	English
Publishing date	2024-01-10
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.04.27.538618
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Article: What Is the Cost of Weight Loss? An Approach to Commercial (Dry and Wet) and Homemade Diets.

Vendramini, Thiago Henrique Annibale / Macedo, Henrique Tobaro / Amaral, Andressa Rodrigues / Zafalon, Rafael Vessecchi Amorim / Carmo, Adrielly Aparecida do / Cesar, Cinthia Gonçalves Lenz / Marchi, Pedro Henrique / Balieiro, Júlio Cesar de Carvalho / Brunetto, Marcio Antonio

Animals : an open access journal from MDPI

2024 Volume 14, Issue 5

Abstract: In the context of the rising prevalence of obesity among pets, this study aimed to assess the economic aspects of weight reduction protocols for dogs and cats, considering the lack of information and the varying costs of commercial and homemade diets. ... ...

Abstract	In the context of the rising prevalence of obesity among pets, this study aimed to assess the economic aspects of weight reduction protocols for dogs and cats, considering the lack of information and the varying costs of commercial and homemade diets. The results indicated an average weekly weight loss rate of 1.02% for dogs and 0.92% for cats, with a reduction in body fat mass (
Language	English
Publishing date	2024-02-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani14050679
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Article: Effects of Increasing Levels of Purified Beta-1,3/1,6-Glucans on the Fecal Microbiome, Digestibility, and Immunity Variables of Healthy Adult Dogs.

Marchi, Pedro Henrique / Vendramini, Thiago Henrique Annibale / Zafalon, Rafael Vessecchi Amorim / Príncipe, Leonardo de Andrade / Cesar, Cinthia Gonçalves Lenz / Perini, Mariana Pamplona / Putarov, Thaila Cristina / Gomes, Cristina Oliveira Massoco Salles / Balieiro, Júlio Cesar de Carvalho / Brunetto, Marcio Antonio

Microorganisms

2024 Volume 12, Issue 1

Abstract: Yeast-purified beta-1,3/1,6-glucans (BG) can modulate dogs' immune systems and microbiome, but the optimal inclusion dose remains unknown. The aim of the study was to evaluate the effects of 0.0, 0.07, 0.14, and 0.28% inclusion of BG in a dry extruded ... ...

Abstract	Yeast-purified beta-1,3/1,6-glucans (BG) can modulate dogs' immune systems and microbiome, but the optimal inclusion dose remains unknown. The aim of the study was to evaluate the effects of 0.0, 0.07, 0.14, and 0.28% inclusion of BG in a dry extruded diet on the digestibility, immunity, and fecal microbiota of healthy adult dogs. Eight male and female border collies [n = 4; body condition score (BCS) = 5] and English cocker spaniels (n = 4; BCS = 5), aged 3.5 ± 0.5 years, were randomly distributed into two 4 × 4 balanced Latin squares. Fecal microbiota (using 16S rRNA sequencing, Illumina
Language	English
Publishing date	2024-01-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms12010113
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Article ; Online: Antioxidant activity of an Mg(II) compound containing ferulic acid as a chelator: potential application for active packaging and riboflavin stabilisation.

Marchi, Rafael C / Kock, Flavio V C / Soares Dos Campos, Isabele A / Jesus, Hugo Cesar R / Venâncio, Tiago / da Silva, Maria Fátima G F / Fernandes, João B / Rollini, Manuela / Limbo, Sara / Carlos, Rose M

Food & function

2024 Volume 15, Issue 3, Page(s) 1527–1538

Abstract: Foods rich in riboflavin (Rf) are susceptible to degradation due to oxidative processes with the formation of radicals. Herein, we describe the features and stability of an Mg(II) complex containing ferulic acid (fer) and 1,10-phenanthroline (phen) as ... ...

Abstract	Foods rich in riboflavin (Rf) are susceptible to degradation due to oxidative processes with the formation of radicals. Herein, we describe the features and stability of an Mg(II) complex containing ferulic acid (fer) and 1,10-phenanthroline (phen) as chelators: henceforth called Mg(phen)(fer). The electrochemical behavior of Mg(phen)(fer) is pH dependent and results from the stabilisation of the corresponding phenoxyl radical
MeSH term(s)	Antioxidants/pharmacology ; Antioxidants/chemistry ; Chelating Agents ; Riboflavin/chemistry ; Coumaric Acids
Chemical Substances	Antioxidants ; ferulic acid (AVM951ZWST) ; Chelating Agents ; Riboflavin (TLM2976OFR) ; Coumaric Acids
Language	English
Publishing date	2024-02-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2612033-1
ISSN	2042-650X ; 2042-6496
ISSN (online)	2042-650X
ISSN	2042-6496
DOI	10.1039/d3fo05039d
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Article: Determining Accessibility of Anterior Cervicothoracic Spine Based on Age and Gender: Radiographic Analysis of Computed Tomography Scans.

