LIVIVO - Search results -

Search results

Result 1 - 10 of total 54

Search options

Article: Particle Therapy for Breast Cancer.

Kowalchuk, Roman O / Corbin, Kimberly S / Jimenez, Rachel B

2022 Volume 14, Issue 4

Abstract: Particle therapy has received increasing attention in the treatment of breast cancer due to its unique physical properties that may enhance patient quality of life and reduce the late effects of therapy. In this review, we will examine the rationale for ... ...

Abstract	Particle therapy has received increasing attention in the treatment of breast cancer due to its unique physical properties that may enhance patient quality of life and reduce the late effects of therapy. In this review, we will examine the rationale for the use of proton and carbon therapy in the treatment of breast cancer and highlight their potential for sparing normal tissue injury. We will discuss the early dosimetric and clinical studies that have been pursued to date in this domain before focusing on the remaining open questions limiting the widespread adoption of particle therapy.
Language	English
Publishing date	2022-02-20
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers14041066
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article: Investigation of the EHV-1 Genotype (N

Pusterla, Nicola / Barnum, Samantha / Lawton, Kaila / Wademan, Cara / Corbin, Rachel / Hodzic, Emir

Journal of equine veterinary science

2023 Volume 123, Page(s) 104244

Abstract: Contemporary data on equine herpesvirus-1 (EHV-1) genotype (non-neuropathogenic or ... ...

Abstract	Contemporary data on equine herpesvirus-1 (EHV-1) genotype (non-neuropathogenic or N
MeSH term(s)	Pregnancy ; Female ; Horses ; Animals ; United States/epidemiology ; Herpesvirus 1, Equid/genetics ; Genotype ; Herpesviridae Infections/epidemiology ; Herpesviridae Infections/veterinary ; Horse Diseases/epidemiology
Language	English
Publishing date	2023-02-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2102631-2
ISSN	1542-7412 ; 0737-0806
ISSN (online)	1542-7412
ISSN	0737-0806
DOI	10.1016/j.jevs.2023.104244
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Toward Improving the Selectivity of Organic Halide Electrocarboxylation with Mechanistically Informed Solvent Selection.

Corbin, Nathan / Junor, Glen P / Ton, Thu N / Baker, Rachel J / Manthiram, Karthish

Journal of the American Chemical Society

2023 Volume 145, Issue 3, Page(s) 1740–1748

Abstract: The use of a liquid electrolyte is nearly ubiquitous in electrosynthetic systems and can have a significant impact on the selectivity and efficiency of electrochemical reactions. Solvent selection is thus a key step during optimization, yet this ... ...

Abstract	The use of a liquid electrolyte is nearly ubiquitous in electrosynthetic systems and can have a significant impact on the selectivity and efficiency of electrochemical reactions. Solvent selection is thus a key step during optimization, yet this selection process usually involves trial-and-error. As a step toward more rational solvent selection, this work examines how the electrolyte solvent impacts the selectivity of electrocarboxylation of organic halides. For the carboxylation of a model alkyl bromide, hydrogenolysis is the primary side reaction. Isotope-labeling studies indicate the hydrogen atom in the hydrogenolysis product comes solely from the aprotic electrolyte solvent. Further mechanistic studies reveal that under synthetically relevant electrocarboxylation conditions, the hydrogenolysis product is formed via deprotonation of the solvent. Guided by these mechanistic findings, a simple computational descriptor based on the free energy to deprotonate a solvent molecule was shown to correlate strongly with carboxylation selectivity, overcoming limitations of traditional solvent descriptors such as p
Language	English
Publishing date	2023-01-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.2c10561
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Bonn / Germany

Z 4' 55/32: Show issues
Z 7.3: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article: Temperate biocrusts: mesic counterparts to their better‐known dryland cousins

Corbin, Jeffrey D / Thiet, Rachel K

Frontiers in ecology and the environment. 2020 Oct., v. 18, no. 8

2020

Abstract: Biological soil crusts (biocrusts) are known to serve crucial functions in many arid and semiarid habitats, but less is understood about biocrusts in temperate biomes, where they are often widespread and can play important roles in aboveground and ... ...

