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Article ; Online: Blood culture identification (BCID) performance in polymicrobial bacteremia.

Bradford, William S / Donnelley, Monica A / Fine, Jeffrey R / Crabtree, Scott J

Diagnostic microbiology and infectious disease

2023 Volume 107, Issue 4, Page(s) 116086

Abstract: The rapid multiplex PCR (rmPCR)-based FilmArray® blood culture identification (BCID) assay reduces time from positive blood culture to organism identification. Polymicrobial bacteremia (PMB) is a known area of reduced diagnostic fidelity for BCID and ... ...

Abstract	The rapid multiplex PCR (rmPCR)-based FilmArray® blood culture identification (BCID) assay reduces time from positive blood culture to organism identification. Polymicrobial bacteremia (PMB) is a known area of reduced diagnostic fidelity for BCID and remains incompletely characterized. All cases of clinically confirmed PMB at a large academic single center from a 23-month period were evaluated in a retrospective cohort analysis. A total of 207 samples were identified and studied. Overall, 49.3% (N = 102) of polymicrobial cultures were incompletely identified by FilmArray® result. There were no significant between-group differences in comorbidity status, length of stay, mortality, or source between patients with PMB who had complete versus incomplete BCID identification. Our results suggest that rmPCR-based assays frequently miss organisms in PMB and should be interpreted accordingly.
MeSH term(s)	Humans ; Blood Culture/methods ; Retrospective Studies ; Bacteremia/diagnosis ; Multiplex Polymerase Chain Reaction ; Time Factors
Language	English
Publishing date	2023-09-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	604920-5
ISSN	1879-0070 ; 0732-8893
ISSN (online)	1879-0070
ISSN	0732-8893
DOI	10.1016/j.diagmicrobio.2023.116086
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Article ; Online: The role of multidisciplinary infection prevention teams in identifying community transmission of SARS-CoV-2 in the United States.

Crabtree, Scott J / Cohen, Stuart H

Infection control and hospital epidemiology

2020 Volume 42, Issue 6, Page(s) 780–781

MeSH term(s)	COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19/transmission ; COVID-19 Testing/methods ; Disease Transmission, Infectious/prevention & control ; Disease Transmission, Infectious/statistics & numerical data ; Humans ; Interdisciplinary Communication ; Patient Care Team ; United States/epidemiology
Keywords	covid19
Language	English
Publishing date	2020-07-23
Publishing country	United States
Document type	Letter
ZDB-ID	639378-0
ISSN	1559-6834 ; 0195-9417 ; 0899-823X
ISSN (online)	1559-6834
ISSN	0195-9417 ; 0899-823X
DOI	10.1017/ice.2020.360
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Article: The role of multidisciplinary infection prevention teams in identifying community transmission of SARS-CoV-2 in the United States

Crabtree, Scott J / Cohen, Stuart H

Infect Control Hosp Epidemiol

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #662429
Database	COVID19

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Article ; Online: The role of multidisciplinary infection prevention teams in identifying community transmission of SARS-CoV-2 in the United States

Crabtree, Scott J. / Cohen, Stuart H.

Infection Control & Hospital Epidemiology

2020 , Page(s) 1–2

Keywords	Microbiology (medical) ; Epidemiology ; Infectious Diseases ; covid19
Language	English
Publisher	Cambridge University Press (CUP)
Publishing country	uk
Document type	Article ; Online
ZDB-ID	639378-0
ISSN	1559-6834 ; 0195-9417 ; 0899-823X
ISSN (online)	1559-6834
ISSN	0195-9417 ; 0899-823X
DOI	10.1017/ice.2020.360
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Article ; Online: Indirect transfer of pyriproxyfen to European honeybees via an autodissemination approach.

Kancharlapalli, Sri Jyosthsna / Crabtree, Cameron J / Surowiec, Kaz / Longing, Scott D / L Brelsfoard, Corey

PLoS neglected tropical diseases

2021 Volume 15, Issue 10, Page(s) e0009824

Abstract: The frequency of arboviral disease epidemics is increasing and vector control remains the primary mechanism to limit arboviral transmission. Container inhabiting mosquitoes such as Aedes albopictus and Aedes aegypti are the primary vectors of dengue, ... ...

