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  1. Book ; Online ; E-Book: Offene Hernienchirurgie

    Dietz, Ulrich A. / Beldi, Guido / Fortelny, René H. / Wiegering, Armin

    2021  

    Author's details Ulrich A. Dietz, Guido Beldi, René H. Fortelny, Armin Wiegering (Hrsg.)
    Keywords Electronic books
    Language German
    Size 1 Online-Ressource (XX, 315 Seiten), Illustrationen, Diagramme
    Publisher Springer
    Publishing place Berlin
    Publishing country Germany
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020902588
    ISBN 978-3-662-61348-1 ; 9783662613474 ; 3-662-61348-4 ; 3662613476
    DOI 10.1007/978-3-662-61348-1
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Infectious Disease in the Workplace: Quantifying Uncertainty in Transmission.

    Hamley, Jonathan I D / Beldi, Guido / Sánchez-Taltavull, Daniel

    Bulletin of mathematical biology

    2024  Volume 86, Issue 3, Page(s) 27

    Abstract: Understanding disease transmission in the workplace is essential for protecting workers. To model disease outbreaks, the small populations in many workplaces require that stochastic effects are considered, which results in higher uncertainty. The aim of ... ...

    Abstract Understanding disease transmission in the workplace is essential for protecting workers. To model disease outbreaks, the small populations in many workplaces require that stochastic effects are considered, which results in higher uncertainty. The aim of this study was to quantify and interpret the uncertainty inherent in such circumstances. We assessed how uncertainty of an outbreak in workplaces depends on i) the infection dynamics in the community, ii) the workforce size, iii) spatial structure in the workplace, iv) heterogeneity in susceptibility of workers, and v) heterogeneity in infectiousness of workers. To address these questions, we developed a multiscale model: A deterministic model to predict community transmission, and a stochastic model to predict workplace transmission. We extended this basic workplace model to allow for spatial structure, and heterogeneity in susceptibility and infectiousness in workers. We found a non-monotonic relationship between the workplace transmission rate and the coefficient of variation (CV), which we use as a measure of uncertainty. Increasing community transmission, workforce size and heterogeneity in susceptibility decreased the CV. Conversely, increasing the level of spatial structure and heterogeneity in infectiousness increased the CV. However, when the model predicts bimodal distributions, for example when community transmission is low and workplace transmission is high, the CV fails to capture this uncertainty. Overall, our work informs modellers and policy makers on how model complexity impacts outbreak uncertainty. In particular: workforce size, community and workplace transmission, spatial structure and individual heterogeneity contribute in a specific and individual manner to the predicted workplace outbreak size distribution.
    MeSH term(s) Humans ; Uncertainty ; Models, Biological ; Mathematical Concepts ; Disease Outbreaks ; Communicable Diseases/epidemiology
    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 184905-0
    ISSN 1522-9602 ; 0007-4985 ; 0092-8240
    ISSN (online) 1522-9602
    ISSN 0007-4985 ; 0092-8240
    DOI 10.1007/s11538-023-01249-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 754: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Safety of core muscle training immediately after abdominal surgery: systematic review.

    Perrodin, Stéphanie F / Salm, Lilian / Beldi, Guido

    BJS open

    2023  Volume 7, Issue 6

    MeSH term(s) Humans ; Muscles ; Abdominal Core/surgery ; Muscle Strength
    Language English
    Publishing date 2023-12-01
    Publishing country England
    Document type Systematic Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2474-9842
    ISSN (online) 2474-9842
    DOI 10.1093/bjsopen/zrad142
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  4. Article ; Online: Letter regarding 'Survival benefit of adequate lymphadenectomy in patients undergoing liver resection for clinically node negative intrahepatic cholangiocarcinoma'.

    Magyar, Christian Tibor Josef / Beldi, Guido / Banz, Vanessa

    Journal of hepatology

    2023  Volume 78, Issue 5, Page(s) e169–e170

    MeSH term(s) Humans ; Cholangiocarcinoma/surgery ; Lymph Node Excision ; Hepatectomy ; Bile Ducts, Intrahepatic ; Bile Duct Neoplasms/surgery ; Retrospective Studies ; Survival Rate ; Prognosis
    Language English
    Publishing date 2023-01-05
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2022.12.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2027: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Impact of MELD 30-allocation policy on liver transplant outcomes in Italy: Considerations.

    Magyar, Christian Tibor Josef / Beldi, Guido / Banz, Vanessa

    Journal of hepatology

    2022  Volume 77, Issue 2, Page(s) 572–573

    MeSH term(s) End Stage Liver Disease/surgery ; Humans ; Italy/epidemiology ; Liver Transplantation ; Policy ; Severity of Illness Index ; Tissue and Organ Procurement ; Waiting Lists
    Language English
    Publishing date 2022-03-28
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2022.03.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2027: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Authors' reply: Methodological biases may render a clinical study underpowered.

