Article ; Online: Effects of Vitamin D Supplementation on Telomere Length: An Analysis of Data from the Randomised Controlled D-Health Trial.
The journal of nutrition, health & aging
2023 Volume 27, Issue 8, Page(s) 609–616
Abstract: Objectives: Observational studies have suggested that a higher 25-hydroxyvitamin D concentration ... trial of monthly vitamin D (the D-Health Trial) for the prevention of all-cause mortality, conducted ... from 2014 to 2020, to assess the effect of vitamin D supplementation on telomere length (measured ...
| Abstract | Objectives: Observational studies have suggested that a higher 25-hydroxyvitamin D concentration may be associated with longer telomere length; however, this has not been investigated in randomised controlled trials. We conducted an ancillary study within a randomised, double-blind, placebo-controlled trial of monthly vitamin D (the D-Health Trial) for the prevention of all-cause mortality, conducted from 2014 to 2020, to assess the effect of vitamin D supplementation on telomere length (measured as the telomere to single copy gene (T/S) ratio). Design, setting, participants, and intervention: Participants were Australians aged 60-84 years and we randomly selected 1,519 D-Health participants (vitamin D: n=744; placebo: n=775) for this analysis. We used quantitative polymerase chain reaction to measure the relative telomere length (T/S ratio) at 4 or 5 years after randomisation. We compared the mean T/S ratio between the vitamin D and placebo groups to assess the effect of vitamin D supplementation on relative telomere length, using a linear regression model with adjustment for age, sex, and state which were used to stratify the randomisation. Results: The mean T/S ratio was 0.70 for both groups (standard deviation 0.18 and 0.16 for the vitamin D and placebo groups respectively). The adjusted mean difference (vitamin D minus placebo) was -0.001 (95% CI -0.02 to 0.02). There was no effect modification by age, sex, body mass index, or predicted baseline 25-hydroxyvitamin D concentration. Conclusion: In conclusion, routinely supplementing older adults, who are largely vitamin D replete, with monthly doses of vitamin D is unlikely to influence telomere length. |
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| MeSH term(s) | Humans ; Aged ; Australia ; Vitamins/pharmacology ; Vitamins/therapeutic use ; Vitamin D ; Calcifediol ; Telomere ; Dietary Supplements ; Randomized Controlled Trials as Topic |
| Chemical Substances | Vitamins ; Vitamin D (1406-16-2) ; Calcifediol (P6YZ13C99Q) |
| Language | English |
| Publishing date | 2023-09-12 |
| Publishing country | France |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2081921-3 |
| ISSN | 1760-4788 ; 1279-7707 |
| ISSN (online) | 1760-4788 |
| ISSN | 1279-7707 |
| DOI | 10.1007/s12603-023-1948-3 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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