Abstract	The frequency of arboviral disease epidemics is increasing and vector control remains the primary mechanism to limit arboviral transmission. Container inhabiting mosquitoes such as Aedes albopictus and Aedes aegypti are the primary vectors of dengue, chikungunya, and Zika viruses. Current vector control methods for these species are often ineffective, suggesting the need for novel control approaches. A proposed novel approach is autodissemination of insect growth regulators (IGRs). The advantage of autodissemination approaches is small amounts of active ingredients compared to traditional insecticide applications are used to impact mosquito populations. While the direct targeting of cryptic locations via autodissemination seems like a significant advantage over large scale applications of insecticides, this approach could actually affect nontarget organisms by delivering these highly potent long lasting growth inhibitors such as pyriproxyfen (PPF) to the exact locations that other beneficial insects visit, such as a nectar source. Here we tested the hypothesis that PPF treated male Ae. albopictus will contaminate nectar sources, which results in the indirect transfer of PPF to European honey bees (Apis mellifera). We performed bioassays, fluorescent imaging, and mass spectrometry on insect and artificial nectar source materials to examine for intra- and interspecific transfer of PPF. Data suggests there is direct transfer of PPF from Ae. albopictus PPF treated males and indirect transfer of PPF to A. mellifera from artificial nectar sources. In addition, we show a reduction in fecundity in Ae. albopictus and Drosophila melanogaster when exposed to sublethal doses of PPF. The observed transfer of PPF to A. mellifera suggests the need for further investigation of autodissemination approaches in a more field like setting to examine for risks to insect pollinators.
MeSH term(s)	Aedes/drug effects ; Aedes/physiology ; Animals ; Bees/chemistry ; Drosophila melanogaster ; Female ; Insecticides/analysis ; Insecticides/pharmacology ; Juvenile Hormones/analysis ; Juvenile Hormones/pharmacology ; Male ; Mosquito Control/methods ; Pyridines/analysis ; Pyridines/pharmacology
Chemical Substances	Insecticides ; Juvenile Hormones ; Pyridines ; pyriproxyfen (3Q9VOR705O)
Language	English
Publishing date	2021-10-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2429704-5
ISSN	1935-2735 ; 1935-2727
ISSN (online)	1935-2735
ISSN	1935-2727
DOI	10.1371/journal.pntd.0009824
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Article ; Online: Indirect transfer of pyriproxyfen to European honeybees via an autodissemination approach.

Sri Jyosthsna Kancharlapalli / Cameron J Crabtree / Kaz Surowiec / Scott D Longing / Corey L Brelsfoard

PLoS Neglected Tropical Diseases, Vol 15, Iss 10, p e

2021 Volume 0009824

Abstract	The frequency of arboviral disease epidemics is increasing and vector control remains the primary mechanism to limit arboviral transmission. Container inhabiting mosquitoes such as Aedes albopictus and Aedes aegypti are the primary vectors of dengue, chikungunya, and Zika viruses. Current vector control methods for these species are often ineffective, suggesting the need for novel control approaches. A proposed novel approach is autodissemination of insect growth regulators (IGRs). The advantage of autodissemination approaches is small amounts of active ingredients compared to traditional insecticide applications are used to impact mosquito populations. While the direct targeting of cryptic locations via autodissemination seems like a significant advantage over large scale applications of insecticides, this approach could actually affect nontarget organisms by delivering these highly potent long lasting growth inhibitors such as pyriproxyfen (PPF) to the exact locations that other beneficial insects visit, such as a nectar source. Here we tested the hypothesis that PPF treated male Ae. albopictus will contaminate nectar sources, which results in the indirect transfer of PPF to European honey bees (Apis mellifera). We performed bioassays, fluorescent imaging, and mass spectrometry on insect and artificial nectar source materials to examine for intra- and interspecific transfer of PPF. Data suggests there is direct transfer of PPF from Ae. albopictus PPF treated males and indirect transfer of PPF to A. mellifera from artificial nectar sources. In addition, we show a reduction in fecundity in Ae. albopictus and Drosophila melanogaster when exposed to sublethal doses of PPF. The observed transfer of PPF to A. mellifera suggests the need for further investigation of autodissemination approaches in a more field like setting to examine for risks to insect pollinators.
Keywords	Arctic medicine. Tropical medicine ; RC955-962 ; Public aspects of medicine ; RA1-1270
Subject code	590
Language	English
Publishing date	2021-10-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Society of Thoracic Surgeons/American Society for Radiation Oncology Updated Clinical Practice Guidelines on Multimodality Therapy for Locally Advanced Cancer of the Esophagus or Gastroesophageal Junction.

