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Article ; Online: Editorial Comment: FDG PET/MRI and CT as Predictive Markers of Response of Borderline Resectable Pancreatic Cancer to Neoadjuvant Therapy.

Lee, Jean H

2020 Volume 217, Issue 3, Page(s) 740

MeSH term(s)	Fluorodeoxyglucose F18 ; Humans ; Magnetic Resonance Imaging ; Neoadjuvant Therapy ; Pancreatic Neoplasms/diagnostic imaging ; Pancreatic Neoplasms/therapy ; Tomography, X-Ray Computed
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2020-11-10
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	82076-3
ISSN	1546-3141 ; 0361-803X ; 0092-5381
ISSN (online)	1546-3141
ISSN	0361-803X ; 0092-5381
DOI	10.2214/AJR.20.25014
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Article ; Online: Editorial of special issue: Pharmacological, gene, and cell-based therapeutics targeting early or late neurodegenerative and neurovascular diseases.

Yin, Ke-Jie / Hamblin, Milton H / Lee, Jean-Pyo

Experimental neurology

2022 Volume 361, Page(s) 114297

MeSH term(s)	Humans ; Neurodegenerative Diseases/drug therapy ; Neurodegenerative Diseases/genetics ; Vascular Diseases/drug therapy ; Vascular Diseases/genetics
Language	English
Publishing date	2022-12-13
Publishing country	United States
Document type	Editorial ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
ZDB-ID	207148-4
ISSN	1090-2430 ; 0014-4886
ISSN (online)	1090-2430
ISSN	0014-4886
DOI	10.1016/j.expneurol.2022.114297
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Article ; Online: How to choose an abdominal imaging fellowship.

Sun, Derek C / Lee, Jean H

Abdominal radiology (New York)

2021 Volume 46, Issue 12, Page(s) 5454–5461

Abstract: Radiologists in training draw from their early experiences in residency when choosing a fellowship. Once they have decided on an abdominal imaging fellowship, applicants must learn to navigate the interview process. During this challenging time, ... ...

Abstract	Radiologists in training draw from their early experiences in residency when choosing a fellowship. Once they have decided on an abdominal imaging fellowship, applicants must learn to navigate the interview process. During this challenging time, applicants explore the difference in clinical curricula and rotations, meet potential mentors and clinical faculty, consider potential academic interests and projects, and choose what location they would like to train for one year after residency. When in training, fellows undergo the challenge of finding employment while learning new skills and refining their abilities to become a well-rounded radiologist and clinician. This article summarizes key points potential applicants should consider when deciding on an abdominal imaging fellowship, how to prepare for the interview season, and how to plan their fellowship year before fellows take the next step to becoming attendings.
MeSH term(s)	Employment ; Fellowships and Scholarships ; Humans ; Internship and Residency ; Mentors ; Surveys and Questionnaires
Language	English
Publishing date	2021-06-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	2839786-1
ISSN	2366-0058 ; 2366-004X
ISSN (online)	2366-0058
ISSN	2366-004X
DOI	10.1007/s00261-021-03170-0
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Article ; Online: Neural Stem Cells for Early Ischemic Stroke.

Hamblin, Milton H / Lee, Jean-Pyo

International journal of molecular sciences

2021 Volume 22, Issue 14

Abstract: Clinical treatments for ischemic stroke are limited. Neural stem cell (NSC) transplantation can be a promising therapy. Clinically, ischemia and subsequent reperfusion lead to extensive neurovascular injury that involves inflammation, disruption of the ... ...

