LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 96

Search options

  1. Article ; Online: Corrigendum to "MEGF6 prevents sepsis-induced acute lung injury in mice" [Int. Immunopharmacol. 123 (2023) 110727].

    Liang, Hui / Liu, Gaoli / Zeng, Wenhui / Fan, Qinglu / Nie, Zhihao / Hu, Haifeng / Zhang, Renquan / Xie, Songping

    International immunopharmacology

    2024  , Page(s) 111787

    Language English
    Publishing date 2024-04-18
    Publishing country Netherlands
    Document type Published Erratum
    ZDB-ID 2043785-7
    ISSN 1878-1705 ; 1567-5769
    ISSN (online) 1878-1705
    ISSN 1567-5769
    DOI 10.1016/j.intimp.2024.111787
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5408: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: CRISPR/Cas9 knockout of Ptgs2 promote apoptosis of hepatic stellate cells.

    Zhou, Hongyu / Wang, Yongzhao / Zhu, Gaoli / Yuan, Shuai / Liu, Mingliang / Chen, Yeqing / Han, Mingwei / Yang, Xuefeng

    Clinics and research in hepatology and gastroenterology

    2024  , Page(s) 102345

    Language English
    Publishing date 2024-04-19
    Publishing country France
    Document type Letter
    ZDB-ID 2594333-9
    ISSN 2210-741X ; 2210-7401
    ISSN (online) 2210-741X
    ISSN 2210-7401
    DOI 10.1016/j.clinre.2024.102345
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Two-Centimeter Single-Port Incision Minimizing Intercostal Nerve Damage Applied in Video-Assisted Thoracoscopic Surgery Segmentectomy for Pulmonary Ground Glass Nodules.

    Hu, Haifeng / Liu, Yanzhuo / Dong, Ping / Zhang, Shaowen / Liu, Gaoli / Mao, Zhangfan

    Journal of laparoendoscopic & advanced surgical techniques. Part A

    2023  Volume 33, Issue 7, Page(s) 648–653

    Abstract: Purposes: ...

    Abstract Purposes:
    MeSH term(s) Humans ; Thoracic Surgery, Video-Assisted/methods ; Pneumonectomy/methods ; Retrospective Studies ; Hypesthesia ; Intercostal Nerves ; Pain, Postoperative/prevention & control
    Language English
    Publishing date 2023-04-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1381909-4
    ISSN 1557-9034 ; 1092-6429
    ISSN (online) 1557-9034
    ISSN 1092-6429
    DOI 10.1089/lap.2022.0541
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3246: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Extracellular Circular RNAs Act as Novel First Messengers Mediating Cell Cross-Talk in Ischemic Cardiac Injury and Myocardial Remodeling.

    Li, Mengyang / Ding, Wei / Liu, Gaoli / Wang, Jianxun

    Journal of cardiovascular translational research

    2022  Volume 15, Issue 3, Page(s) 444–455

    Abstract: Myocardial infarction (MI) causes most of the mortality worldwide. Coronary obstruction-caused myocardial ischemic injury leads to permanent loss of the myocardium. Subsequent compensatory myocardial remodeling and heart failure would result in ... ...

    Abstract Myocardial infarction (MI) causes most of the mortality worldwide. Coronary obstruction-caused myocardial ischemic injury leads to permanent loss of the myocardium. Subsequent compensatory myocardial remodeling and heart failure would result in arrhythmia and even sudden death. The molecular mechanisms of these pathological processes remain to be thoroughly revealed. Circular RNAs (circRNAs) are special types of non-coding RNAs which can durably regulate gene expression and modulate cell fate. They had been reported to mediate ischemic myocardial injury and myocardial remodeling. circRNAs can be loaded into extracellular vesicles and released into extracellular space. More recently, it was uncovered that the extracellular circRNAs can regulate intercellular communications, similar to "first messengers." The cross-talk mediated by extracellular circRNAs had been demonstrated to play important roles in pathological processes. Here, we would like to review the modulation of extracellular circRNAs in ischemic myocardial injury and myocardial remodeling. We believe the extracellular circRNAs can bring new strategies of MI treatment.
    MeSH term(s) Extracellular Vesicles/metabolism ; Humans ; MicroRNAs/genetics ; Myocardial Infarction/metabolism ; Myocardium/pathology ; RNA, Circular/genetics
    Chemical Substances MicroRNAs ; RNA, Circular
    Language English
    Publishing date 2022-02-19
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2422411-X
    ISSN 1937-5395 ; 1937-5387
    ISSN (online) 1937-5395
    ISSN 1937-5387
    DOI 10.1007/s12265-022-10219-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Reticular Synthesis of Highly Crystalline Three-Dimensional Mesoporous Covalent-Organic Frameworks for Lipase Inclusion.

