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  1. Article: What's New in Emergencies, Trauma and Shock? Trauma-associated Venous Thromboembolism: A Potentially Preventable Cause of Morbidity and Mortality.

    Mahajan, Kunal

    Journal of emergencies, trauma, and shock

    2020  Volume 13, Issue 2, Page(s) 105–106

    Language English
    Publishing date 2020-06-10
    Publishing country India
    Document type Editorial
    ZDB-ID 2461111-6
    ISSN 0974-519X ; 0974-2700
    ISSN (online) 0974-519X
    ISSN 0974-2700
    DOI 10.4103/JETS.JETS_34_20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Impact of early initiation of ezetimibe in patients with acute coronary syndrome: A systematic review and meta-analysis.

    Mahajan, Kunal / Nagendra, Lakshmi / Dhall, Anil / Dutta, Deep

    European journal of internal medicine

    2024  

    Abstract: Objective: Scant data is available on the efficacy and safety of adding ezetimibe to high-intensity statin therapy for early and rapid reduction of low-density lipoprotein cholesterol (LDL-C) within 4-12 weeks of an acute-event in acute coronary ... ...

    Abstract Objective: Scant data is available on the efficacy and safety of adding ezetimibe to high-intensity statin therapy for early and rapid reduction of low-density lipoprotein cholesterol (LDL-C) within 4-12 weeks of an acute-event in acute coronary syndrome (ACS). We undertook this meta-analysis to address this knowledge-gap.
    Methods: Electronic databases were searched for RCTs involving patients with ACS receiving ezetimibe in intervention arm, and placebo/active comparator in control arm. Primary outcome was to evaluate changes in LDL-C levels post-ACS. Secondary outcomes were to evaluate alterations in other lipid parameters and adverse events.
    Results: From initially screened 4561 articles, data from 11 studies (20,291 patients) were analyzed. Compared to controls, patients receiving ezetimibe had significantly lower LDL-C at 7-days [MD -19.55 mg/dl(95 %CI:-36.46 to -2.63);P = 0.02;I
    Conclusion: Addition of ezetimibe to high-intensity statin therapy at the time of ACS event is associated with significantly better cholesterol reduction at day-7,1-month, 3- months and 1-year of follow-up, which translates into a significantly lower recurrent cardiovascular events post an index event of ACS.
    Concise summary of findings: Addition of ezetimibe to high-intensity statin therapy at the time of acute coronary syndrome (ACS) index event is associated with significantly better low density lipoprotein cholesterol and total cholesterol reduction at day-7, 1-month, 3-months and 1-year of follow-up, which translates into a significantly lower recurrent cardiovascular events (death from any cause, major ACS, non-fatal stroke, non-fatal myocardial infarction, and ischemic stroke) post an index event of ACS.
    Language English
    Publishing date 2024-02-08
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2024.02.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2608: Show issues Location:
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  3. Article: Obstructive sleep apnea and coronary artery disease: An unholy nexus or a holy alliance?

    Mahajan, Sanyam K / Mahajan, Kunal / Sharma, Sunil

    Lung India : official organ of Indian Chest Society

    2023  Volume 39, Issue 5, Page(s) 460–465

    Abstract: Coronary artery disease (CAD) is a significant cause of morbidity and mortality globally, and hypertension, dyslipidemia, diabetes mellitus, and smoking are major cardiovascular (CV) risk factors. Obstructive sleep apnea (OSA) and CAD share an exciting ... ...

