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  1. Book ; Online: Imagem, Informação e Memória

    Manini, Miriam Paula / Oliveira, Eliane Braga de / Gomes, Ana Lucia de Abreu

    abordagens acerca da preservação do audiovisual, do cinema e da fotografia

    2022  

    Keywords GL ; Ciência da informação ; Recursos audiovisuais - Preservação ; Fotografia ; Cinema ; Memória na arte ; Patrimônio cultural - Proteção
    Language Portuguese
    Size 1 electronic resource (258 pages)
    Publisher Editora Oficina Universitária
    Publishing place Marília, São Paulo, Brazil
    Document type Book ; Online
    Note Portuguese
    HBZ-ID HT030377411
    ISBN 9786559542710 ; 6559542718
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Unveiling the Central Regulation of Pubertal Development.

    Abreu, Ana Paula

    The Journal of clinical endocrinology and metabolism

    2023  Volume 109, Issue 3, Page(s) e1307–e1308

    MeSH term(s) Humans ; Prevalence ; Puberty/physiology ; Puberty, Delayed/etiology ; Receptor, Melanocortin, Type 3
    Chemical Substances MC3R protein, human ; Receptor, Melanocortin, Type 3
    Language English
    Publishing date 2023-08-16
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgad486
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.134: Show issues Location:
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  3. Article ; Online: Hypothalamic and Pituitary Dysfunction After Extensive Brain Surgery: There Is Thirst for More Knowledge.

    Galbiati, Francesca / Stamatiades, George A / Bi, Wenya L / Abreu, Ana Paula

    JCEM case reports

    2023  Volume 1, Issue 6, Page(s) luad137

    Abstract: Craniopharyngiomas are tumors originating from the infundibular stalk, extending to the parasellar and suprasellar region, thereby conferring multiple risks of this region. In particular, hypothalamic and pituitary damage related to its natural history ... ...

    Abstract Craniopharyngiomas are tumors originating from the infundibular stalk, extending to the parasellar and suprasellar region, thereby conferring multiple risks of this region. In particular, hypothalamic and pituitary damage related to its natural history as well as treatment effects of craniopharyngiomas substantially affect life expectancy and quality of life. Here, we describe an adult patient presenting with polyuria, memory, and visual field impairment secondary to concurrent craniopharyngioma and intraventricular glioma. He was treated with surgical resection with postoperative course notable for hypothalamic-pituitary dysfunction, including central hypothyroidism, central adrenal insufficiency, arginine vasopressin deficiency (AVP-D, formerly diabetes insipidus) with loss of sense of thirst, and hypothalamic hypothermia. The adipsia, combined with memory dysfunction, challenged the management of constant fluctuations in his sodium (129-168 mEq/L), with ultimate treatment through vasopressin repletion, fixed fluid intake, strict urine output monitoring, and close counseling of the patient and his caregiver. This case exemplifies the complexity of the endocrine care of patients with craniopharyngiomas and highlights the need for step-wise algorithms in the treatment of hypothalamic deficiencies such as adipsia.
    Language English
    Publishing date 2023-11-16
    Publishing country England
    Document type Case Reports
    ISSN 2755-1520
    ISSN (online) 2755-1520
    DOI 10.1210/jcemcr/luad137
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Genetics of pubertal timing.

    Mancini, Alessandra / Magnotto, John C / Abreu, Ana Paula

    Best practice & research. Clinical endocrinology & metabolism

    2022  Volume 36, Issue 1, Page(s) 101618

    Abstract: Puberty marks the end of childhood and is a period when individuals undergo physiological and psychological changes to achieve sexual maturation and fertility. The onset of puberty is first detected as an increase in pulsatile secretion of gonadotropin- ... ...

    Abstract Puberty marks the end of childhood and is a period when individuals undergo physiological and psychological changes to achieve sexual maturation and fertility. The onset of puberty is first detected as an increase in pulsatile secretion of gonadotropin-releasing hormone (GnRH). Pubertal onset is regulated by genetic, nutritional, environmental, and socio-economic factors. Disturbances affecting pubertal timing result in adverse health conditions later in life. Human genetic studies show that around 50-80% of the variation in pubertal onset is genetically determined. The genetic control of pubertal timing has been a field of active investigation in attempt to better understand the neuroendocrine control of this relevant period of life. Large populational studies and patient cohort-based studies have provided insights into the genetic regulation of pubertal onset. In this review, we discuss these discoveries and discuss potential mechanisms for how implicated genes may affect pubertal timing.
    MeSH term(s) Gonadotropin-Releasing Hormone/genetics ; Humans ; Puberty/genetics ; Puberty, Delayed/genetics ; Sexual Maturation/genetics
    Chemical Substances Gonadotropin-Releasing Hormone (33515-09-2)
    Language English
    Publishing date 2022-02-05
    Publishing country Netherlands
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2052339-7
    ISSN 1878-1594 ; 1532-1908 ; 1521-690X
    ISSN (online) 1878-1594 ; 1532-1908
    ISSN 1521-690X
    DOI 10.1016/j.beem.2022.101618
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Se 1075: Show issues Location:
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  5. Article ; Online: Acesso equitativo a vacinas

    Ariane de Jesus Lopes de Abreu / Ana Paula Sayuri Sato / Eliseu Alves Waldman

    Saúde e Sociedade, Vol 32, Iss

    lições aprendidas e perspectivas futuras

    2023  Volume 3

    Abstract: Resumo A vacinação é um componente essencial da atenção primária à saúde e do enfrentamento de emergências em saúde. No entanto, apesar do progresso ocorrido nas últimas décadas, persistem importantes barreiras que resultam na queda de coberturas e ... ...