Abstract	Clinical treatments for ischemic stroke are limited. Neural stem cell (NSC) transplantation can be a promising therapy. Clinically, ischemia and subsequent reperfusion lead to extensive neurovascular injury that involves inflammation, disruption of the blood-brain barrier, and brain cell death. NSCs exhibit multiple potentially therapeutic actions against neurovascular injury. Currently, tissue plasminogen activator (tPA) is the only FDA-approved clot-dissolving agent. While tPA's thrombolytic role within the vasculature is beneficial, tPA's non-thrombolytic deleterious effects aggravates neurovascular injury, restricting the treatment time window (time-sensitive) and tPA eligibility. Thus, new strategies are needed to mitigate tPA's detrimental effects and quickly mediate vascular repair after stroke. Up to date, clinical trials focus on the impact of stem cell therapy on neuro-restoration by delivering cells during the chronic stroke stage. Also, NSCs secrete factors that stimulate endogenous repair mechanisms for early-stage ischemic stroke. This review will present an integrated view of the preclinical perspectives of NSC transplantation as a promising treatment for neurovascular injury, with an emphasis on early-stage ischemic stroke. Further, this will highlight the impact of early sub-acute NSC delivery on improving short-term and long-term stroke outcomes.
MeSH term(s)	Animals ; Blood-Brain Barrier/metabolism ; Brain/metabolism ; Brain Ischemia/metabolism ; Brain Ischemia/therapy ; Fibrinolytic Agents/administration & dosage ; Humans ; Ischemic Stroke/metabolism ; Ischemic Stroke/therapy ; Metalloendopeptidases/metabolism ; Neural Stem Cells/transplantation ; Reperfusion Injury/prevention & control ; Reperfusion Injury/therapy ; Stem Cell Transplantation/methods ; Stem Cell Transplantation/trends ; Stroke/metabolism ; Stroke/therapy ; Tissue Plasminogen Activator/therapeutic use
Chemical Substances	Fibrinolytic Agents ; Tissue Plasminogen Activator (EC 3.4.21.68) ; Metalloendopeptidases (EC 3.4.24.-)
Language	English
Publishing date	2021-07-19
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22147703
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Global economic burden per episode for multiple diseases caused by group A Streptococcus.

Lee, Jung-Seok / Kim, Sol / Excler, Jean-Louis / Kim, Jerome H / Mogasale, Vittal

NPJ vaccines

2023 Volume 8, Issue 1, Page(s) 69

Abstract: Considering the lack of existing evidence on economic burden for diseases caused by group A Streptococcus, we estimated the economic burden per episode for selected diseases. Each cost component of direct medical costs (DMCs), direct non-medical costs ( ... ...

Abstract	Considering the lack of existing evidence on economic burden for diseases caused by group A Streptococcus, we estimated the economic burden per episode for selected diseases. Each cost component of direct medical costs (DMCs), direct non-medical costs (DNMCs), and indirect costs (ICs) was separately extrapolated and aggregated to estimate the economic burden per episode by income group as classified by the World Bank. Adjustment factors for DMC and DNMC were generated to overcome related data insufficiencies. To address uncertainty surrounding input parameters, a probabilistic multivariate sensitivity was carried out. The average economic burden per episode ranged from $22 to $392 for pharyngitis, $25 to $2,903 for impetigo, $47 to $2,725 for cellulitis, $662 to $34,330 for invasive and toxin-mediated infections, $231 to $6,332 for acute rheumatic fever (ARF), $449 to $11,717 for rheumatic heart disease (RHD), and $949 to $39,560 for severe RHD across income groups. The economic burden for multiple Group A Streptococcus diseases underscores an urgent need to develop effective prevention strategies including vaccines.
Language	English
Publishing date	2023-05-15
Publishing country	England
Document type	Journal Article
ISSN	2059-0105
ISSN (online)	2059-0105
DOI	10.1038/s41541-023-00659-1
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Article ; Online: The cycad genotoxin methylazoxymethanol, linked to Guam ALS/PDC, induces transcriptional mutagenesis.