Abstract	Biological soil crusts (biocrusts) are known to serve crucial functions in many arid and semiarid habitats, but less is understood about biocrusts in temperate biomes, where they are often widespread and can play important roles in aboveground and belowground processes. Because the distinctive conditions that support biocrusts in temperate biomes – sandy, acidic, and/or nutrient‐poor soils or exposed bedrock – frequently also support rare plant and animal communities, such sites can have considerable conservation value. We detail the distribution of biocrusts in temperate habitats, including many in the northeastern US, where they have not previously been described. Besides adding another layer of biodiversity to the sites in which they occur, biocrusts may also play a critical role in site‐level ecology and functioning. As such, integrating temperate biocrust composition, distribution, and functions into ecosystem management may contribute to the stability and resilience of the ecosystems in which they are found in the face of global climate change and other disturbances.
Keywords	animals ; arid lands ; bedrock ; biodiversity ; biological soil crusts ; climate change ; ecosystem management ; environment ; rare species ; Northeastern United States
Language	English
Dates of publication	2020-10
Size	p. 456-464.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	NAL-AP-2-clean ; JOURNAL ARTICLE
ZDB-ID	2110853-5
ISSN	1540-9309 ; 1540-9295
ISSN (online)	1540-9309
ISSN	1540-9295
DOI	10.1002/fee.2234
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 7542: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Inhibition of Caspase 1 Reduces Blood Pressure, Cytotoxic NK Cells, and Inflammatory T-Helper 17 Cells in Placental Ischemic Rats.

Shields, Corbin A / Tardo, Geilda A / Wang, Xi / Peacock, Gregory / Robbins, Marcus / Glenn, Hannah / Wilson, Rachel / Williams, Jan M / Cornelius, Denise C

International journal of molecular sciences

2024 Volume 25, Issue 2

Abstract: Preeclampsia (PE) is characterized by maternal hypertension, fetal growth restriction (FGR), and increased inflammation and populations of cytotoxic NK cells (cNKs) and inflammatory T-Helper 17 cells (TH17s). Both cytotoxic NK cells and TH17 cells are ... ...

Abstract	Preeclampsia (PE) is characterized by maternal hypertension, fetal growth restriction (FGR), and increased inflammation and populations of cytotoxic NK cells (cNKs) and inflammatory T-Helper 17 cells (TH17s). Both cytotoxic NK cells and TH17 cells are heavily influenced via IL-1β signaling. Caspase 1 activity leads to the release of the inflammatory cytokine IL-1β, which is increased in women with PE. Therefore, we tested the hypothesis that the inhibition of Caspase 1 with VX-765 in rats with reduced uterine perfusion pressure (RUPP) will attenuate PE pathophysiology. On gestation day (GD) 14, timed pregnant Sprague-Dawley rats underwent the RUPP or Sham procedure and were separated into groups that received either vehicle or VX-765 (50 mg/kg/day i.p.). On GD19, MAP was measured via carotid catheter and blood and tissues were collected. Bio-Plex and flow cytometry analysis were performed on placental tissues. Placental IL-1β was increased in the RUPP rats vs. the Sham rats and treatment with VX-765 reduced IL-1β in the RUPP rats. Caspase 1 inhibition reduced placental cNKs and TH17s in RUPP rats compared to vehicle-treated RUPP rats. Increased MAP was observed in RUPP rats compared with Sham rats and was reduced in RUPP + VX-765 rats. Placental reactive oxygen species (ROS) were elevated in RUPP rats compared to Sham rats. VX-765 administration reduced ROS in treated RUPP rats. Caspase 1 inhibition increased the number of live pups, yet had no effect on fetal weight or placental efficiency in the treated groups. In conclusion, Caspase 1 inhibition reduces placental IL-1β, inflammatory TH17 and cNK populations, and reduces MAP in RUPP rats. These data suggest that Caspase 1 is a key contributor to PE pathophysiology. This warrants further investigation of Caspase 1 as a potential therapeutic target to improve maternal outcomes in PE.
MeSH term(s)	Animals ; Female ; Humans ; Pregnancy ; Rats ; Antineoplastic Agents ; Blood Pressure ; Caspase 1/metabolism ; Killer Cells, Natural ; Placenta ; Pre-Eclampsia/drug therapy ; Rats, Sprague-Dawley ; Reactive Oxygen Species ; Th17 Cells
Chemical Substances	Antineoplastic Agents ; Caspase 1 (EC 3.4.22.36) ; Reactive Oxygen Species ; belnacasan (00OLE78529)
Language	English
Publishing date	2024-01-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25020863
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Drinking less on cannabis use days: The moderating role of UPPS-P impulsive personality traits.

Waddell, Jack T / Gunn, Rachel L / Corbin, William R / Borsari, Brian / Metrik, Jane

Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors

2021 Volume 35, Issue 6, Page(s) 737–748

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Alcohol Drinking ; Cannabis ; Humans ; Impulsive Behavior ; Personality ; Substance-Related Disorders ; Veterans
Language	English
Publishing date	2021-04-22
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	2101111-4
ISSN	1939-1501 ; 0893-164X
ISSN (online)	1939-1501
ISSN	0893-164X
DOI	10.1037/adb0000727
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Isolation and Assessment of Pancreatic Islets Versus Dispersed Beta Cells: A Straightforward Approach to Examine Cell-Cell Communication.