    Abstract Coronary artery disease (CAD) is a significant cause of morbidity and mortality globally, and hypertension, dyslipidemia, diabetes mellitus, and smoking are major cardiovascular (CV) risk factors. Obstructive sleep apnea (OSA) and CAD share an exciting relationship, and recently, OSA has emerged as a non-traditional CV risk factor. OSA is characterized by episodic sleep state-dependent collapse of the upper airway, resulting in periodic reductions or cessations in ventilation, with consequent hypoxia, hypercapnia, or arousals from sleep. The oxidative stress and vascular inflammation resulting from the nocturnal hypoxia followed by reoxygenation cycles predispose the patients to the development of atherosclerotic cardiovascular disease (CVD). Untreated OSA is associated with long-term health consequences, including CVD, metabolic disorders, cognitive impairment, and depression. Paradoxically, some recent studies have reported that patients with OSA may suffer less severe CAD due to the development of collateral circulation due to repetitive hypoxia experienced due to OSA.
    Language English
    Publishing date 2023-01-10
    Publishing country India
    Document type Journal Article
    ZDB-ID 2410801-7
    ISSN 0974-598X ; 0970-2113
    ISSN (online) 0974-598X
    ISSN 0970-2113
    DOI 10.4103/lungindia.lungindia_597_21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Impact of early initiation of proprotein convertase subtilisin/kexin type 9 inhibitors in patients with acute coronary syndrome: A systematic review meta-analysis.

    Nagendra, Lakshmi / Mahajan, Kunal / Gupta, Gunjan / Dutta, Deep

    Indian heart journal

    2023  Volume 75, Issue 6, Page(s) 416–422

    Abstract: Objective: Scant data is available on the efficacy and safety of proprotein convertase subtilisin/kexin type-9 inhibitors (PCSK9i) for early and rapid reduction of low-density lipoprotein cholesterol (LDL-C) within 4-8 weeks of an acute event in ... ...

    Abstract Objective: Scant data is available on the efficacy and safety of proprotein convertase subtilisin/kexin type-9 inhibitors (PCSK9i) for early and rapid reduction of low-density lipoprotein cholesterol (LDL-C) within 4-8 weeks of an acute event in patients with acute coronary syndrome (ACS). We undertook this meta-analysis to address this knowledge-gap.
    Methods: Electronic databases were searched for RCTs involving patients with ACS receiving PCSK9i in intervention arm, and placebo/active comparator in control arm. Primary outcome was to evaluate changes in 1-month LDL-C post ACS. Secondary outcomes were to evaluate alterations in other lipid parameters and adverse events.
    Results: From initially screened 194 articles, data from 3 studies was analyzed. After 4-weeks therapy, patients receiving PCSK9i had lower LDL-C [MD -0.95 mmol/L (95%CI:-1.51 to -0.40); P = 0.0007; I
    Conclusion: PCSK9i are highly effective in early reduction of LDL-C along with reduction of early hospital readmissions post-ACS.
    MeSH term(s) Humans ; Acute Coronary Syndrome/drug therapy ; Anticholesteremic Agents/therapeutic use ; Cholesterol, HDL ; Cholesterol, LDL ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects ; Proprotein Convertase 9 ; Subtilisins
    Chemical Substances Anticholesteremic Agents ; Cholesterol, HDL ; Cholesterol, LDL ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Proprotein Convertase 9 (EC 3.4.21.-) ; Subtilisins (EC 3.4.21.-)
    Language English
    Publishing date 2023-09-29
    Publishing country India
    Document type Systematic Review ; Meta-Analysis ; Journal Article
    ZDB-ID 604366-5
    ISSN 2213-3763 ; 0019-4832
    ISSN (online) 2213-3763
    ISSN 0019-4832
    DOI 10.1016/j.ihj.2023.09.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 616: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  5. Article: Hemiazygous continuation of inferior vena cava draining into the coronary sinus via persistent left superior vena cava: a rare anomaly.

    Bhutani, Jaikrit / Batra, Aditya / Doomra, Mridul / Mahajan, Kunal

    Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace

    2022  Volume 93, Issue 1

    Abstract: We present a case of left sided inferior vena cava with hemiazygous continuation draining into the coronary sinus via the left persistent superior vena cava. This was incidentally found in an individual referred to our centre for evaluation of ... ...