    Abstract Resumo A vacinação é um componente essencial da atenção primária à saúde e do enfrentamento de emergências em saúde. No entanto, apesar do progresso ocorrido nas últimas décadas, persistem importantes barreiras que resultam na queda de coberturas e disparidades entre os países no acesso a novas vacinas. Neste cenário, a Organização Mundial da Saúde (OMS) lançou, em 2020, a Agenda de Imunização para o decênio 2021-2030 (AI2030). Este artigo tem o objetivo de debater os principais fatores que afetam o acesso às vacinas e as estratégias para promoção da equidade no acesso a elas a nível global e nacional. Tais fatores são multisetoriais e precisam ser considerados em ambos os níveis, destacando-se as barreiras financeiras e geográficas, os desafios de infraestrutura, fatores socioeconômicos e culturais, políticas públicas e governança. O texto aponta a necessidade de remodelação da arquitetura global das cadeias produtivas e dos centros de pesquisa e inovação, criando e/ou fortalecendo as existentes em países de baixa e média renda. Além disso, é necessário estabelecer novos mecanismos e modelos de produção e comercialização de vacinas. As estratégias adotadas para acesso a vacinas e outras tecnologias em saúde estão no centro do debate da agenda de saúde global.
    Keywords Equidade ; Vacina ; Acesso a fármacos essenciais e tecnologias de saúde ; Saúde Global ; Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher Universidade de São Paulo
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  6. Article ; Online: An Approach for Engineering Peptides for Competitive Inhibition of the SARS-COV-2 Spike Protein.

    de Abreu, Ana Paula / Carvalho, Frederico Chaves / Mariano, Diego / Bastos, Luana Luiza / Silva, Juliana Rodrigues Pereira / de Oliveira, Leandro Morais / de Melo-Minardi, Raquel C / Sabino, Adriano de Paula

    Molecules (Basel, Switzerland)

    2024  Volume 29, Issue 7

    Abstract: SARS-CoV-2 is the virus responsible for a respiratory disease called COVID-19 that devastated global public health. Since 2020, there has been an intense effort by the scientific community to develop safe and effective prophylactic and therapeutic agents ...

    Abstract SARS-CoV-2 is the virus responsible for a respiratory disease called COVID-19 that devastated global public health. Since 2020, there has been an intense effort by the scientific community to develop safe and effective prophylactic and therapeutic agents against this disease. In this context, peptides have emerged as an alternative for inhibiting the causative agent. However, designing peptides that bind efficiently is still an open challenge. Here, we show an algorithm for peptide engineering. Our strategy consists of starting with a peptide whose structure is similar to the interaction region of the human ACE2 protein with the SPIKE protein, which is important for SARS-COV-2 infection. Our methodology is based on a genetic algorithm performing systematic steps of random mutation, protein-peptide docking (using the PyRosetta library) and selecting the best-optimized peptides based on the contacts made at the peptide-protein interface. We performed three case studies to evaluate the tool parameters and compared our results with proposals presented in the literature. Additionally, we performed molecular dynamics (MD) simulations (three systems, 200 ns each) to probe whether our suggested peptides could interact with the spike protein. Our results suggest that our methodology could be a good strategy for designing peptides.
    MeSH term(s) Humans ; Spike Glycoprotein, Coronavirus ; COVID-19 ; SARS-CoV-2 ; Peptides/pharmacology
    Chemical Substances spike protein, SARS-CoV-2 ; Spike Glycoprotein, Coronavirus ; Peptides
    Language English
    Publishing date 2024-04-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules29071577
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  7. Article: Current Progress and Future Perspectives on the Use of Bacillus clausii

    Ghelardi, Emilia / Abreu Y Abreu, Ana Teresa / Marzet, Christian Boggio / Álvarez Calatayud, Guillermo / Perez, Marcos / Moschione Castro, Ana Paula

    Microorganisms

    2022  Volume 10, Issue 6

    Abstract: Bacillus clausii is a probiotic that benefits human health. Its key characteristics include the ability to form spores; the resulting tolerance to heat, acid, and salt ensures safe passage through the human gastrointestinal tract with no loss of cells. ... ...

