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  1. Article ; Online: An Evolution of the Surgical Management of Synpolydactyly: A Case Series of 21 Hands.

    Xu, Wen / Graham, Emily M / Shubinets, Valeriy / Mendenhall, Shaun D / Chang, Benjamin / Lin, Ines C

    Annals of plastic surgery

    2023  Volume 90, Issue 6S Suppl 5, Page(s) S583–S592

    Abstract: Introduction: Synpolydactyly is a rare congenital anomaly characterized by syndactyly and polydactyly in the central hand. Limited treatment guidelines exist for this complex condition.: Methods: A retrospective review of synpolydactyly patients was ... ...

    Abstract Introduction: Synpolydactyly is a rare congenital anomaly characterized by syndactyly and polydactyly in the central hand. Limited treatment guidelines exist for this complex condition.
    Methods: A retrospective review of synpolydactyly patients was conducted at a large, tertiary pediatric referral center to describe our surgical experience and evolution of management. The Wall classification system was used to categorize cases.
    Results: Eleven patients (21 hands) with synpolydactyly were identified. Most of the patients were White and had at least one first-degree relative who also had synpolydactyly. The Wall classification yielded the following results: 7 type 1A hands, 4 type 2B hands, 6 type 3 hands, and 4 uncategorizable hands. Each patient had an average of 2.6 surgeries and an average follow-up time of 5.2 years. The rates of postoperative angulation and flexion deformities were 24% and 38%, respectively, with many of these cases also demonstrating preoperative alignment abnormalities. These cases often required additional surgeries including osteotomies, capsulectomies, and/or soft tissue releases. The rate of web creep was 14% with 2 of these patients requiring revision surgery. Despite these findings, at the time of final follow-up, most patients had favorable functional outcomes, were able to engage in bimanual tasks, and were able to perform activities of daily living independently.
    Conclusions: Synpolydactyly is a rare congenital hand anomaly with a significant degree of variability in clinical presentation. The rates of angulation and flexion deformities as well as web creep are not insignificant. We have learned to prioritize correcting contractures, angulation deformities, and skin fusion, over simply trying to delete the "extra" number of bones as this may destabilize the digit(s).
    MeSH term(s) Humans ; Child ; Fingers/surgery ; Fingers/abnormalities ; Activities of Daily Living ; Syndactyly/surgery ; Hand/surgery ; Contracture
    Language English
    Publishing date 2023-03-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 423835-7
    ISSN 1536-3708 ; 0148-7043
    ISSN (online) 1536-3708
    ISSN 0148-7043
    DOI 10.1097/SAP.0000000000003513
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Midgut transcriptomic responses to dengue and chikungunya viruses in the vectors Aedes albopictus and Aedes malayensis.

    Modahl, Cassandra M / Chowdhury, Avisha / Low, Dolyce H W / Manuel, Menchie C / Missé, Dorothée / Kini, R Manjunatha / Mendenhall, Ian H / Pompon, Julien

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 11271

    Abstract: Dengue (DENV) and chikungunya (CHIKV) viruses are among the most preponderant arboviruses. Although primarily transmitted through the bite of Aedes aegypti mosquitoes, Aedes albopictus and Aedes malayensis are competent vectors and have an impact on ... ...

    Abstract Dengue (DENV) and chikungunya (CHIKV) viruses are among the most preponderant arboviruses. Although primarily transmitted through the bite of Aedes aegypti mosquitoes, Aedes albopictus and Aedes malayensis are competent vectors and have an impact on arbovirus epidemiology. Here, to fill the gap in our understanding of the molecular interactions between secondary vectors and arboviruses, we used transcriptomics to profile the whole-genome responses of A. albopictus to CHIKV and of A. malayensis to CHIKV and DENV at 1 and 4 days post-infection (dpi) in midguts. In A. albopictus, 1793 and 339 genes were significantly regulated by CHIKV at 1 and 4 dpi, respectively. In A. malayensis, 943 and 222 genes upon CHIKV infection, and 74 and 69 genes upon DENV infection were significantly regulated at 1 and 4 dpi, respectively. We reported 81 genes that were consistently differentially regulated in all the CHIKV-infected conditions, identifying a CHIKV-induced signature. We identified expressed immune genes in both mosquito species, using a de novo assembled midgut transcriptome for A. malayensis, and described the immune architectures. We found the JNK pathway activated in all conditions, generalizing its antiviral function to Aedines. Our comprehensive study provides insight into arbovirus transmission by multiple Aedes vectors.
    MeSH term(s) Animals ; Transcriptome ; Aedes/genetics ; Chikungunya virus/genetics ; Chikungunya Fever/genetics ; Mosquito Vectors/genetics ; Dengue/genetics
    Language English
    Publishing date 2023-07-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-38354-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Imatinib is not a potent anti-SARS-CoV-2 drug.