Sugino, Rafael Lindi / Iutaka, Alexandre Sadao / Cho, Samuel K / Cataldo, Daniel R / Marchi, Luis / Herrero, Carlos Fernando Pereira da Silva

Revista brasileira de ortopedia

2022 Volume 57, Issue 1, Page(s) 61–68

Abstract: ... ...

Abstract	Objective
Language	English
Publishing date	2022-01-21
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2411301-3
ISSN	1982-4378 ; 0102-3616
ISSN (online)	1982-4378
ISSN	0102-3616
DOI	10.1055/s-0041-1740295
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Article: MiRNAs Action and Impact on Mitochondria Function, Metabolic Reprogramming and Chemoresistance of Cancer Cells: A Systematic Review.

Rosolen, Daiane / Nunes-Souza, Emanuelle / Marchi, Rafael / Tofolo, Maria Vitoria / Antunes, Valquíria C / Berti, Fernanda C B / Fonseca, Aline S / Cavalli, Luciane R

Biomedicines

2023 Volume 11, Issue 3

Abstract: MicroRNAs (miRNAs) are involved in the regulation of mitochondrial function and homeostasis, and in the modulation of cell metabolism, by targeting known oncogenes and tumor suppressor genes of metabolic-related signaling pathways involved in the ... ...

Abstract	MicroRNAs (miRNAs) are involved in the regulation of mitochondrial function and homeostasis, and in the modulation of cell metabolism, by targeting known oncogenes and tumor suppressor genes of metabolic-related signaling pathways involved in the hallmarks of cancer. This systematic review focuses on articles describing the role, association, and/or involvement of miRNAs in regulating the mitochondrial function and metabolic reprogramming of cancer cells. Following the PRISMA guidelines, the articles reviewed were published from January 2010 to September 2022, with the search terms "mitochondrial microRNA" and its synonyms (mitochondrial microRNA, mitochondrial miRNA, mito microRNA, or mitomiR), "reprogramming metabolism," and "cancer" in the title or abstract). Thirty-six original research articles were selected, revealing 51 miRNAs with altered expression in 12 cancers: bladder, breast, cervical, colon, colorectal, liver, lung, melanoma, osteosarcoma, pancreatic, prostate, and tongue. The actions of miRNAs and their corresponding target genes have been reported mainly in cell metabolic processes, mitochondrial dynamics, mitophagy, apoptosis, redox signaling, and resistance to chemotherapeutic agents. Altogether, these studies support the role of miRNAs in the metabolic reprogramming hallmark of cancer cells and highlight their potential as predictive molecular markers of treatment response and/or targets that can be used for therapeutic intervention.
Language	English
Publishing date	2023-02-24
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines11030693
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Article ; Online: Glycogen Storage Disease: Expert Opinion on Clinical Diagnosis Revisited after Molecular Testing.

de Marchi, Rafael / Nalin, Tatiele / Sperb-Ludwig, Fernanda / Pinheiro, Franciele Cabral / Schwartz, Ida Vanessa Doederlein / Steiner, Carlos Eduardo

Genes

2023 Volume 14, Issue 12

Abstract: This study sought to analyze whether an accurate diagnosis of the type and subtype of hepatic Glycogen Storage Diseases (GSDs) could be performed based on general clinical and biochemical aspects via comparing the proposed diagnostic hypotheses with the ... ...

Abstract	This study sought to analyze whether an accurate diagnosis of the type and subtype of hepatic Glycogen Storage Diseases (GSDs) could be performed based on general clinical and biochemical aspects via comparing the proposed diagnostic hypotheses with the molecular results. Twelve physicians with experience in hepatic GSDs reviewed 45 real cases comprising a standardized summary of clinical and laboratory data. There was no relation between the hit rate and the time since graduation, the time of experience in GSD, and the number of patients treated during their careers. The average assertiveness was 47%, with GSD Ia and Ib being the best-identified types, while no expert correctly identified GSD IXc. Underage investigation for later manifestations, incomplete clinical description, and complementary analysis, the overvaluation of a specific clinical finding ("false positive") or the discarding of the diagnosis in the absence of it ("false negative"), as well as the lack of knowledge of the rarest GSD types, may have impacted the accuracy of the assessment. This study emphasized that characteristics considered as determinants in identifying the specific types or subtypes of GSD are not exclusive, thus becoming factors that may have induced the evaluators to misdiagnose.
MeSH term(s)	Humans ; Expert Testimony ; Glycogen Storage Disease/diagnosis ; Glycogen Storage Disease/genetics ; Glycogen Storage Disease Type I/diagnosis ; Molecular Diagnostic Techniques
Language	English
Publishing date	2023-12-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527218-4
ISSN	2073-4425 ; 2073-4425
ISSN (online)	2073-4425
ISSN	2073-4425
DOI	10.3390/genes14122219
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Article ; Online: Influence of bioactive particles and onium salt on the physicochemical properties of experimental infiltrants.