Scarl, Rachel T / Koch, William J / Corbin, Kathryn L / Nunemaker, Craig S

Methods in molecular biology (Clifton, N.J.)

2020 Volume 2346, Page(s) 151–164

Abstract: Islets of Langerhans, found in the pancreas, are microorgans essential for glucose homeostasis within the body. Many cells are found with an islet, such as beta cells (~70%), alpha cells (~20%), delta cells (~5%), F cells (~4%), and epsilon cells (1%), ... ...

Abstract	Islets of Langerhans, found in the pancreas, are microorgans essential for glucose homeostasis within the body. Many cells are found with an islet, such as beta cells (~70%), alpha cells (~20%), delta cells (~5%), F cells (~4%), and epsilon cells (1%), each with its own unique function. To better understand the roles of these cells and how cell communication alters their function, several techniques have been established such as islet isolation and beta cell dispersion. Here we describe how to isolate primary rodent islets, disperse pancreatic islets, measure intracellular calcium, and use immunofluorescent staining to distinguish beta cells and alpha cells.
MeSH term(s)	Animals ; Calcium/analysis ; Cell Communication ; Cell Separation ; Fluorescent Antibody Technique ; Insulin-Secreting Cells/cytology ; Islets of Langerhans/cytology ; Rats ; Staining and Labeling
Chemical Substances	Calcium (SY7Q814VUP)
Language	English
Publishing date	2020-11-17
Publishing country	United States
Document type	Journal Article
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/7651_2020_338
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- Full text online
- Order with fees

Article ; Online: What have we learned from 7 years of equine rhinitis B virus qPCR testing in nasal secretions from horses with respiratory signs.

Bernardino, Pedro / James, Kaitlyn / Barnum, Samantha / Corbin, Rachel / Wademan, Cara / Pusterla, Nicola

The Veterinary record

2021 Volume 188, Issue 10, Page(s) e26

Abstract: Background: Equine rhinitis B virus (ERBV) has been given little attention by practitioners compared to other respiratory viruses, mainly because of the lack of diagnostic modalities and association with clinical disease. The objective of the study was ... ...

Abstract	Background: Equine rhinitis B virus (ERBV) has been given little attention by practitioners compared to other respiratory viruses, mainly because of the lack of diagnostic modalities and association with clinical disease. The objective of the study was to determine the frequency of detection of ERBV in nasal secretions from 6568 horses with acute onset of respiratory signs. Methods: ERBV-positive qPCR results from nasal secretions submitted to a molecular diagnostic laboratory from 2013 to 2019 were reviewed. Results: A total of 333 ERBV qPCR-positive samples (5.1%) were detected with increasing yearly frequency since the introduction of the assay in 2013. In comparison, only three of 356 (0.8%) healthy horses tested qPCR-positive for ERBV. Median age for ERBV qPCR-positive horses was 3 years of age, and fever, coughing and nasal discharge were the most common signs reported. Further, co-infections with other respiratory pathogens were reported in 73 (21.9%) of ERBV qPCR-positive samples. Conclusion: ERBV is a commonly detected respiratory virus from nasal secretions of young horses presenting with fever, nasal discharge and coughing.
MeSH term(s)	Animals ; Bodily Secretions/virology ; Cough/veterinary ; Erbovirus/isolation & purification ; Female ; Fever/veterinary ; Horse Diseases/diagnosis ; Horse Diseases/virology ; Horses ; Humans ; Male ; Nose/virology ; Picornaviridae Infections/diagnosis ; Picornaviridae Infections/veterinary ; Real-Time Polymerase Chain Reaction/veterinary
Language	English
Publishing date	2021-03-24
Publishing country	England
Document type	Journal Article
ZDB-ID	390015-0
ISSN	2042-7670 ; 0042-4900
ISSN (online)	2042-7670
ISSN	0042-4900
DOI	10.1002/vetr.26
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.B 645: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: Frequency of Detection of Respiratory Pathogens in Clinically Healthy Show Horses Following a Multi-County Outbreak of Equine Herpesvirus-1 Myeloencephalopathy in California.