    Zhao, Helong / Mendenhall, Michelle / Deininger, Michael W

    Leukemia

    2020  Volume 34, Issue 11, Page(s) 3085–3087

    MeSH term(s) Antiviral Agents/pharmacology ; Betacoronavirus/drug effects ; Betacoronavirus/growth & development ; Betacoronavirus/pathogenicity ; COVID-19 ; Caco-2 Cells ; Coronavirus Infections/drug therapy ; Coronavirus Infections/virology ; Drug Repositioning ; Humans ; Imatinib Mesylate/pharmacology ; Inhibitory Concentration 50 ; Niacinamide/analogs & derivatives ; Niacinamide/pharmacology ; Pandemics ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/virology ; Protein Kinase Inhibitors/pharmacology ; Pyrazoles/pharmacology ; Randomized Controlled Trials as Topic ; SARS-CoV-2 ; Virus Internalization/drug effects ; Virus Replication/drug effects
    Chemical Substances Antiviral Agents ; Protein Kinase Inhibitors ; Pyrazoles ; asciminib ; Niacinamide (25X51I8RD4) ; Imatinib Mesylate (8A1O1M485B)
    Keywords covid19
    Language English
    Publishing date 2020-09-30
    Publishing country England
    Document type Letter ; Research Support, N.I.H., Extramural
    ZDB-ID 807030-1
    ISSN 1476-5551 ; 0887-6924
    ISSN (online) 1476-5551
    ISSN 0887-6924
    DOI 10.1038/s41375-020-01045-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Radiotherapy for extranodal classic Hodgkin lymphoma of the maxillary sinus: Case report and literature review.

    Mokhtech, Meriem / Mercado, Catherine E / Lynch, James W / Mendenhall, Nancy P / Mendenhall, William M

    Head & neck

    2018  Volume 40, Issue 9, Page(s) E96–E99

    Abstract: Background: Classic Hodgkin lymphoma is a malignant neoplasm of the lymphatic system that commonly presents with cervical and mediastinal lymphadenopathy. Primary extranodal disease of the head and neck is rare, with only a few cases reported in the ... ...

    Abstract Background: Classic Hodgkin lymphoma is a malignant neoplasm of the lymphatic system that commonly presents with cervical and mediastinal lymphadenopathy. Primary extranodal disease of the head and neck is rare, with only a few cases reported in the literature. In this case report, we describe the presentation, treatment, and clinical outcome of a patient who presented with extranodal Hodgkin lymphoma of the maxillary sinus.
    Methods: We report a case of extranodal classic Hodgkin lymphoma of the maxillary sinus treated with 2 cycles of chemotherapy and consolidative radiotherapy (RT). We also reviewed the literature.
    Results: The patient tolerated treatment without complications and has experienced no evidence of recurrence 2 years after treatment.
    Conclusion: This is one of the few reports of extranodal Hodgkin lymphoma of the maxillary sinus. To our knowledge, this report represents the longest follow-up of any patient with this presentation.
    MeSH term(s) Aged ; Female ; Hodgkin Disease/diagnostic imaging ; Hodgkin Disease/radiotherapy ; Humans ; Maxillary Sinus Neoplasms/diagnostic imaging ; Maxillary Sinus Neoplasms/radiotherapy
    Language English
    Publishing date 2018-07-26
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 645165-2
    ISSN 1097-0347 ; 0148-6403 ; 1043-3074
    ISSN (online) 1097-0347
    ISSN 0148-6403 ; 1043-3074
    DOI 10.1002/hed.25346
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: In vitro effect of a non-immunosuppressive FKBP ligand, FK1706, on SARS-CoV-2 replication in combination with antivirals

