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Article ; Online: N-Cinnamoyltetraketide Derivatives from the Leaves of Toussaintia orientalis.

Nyandoro, Stephen S / Ndanu, Joseph / Munissi, Joan J E / Gruhonjic, Amra / Fitzpatrick, Paul A / Landberg, Göran / Lu, Yu / Wang, Bin / Pan, Fangfang / Rissanen, Kari / Erdélyi, Máté

Journal of natural products

2015 Volume 78, Issue 8, Page(s) 2045–2050

Abstract: Seven N-cinnamoyltetraketides (1-7), including the new Z-toussaintine E (2), toussaintine F (6 ...

Abstract	Seven N-cinnamoyltetraketides (1-7), including the new Z-toussaintine E (2), toussaintine F (6), and toussaintine G (7), were isolated from the methanol extract of the leaves of Toussaintia orientalis using column chromatography and HPLC. The configurations of E-toussaintine E (1) and toussaintines A (3) and D (5) are revised based on single-crystal X-ray diffraction data from racemic crystals. Both the crude methanol extract and the isolated constituents exhibit antimycobacterial activities (MIC 83.3-107.7 μM) against the H37Rv strain of Mycobacterium tuberculosis. Compounds 1, 3, 4, and 5 are cytotoxic (ED50 15.3-105.7 μM) against the MDA-MB-231 triple negative aggressive breast cancer cell line.
MeSH term(s)	Annonaceae/chemistry ; Antitubercular Agents/chemistry ; Antitubercular Agents/isolation & purification ; Antitubercular Agents/pharmacology ; Cinnamates/chemistry ; Cinnamates/isolation & purification ; Cinnamates/pharmacology ; Cyclohexanones/chemistry ; Cyclohexanones/isolation & purification ; Cyclohexanones/pharmacology ; Drug Screening Assays, Antitumor ; Female ; Humans ; Microbial Sensitivity Tests ; Molecular Structure ; Mycobacterium tuberculosis/drug effects ; Nuclear Magnetic Resonance, Biomolecular ; Plant Leaves/chemistry ; Tanzania
Chemical Substances	Antitubercular Agents ; Cinnamates ; Cyclohexanones ; N-cinnamoyl-1-acetoxymethyl-2-amino-1-hydroxycyclohexx-5-en-4-one
Language	English
Publishing date	2015-08-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	304325-3
ISSN	1520-6025 ; 0163-3864
ISSN (online)	1520-6025
ISSN	0163-3864
DOI	10.1021/acs.jnatprod.5b00356
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Zs.A 1144: Show issues

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Article ; Online: Sleep is of the muscle, by the muscle, and for the muscle.

Brager, Allison J / Paul, Ketema N

Sleep

2023 Volume 46, Issue 9

MeSH term(s)	Sleep/physiology ; Muscles
Language	English
Publishing date	2023-07-25
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	424441-2
ISSN	1550-9109 ; 0161-8105
ISSN (online)	1550-9109
ISSN	0161-8105
DOI	10.1093/sleep/zsac283
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Zs.A 1475: Show issues

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Article: N-Cinnamoyltetraketide Derivatives from the Leaves of Toussaintia orientalis

Nyandoro, Stephen S / ErdeÌlyi MaÌteÌ / Fitzpatrick Paul A / Gruhonjic Amra / Landberg GoÌran / Lu Yu / Munissi Joan J. E / Ndanu Joseph / Pan Fangfang / Rissanen Kari / Wang Bin

Journal of natural products. 2015 Aug. 28, v. 78, no. 8

2015

Abstract: Seven N-cinnamoyltetraketides (1â7), including the new Z-toussaintine E (2), toussaintine F (6 ...

Abstract	Seven N-cinnamoyltetraketides (1â7), including the new Z-toussaintine E (2), toussaintine F (6), and toussaintine G (7), were isolated from the methanol extract of the leaves of Toussaintia orientalis using column chromatography and HPLC. The configurations of E-toussaintine E (1) and toussaintines A (3) and D (5) are revised based on single-crystal X-ray diffraction data from racemic crystals. Both the crude methanol extract and the isolated constituents exhibit antimycobacterial activities (MIC 83.3â107.7 Î¼M) against the H37Rv strain of Mycobacterium tuberculosis. Compounds 1, 3, 4, and 5 are cytotoxic (EDââ 15.3â105.7 Î¼M) against the MDA-MB-231 triple negative aggressive breast cancer cell line.
Keywords	antibacterial properties ; breast neoplasms ; crystals ; cytotoxicity ; high performance liquid chromatography ; leaves ; methanol ; Mycobacterium tuberculosis ; X-ray diffraction
Language	English
Dates of publication	2015-0828
Size	p. 2045-2050.
Publishing place	American Chemical Society and American Society of Pharmacognosy
Document type	Article
ZDB-ID	304325-3
ISSN	1520-6025 ; 0163-3864
ISSN (online)	1520-6025
ISSN	0163-3864
DOI	10.1021%2Facs.jnatprod.5b00356
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Synthesis, structure, and antiproliferative activity of ruthenium(II) arene complexes with N,O-chelating pyrazolone-based β-ketoamine ligands.

Pettinari, Riccardo / Marchetti, Fabio / Pettinari, Claudio / Petrini, Agnese / Scopelliti, Rosario / Clavel, Catherine M / Dyson, