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  1. Article ; Online: Inhibitory Effect of

    Kim, Jeonghyun / Lee, Chang-Gun / Yun, Seung-Hee / Hwang, Seokjin / Jeon, Hyoju / Park, Eunkuk / Jeong, Seon-Yong

    Medicina (Kaunas, Lithuania)

    2022  Volume 58, Issue 4

    Abstract: Background and Objectives: ...

    Abstract Background and Objectives:
    MeSH term(s) Animals ; Cell Differentiation ; Cornus ; Female ; Humans ; Mice ; Osteoclasts ; Osteoporosis, Postmenopausal/drug therapy ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Ulmus/chemistry
    Chemical Substances Plant Extracts
    Language English
    Publishing date 2022-03-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina58040466
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6270: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Anti-Obesity Effects of Combined

    Park, Eunkuk / Lee, Chang-Gun / Jeon, Hyoju / Jeong, Hyesoo / Yeo, Subin / Yong, Yoonjoong / Jeong, Seon-Yong

    Animals : an open access journal from MDPI

    2021  Volume 11, Issue 11

    Abstract: Medicinal plants are widely used as supplements for the treatment of various diseases because of their few side-effects. Here, we examined the anti-obesity effects of a mixture extract ... ...

    Abstract Medicinal plants are widely used as supplements for the treatment of various diseases because of their few side-effects. Here, we examined the anti-obesity effects of a mixture extract of
    Language English
    Publishing date 2021-11-08
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani11113187
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Anti-Menopausal Effects of

    Park, Eunkuk / Lim, Eunguk / Yeo, Subin / Yong, Yoonjoong / Yang, Junga / Jeong, Seon-Yong

    Nutrients

    2020  Volume 12, Issue 2

    Abstract: ...

    Abstract :
    MeSH term(s) 3T3-L1 Cells ; Adipocytes/drug effects ; Animals ; Bone Density/drug effects ; Bone Resorption/prevention & control ; Cell Differentiation/drug effects ; Cornus ; Female ; Femur/drug effects ; Granulosa Cells/drug effects ; Humans ; Menopause/drug effects ; Mice ; Models, Animal ; Osteoblasts/drug effects ; Osteoporosis, Postmenopausal/prevention & control ; Ovariectomy ; Plant Extracts/pharmacology ; Ribes
    Chemical Substances Plant Extracts
    Language English
    Publishing date 2020-01-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu12020369
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Inhibitory Effect of Ulmus davidiana and Cornus officinalis Extracts on Osteoporotic Bone Loss In Vitro and In Vivo

    Jeonghyun Kim / Chang-Gun Lee / Seung-Hee Yun / Seokjin Hwang / Hyoju Jeon / Eunkuk Park / Seon-Yong Jeong

    Medicina, Vol 58, Iss 4, p

    2022  Volume 466

    Abstract: Background and Objectives: Traditional herbal medicines are becoming more popular as a complementary medication as they have the advantages of being mostly harmless and safe, causing fewer side-effects than conventional medications. Here, we demonstrate ... ...

    Abstract Background and Objectives: Traditional herbal medicines are becoming more popular as a complementary medication as they have the advantages of being mostly harmless and safe, causing fewer side-effects than conventional medications. Here, we demonstrate the inhibitory effects of the combination of Ulmus davidiana (UD) and Cornus officinalis (CO) extracts on osteoporotic bone loss. Materials and Methods : This study presented osteogenic effects in primary cultured osteoblasts, pre-osteoblastic MC3T3-E1 cell lines, and osteoclastogenic effects in osteoclasts derived from bone marrow monocytes, and finally, protective effects on bone loss in an ovariectomy (OVX)-induced osteoporotic animal model. Results : A significant increase in alkaline phosphatase (ALP) activity was observed following treatment with UD and CO mixtures (8:2, 7:3, and 5:5 ratios) and individual UD and CO extracts, with the highest ALP activity being detected for the treatment with UD and CO extracts at a 5:5 ratio. An optimal ratio of UD and CO (UC) extract promoted osteoblast differentiation in both pre-osteoblastic cells and primary osteoblasts by increasing osteoblastic markers such as Alpl , Runx2 , and Bglap . However, treatment with the UC extract inhibited osteoclast differentiation with a decreased expression of osteoclastogenesis-related genes, including Ctsk , Acp5 , Mmp9 , and Nfatc1 . In addition, UC treatment prevented osteoporotic bone loss in OVX mice and improved impaired skeletal structure parameters. Conclusions : This study suggests that combined UD and CO extracts may be a beneficial traditional medicine for the prevention of postmenopausal osteoporosis.
    Keywords Ulmus davidiana ; Cornus officinalis ; primary osteoblasts ; primary osteoclasts ; ovariectomized mice ; herbal medicine ; Medicine (General) ; R5-920
    Subject code 616
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Neurofibromin Deficiency Causes Epidermal Growth Factor Receptor Upregulation through the Activation of Ras/ERK/SP1 Signaling Pathway in Neurofibromatosis Type 1-Associated Malignant Peripheral Nerve Sheet Tumor.