Wilcox, Abigail / Barnum, Samantha / Wademan, Cara / Corbin, Rachel / Escobar, Edlin / Hodzic, Emir / Schumacher, Stephen / Pusterla, Nicola

Pathogens (Basel, Switzerland)

2022 Volume 11, Issue 10

Abstract: Actively shedding healthy horses have been indicated as a possible source of respiratory pathogen outbreak, transmission, and spread. Using nasal swabs from clinically healthy sport horses submitted for qPCR testing after an outbreak of equine ... ...

Abstract	Actively shedding healthy horses have been indicated as a possible source of respiratory pathogen outbreak, transmission, and spread. Using nasal swabs from clinically healthy sport horses submitted for qPCR testing after an outbreak of equine herpesvirus-1 (EHV-1) myeloencephalopathy (EHM) in the spring of 2022, this study aimed to identify the rate of clinically healthy horses shedding common and less characterized respiratory pathogens within the sport horse population to better understand their role in outbreaks. Swabs were collected during a required quarantine and testing period, according to the United States Equestrian Federation (USEF), and showed return-to-competition requirements. Common respiratory pathogens, such as equine influenza virus (EIV), EHV-4, and equine rhinitis B virus (ERBV), were found at low but stable frequencies within previously reported ranges, whereas EHV-1 and
Language	English
Publishing date	2022-10-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens11101161
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Opportunistic dried blood spot sampling validates and optimizes a pediatric population pharmacokinetic model of metronidazole.

Randell, Rachel L / Balevic, Stephen J / Greenberg, Rachel G / Cohen-Wolkowiez, Michael / Thompson, Elizabeth J / Venkatachalam, Saranya / Smith, Michael J / Bendel, Catherine / Bliss, Joseph M / Chaaban, Hala / Chhabra, Rakesh / Dammann, Christiane E L / Downey, L Corbin / Hornik, Chi / Hussain, Naveed / Laughon, Matthew M / Lavery, Adrian / Moya, Fernando / Saxonhouse, Matthew /

Sokol, Gregory M / Trembath, Andrea / Weitkamp, Joern-Hendrik / Hornik, Christoph P

Antimicrobial agents and chemotherapy

2024 Volume 68, Issue 4, Page(s) e0153323

Abstract: Pharmacokinetic models rarely undergo external validation in vulnerable populations such as critically ill infants, thereby limiting the accuracy, efficacy, and safety of model-informed dosing in real-world settings. Here, we describe an opportunistic ... ...

Abstract	Pharmacokinetic models rarely undergo external validation in vulnerable populations such as critically ill infants, thereby limiting the accuracy, efficacy, and safety of model-informed dosing in real-world settings. Here, we describe an opportunistic approach using dried blood spots (DBS) to evaluate a population pharmacokinetic model of metronidazole in critically ill preterm infants of gestational age (GA) ≤31 weeks from the Metronidazole Pharmacokinetics in Premature Infants (PTN_METRO, NCT01222585) study. First, we used linear correlation to compare 42 paired DBS and plasma metronidazole concentrations from 21 preterm infants [mean (SD): post natal age 28.0 (21.7) days, GA 26.3 (2.4) weeks]. Using the resulting predictive equation, we estimated plasma metronidazole concentrations (ePlasma) from 399 DBS collected from 122 preterm and term infants [mean (SD): post natal age 16.7 (15.8) days, GA 31.4 (5.1) weeks] from the Antibiotic Safety in Infants with Complicated Intra-Abdominal Infections (SCAMP, NCT01994993) trial. When evaluating the PTN_METRO model using ePlasma from the SCAMP trial, we found that the model generally predicted ePlasma well in preterm infants with GA ≤31 weeks. When including ePlasma from term and preterm infants with GA >31 weeks, the model was optimized using a sigmoidal Emax maturation function of postmenstrual age on clearance and estimated the exponent of weight on volume of distribution. The optimized model supports existing dosing guidelines and adds new data to support a 6-hour dosing interval for infants with postmenstrual age >40 weeks. Using an opportunistic DBS to externally validate and optimize a metronidazole population pharmacokinetic model was feasible and useful in this vulnerable population.
MeSH term(s)	Child ; Infant ; Humans ; Infant, Newborn ; Adult ; Adolescent ; Metronidazole/pharmacokinetics ; Infant, Premature ; Critical Illness ; Anti-Bacterial Agents/pharmacokinetics ; Gestational Age
Chemical Substances	Metronidazole (140QMO216E) ; Anti-Bacterial Agents
Language	English
Publishing date	2024-03-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	217602-6
ISSN	1098-6596 ; 0066-4804
ISSN (online)	1098-6596
ISSN	0066-4804
DOI	10.1128/aac.01533-23
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 809: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Einzelsignatur: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito