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Article ; Online: -116A and K BCHE gene variants associated with obesity and hypertriglyceridemia in adolescents from Southern Brazil.

Chaves, Thaís Jannuzzi / Leite, Neiva / Milano, Gerusa Eisfeld / Milano, Gisele Eisfeld / Souza, Ricardo Lehtonen Rodrigues / Chautard-Freire-Maia, Eleidi Alice / Furtado-Alle, Lupe

Chemico-biological interactions

2013 Volume 203, Issue 1, Page(s) 341–343

Abstract: ... triglyceride levels. -116A (rs1126680) and K (A539T, 1615A, rs1803274) BCHE gene variants had previously been ... associated to BChE activity, weight and BMI variance in adults. The present study examined -116A and K ... 120 obese and 150 non-obese from Curitiba, Brazil). Both -116A and K variants were found ...

Abstract	Butyrylcholinesterase (BChE) has been associated to body mass index (BMI), weight, cholesterol and triglyceride levels. -116A (rs1126680) and K (A539T, 1615A, rs1803274) BCHE gene variants had previously been associated to BChE activity, weight and BMI variance in adults. The present study examined -116A and K variants, BChE activity, anthropometric and biochemical variables associated with obesity in adolescents (120 obese and 150 non-obese from Curitiba, Brazil). Both -116A and K variants were found with significantly lower frequencies (p<0.05) in obese adolescents when compared with non-obese adolescents and with the general population. Mean BChE activity (KU/L) was significantly higher in obese adolescents when compared with non-obese adolescents and with the general population. Analyzing only the obese adolescents, it was found that carriers of the -116A variant showed lower BChE activity and higher triglyceride levels than homozygotes for the usual allele. Indeed, obese carriers of the -116A variant had triglyceride levels considered high according to reference values for serum triglycerides in Brazilian adolescents. These results show: (1) a protective effect of -116A and K variants on juvenile obesity risk, suggesting a role for the BCHE gene on juvenile onset obesity different from that observed on adult onset obesity and (2) an association of the -116A variant with hypertriglyceridemia in obese adolescents probably because of its effect on lowering BChE activity and consequently diminishing the enzyme capability of maintaining homeostasis on lipid metabolism during the metabolic stress caused by obesity.
MeSH term(s)	Adolescent ; Age of Onset ; Brazil ; Butyrylcholinesterase/blood ; Butyrylcholinesterase/genetics ; Case-Control Studies ; Child ; Female ; Gene Frequency ; Genetic Variation ; Humans ; Hypertriglyceridemia/blood ; Hypertriglyceridemia/enzymology ; Hypertriglyceridemia/genetics ; Lipids/blood ; Male ; Obesity/blood ; Obesity/enzymology ; Obesity/genetics ; Risk Factors ; Triglycerides/blood
Chemical Substances	Lipids ; Triglycerides ; Butyrylcholinesterase (EC 3.1.1.8)
Language	English
Publishing date	2013-03-25
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218799-1
ISSN	1872-7786 ; 0009-2797
ISSN (online)	1872-7786
ISSN	0009-2797
DOI	10.1016/j.cbi.2012.09.006
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Article: −116A and K BCHE gene variants associated with obesity and hypertriglyceridemia in adolescents from Southern Brazil

Chaves, Thaís Jannuzzi / Leite, Neiva / Milano, Gerusa Eisfeld / Milano, Gisele Eisfeld / Souza, Ricardo Lehtonen Rodrigues / Chautard-Freire-Maia, Eleidi Alice / Furtado-Alle, Lupe

Chemico-biological interactions. 2013 Mar. 25, v. 203, no. 1

2013

Abstract: ... triglyceride levels. −116A (rs1126680) and K (A539T, 1615A, rs1803274) BCHE gene variants had previously been ... associated to BChE activity, weight and BMI variance in adults. The present study examined −116A and K ... 120 obese and 150 non-obese from Curitiba, Brazil). Both −116A and K variants were found ...

Abstract	Butyrylcholinesterase (BChE) has been associated to body mass index (BMI), weight, cholesterol and triglyceride levels. −116A (rs1126680) and K (A539T, 1615A, rs1803274) BCHE gene variants had previously been associated to BChE activity, weight and BMI variance in adults. The present study examined −116A and K variants, BChE activity, anthropometric and biochemical variables associated with obesity in adolescents (120 obese and 150 non-obese from Curitiba, Brazil). Both −116A and K variants were found with significantly lower frequencies (p<0.05) in obese adolescents when compared with non-obese adolescents and with the general population. Mean BChE activity (KU/L) was significantly higher in obese adolescents when compared with non-obese adolescents and with the general population. Analyzing only the obese adolescents, it was found that carriers of the −116A variant showed lower BChE activity and higher triglyceride levels than homozygotes for the usual allele. Indeed, obese carriers of the −116A variant had triglyceride levels considered high according to reference values for serum triglycerides in Brazilian adolescents. These results show: (1) a protective effect of −116A and K variants on juvenile obesity risk, suggesting a role for the BCHE gene on juvenile onset obesity different from that observed on adult onset obesity and (2) an association of the −116A variant with hypertriglyceridemia in obese adolescents probably because of its effect on lowering BChE activity and consequently diminishing the enzyme capability of maintaining homeostasis on lipid metabolism during the metabolic stress caused by obesity.
Keywords	adolescents ; adults ; alleles ; blood serum ; body mass index ; cholesterol ; homeostasis ; homozygosity ; hypertriglyceridemia ; lipid metabolism ; normal values ; obesity ; protective effect ; risk ; triacylglycerols ; variance ; Brazil
Language	English
Dates of publication	2013-0325
Size	p. 341-343.
Publishing place	Elsevier Ireland Ltd
Document type	Article
ZDB-ID	218799-1
ISSN	1872-7786 ; 0009-2797
ISSN (online)	1872-7786
ISSN	0009-2797
DOI	10.1016/j.cbi.2012.09.006
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Article ; Online: Immediate single-tooth replacement with acellular dermal matrix allogeneic bone on sloped platform-switching implants: A case series.

Barack, David / Rubinstein, Sergio / Milin, Kenneth / Wang, Yu / Neiva, Rodrigo

International journal of oral implantology (Berlin, Germany)

2021 Volume 14, Issue 2, Page(s) 213–222

Abstract: Achieving predictable success with implants in the aesthetic zone is essential for clinicians. Promoting marginal bone and stability of the gingival environment is key to obtaining a predictable aesthetic outcome. The present study aimed to describe a ... ...

Abstract	Achieving predictable success with implants in the aesthetic zone is essential for clinicians. Promoting marginal bone and stability of the gingival environment is key to obtaining a predictable aesthetic outcome. The present study aimed to describe a technique that combines a flapless approach to immediate extraction and placement of sloped implants, using an acellular dermal matrix to contain the coronal aspect of a deproteinised bovine bone mineral graft. This minimally invasive technique results in stable augmentation of soft tissue thickness to ensure predictable aesthetic results. A collection of case reports with a follow-up period of up to 45 months is presented to demonstrate the surgical technique. Clinical presentation showed relative stability of the soft tissue margins during the evaluation period.
MeSH term(s)	Acellular Dermis ; Animals ; Cattle ; Dental Implants ; Esthetics, Dental ; Hematopoietic Stem Cell Transplantation ; Humans ; Retrospective Studies
Chemical Substances	Dental Implants
Language	English
Publishing date	2021-05-15
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2968002-5
ISSN	2631-6439 ; 2631-6420
ISSN (online)	2631-6439
ISSN	2631-6420
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Article: Effects of Osseodensification on Immediate Implant Placement: Retrospective Analysis of 211 Implants.

de Carvalho Formiga, Márcio / Grzech-Leśniak, Kinga / Moraschini, Vittorio / Shibli, Jamil Awad / Neiva, Rodrigo

Materials (Basel, Switzerland)

2022 Volume 15, Issue 10

Abstract: Osseodensification is a new method of bone instrumentation for dental implant placement that preserves bulk bone and increases primary implant stability, and may accelerate the implant rehabilitation treatment period and provide higher success and ... ...

Abstract	Osseodensification is a new method of bone instrumentation for dental implant placement that preserves bulk bone and increases primary implant stability, and may accelerate the implant rehabilitation treatment period and provide higher success and survival rates than conventional methods. The aim of this retrospective study was to evaluate and discuss results obtained on immediate implant placement with immediate and delayed loading protocols under Osseodensification bone instrumentation. This study included private practice patients that required dental implant rehabilitation, between February 2017 and October 2019. All implants were placed under Osseodensification and had to be in function for at least 12 months to be included on the study. A total of 211 implants were included in the study, with a 98.1% total survival rate (97.9% in the maxilla and 98.5% in the mandible). For immediate implants with immediate load, 99.2% survival rate was achieved, and 100% survival rate for immediate implant placement without immediate load cases. A total of four implants were lost during this period, and all of them were lost within two months after placement. Within the limitations of this study, it can be concluded that Osseodensification bone instrumentation provided similar or better results on survival rates than conventional bone instrumentation.
Language	English
Publishing date	2022-05-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma15103539
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Article ; Online: Scales to graduate oral mucositis: What are the limitations?

de Freitas Neiva Lessa, Adriele / Meirelles, Daniela Pereira / Do Couto, Aline Maria / Duarte Da Silva, Karine / De Aguiar, Maria Cássia Ferreira

Oral oncology

2023 Volume 144, Page(s) 106489

Abstract: Oral mucositis is a common acute complication of a head and neck squamous cell carcinoma treatment. Multiple scales can be used to diagnose and grade this lesion, but they all have some limitation regarding this group of patients. Most of these issues ... ...

Abstract	Oral mucositis is a common acute complication of a head and neck squamous cell carcinoma treatment. Multiple scales can be used to diagnose and grade this lesion, but they all have some limitation regarding this group of patients. Most of these issues are associated with the hardness to differentiate signs and symptoms from oral mucositis vs. the inherent neoplasm. This study highlights the importance of a specifically developed scale for patients with head and neck squamous cell carcinoma.
MeSH term(s)	Humans ; Squamous Cell Carcinoma of Head and Neck/complications ; Head and Neck Neoplasms/diagnosis ; Head and Neck Neoplasms/complications ; Carcinoma, Squamous Cell/pathology ; Stomatitis/diagnosis ; Stomatitis/etiology ; Mucositis
Language	English
Publishing date	2023-07-06
Publishing country	England
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	1120465-5
ISSN	1879-0593 ; 0964-1955 ; 1368-8375
ISSN (online)	1879-0593
ISSN	0964-1955 ; 1368-8375
DOI	10.1016/j.oraloncology.2023.106489
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Zs.A 4869: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.A 456: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Volatile Organic Compounds from Offspring of Stingless Bee Sacrificed in Hygienic Behavior Test.

Neiva de Jesus, Jossimara / Ribeiro Mesquita, Paulo Roberto / Barbosa da Silva, Kelly / de Medeiros Rodrigues, Frederico / Lopes de Carvalho, Carlos Alfredo / Gomes da Costa, João / Lima Aguiar, Cândida Maria

Chemistry & biodiversity

2024 Volume 21, Issue 3, Page(s) e202301641

Abstract: This study shows the profile of volatile organic compounds (VOCs) from pupae and larvae of Melipona quadrifasciata anthidioides Lepeletier subjected to three death induction techniques for hygienic behavior (HB) studies: freezing in liquid nitrogen (LN2), ...

Abstract	This study shows the profile of volatile organic compounds (VOCs) from pupae and larvae of Melipona quadrifasciata anthidioides Lepeletier subjected to three death induction techniques for hygienic behavior (HB) studies: freezing in liquid nitrogen (LN2), freezing in a freezer (FRZ) and piercing of offspring with an entomological pin (PIN). The VOCs from larvae and pupae were obtained through headspace solid-phase microextraction and characterized using gas chromatography coupled to mass spectrometry. In addition, an HB test was performed on the colonies. The main classes of VOCs were hydrocarbons, terpenes and alcohols. Multivariate analysis was applied and showed that there was a separation in the compound profiles between the different treatments. The HB test in the colonies showed that 24 hours after the application of the techniques, the bees removed more dead larvae in LN2 treatment (83.5 %), while after 48 hours more larvae were removed in the LN2 and FRZ treatments (92.3 %). When compared to pupae removal, larvae removal was significantly faster in LN2.
MeSH term(s)	Bees ; Animals ; Volatile Organic Compounds/analysis ; Behavior Rating Scale ; Gas Chromatography-Mass Spectrometry ; Larva ; Mass Spectrometry ; Pupa ; Solid Phase Microextraction
Chemical Substances	Volatile Organic Compounds
Language	English
Publishing date	2024-02-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2139001-0
ISSN	1612-1880 ; 1612-1872
ISSN (online)	1612-1880
ISSN	1612-1872
DOI	10.1002/cbdv.202301641
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Article ; Online: WOMEN ACTIVISTS IN THE FIELD OF HUMAN RIGHTS AND BUSINESS

Amanda Romero Medina / Júlia Mello Neiva

Sur: International Journal on Human Rights, Vol 17, Iss 30, Pp 227-

2020 Volume 237

Abstract: ... on the impacts of business on human rights and the rights of nature. Júlia Neiva, from Brazil, worked for seven ...

Abstract	This article presents the views of two Latin American women who are Regional Representatives of the Business & Human Rights Resource Centre (or CIEDH for its acronym in Spanish) in the context of the debate on the impacts of business on human rights and the rights of nature. Júlia Neiva, from Brazil, worked for seven years at CIEDH on Brazil, Portugal and Portuguese-speaking African countries and then, returned to Conectas. Amanda Romero has worked as the South America Representative for CIEDH for nine years and counting. Raising more questions than answers, they make it clear that the business and human rights field is developing rapidly and more collective efforts are needed to overcome the serious problems that the communities face.
Keywords	civil society ; human rights ; businesses ; full compensation ; Law ; K ; International relations ; JZ2-6530 ; Social sciences (General) ; H1-99
Language	English
Publishing date	2020-08-01T00:00:00Z
Publisher	Associação Direitos Humanos em Rede
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Bark residues valorization potential regarding antioxidant and antimicrobial extracts

Neiva, Duarte M / Luís, Ângelo / Gominho, Jorge / Domingues, Fernanda / Duarte, Ana P / Pereira, Helena

Wood science and technology. 2020 May, v. 54, no. 3

2020

Abstract: ... mg/mL), while Ad presented the best results among polar extracts regarding bacteria (0.16 mg/mL for K ...

Abstract	Bark residual side streams from industries (Eucalyptus globulus—Eg and Picea abies—Pa) or from control of invasive species in Mediterranean countries (Acacia melanoxylon—Am and Acacia dealbata—Ad) are burned for energy production, although their high content of extractable compounds points to a possible valorization as sources of phytochemicals with antioxidant and antimicrobial activities. Non-polar and polar extracts were obtained, and their phenolic contents, antioxidant activity, antiquorum sensing and antimicrobial potential against several human pathogenic microbes (nine bacteria and two yeasts) were determined. Extraction yield ranged from 0.5 to 37% of barks dry weight varying with species and solvent used, and both water and ethanol extracts presented strong or very strong scavenging antioxidant ability. Eg and Pa non-polar extracts showed the lowest minimum inhibitory concentration for gram-positive bacteria (0.04–1.25 mg/mL), while Ad presented the best results among polar extracts regarding bacteria (0.16 mg/mL for K. pneumoniae) and yeast strains (0.02–0.04 mg/mL). Non-polar extracts showed great response against both Candida species (MIC = 0.04–0.63 mg/mL). Each extract had different antimicrobial activity showing that species and solvents can be used to tailor compounds to target specific pathogens. Information regarding these bioactive extracts from residual forest side streams can provide possible utilization routes for natural compounds recovery prior to combustion.
Keywords	Acacia ; Candida ; Eucalyptus ; Picea ; antimicrobial properties ; antioxidant activity ; antioxidants ; bark ; combustion ; energy ; ethanol ; invasive species ; minimum inhibitory concentration ; pathogens ; phytochemicals ; residual forests ; solvents ; technology ; wood ; yeasts
Language	English
Dates of publication	2020-05
Size	p. 559-585.
Publishing place	Springer Berlin Heidelberg
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	241313-9
ISSN	0043-7719
ISSN	0043-7719
DOI	10.1007/s00226-020-01168-3
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Article ; Online: Quantified analysis of facial movement: A reference for clinical applications.

Sarhan, François-Régis / Olivetto, Matthieu / Ben Mansour, Khalil / Neiva, Cécilia / Colin, Emilien / Choteau, Baptiste / Marie, Jean-Paul / Testelin, Sylvie / Marin, Frédéric / Dakpé, Stéphanie

Clinical anatomy (New York, N.Y.)

2023 Volume 36, Issue 3, Page(s) 492–502

Abstract: Most techniques for evaluating unilateral impairments in facial movement yield subjective measurements. The objective of the present study was to define a reference dataset and develop a visualization tool for clinical assessments. In this prospective ... ...