    Abstract We present a case of left sided inferior vena cava with hemiazygous continuation draining into the coronary sinus via the left persistent superior vena cava. This was incidentally found in an individual referred to our centre for evaluation of palpitations. These caval anomalies are rare, and are often associated with no clinical manifestations. However, it is necessary to recognize them during routine workup to avoid diagnostic and procedural pitfalls.
    MeSH term(s) Humans ; Vena Cava, Superior/abnormalities ; Coronary Sinus ; Persistent Left Superior Vena Cava ; Vena Cava, Inferior ; Drainage
    Language English
    Publishing date 2022-06-28
    Publishing country Italy
    Document type Case Reports ; Journal Article
    ZDB-ID 1160940-0
    ISSN 1122-0643 ; 1120-0391
    ISSN 1122-0643 ; 1120-0391
    DOI 10.4081/monaldi.2022.2275
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 65: Show issues Location:
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  6. Article ; Online: Efficacy and safety of luseogliflozin in improving glycaemic and non-glycaemic outcomes in type-2 diabetes: A meta-analysis.

    Dutta, Deep / Kadian, Jyoti / Mahajan, Kunal / Dhall, Anil / Sharma, Meha

    Diabetes & metabolic syndrome

    2023  Volume 17, Issue 3, Page(s) 102742

    Abstract: Background & aims: No meta-analysis is available analysing the role of luseogliflozin in type-2 diabetes. We undertook this meta-analysis to address this knowledge-gap.: Methods: Electronic databases were searched for RCTs involving diabetes patients ...

    Abstract Background & aims: No meta-analysis is available analysing the role of luseogliflozin in type-2 diabetes. We undertook this meta-analysis to address this knowledge-gap.
    Methods: Electronic databases were searched for RCTs involving diabetes patients receiving luseogliflozin in intervention arm, and placebo/active comparator in control arm. Primary outcome was to evaluate changes in HbA1c. Secondary outcomes were to evaluate alterations in glucose, blood pressure, weight, lipids, and adverse events.
    Results: From initially screened 151 articles, data from 10 RCTs involving 1304 patients was analysed. Individuals receiving luseogliflozin 2.5 mg/d had a significantly lower HbA1c [MD -0.76% (95% CI: 1.01 to -0.51); P < 0.01; I
    Conclusion: Luseogliflozin has good glycaemic and non-glycaemic benefits similar to other SGLT2 inhibitors and is well tolerated.
    MeSH term(s) Humans ; Hypoglycemic Agents/therapeutic use ; Glycated Hemoglobin ; Diabetes Mellitus, Type 2/complications ; Glucose ; Blood Glucose
    Chemical Substances Hypoglycemic Agents ; Glycated Hemoglobin ; 1,5-anhydro-1-(5-(4-ethoxybenzyl)-2-methoxy-4-methylphenyl)-1-thioglucitol (C596HWF74Z) ; Glucose (IY9XDZ35W2) ; Blood Glucose
    Language English
    Publishing date 2023-03-13
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2273766-2
    ISSN 1878-0334 ; 1871-4021
    ISSN (online) 1878-0334
    ISSN 1871-4021
    DOI 10.1016/j.dsx.2023.102742
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Letter in response to the article: Comorbidities in COVID-19: Outcomes in hypertensive cohort and controversies with renin angiotensin system blockers (Singh et al.).

    Mahajan, Kunal / Gaur, Naresh

    Diabetes & metabolic syndrome

    2020  Volume 14, Issue 5, Page(s) 723–724

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; Renin-Angiotensin System ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-23
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 2273766-2
    ISSN 1878-0334 ; 1871-4021
    ISSN (online) 1878-0334
    ISSN 1871-4021
    DOI 10.1016/j.dsx.2020.05.029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Early de-escalation of DAPT after PCI: implications of the latest randomized trials in the COVID era.