    Fitzsimmons, William / Chen, Catherine / Mendenhall, Michelle / Hartman, Tracy L

    bioRxiv

    Abstract: FKBP, a naturally occurring ubiquitous intracellular protein, has been proposed as a potential target for coronavirus replication. A non-immunosuppressive FKBP ligand, FK1706, was studied in vitro in a Vero cell model to assess potential activity alone ... ...

    Abstract FKBP, a naturally occurring ubiquitous intracellular protein, has been proposed as a potential target for coronavirus replication. A non-immunosuppressive FKBP ligand, FK1706, was studied in vitro in a Vero cell model to assess potential activity alone and in combination with antivirals against SARS-CoV-2 replication. When combined with remdesivir, synergistic activity was seen (summary synergy score 24.7+9.56). FK1706 warrants in vivo testing as a potential new combination therapeutic for the treatment of COVID-19 infections.
    Keywords covid19
    Language English
    Publishing date 2022-02-04
    Publisher Cold Spring Harbor Laboratory
    Document type Article ; Online
    DOI 10.1101/2022.02.03.479080
    Database COVID19

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  6. Article ; Online: Prevention of Venous Thromboembolism in Microvascular Surgery Patients Using Weight-Based Unfractionated Heparin Infusions.

    Bertolaccini, Corinne M / Prazak, Ann Marie B / Goodwin, Isak A / Kwok, Alvin / Mendenhall, Shaun D / Rockwell, W Bradford / Agarwal, Jayant / Pannucci, Christopher J

    Journal of reconstructive microsurgery

    2021  Volume 38, Issue 5, Page(s) 395–401

    Abstract: Background:  Unfractionated heparin infusions are commonly used in microvascular surgery to prevent microvascular thrombosis. Previously, fixed-dose heparin infusions were believed to provide sufficient venous thromboembolism (VTE) prophylaxis; however, ...

    Abstract Background:  Unfractionated heparin infusions are commonly used in microvascular surgery to prevent microvascular thrombosis. Previously, fixed-dose heparin infusions were believed to provide sufficient venous thromboembolism (VTE) prophylaxis; however, we now know that this practice is inadequate for the majority of patients. Anti-factor Xa (aFXa) level is a measure of unfractionated heparin efficacy and safety. This study evaluated the pharmacodynamics of weight-based dose heparin infusions and the impacts of real-time aFXa-guided heparin dose adjustments.
    Methods:  This prospective clinical trial enrolled adult microvascular surgery patients who received a weight-based heparin dose following a microsurgical procedure. Steady-state aFXa levels were monitored, and patients with out-of-range levels received dose adjustments. The study outcomes assessed were aFXa levels at a dose of heparin 10 units/kg/hour, time to adequate aFXa level, number of dose adjustments required to reach in-range aFXa levels, and clinically relevant bleeding and VTE at 90 days.
    Results:  Twenty-one patients were prospectively recruited, and usable data were available for twenty patients. Four of twenty patients (20%) had adequate prophylaxis at a heparin dose of 10 units/kg/hour. Among patients who received dose adjustments and achieved in-range aFXa levels, the median number of dose adjustments was 2 and the median weight-based dose was 11 units/kg/hour. The percentage of patients with in-range levels was significantly increased (65 vs. 15%,
    Conclusion:  Weight-based heparin infusions at a rate of 10 units/kg/hour provide a detectable level of anticoagulation for some patients following microsurgical procedures, but most patients require dose adjustment to ensure adequate VTE prophylaxis.
    MeSH term(s) Adult ; Anticoagulants/therapeutic use ; Heparin ; Humans ; Microsurgery ; Prospective Studies ; Venous Thromboembolism/drug therapy ; Venous Thromboembolism/prevention & control
    Chemical Substances Anticoagulants ; Heparin (9005-49-6)
    Language English
    Publishing date 2021-08-24
    Publishing country United States
    Document type Clinical Trial ; Journal Article
    ZDB-ID 605983-1
    ISSN 1098-8947 ; 0743-684X ; 0743-684X
    ISSN (online) 1098-8947 ; 0743-684X
    ISSN 0743-684X
    DOI 10.1055/s-0041-1735225
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Current Radiotherapy Considerations for Nasopharyngeal Carcinoma.