Abstract	Most techniques for evaluating unilateral impairments in facial movement yield subjective measurements. The objective of the present study was to define a reference dataset and develop a visualization tool for clinical assessments. In this prospective study, a motion capture system was used to quantify facial movements in 30 healthy adults and 2 patients. We analyzed the displacements of 105 reflective markers placed on the participant's face during five movements (M1-M5). For each marker, the primary endpoint was the maximum amplitude of displacement from the static position (M0) in an analysis of variance. The measurement precision was 0.1 mm. Significant displacements of markers were identified for M1-M5, and displacement patterns were defined. The patients and age-matched healthy participants were compared with regard to the amplitude of displacement. We created a new type of radar plot to visually represent the diagnosis and facilitate effective communication between medical professionals. In proof-of-concept experiments, we collected quantitative data on patients with facial palsy and created a patient-specific radar plot. Our new protocol for clinical facial motion capture ("quantified analysis of facial movement," QAFM) was accurate and should thus facilitate the long-term clinical follow-up of patients with facial palsy. To take account of the limitations affecting the comparison with the healthy side, we created a dataset of healthy facial movements; our method might therefore be applicable to other conditions in which movements on one or both sides of the face are impaired. The patient-specific radar plot enables clinicians to read and understand the results rapidly.
MeSH term(s)	Adult ; Humans ; Facial Paralysis/diagnosis ; Facial Muscles ; Prospective Studies ; Movement ; Healthy Volunteers ; Facial Expression
Language	English
Publishing date	2023-01-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	1025505-9
ISSN	1098-2353 ; 0897-3806
ISSN (online)	1098-2353
ISSN	0897-3806
DOI	10.1002/ca.23999
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Article: Evaluation of machine learning algorithms in the prediction of hydraulic conductivity and soil moisture at the Brazilian Savannah

Veloso, Mariana Faria / Rodrigues, Lineu Neiva / Filho, Elpídio Inácio Fernandes

Geoderma regional. 2022 Sept., v. 30

2022

Abstract: ... Random Forest (RF), Support Vector Regression (SVR), and K Nearest Neighbors (KNN). Four combinations ...

Abstract	The Brazilian Savannah (Cerrado biome) is the the main agricultural region in Brazil. The Cerrado has experienced a growing intensification of agriculture and an increase in disputes over water use, highlighting the need to establish strategies to reduce the water withdrawn from waterbodies, mainly through irrigation. The lack of data at a proper scale on soil hydraulic properties in the region brings uncertainties to the process of water resources management. Obtaining these data, however, is difficult and costly, thus, opening the opportunity for the use of Pedotransfer Functions (PTFs). Various methods can be used to obtain PTFs, but currently, machine learning techniques are gaining strength. In this context, it becomes important to evaluate the quality of machine learning algorithms in predicting PTFs. The present work aimed to evaluate the performance of machine learning algorithms in the prediction of saturated soil hydraulic conductivity (Ks) and soil moisture at tensions of 0, 6, 10, 33, 100, and 1500 kPa for the Cerrado Biome. Four machine learning algorithms were tested: Multiple Adaptive Regression Splines (MARS), Random Forest (RF), Support Vector Regression (SVR), and K Nearest Neighbors (KNN). Four combinations of soil data were evaluated and the predictor variables used in each set were different. In set A1, the following variables were used: sand (Sa), silt (Si), and clay (Cl) contents; in set A2: Sa, Si, Cl, and bulk density (BD); in set A3: Sa, Si, Cl, BD, particle density (Dp), total porosity (Pt), microporosity (Micro), and macroporosity (Macro); and in set A4: Sa, Si, Cl, BD, Dp, Pt, Micro, Macro, soil moisture at field capacity (θ₁₀), and soil moisture at permanent wilting point (θ₁₅₀₀). The set A4 along with the RF and SVR models had the best performances in the prediction of Ks. As for soil moisture, the RF, SVR, and MARS models showed the best performances with low RMSE and ME values, and R² above 0.8 using predictor sets A3 and A4.
Keywords	bulk density ; cerrado ; clay ; ecosystems ; field capacity ; hydraulic conductivity ; irrigation ; porosity ; prediction ; regression analysis ; sand ; silt ; soil water ; surface water ; Brazil
Language	English
Dates of publication	2022-09
Publishing place	Elsevier B.V.
Document type	Article
ISSN	2352-0094
DOI	10.1016/j.geodrs.2022.e00569
Database	NAL-Catalogue (AGRICOLA)

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