    Mahajan, Kunal / Batra, Aditya

    Indian heart journal

    2020  Volume 72, Issue 3, Page(s) 209–211

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronary Artery Disease/complications ; Coronary Artery Disease/epidemiology ; Coronary Artery Disease/therapy ; Coronavirus Infections/complications ; Coronavirus Infections/epidemiology ; Drug-Eluting Stents ; Global Health ; Humans ; Morbidity/trends ; Pandemics ; Percutaneous Coronary Intervention/methods ; Platelet Aggregation Inhibitors/therapeutic use ; Pneumonia, Viral/complications ; Pneumonia, Viral/epidemiology ; Randomized Controlled Trials as Topic ; SARS-CoV-2 ; Treatment Outcome
    Chemical Substances Platelet Aggregation Inhibitors
    Keywords covid19
    Language English
    Publishing date 2020-05-23
    Publishing country India
    Document type Letter ; Review
    ZDB-ID 604366-5
    ISSN 2213-3763 ; 0019-4832
    ISSN (online) 2213-3763
    ISSN 0019-4832
    DOI 10.1016/j.ihj.2020.05.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 616: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Hemiazygous continuation of inferior vena cava draining into the coronary sinus via persistent left superior vena cava

    Jaikrit Bhutani / Aditya Batra / Mridul Doomra / Kunal Mahajan

    Monaldi Archives for Chest Disease (2022)

    a rare anomaly

    2022  

    Abstract: We present a case of left sided inferior vena cava with hemiazygous continuation draining into the coronary sinus via the left persistent superior vena cava. This was incidentally found in an individual referred to our centre for evaluation of ... ...

    Abstract We present a case of left sided inferior vena cava with hemiazygous continuation draining into the coronary sinus via the left persistent superior vena cava. This was incidentally found in an individual referred to our centre for evaluation of palpitations. These caval anomalies are rare, and are often associated with no clinical manifestations. However, it is necessary to recognize them during routine workup to avoid diagnostic and procedural pitfalls.
    Keywords venous system abnormalities ; congenital caval anomalies ; dilated coronary sinus ; Medicine ; R
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher PAGEPress Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Efficacy and safety of long-acting growth hormone in adult growth hormone deficiency: A systematic review and meta-analysis.

    Dutta, Deep / Mahajan, Kunal / Kumar, Manoj / Sharma, Meha

    Diabetes & metabolic syndrome

    2022  Volume 16, Issue 2, Page(s) 102421

    Abstract: Background & aims: No meta-analysis has analysed efficacy and safety of long-acting growth hormone (GH) therapy in adult GH deficiency. We undertook this meta-analysis to address this gap in knowledge METHODS: Electronic databases were searched for RCTs ...

    Abstract Background & aims: No meta-analysis has analysed efficacy and safety of long-acting growth hormone (GH) therapy in adult GH deficiency. We undertook this meta-analysis to address this gap in knowledge METHODS: Electronic databases were searched for RCTs involving adult GH deficiency patients receiving weekly long-acting GH as compared to daily GH/placebo controls. Primary outcome was to evaluate changes in body-composition parameters. Secondary outcomes were to evaluate alterations in glycaemia and adverse-events.
    Results: Data from 5 studies involving 648 patients were analysed (4 studies having daily GH as active controls; 1 study having placebo as passive controls). Over 24-34 weeks clinical use, patients receiving long-acting GH had comparable change in lean mass [MD-0.28 kg (95%CI: 0.94 - 0.38); P = 0.41; I
    Conclusion: Long-acting GH has comparable beneficial impact on body composition parameters in adult GH deficiency, is well tolerated without any increased adverse events.
    MeSH term(s) Adult ; Blood Glucose ; Body Composition ; Diabetes Mellitus/drug therapy ; Growth Hormone ; Human Growth Hormone/therapeutic use ; Humans
    Chemical Substances Blood Glucose ; Human Growth Hormone (12629-01-5) ; Growth Hormone (9002-72-6)
    Language English
    Publishing date 2022-02-08
    Publishing country Netherlands
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 2273766-2
    ISSN 1878-0334 ; 1871-4021
    ISSN (online) 1878-0334
    ISSN 1871-4021
    DOI 10.1016/j.dsx.2022.102421
    Database MEDical Literature Analysis and Retrieval System OnLINE

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