    Abstract Bacillus clausii is a probiotic that benefits human health. Its key characteristics include the ability to form spores; the resulting tolerance to heat, acid, and salt ensures safe passage through the human gastrointestinal tract with no loss of cells. Although B. clausii has been widely used for many decades, the beneficial properties of other probiotics, such as Lactobacillus spp. and Bifidobacterium spp., are better disseminated in the literature. In this review, we summarize the physiological, antimicrobial, and immunomodulatory properties of probiotic B. clausii strains. We also describe findings from studies that have investigated B. clausii probiotics from the perspective of quality and safety. We highlight innovative properties based on biochemical investigations of non-probiotic strains of B. clausii, revealing that B. clausii may have further health benefits in other therapeutic areas.
    Language English
    Publishing date 2022-06-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms10061246
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Hydrogen peroxide enhances the efficacy of photodynamic therapy against

    Viana de Sousa, Tábata / Carolina Jordão, Cláudia / Augusto Abreu-Pereira, César / Gorayb Pereira, Ana Luiza / Barbugli, Paula Aboud / Klein, Marlise Inêz / Pavarina, Ana Claudia

    Biofouling

    2023  Volume 39, Issue 1, Page(s) 94–109

    Abstract: The present study aimed to evaluate the effectiveness of hydrogen peroxide ( ... ...

    Abstract The present study aimed to evaluate the effectiveness of hydrogen peroxide (H
    MeSH term(s) Candida albicans ; Hydrogen Peroxide/pharmacology ; Photosensitizing Agents/pharmacology ; Biofilms ; Photochemotherapy/methods ; Anti-Infective Agents
    Chemical Substances Hydrogen Peroxide (BBX060AN9V) ; Photosensitizing Agents ; Anti-Infective Agents
    Language English
    Publishing date 2023-03-14
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1029-2454
    ISSN (online) 1029-2454
    DOI 10.1080/08927014.2023.2189011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Randomized Double-Blind Placebo-Controlled Study of Salivary Substitute with Enzymatic System for Xerostomia in Patients Irradiated in Head and Neck Region.

    Porangaba, Letícia Pacheco / de Melo Garcia, Flávio / Rabelo, Ana Paula Alvarenga Antonio / Andrade, Amanda Puche / de Abreu Alves, Fabio / Pellizzon, Antonio Cássio Assis / Jaguar, Graziella Chagas

    Current oncology (Toronto, Ont.)

    2024  Volume 31, Issue 2, Page(s) 1102–1112

    Abstract: This study aims to compare whether the use of a salivary substitute including an enzymatic system clinically reduces the intensity of xerostomia, as well as exploring the impact that this has on the quality of life, in patients who had received ... ...

    Abstract This study aims to compare whether the use of a salivary substitute including an enzymatic system clinically reduces the intensity of xerostomia, as well as exploring the impact that this has on the quality of life, in patients who had received radiotherapy in the head and neck (HNC) region. Forty patients who had completed radiotherapy treatment within 6 months to 1 year previously were allocated into an Enzymatic Spray group (
    MeSH term(s) Humans ; Head and Neck Neoplasms/radiotherapy ; Quality of Life ; Saliva ; Surveys and Questionnaires ; Xerostomia/etiology ; Xerostomia/therapy
    Language English
    Publishing date 2024-02-18
    Publishing country Switzerland
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 1236972-x
    ISSN 1718-7729 ; 1198-0052
    ISSN (online) 1718-7729
    ISSN 1198-0052
    DOI 10.3390/curroncol31020082
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4305: Show issues Location:
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  10. Article ; Online: UPLC-QTOF-MS

    Santos, Glauber Batista Moreira / de Abreu, Fernando Antônio Pinto / da Silva, Gisele Silvestre / Guedes, Jhonyson Arruda Carvalho / Lira, Sandra Machado / Dionísio, Ana Paula / Pontes, Dorasilvia Ferreira / Zocolo, Guilherme Julião

    Food research international (Ottawa, Ont.)

    2024  Volume 178, Page(s) 113957

    Abstract: The search for knowledge related to the Pitaya (Hylocereus polyrhizus [F.A.C. Weber] Britton & Rose, family Cactaceae) is commonly due to its beneficial health properties e aesthetic values. But process to obtain pitaya pulp is a first and important step ...

    Abstract The search for knowledge related to the Pitaya (Hylocereus polyrhizus [F.A.C. Weber] Britton & Rose, family Cactaceae) is commonly due to its beneficial health properties e aesthetic values. But process to obtain pitaya pulp is a first and important step in providing information for the subsequent use of this fruit as colorant, for example. Therefore, the effects of the pulping process on the metabolomic and chemometric profile of non-volatile compounds of pitaya were assessed for the first time. The differences in metabolic fingerprints using UPLC-QTOF-MS
    MeSH term(s) Chemometrics ; Chromatography, High Pressure Liquid ; Cactaceae/chemistry ; Ascorbic Acid/metabolism
    Chemical Substances Ascorbic Acid (PQ6CK8PD0R)
    Language English
    Publishing date 2024-01-03
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 1111695-x
    ISSN 1873-7145 ; 0963-9969
    ISSN (online) 1873-7145
    ISSN 0963-9969
    DOI 10.1016/j.foodres.2024.113957
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 2972: Show issues

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