Worrell, Stephanie G / Goodman, Karyn A / Altorki, Nasser K / Ashman, Jonathan B / Crabtree, Traves D / Dorth, Jennifer / Firestone, Scott / Harpole, David H / Hofstetter, Wayne L / Hong, Theodore S / Kissoon, Kalie / Ku, Geoffrey Y / Molena, Daniela / Tepper, Joel E / Watson, Thomas J / Williams, Terence / Willett, Christopher

The Annals of thoracic surgery

2023 Volume 117, Issue 1, Page(s) 15–32

Abstract: Outcomes for patients with esophageal cancer have improved over the last decade with the implementation of multimodality therapy. There are currently no comprehensive guidelines addressing multidisciplinary management of esophageal cancer that have ... ...

Abstract	Outcomes for patients with esophageal cancer have improved over the last decade with the implementation of multimodality therapy. There are currently no comprehensive guidelines addressing multidisciplinary management of esophageal cancer that have incorporated the input of surgeons, radiation oncologists, and medical oncologists. To address the need for multidisciplinary input in the management of esophageal cancer and to meet current best practices for clinical practice guidelines, the current guidelines were created as a collaboration between The Society of Thoracic Surgeons (STS), American Society for Radiation Oncology (ASTRO), and the American Society of Clinical Oncology (ASCO). Physician representatives chose 8 key clinical questions pertinent to the care of patients with locally advanced, resectable thoracic esophageal cancer (excluding cervical location). A comprehensive literature review was performed identifying 227 articles that met the inclusion criteria covering the use of induction chemotherapy, chemotherapy vs chemoradiotherapy before surgery, optimal radiation dose, the value of esophagectomy, timing of esophagectomy, the approach and extent of lymphadenectomy, the use of minimally invasive esophagectomy, and the value of adjuvant therapy after resection. The relevant data were reviewed and voted on by the panel with 80% of the authors, with 75% agreement on class and level of evidence. These data were then complied into the guidelines document.
MeSH term(s)	Humans ; United States ; Radiation Oncology ; Combined Modality Therapy ; Esophageal Neoplasms/surgery ; Surgeons ; Esophagogastric Junction/surgery
Language	English
Publishing date	2023-11-02
Publishing country	Netherlands
Document type	Review ; Practice Guideline
ZDB-ID	211007-6
ISSN	1552-6259 ; 0003-4975
ISSN (online)	1552-6259
ISSN	0003-4975
DOI	10.1016/j.athoracsur.2023.09.021
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Article ; Online: The Society of Thoracic Surgeons/American Society for Radiation Oncology Updated Clinical Practice Guidelines on Multimodality Therapy for Locally Advanced Cancer of the Esophagus or Gastroesophageal Junction.