Verheijen, Bert M / Chung, Claire / Thompson, Ben / Kim, Hyunjin / Nakahara, Asa / Anink, Jasper J / Mills, James D / Lee, Jeong H / Aronica, Eleonora / Oyanagi, Kiyomitsu / Kakita, Akiyoshi / Gout, Jean-Francois / Vermulst, Marc

Acta neuropathologica communications

2024 Volume 12, Issue 1, Page(s) 30

MeSH term(s)	Humans ; Mutagens ; Guam ; Methylazoxymethanol Acetate/analogs & derivatives ; Mutagenesis ; Amyotrophic Lateral Sclerosis/genetics
Chemical Substances	methylazoxymethanol (JGG19N3YDQ) ; Mutagens ; Methylazoxymethanol Acetate (592-62-1)
Language	English
Publishing date	2024-02-21
Publishing country	England
Document type	Letter
ZDB-ID	2715589-4
ISSN	2051-5960 ; 2051-5960
ISSN (online)	2051-5960
ISSN	2051-5960
DOI	10.1186/s40478-024-01725-y
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Article ; Online: State transitions across the Strep A disease spectrum: scoping review and evidence gaps.

Parajulee, Prerana / Lee, Jung-Seok / Abbas, Kaja / Cannon, Jeffrey / Excler, Jean Louis / Kim, Jerome H / Mogasale, Vittal

BMC infectious diseases

2024 Volume 24, Issue 1, Page(s) 108

Abstract: The spectrum of diseases caused by Streptococcus pyogenes (Strep A) ranges from superficial to serious life-threatening invasive infections. We conducted a scoping review of published articles between 1980 and 2021 to synthesize evidence of state ... ...

Abstract	The spectrum of diseases caused by Streptococcus pyogenes (Strep A) ranges from superficial to serious life-threatening invasive infections. We conducted a scoping review of published articles between 1980 and 2021 to synthesize evidence of state transitions across the Strep A disease spectrum. We identified 175 articles reporting 262 distinct observations of Strep A disease state transitions. Among the included articles, the transition from an invasive or toxin-mediated disease state to another disease state (i.e., to recurrent ARF, RHD or death) was described 115 times (43.9% of all included transition pairs) while the transition to and from locally invasive category was the lowest (n = 7; 0.02%). Transitions from well to any other state was most frequently reported (49%) whereas a relatively higher number of studies (n = 71) reported transition from invasive disease to death. Transitions from any disease state to locally invasive, Strep A pharyngitis to invasive disease, and chronic kidney disease to death were lacking. Transitions related to severe invasive diseases were more frequently reported than superficial ones. Most evidence originated from high-income countries and there is a critical need for new studies in low- and middle-income countries to infer the state transitions across the Strep A disease spectrum in these high-burden settings.
MeSH term(s)	Humans ; Streptococcus pyogenes ; Evidence Gaps ; Pharyngitis ; Streptococcal Infections/epidemiology ; Rheumatic Fever
Language	English
Publishing date	2024-01-19
Publishing country	England
Document type	Review ; Journal Article
ZDB-ID	2041550-3
ISSN	1471-2334 ; 1471-2334
ISSN (online)	1471-2334
ISSN	1471-2334
DOI	10.1186/s12879-023-08888-4
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Article ; Online: Neural Stem Cells for Early Ischemic Stroke

Milton H. Hamblin / Jean-Pyo Lee

International Journal of Molecular Sciences, Vol 22, Iss 7703, p

2021 Volume 7703

Abstract	Clinical treatments for ischemic stroke are limited. Neural stem cell (NSC) transplantation can be a promising therapy. Clinically, ischemia and subsequent reperfusion lead to extensive neurovascular injury that involves inflammation, disruption of the blood-brain barrier, and brain cell death. NSCs exhibit multiple potentially therapeutic actions against neurovascular injury. Currently, tissue plasminogen activator (tPA) is the only FDA-approved clot-dissolving agent. While tPA’s thrombolytic role within the vasculature is beneficial, tPA’s non-thrombolytic deleterious effects aggravates neurovascular injury, restricting the treatment time window (time-sensitive) and tPA eligibility. Thus, new strategies are needed to mitigate tPA’s detrimental effects and quickly mediate vascular repair after stroke. Up to date, clinical trials focus on the impact of stem cell therapy on neuro-restoration by delivering cells during the chronic stroke stage. Also, NSCs secrete factors that stimulate endogenous repair mechanisms for early-stage ischemic stroke. This review will present an integrated view of the preclinical perspectives of NSC transplantation as a promising treatment for neurovascular injury, with an emphasis on early-stage ischemic stroke. Further, this will highlight the impact of early sub-acute NSC delivery on improving short-term and long-term stroke outcomes.
Keywords	blood-brain barrier ; matrix metalloproteinases ; neural stem cells ; stroke ; tissue plasminogen activator ; transplantation ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	610
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Determination of CO

Lee, Jung H / Mahmood, S Hassan / Pin, Jean-Mathieu / Li, Ruosong / Lee, Patrick C / Park, Chul B

International journal of biological macromolecules

2022 Volume 204, Page(s) 274–283

Abstract: Due to phase heterogeneity in semi-crystalline polymers, accurate determination of gas solubility has been a challenge. In this regard, PLA/ ... ...

Abstract	Due to phase heterogeneity in semi-crystalline polymers, accurate determination of gas solubility has been a challenge. In this regard, PLA/CO
MeSH term(s)	Carbon Dioxide ; Crystallization ; Polyesters ; Solubility ; Thermodynamics
Chemical Substances	Polyesters ; Carbon Dioxide (142M471B3J) ; poly(lactide) (459TN2L5F5)
Language	English
Publishing date	2022-02-02
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2022.01.182
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Article ; Online: The Impact of Race and Sex on the Clinical Outcomes of Homeless Patients With Alcoholic Liver Disease: Propensity Score Matched Analysis of US Hospitals.

Lee, David U / Kwon, Jean / Han, John / Chang, Kevin / Kolachana, Sindhura / Bahadur, Aneesh / Lee, Ki Jung / Fan, Gregory H / Malik, Raza

Journal of clinical gastroenterology

2023

Abstract: Background: Among patients with alcoholic liver disease (ALD), homelessness poses significant medical and psychosocial risks; however, less is known about the effects of race and sex on the hospital outcomes of admitted homeless patients with ALD.: ... ...

Abstract	Background: Among patients with alcoholic liver disease (ALD), homelessness poses significant medical and psychosocial risks; however, less is known about the effects of race and sex on the hospital outcomes of admitted homeless patients with ALD. Methods: The National Inpatient Sample database from 2012 to 2017 was used to isolate homeless patients with ALD, and the cohort was further stratified by race and sex for comparisons. Propensity score matching was utilized to minimize covariate confounding. The primary endpoints of this study include mortality, hospital length of stay, and hospital costs; secondary endpoints included the incidence of liver complications. Results: There were 3972 females/males postmatch, as well as 2224 Blacks/Whites and 4575 Hispanics/Whites postmatch. In multivariate, there were no significant differences observed in mortality rate, length of stay, and costs between sexes. Comparing liver outcomes, females had a higher incidence of hepatic encephalopathy [adjusted odds ratio (aOR) 1.02, 95% CI: 1.01-1.04, P<0.001]. In comparing Blacks versus Whites, Black patients had higher hospitalization costs (aOR 1.13, 95% CI: 1.03-1.24, P=0.01); however, there were no significant differences in mortality, length of stay, or liver complications. In comparing Hispanics versus Whites, Hispanic patients had longer length of hospital stay (aOR 1.12, 95% CI: 1.06-1.19, P<0.001), greater costs (aOR 1.15, 95% CI: 1.09-1.22, P<0.001), as well as higher prevalence of liver complications including varices (aOR 1.04, 95% CI: 1.02-1.06, P<0.001), hepatic encephalopathy (aOR 1.03, 95% CI: 1.02-1.04, P<0.001), and hepatorenal syndrome (aOR 1.01, 95% CI 1.00-1.01, P=0.03). However, there was no difference in mortality between White and Hispanic patients. Conclusions: Black and Hispanic ALD patients experiencing homelessness were found to incur higher hospital charges; furthermore, Hispanic patients also had greater length of stay and higher incidence of liver-related complications compared with White counterparts.
Language	English
Publishing date	2023-10-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	448460-5
ISSN	1539-2031 ; 0192-0790
ISSN (online)	1539-2031
ISSN	0192-0790
DOI	10.1097/MCG.0000000000001919
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