Mathias, Caroline / Gomes, Rafael Soares / Pfeifer, Carmem Silvia / Pedreira, Priscila Regis / Damasceno, Janaina Emanuela / Marchi, Giselle Maria

Brazilian oral research

2023 Volume 37, Page(s) e088

Abstract: This study evaluated physicochemical properties of experimental infiltrants after addition of hydroxyapatite nanoparticles (HAp) or 58S bioactive glass (BAG) and diphenyliodonium hexafluorophosphate (DPI). The resin matrix was composed of TEGDMA/Bis-EMA ( ...

Abstract	This study evaluated physicochemical properties of experimental infiltrants after addition of hydroxyapatite nanoparticles (HAp) or 58S bioactive glass (BAG) and diphenyliodonium hexafluorophosphate (DPI). The resin matrix was composed of TEGDMA/Bis-EMA (3:1), 0.5 mol% CQ, and 1 mol% EDAB. The blends received or not 0.5 mol% DPI and 10% wt BAG or HAp. Icon was used as commercial control. The groups were characterized by XRD, FT-IR spectrometry, and SEM before and after simulated body fluid (SBF) immersion for up to 7 days. Polymerization kinetics (n =3 ), water sorption and solubility (n=10), and viscosity (n = 3) were surveyed. For polymerization kinetics, the samples were polymerized for 5 min and the data were obtained from 40 s and 5 min. Statistical analysis was made using ANOVA and Tukey's test (a = 0.05). After 7 days of SBF immersion, XRD and FT-IR showed that the HAp crystalline phase was present only in the HAp groups. A lower degree of conversion (DC) and polymerization rate were observed for the Icon and BAG groups, whereas HAp showed higher values. For the BAG group, DPI increased polymerization rate and DC in 40 s. After 5 min, all groups presented DC above 80%. In groups with particles, the HAp groups exhibited higher viscosity, whereas DPI groups showed a decrease in viscosity. Icon had the highest water sorption. To conclude, BAG neither improved the physicochemical properties studied, nor did it show bioactive properties. The addition of DPI reduced viscosity caused by particle addition and also attenuated the DC decrease caused by BAG addition. The addition of bioactive particles to infiltrants should be seen with caution because they increase viscosity and may not bring major clinical improvements that justify their use. DPI might be indicated only if any component is added to the infiltrant to act as a compensation mechanism.
MeSH term(s)	Spectroscopy, Fourier Transform Infrared ; Sodium Chloride ; Sodium Chloride, Dietary ; Durapatite ; Nanoparticles
Chemical Substances	Sodium Chloride (451W47IQ8X) ; Sodium Chloride, Dietary ; Durapatite (91D9GV0Z28)
Language	English
Publishing date	2023-09-04
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2179332-3
ISSN	1807-3107 ; 1806-8324 ; 1517-7491
ISSN (online)	1807-3107
ISSN	1806-8324 ; 1517-7491
DOI	10.1590/1807-3107bor-2023.vol37.0088
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Article ; Online: Tendências de mercado e o potencial do Oeste Catarinense para a fruticultura

Rafael Roveri Sabiao / Eduardo Cesar Brugnara / Thiago Marchi / Ivan Tormem

Agropecuária Catarinense, Vol 34, Iss

2021 Volume 2

Abstract: Antes de iniciar o cultivo de frutíferas, o agricultor, investidor ou empreendedor deve procurar responder uma importante questão: “Existe mercado para minha produção?”. É necessário buscar informações de demanda do consumidor, volume, sazonalidade, ... ...

Abstract	Antes de iniciar o cultivo de frutíferas, o agricultor, investidor ou empreendedor deve procurar responder uma importante questão: “Existe mercado para minha produção?”. É necessário buscar informações de demanda do consumidor, volume, sazonalidade, padrão de qualidade, embalagem e logística de entrega no planejamento do empreendimento, principalmente pela perecibilidade das frutas, e as estratégias de comercialização devem estar definidas antes mesmo de iniciar o plantio. Depois de conhecer o mercado a ser atendido, deve-se buscar as informações técnicas para o planejamento de implantação do pomar, como: clima e solo favoráveis para cada espécie, escolha e preparo da área, aquisição de mudas de qualidade e todos os manejos subsequentes no pomar. A fruticultura mostra-se como alternativa às outras atividades, sendo uma opção de maior rentabilidade a produtores em pequenas áreas, diversificando a produção e a renda familiar. Desta forma, o objetivo desta publicação é contextualizar as tendências para o mercado de frutas e sugerir potencialidades para o desenvolvimento da fruticultura na região oeste catarinense.
Keywords	Planejamento estratégico ; cadeia produtiva ; frutíferas ; demandas ; consumo ; Agriculture (General) ; S1-972
Language	English
Publishing date	2021-08-01T00:00:00Z
Publisher	Empresa de Pesquisa Agropecuária e Extensão Rural de Santa Catarina
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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