    Liu, Haoyu / Zhou, Yi / Guo, Jinbiao / Feng, Rui / Hu, Gaoli / Pang, Jiandong / Chen, Yao / Terasaki, Osamu / Bu, Xian-He

    Journal of the American Chemical Society

    2023  Volume 145, Issue 42, Page(s) 23227–23237

    Abstract: The synthesis and application of three-dimensional (3D) mesoporous covalent-organic frameworks (COFs) are still to be developed. Herein, two mesoporous 3D COFs with ... ...

    Abstract The synthesis and application of three-dimensional (3D) mesoporous covalent-organic frameworks (COFs) are still to be developed. Herein, two mesoporous 3D COFs with an
    Language English
    Publishing date 2023-10-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.3c07904
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 4' 55/32: Show issues
    Z 7.3: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: A Web-Based Prediction Model for Cancer-Specific Survival of Elderly Patients With Early Hepatocellular Carcinoma: A Study Based on SEER Database.

    He, Taiyu / Chen, Tianyao / Liu, Xiaozhu / Zhang, Biqiong / Yue, Song / Cao, Junyi / Zhang, Gaoli

    Frontiers in public health

    2022  Volume 9, Page(s) 789026

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Aged ; Carcinoma, Hepatocellular/therapy ; Humans ; Internet ; Liver Neoplasms/therapy ; Nomograms ; SEER Program
    Language English
    Publishing date 2022-01-13
    Publishing country Switzerland
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2021.789026
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Book ; Online: HrSegNet

    Li, Yongshang / Ma, Ronggui / Liu, Han / Cheng, Gaoli

    Real-time High-Resolution Neural Network with Semantic Guidance for Crack Segmentation

    2023  

    Abstract: Through extensive research on deep learning in recent years and its application in construction, crack detection has evolved rapidly from rough detection at the image-level and patch-level to fine-grained detection at the pixel-level, which better suits ... ...

    Abstract Through extensive research on deep learning in recent years and its application in construction, crack detection has evolved rapidly from rough detection at the image-level and patch-level to fine-grained detection at the pixel-level, which better suits the nature of this field. Despite numerous existing studies utilizing off-the-shelf deep learning models or enhancing them, these models are not always effective or efficient in real-world applications. In order to bridge this gap, we propose a High-resolution model with Semantic guidance, specifically designed for real-time crack segmentation, referred to as HrSegNet. Our model maintains high resolution throughout the entire process, as opposed to recovering from low-resolution features to high-resolution ones, thereby maximizing the preservation of crack details. Moreover, to enhance the context information, we use low-resolution semantic features to guide the reconstruction of high-resolution features. To ensure the efficiency of the algorithm, we design a simple yet effective method to control the computation cost of the entire model by controlling the capacity of high-resolution channels, while providing the model with extremely strong scalability. Extensive quantitative and qualitative evaluations demonstrate that our proposed HrSegNet has exceptional crack segmentation capabilities, and that maintaining high resolution and semantic guidance are crucial to the final prediction. Compared to state-of-the-art segmentation models, HrSegNet achieves the best trade-off between efficiency and effectiveness. Specifically, on the crack dataset CrackSeg9k, our fastest model HrSegNet-B16 achieves a speed of 182 FPS with 78.43% mIoU, while our most accurate model HrSegNet-B48 achieves 80.32% mIoU with an inference speed of 140.3 FPS.
    Keywords Computer Science - Computer Vision and Pattern Recognition
    Subject code 006
    Publishing date 2023-07-01
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article ; Online: Limonin, a novel AMPK activator, protects against LPS-induced acute lung injury.