    Jakob, Manuel O / Beldi, Guido

    The journal of trauma and acute care surgery

    2020  Volume 90, Issue 2, Page(s) e59–e60

    MeSH term(s) Bias
    Language English
    Publishing date 2020-10-16
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2651070-4
    ISSN 2163-0763 ; 2163-0755
    ISSN (online) 2163-0763
    ISSN 2163-0755
    DOI 10.1097/TA.0000000000002992
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 127: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Laparoscopic resection of hepatic alveolar echinococcosis: A single-center experience.

    Gloor, Severin / Candinas, Daniel / Beldi, Guido / Lachenmayer, Anja

    PLoS neglected tropical diseases

    2022  Volume 16, Issue 9, Page(s) e0010708

    Abstract: Introduction: Alveolar echinococcosis (AE) remains a very rare disease requiring complete radical resection for curative treatment. While open approaches are common, safety and efficacy of laparoscopic resections remain unknown.: Methods: This is a ... ...

    Abstract Introduction: Alveolar echinococcosis (AE) remains a very rare disease requiring complete radical resection for curative treatment. While open approaches are common, safety and efficacy of laparoscopic resections remain unknown.
    Methods: This is a single-center, retrospective cohort study with patients undergoing liver resection for hepatic AE at the Department of Visceral Surgery and Medicine, Bern University Hospital from December 2002 to December 2020. Postoperative outcomes of patients following laparoscopic hepatectomy (LH) for hepatic AE were compared with those of patients undergoing open hepatectomy (OH).
    Results: A total of 93 patients underwent liver resection for hepatic AE. Laparoscopic hepatectomy was performed in 23 patients and open hepatectomy in 70 patients. While there were no significant differences in terms of gender, age and diagnostic tools, the majority of patients of the LH cohort were PNM stage 1 (78%) in contrast to only 39% in the OH cohort (p = 0.002). Patients undergoing laparoscopic hepatectomy were treated by minor liver resections in 91% and in 9% by major liver resections in comparison to the open hepatectomy cohort with 61% major liver resections and 39% minor resections. Laparoscopic hepatectomy was associated with shorter mean operation time (127 minutes vs. 242 minutes, p <0.001), lower major complication rate (0% vs. 11%, p = 0.322) and shorter mean length of hospital stay (4 days vs. 13 days, p <0.001). Patients with LH had a distinct, but not significant lower recurrence rate (0% vs. 4%, p = 0.210) during a mean follow-up of 55 months compared with a follow-up of 76 months in the OH cohort. After subgroup analysis of PNM stage 1 patients, similar results are seen with persistent shorter mean operation time (120 minutes vs. 223 minutes, p <0.001), lower major complication rate (0% vs. 8%, p = 0.759) and shorter length of hospital stay (4 days vs. 12 days, p <0.001).
    Conclusion: Laparoscopy appears as a feasible and safe approach for patients with PNM stage 1 alveolar echinococcosis without impact on early disease recurrence.
    MeSH term(s) Echinococcosis ; Echinococcosis, Hepatic/surgery ; Hepatectomy/methods ; Humans ; Laparoscopy/adverse effects ; Laparoscopy/methods ; Length of Stay ; Liver Neoplasms/complications ; Liver Neoplasms/surgery ; Neoplasm Recurrence, Local/complications ; Neoplasm Recurrence, Local/surgery ; Retrospective Studies ; Treatment Outcome
    Language English
    Publishing date 2022-09-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2429704-5
    ISSN 1935-2735 ; 1935-2735
    ISSN (online) 1935-2735
    ISSN 1935-2735
    DOI 10.1371/journal.pntd.0010708
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Extracellular ATP as an Inter-Kingdom Signaling Molecule: Release Mechanisms by Bacteria and Its Implication on the Host.

    Spari, Daniel / Beldi, Guido

    International journal of molecular sciences

    2020  Volume 21, Issue 15

    Abstract: The purine adenosine 5'-triphosphate (ATP) is not only a universal intracellular energy carrier but plays also an important role as extracellular signaling molecule. Purinergic signaling is involved in many physiological and pathological processes like ... ...