    Park, Gun-Hoo / Lee, Su-Jin / Lee, Chang-Gun / Kim, Jeonghyun / Park, Eunkuk / Jeong, Seon-Yong

    International journal of molecular sciences

    2021  Volume 22, Issue 24

    Abstract: Neurofibromatosis type 1 (NF1) is an autosomal dominant human genetic disorder. The progression of benign plexiform neurofibromas to malignant peripheral nerve sheet tumors (MPNSTs) is a major cause of mortality in patients with NF1. Although elevated ... ...

    Abstract Neurofibromatosis type 1 (NF1) is an autosomal dominant human genetic disorder. The progression of benign plexiform neurofibromas to malignant peripheral nerve sheet tumors (MPNSTs) is a major cause of mortality in patients with NF1. Although elevated epidermal growth factor receptor (EGFR) expression plays a crucial role in the pathogenesis of MPNST, the cause of EGFR overexpression remains unclear. Here, we assessed EGFR expression levels in MPNST tissues of NF1 patients and NF1 patient-derived MPNST cells. We found that the expression of EGFR was upregulated in MPNST tissues and MPNST cells, while the expression of neurofibromin was significantly decreased. Manipulation of
    MeSH term(s) Cell Line, Tumor ; ErbB Receptors/biosynthesis ; ErbB Receptors/genetics ; Extracellular Signal-Regulated MAP Kinases/genetics ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Gene Expression Regulation, Neoplastic ; Humans ; MAP Kinase Signaling System ; Neurofibromatosis 1/genetics ; Neurofibromatosis 1/metabolism ; Neurofibromin 1/genetics ; Neurofibromin 1/metabolism ; Sp1 Transcription Factor/genetics ; Sp1 Transcription Factor/metabolism ; Up-Regulation ; ras Proteins/genetics ; ras Proteins/metabolism
    Chemical Substances NF1 protein, human ; Neurofibromin 1 ; Sp1 Transcription Factor ; SP1 protein, human ; EGFR protein, human (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1) ; Extracellular Signal-Regulated MAP Kinases (EC 2.7.11.24) ; ras Proteins (EC 3.6.5.2)
    Language English
    Publishing date 2021-12-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms222413308
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Anti-Osteoarthritic Effects of Prunella Vulgaris and Gentiana Lutea In Vitro and In Vivo.

    Kim, Jeonghyun / Lee, Chang-Gun / Hwang, Seokjin / Yun, Seung-Hee / Uprety, Laxmi Prasad / Oh, Kang-Il / Singh, Shivani / Yoo, Jisu / Jeong, Hyesoo / Yong, Yoonjoong / Yeo, Subin / Park, Eunkuk / Jeong, Seon-Yong

    Antioxidants (Basel, Switzerland)

    2022  Volume 12, Issue 1

    Abstract: Osteoarthritis (OA) is the progressive destruction of articular cartilage with severe symptoms, including pain and stiffness. We investigated the anti-osteoarthritic effects ... ...

    Abstract Osteoarthritis (OA) is the progressive destruction of articular cartilage with severe symptoms, including pain and stiffness. We investigated the anti-osteoarthritic effects of
    Language English
    Publishing date 2022-12-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox12010047
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  7. Article ; Online: Inhibitory Effects of Loganin on Adipogenesis In Vitro and In Vivo

    Hyoju Jeon / Chang-Gun Lee / Hyesoo Jeong / Seong-Hoon Yun / Jeonghyun Kim / Laxmi Prasad Uprety / Kang-Il Oh / Shivani Singh / Jisu Yoo / Eunkuk Park / Seon-Yong Jeong

    International Journal of Molecular Sciences, Vol 24, Iss 4752, p

    2023  Volume 4752

    Abstract: Obesity is characterized by the excessive accumulation of mature adipocytes that store surplus energy in the form of lipids. In this study, we investigated the inhibitory effects of loganin on adipogenesis in mouse preadipocyte 3T3-L1 cells and primary ... ...