    Liang, Hui / Liu, Gaoli / Fan, Qinglu / Nie, Zhihao / Xie, Songping / Zhang, Renquan

    International immunopharmacology

    2023  Volume 122, Page(s) 110678

    Abstract: AMP-activated protein kinase (AMPK) activation plays crucial roles in the treatment of many oxidative stress- and inflammation-induced diseases, including acute lung injury (ALI). Limonin is a naturally occurring tetracyclic triterpenoid extracted from ... ...

    Abstract AMP-activated protein kinase (AMPK) activation plays crucial roles in the treatment of many oxidative stress- and inflammation-induced diseases, including acute lung injury (ALI). Limonin is a naturally occurring tetracyclic triterpenoid extracted from the plants of Rutaceae and Meliaceae. Limonin also serves as an AMPK activator with anti-inflammatory and anti-oxidation effects. However, the potential beneficial effects of limonin on ALI and the possible mechanisms have never been disclosed till now. Here, the effects of limonin on lipopolysaccharide (LPS)-induced ALI in C57 BL/6 mice, plus bone marrow-derived macrophages (BMDM) stimulated with LPS to induce in vitro ALI model were investigated. Limonin significantly improved pulmonary function and alleviated lung pathological injury in LPS-induced mice. Meanwhile, limonin also markedly decreased inflammation and oxidative stress in lung tissues from LPS-treated mice. In vitro experiments also unveiled that limonin could decrease inflammation and oxidative stress in LPS-induced BMDM in a concentration-dependent manner. Mechanically, limonin could promote the activation of AMPKα and upregulate the expression of nuclear factor erythroid 2-related factor 2 (NRF2) in lung tissues and BMDM. Pharmacological inhibition of AMPKα by Compound C or AMPKα knockout could abolish the pulmonary protection from limonin during ALI. In conclusion, limonin mediates the activation of AMPKα/NRF2 pathway, providing an attractive therapeutic target for ALI in the future.
    MeSH term(s) Animals ; Mice ; Lipopolysaccharides/pharmacology ; AMP-Activated Protein Kinases/metabolism ; Limonins/pharmacology ; Limonins/therapeutic use ; NF-E2-Related Factor 2/metabolism ; Acute Lung Injury/chemically induced ; Acute Lung Injury/drug therapy ; Acute Lung Injury/metabolism ; Lung/pathology ; Inflammation/pathology ; Mice, Inbred C57BL
    Chemical Substances Lipopolysaccharides ; AMP-Activated Protein Kinases (EC 2.7.11.31) ; Limonins ; NF-E2-Related Factor 2
    Language English
    Publishing date 2023-07-21
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2043785-7
    ISSN 1878-1705 ; 1567-5769
    ISSN (online) 1878-1705
    ISSN 1567-5769
    DOI 10.1016/j.intimp.2023.110678
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5408: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Extremely Large 3D Cages in Metal-Organic Frameworks for Nucleic Acid Extraction.

    Hu, Gaoli / Liu, Qi / Zhou, Yi / Yan, Wei / Sun, Yuqing / Peng, Shuang / Zhao, Chengbin / Zhou, Xiang / Deng, Hexiang

    Journal of the American Chemical Society

    2023  Volume 145, Issue 24, Page(s) 13181–13194

    Abstract: Three-dimensional (3D) cages in the mesopore regime (2-50 nm) assembled from molecular building blocks are highly desirable in biological applications; however, their synthesis in crystalline form is quite challenging, as well as their structure ... ...

    Abstract Three-dimensional (3D) cages in the mesopore regime (2-50 nm) assembled from molecular building blocks are highly desirable in biological applications; however, their synthesis in crystalline form is quite challenging, as well as their structure characterization. Here, we report the synthesis of extremely large 3D cages in MOF crystals, with internal cage sizes of 6.9, and 8.5 nm in MOF-929; 9.3 and 11.4 nm in MOF-939, in cubic unit cells,
    Language English
    Publishing date 2023-05-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.3c02128
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 4' 55/32: Show issues
    Z 7.3: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article ; Online: Interleukin-17A pretreatment attenuates the anti-hepatitis B virus efficacy of interferon-alpha by reducing activation of the interferon-stimulated gene factor 3 transcriptional complex in hepatitis B virus-expressing HepG2 cells.