    Abstract The purine adenosine 5'-triphosphate (ATP) is not only a universal intracellular energy carrier but plays also an important role as extracellular signaling molecule. Purinergic signaling is involved in many physiological and pathological processes like coagulation, inflammation, or sepsis in mammals. ATP is well-known as a messenger for intercellular communications in multicellular organisms, but phylogenetically much older unicellular organisms like yeast or bacteria use ATP as an extracellular signaling molecule as well. However, the mechanisms of ATP secretion by bacteria and its extracellular implications still have to be elucidated. This review will provide an overview of the current knowledge about bacterial extracellular ATP (eATP) under homeostatic conditions and during growth. Possible secretion mechanisms of ATP by bacteria will be discussed and implications of bacterial ATP are shown, with a focus on bacteria-host interactions.
    MeSH term(s) Adenosine Triphosphate/genetics ; Animals ; Bacteria/genetics ; Bacteria/pathogenicity ; Bacterial Infections/genetics ; Bacterial Infections/microbiology ; Host-Pathogen Interactions/genetics ; Humans ; Signal Transduction/genetics
    Chemical Substances Adenosine Triphosphate (8L70Q75FXE)
    Language English
    Publishing date 2020-08-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21155590
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Physical activity decreases in patients on the liver transplant waiting list and influences postoperative outcome-a prospective cohort study.

    Magyar, Christian T J / Bühlmann, Lea / Becchetti, Chiara / Beekman, Lara / Candinas, Daniel / Beldi, Guido / Kim-Fuchs, Corina / Berzigotti, Annalisa / Banz, Vanessa

    Hepatobiliary surgery and nutrition

    2024  Volume 13, Issue 2, Page(s) 229–240

    Abstract: Background: Physical deconditioning affects patients suffering from end-stage liver disease (ESLD). Liver transplantation (LT) is the only curative option for ESLD. Growing evidence suggests that pre-habilitation is beneficial in reducing post-surgical ... ...

    Abstract Background: Physical deconditioning affects patients suffering from end-stage liver disease (ESLD). Liver transplantation (LT) is the only curative option for ESLD. Growing evidence suggests that pre-habilitation is beneficial in reducing post-surgical morbidity and mortality. We investigated physical activity (PA) in patients awaiting LT in a country with long waiting times.
    Methods: Prospective, single center, longitudinal study in Bern, Switzerland between June 2019 and February 2020 (halted due to SARS-CoV-2 pandemic), with follow-up data up to six months post-transplant. Patients were instructed to use a wrist tracker (FitBit) to monitor PA, which was assessed using mixed-effects generalized linear models. The study was approved by the local ethics committee (BASEC ID 2019-00606).
    Results: Thirty-five patients were included [71% male, median 59 years, body mass index (BMI) 28 kg/m
    Conclusions: In patients listed for LT, MPA decreased over time, showing a significant association with adverse outcome, specifically after week 30 on the waiting list. Our data support the implementation of routine pre-habilitation in patients awaiting LT.
    Language English
    Publishing date 2024-02-02
    Publishing country China (Republic : 1949- )
    Document type Journal Article
    ZDB-ID 2812398-0
    ISSN 2304-389X ; 2304-3881
    ISSN (online) 2304-389X
    ISSN 2304-3881
    DOI 10.21037/hbsn-23-399
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Intestinal dysbiosis as an intraoperative predictor of septic complications: evidence from human surgical cohorts and preclinical models of peritoneal sepsis.

    Spari, Daniel / Zwicky, Simone N / Yilmaz, Bahtiyar / Salm, Lilian / Candinas, Daniel / Beldi, Guido

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 22921

    Abstract: Major surgery exposes the intestinal microbiota to inflammatory and antibiotic stressors, which alter the microbiota composition of the intestinal lumen and fecal contents. However, it is not sufficiently understood, if such dysbiosis develops already ... ...

    Abstract Major surgery exposes the intestinal microbiota to inflammatory and antibiotic stressors, which alter the microbiota composition of the intestinal lumen and fecal contents. However, it is not sufficiently understood, if such dysbiosis develops already during surgery and if alterations in microbiota may be the cause of surgical complications. End-of-surgery composition of the microbiota in the rectum was assessed in 41 patients undergoing either rectal or duodenopancreatic resection and was compared to baseline before surgery using 16S-rRNA sequencing. A subset of patients developed severe dysbiosis at the end of surgery, which was characterized by an overgrowth of the Proteobacteria phylum that includes the facultative pathogen E. coli. To test if dysbiosis impacts on surgical outcomes, dysbiosis was modeled in mice by a single oral administration of vancomycin prior to cecal ligation and puncture. Dysbiosis was associated with impaired post-surgical survival, dysregulation of the host's immune response, elevated bacterial virulence and reduced bacterial metabolism of carbon sources. In conclusion, dysbiosis can be detected already at the end of surgery in a fraction of patients undergoing major surgery. Modelling surgery-associated dysbiosis in mice using single-shot administration of vancomycin induced dysbiosis and resulted in elevated mortality.
    MeSH term(s) Humans ; Mice ; Animals ; Dysbiosis/microbiology ; Vancomycin ; Escherichia coli/genetics ; Rectum ; Sepsis/microbiology ; RNA, Ribosomal, 16S/genetics
    Chemical Substances Vancomycin (6Q205EH1VU) ; RNA, Ribosomal, 16S
    Language English
    Publishing date 2023-12-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-49034-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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