Practical radiation oncology

2023 Volume 14, Issue 1, Page(s) 28–46

Abstract	Outcomes for patients with esophageal cancer have improved over the last decade with the implementation of multimodality therapy. There are currently no comprehensive guidelines addressing multidisciplinary management of esophageal cancer that have incorporated the input of surgeons, radiation oncologists, and medical oncologists. To address the need for multidisciplinary input in the management of esophageal cancer and to meet current best practices for clinical practice guidelines, the current guidelines were created as a collaboration between The Society of Thoracic Surgeons (STS), American Society for Radiation Oncology (ASTRO), and the American Society of Clinical Oncology (ASCO). Physician representatives chose 8 key clinical questions pertinent to the care of patients with locally advanced, resectable thoracic esophageal cancer (excluding cervical location). A comprehensive literature review was performed identifying 227 articles that met the inclusion criteria covering the use of induction chemotherapy, chemotherapy vs chemoradiotherapy before surgery, optimal radiation dose, the value of esophagectomy, timing of esophagectomy, the approach and extent of lymphadenectomy, the use of minimally invasive esophagectomy, and the value of adjuvant therapy after resection. The relevant data were reviewed and voted on by the panel with 80% of the authors, with 75% agreement on class and level of evidence. These data were then complied into the guidelines document.
MeSH term(s)	Humans ; United States ; Radiation Oncology ; Combined Modality Therapy ; Esophageal Neoplasms/radiotherapy ; Surgeons ; Esophagogastric Junction
Language	English
Publishing date	2023-11-02
Publishing country	United States
Document type	Review ; Practice Guideline
ZDB-ID	2655748-4
ISSN	1879-8519 ; 1879-8500
ISSN (online)	1879-8519
ISSN	1879-8500
DOI	10.1016/j.prro.2023.10.001
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Article ; Online: Safety of fluconazole in kidney transplant recipients for prevention of coccidioidomycosis.

Reddy, Laya / Thompson Iii, George R / Tuznik, Natascha / Zolfaghari, Tina A / Dray, Joy Vongspanich / Ames, Janneca / Ho, Daniel / Crabtree, Scott / Fine, Jeffrey / Wilson, Machelle D / Alnimri, Muna / Cohen, Stuart H / Koff, Alan

Medical mycology

2024 Volume 62, Issue 3

Abstract: Coccidioides is an endemic fungus that causes infections ranging from mild respiratory illness to life-threatening disease, and immunocompromised hosts such as solid organ transplant recipients are at higher risk for disseminated infection and mortality. ...

Abstract	Coccidioides is an endemic fungus that causes infections ranging from mild respiratory illness to life-threatening disease, and immunocompromised hosts such as solid organ transplant recipients are at higher risk for disseminated infection and mortality. Our center administers fluconazole prophylaxis to kidney transplant recipients residing in geographic areas with higher incidences of coccidioidomycosis. However, because drug-drug interactions occur between triazoles and immunosuppressants used in transplant medicine, we undertook a study to ascertain whether fluconazole prophylaxis was associated with any important safety outcomes in kidney transplant recipients. This retrospective study evaluated patients who had undergone kidney transplantation between 2016 and 2019. Data on patient demographics, transplant-related clinical information, use of fluconazole prophylaxis (200 mg daily for 6-12 months post-transplant), and patient outcomes were obtained. The primary outcome was mean estimated glomerular filtration rate (eGFR) at 12 months, comparing those who received fluconazole prophylaxis to those who did not. Secondary outcomes included mean eGFR at 3 months, 6 months, and 9 months post-transplant, patient survival, biopsy-proven graft rejection, graft loss, or a new requirement for post-transplant dialysis, all within 12 months post-transplant. The mean eGFR at 12 months was similar between both groups, with 66.4 ml/min/1.73 m² in the fluconazole prophylaxis group vs. 64.3 ml/min/1.73 m² in the non-fluconazole prophylaxis group (P = 0.55). Secondary outcomes were similar across both groups. Multivariable linear regression found no significant association between fluconazole use and graft function. Fluconazole prophylaxis for prevention of coccidioidomycosis was not associated with adverse graft outcomes in kidney transplant recipients.
MeSH term(s)	Humans ; Fluconazole/adverse effects ; Coccidioidomycosis/epidemiology ; Coccidioidomycosis/veterinary ; Antifungal Agents/adverse effects ; Kidney Transplantation/adverse effects ; Kidney Transplantation/veterinary ; Retrospective Studies ; Transplant Recipients
Chemical Substances	Fluconazole (8VZV102JFY) ; Antifungal Agents
Language	English
Publishing date	2024-03-01
Publishing country	England
Document type	Journal Article
ZDB-ID	1421796-x
ISSN	1460-2709 ; 1369-3786
ISSN (online)	1460-2709
ISSN	1369-3786
DOI	10.1093/mmy/myae017
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Article ; Online: The Association of Intra-Abdominal Adhesions with Peritoneal Dialysis Catheter-Related Complications.