    Zhang, Jiaxuan / Liu, Kai / Zhang, Gaoli / Ling, Ning / Chen, Min

    Virology journal

    2022  Volume 19, Issue 1, Page(s) 28

    Abstract: Background: Some cytokine signaling pathways can interact with interferon (IFN)-α pathway and thus regulate cell responses to IFN-α. Levels of the pro-inflammatory cytokine interleukin-17A (IL-17A) were found to be elevated in both the peripheral blood ... ...

    Abstract Background: Some cytokine signaling pathways can interact with interferon (IFN)-α pathway and thus regulate cell responses to IFN-α. Levels of the pro-inflammatory cytokine interleukin-17A (IL-17A) were found to be elevated in both the peripheral blood and liver in chronic hepatitis B (CHB) patients. However, how IL-17A affects the anti-HBV activity of IFN-α remains unclear.
    Methods: The effects of IL-17A on anti-HBV activity of IFN-α were evaluated in HBV-expressing HepG2 cells (HepG2-HBV1.3) with IL-17A pretreatment and IFN-α stimulation. Culture supernatant levels of HBsAg, HBeAg, and HBV DNA, or intracellular expression of HBsAg and HBcAg were detected by ELISA, real-time quantitative PCR (RT-qPCR), or western blotting (WB). The expression of canonical IFN-α signaling pathway components, including the interferon-α/β receptor (IFNAR), Janus Kinase 1 (JAK1), Tyrosine Kinase 2 (TYK2), the Interferon Stimulated Gene Factor 3 complex (ISGF3) and IFN-stimulated genes (ISGs), was also examined by RT-qPCR, Immunofluorescence or WB. The effects of IL-17A were further investigated by the suppression of the IL-17A pathway with a TRAF6 inhibitor.
    Results: Compared to IFN-α stimulation alone, IL-17A pretreatment followed by IFN-α stimulation increased the levels of HBsAg, HBeAg, and HBV DNA, and decreased the levels of ISGF3 complex (phosphorylated (p)-signal transducer and activator of transcription (STAT1)/p-STAT2/IRF9) and antiviral-related ISGs (ISG15, ISG20 and Mx1). Interestingly, IL-17A pretreatment increased the expression of suppressor of cytokine signaling (SOCS) 1, SOCS3 and USP18, which were also the ISGs negatively regulating activity of ISGF3. Moreover, IFNAR1 protein expression declined more sharply in the group with IL-17A pretreatment than in the group with IFN-α stimulation alone. Blocking the IL-17A pathway reversed the effects of IL-17A on the IFN-α-induced activation of ISGF3 and anti-HBV efficacy.
    Conclusions: Our results demonstrate that IL-17A pretreatment could attenuate IFN-α-induced anti-HBV activity by upregulating negative regulators of the critical transcriptional ISGF3 complex. Thus, this might be a potential target for improving response to IFN-α therapy.
    MeSH term(s) Hep G2 Cells ; Hepatitis B Surface Antigens/metabolism ; Hepatitis B virus/genetics ; Humans ; Interferon-alpha/metabolism ; Interferon-alpha/pharmacology ; Interleukin-17 ; STAT1 Transcription Factor/genetics ; Ubiquitin Thiolesterase
    Chemical Substances Hepatitis B Surface Antigens ; Interferon-alpha ; Interleukin-17 ; STAT1 Transcription Factor ; USP18 protein, human (EC 3.4.19.12) ; Ubiquitin Thiolesterase (EC 3.4.19.12)
    Language English
    Publishing date 2022-02-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2160640-7
    ISSN 1743-422X ; 1743-422X
    ISSN (online) 1743-422X
    ISSN 1743-422X
    DOI 10.1186/s12985-022-01753-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top