    Ng, Wai Tong / Chow, James C H / Beitler, Jonathan J / Corry, June / Mendenhall, William / Lee, Anne W M / Robbins, K Thomas / Nuyts, Sandra / Saba, Nabil F / Smee, Robert / Stokes, William A / Strojan, Primož / Ferlito, Alfio

    Cancers

    2022  Volume 14, Issue 23

    Abstract: Radiotherapy is the primary treatment modality for nasopharyngeal carcinoma (NPC). Successful curative treatment requires optimal radiotherapy planning and precise beam delivery that maximizes locoregional control while minimizing treatment-related side ... ...

    Abstract Radiotherapy is the primary treatment modality for nasopharyngeal carcinoma (NPC). Successful curative treatment requires optimal radiotherapy planning and precise beam delivery that maximizes locoregional control while minimizing treatment-related side effects. In this article, we highlight considerations in target delineation, radiation dose, and the adoption of technological advances with the aim of optimizing the benefits of radiotherapy in NPC patients.
    Language English
    Publishing date 2022-11-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14235773
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Evidence that conserved essential genes are enriched for pro-longevity factors.

    Oz, Naci / Vayndorf, Elena M / Tsuchiya, Mitsuhiro / McLean, Samantha / Turcios-Hernandez, Lesly / Pitt, Jason N / Blue, Benjamin W / Muir, Michael / Kiflezghi, Michael G / Tyshkovskiy, Alexander / Mendenhall, Alexander / Kaeberlein, Matt / Kaya, Alaattin

    GeroScience

    2022  Volume 44, Issue 4, Page(s) 1995–2006

    Abstract: At the cellular level, many aspects of aging are conserved across species. This has been demonstrated by numerous studies in simple model organisms like Saccharomyces cerevisiae, Caenorhabdits elegans, and Drosophila melanogaster. Because most genetic ... ...

    Abstract At the cellular level, many aspects of aging are conserved across species. This has been demonstrated by numerous studies in simple model organisms like Saccharomyces cerevisiae, Caenorhabdits elegans, and Drosophila melanogaster. Because most genetic screens examine loss of function mutations or decreased expression of genes through reverse genetics, essential genes have often been overlooked as potential modulators of the aging process. By taking the approach of increasing the expression level of a subset of conserved essential genes, we found that 21% of these genes resulted in increased replicative lifespan in S. cerevisiae. This is greater than the ~ 3.5% of genes found to affect lifespan upon deletion, suggesting that activation of essential genes may have a relatively disproportionate effect on increasing lifespan. The results of our experiments demonstrate that essential gene overexpression is a rich, relatively unexplored means of increasing eukaryotic lifespan.
    MeSH term(s) Animals ; Longevity/genetics ; Saccharomyces cerevisiae/genetics ; Genes, Essential/genetics ; Drosophila melanogaster/genetics ; Aging/physiology
    Language English
    Publishing date 2022-06-13
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2886586-8
    ISSN 2509-2723 ; 2509-2715
    ISSN (online) 2509-2723
    ISSN 2509-2715
    DOI 10.1007/s11357-022-00604-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Imatinib is not a potent anti-SARS-CoV-2 drug

    Zhao, Helong / Mendenhall, Michelle / Deininger, Michael W.

    Leukemia ; ISSN 0887-6924 1476-5551

    2020  

    Keywords Anesthesiology and Pain Medicine ; Cancer Research ; Hematology ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    DOI 10.1038/s41375-020-01045-9
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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