    Abstract Obesity is characterized by the excessive accumulation of mature adipocytes that store surplus energy in the form of lipids. In this study, we investigated the inhibitory effects of loganin on adipogenesis in mouse preadipocyte 3T3-L1 cells and primary cultured adipose-derived stem cells (ADSCs) in vitro and in mice with ovariectomy (OVX)- and high-fat diet (HFD)-induced obesity in vivo. For an in vitro study, loganin was co-incubated during adipogenesis in both 3T3-L1 cells and ADSCs, lipid droplets were evaluated by oil red O staining, and adipogenesis-related factors were assessed by qRT-PCR. For in vivo studies, mouse models of OVX- and HFD-induced obesity were orally administered with loganin, body weight was measured, and hepatic steatosis and development of excessive fat were evaluated by histological analysis. Loganin treatment reduced adipocyte differentiation by accumulating lipid droplets through the downregulation of adipogenesis-related factors, including peroxisome proliferator-activated receptor γ ( Pparg ), CCAAT/enhancer-binding protein α ( Cebpa ), perilipin 2 ( Plin2 ), fatty acid synthase ( Fasn ), and sterol regulatory element binding transcription protein 1 ( Srebp1 ). Loganin administration prevented weight gain in mouse models of obesity induced by OVX and HFD. Further, loganin inhibited metabolic abnormalities, such as hepatic steatosis and adipocyte enlargement, and increased the serum levels of leptin and insulin in both OVX- and HFD-induced obesity models. These results suggest that loganin is a potential candidate for preventing and treating obesity.
    Keywords loganin ; anti-adipogenic effect ; ovariectomized mice ; high-fat diet mice ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: A reply to a commentary on identification of the rare compound heterozygous variants in the NEB gene in a Korean family with intellectual disability, epilepsy and early-childhood-onset generalized muscle weakness.

    Yim, Shin-Young / Jeong, Seon-Yong

    Journal of human genetics

    2015  Volume 60, Issue 3, Page(s) 163–164

    MeSH term(s) Epilepsy/genetics ; Female ; Humans ; Intellectual Disability/genetics ; Male ; Muscle Proteins/genetics ; Muscle Weakness/genetics
    Chemical Substances Muscle Proteins
    Language English
    Publishing date 2015-03
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 1425192-9
    ISSN 1435-232X ; 1434-5161
    ISSN (online) 1435-232X
    ISSN 1434-5161
    DOI 10.1038/jhg.2014.119
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 201: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Anti-Obesity Effects of Combined Cornus officinalis and Ribes fasciculatum Extract in High-Fat Diet-Induced Obese Male Mice

    Eunkuk Park / Chang-Gun Lee / Hyoju Jeon / Hyesoo Jeong / Subin Yeo / Yoonjoong Yong / Seon-Yong Jeong

    Animals, Vol 11, Iss 3187, p

    2021  Volume 3187

    Abstract: Medicinal plants are widely used as supplements for the treatment of various diseases because of their few side-effects. Here, we examined the anti-obesity effects of a mixture extract of Cornus officinalis and Ribes fasciculatum (CR) in high-fat diet ( ... ...

    Abstract Medicinal plants are widely used as supplements for the treatment of various diseases because of their few side-effects. Here, we examined the anti-obesity effects of a mixture extract of Cornus officinalis and Ribes fasciculatum (CR) in high-fat diet (HFD)-induced obese male mice. Four week old male C57BL/6J mice were fed a normal diet (ND) or 60% high-fat diet (HFD) with different concentrations of CR extracts (75, 150, and 300 mg/kg/day) by oral administration for 12 weeks. CR extract administration prevented HFD-induced weight gain, hepatic steatosis, and adipocyte enlargement through the downregulation of adipogenesis-associated genes in obese male mice. In addition, CR administration improved the impaired glucose metabolism, insulin action, biochemical obesity parameters, and metabolic profiles in HFD-induced male mice. Consequently, the CR extract exhibited beneficial effects on HFD-induced systemic metabolic challenges. Taken together, our findings suggest that CR extract may be a potent therapeutic supplement for the treatment and prevention of obesity.
    Keywords anti-obesity ; Cornus officinalis ; Ribes fasciculatum ; high-fat diet ; obese male mice ; Veterinary medicine ; SF600-1100 ; Zoology ; QL1-991
    Language English
    Publishing date 2021-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Efficacy and Safety of Combined Extracts of

    Park, Eunkuk / Lee, Chang Gun / Kim, Jeonghyun / Kang, Jae-Heon / Cho, Young Gyu / Jeong, Seon-Yong

    Journal of clinical medicine

    2020  Volume 9, Issue 11

    Abstract: Obesity is a medical condition that presents excessive fat accumulation with high risk of serious chronic diseases. The aim of this clinical trial is to investigate the anti-obesity effects ... ...

    Abstract Obesity is a medical condition that presents excessive fat accumulation with high risk of serious chronic diseases. The aim of this clinical trial is to investigate the anti-obesity effects of
    Language English
    Publishing date 2020-11-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm9113629
    Database MEDical Literature Analysis and Retrieval System OnLINE

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