Qureshi, Mohammad Azfar / Maierean, Serban / Crabtree, John H / Clarke, Alix / Armstrong, Sean / Fissell, Rachel / Jain, Arsh K / Jassal, Sarbjit V / Hu, Susie L / Kennealey, Peter / Liebman, Scott / McCormick, Brendan / Momciu, Bogdan / Pauly, Robert P / Pellegrino, Beth / Perl, Jeffrey / Pirkle, James L / Plumb, Troy J / Seshasai, Rebecca /

Shah, Ankur / Shah, Nikhil / Shen, Jenny / Singh, Gurmukteshwar / Tennankore, Karthik / Uribarri, Jaime / Vasilevsky, Murray / Yang, Robert / Quinn, Robert R / Nadler, Ashlie / Oliver, Matthew J

Clinical journal of the American Society of Nephrology : CJASN

2024 Volume 19, Issue 4, Page(s) 472–482

Abstract: Background: This study investigated the association of intra-abdominal adhesions with the risk of peritoneal dialysis (PD) catheter complications.: Methods: Individuals undergoing laparoscopic PD catheter insertion were prospectively enrolled from ... ...

Abstract	Background: This study investigated the association of intra-abdominal adhesions with the risk of peritoneal dialysis (PD) catheter complications. Methods: Individuals undergoing laparoscopic PD catheter insertion were prospectively enrolled from eight centers in Canada and the United States. Patients were grouped based on the presence of adhesions observed during catheter insertion. The primary outcome was the composite of PD never starting, termination of PD, or the need for an invasive procedure caused by flow restriction or abdominal pain. Results: Seven hundred and fifty-eight individuals were enrolled, of whom 201 (27%) had adhesions during laparoscopic PD catheter insertion. The risk of the primary outcome occurred in 35 (17%) in the adhesion group compared with 58 (10%) in the no adhesion group (adjusted HR, 1.64; 95% confidence interval [CI], 1.05 to 2.55) within 6 months of insertion. Lower abdominal or pelvic adhesions had an adjusted HR of 1.80 (95% CI, 1.09 to 2.98) compared with the no adhesion group. Invasive procedures were required in 26 (13%) and 47 (8%) of the adhesion and no adhesion groups, respectively (unadjusted HR, 1.60: 95% CI, 1.04 to 2.47) within 6 months of insertion. The adjusted odds ratio for adhesions for women was 1.65 (95% CI, 1.12 to 2.41), for body mass index per 5 kg/m 2 was 1.16 (95% CI, 1.003 to 1.34), and for prior abdominal surgery was 8.34 (95% CI, 5.5 to 12.34). Common abnormalities found during invasive procedures included PD catheter tip migration, occlusion of the lumen with fibrin, omental wrapping, adherence to the bowel, and the development of new adhesions. Conclusions: People with intra-abdominal adhesions undergoing PD catheter insertion were at higher risk for abdominal pain or flow restriction preventing PD from starting, PD termination, or requiring an invasive procedure. However, most patients, with or without adhesions, did not experience complications, and most complications did not lead to the termination of PD therapy.
MeSH term(s)	Humans ; Female ; Catheters, Indwelling/adverse effects ; Peritoneal Dialysis/adverse effects ; Peritoneal Dialysis/methods ; Catheterization ; Laparoscopy/adverse effects ; Laparoscopy/methods ; Abdominal Pain ; Retrospective Studies
Language	English
Publishing date	2024-01-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2226665-3
ISSN	1555-905X ; 1555-9041
ISSN (online)	1555-905X
ISSN	1555-9041
DOI	10.2215/CJN.0000000000000404
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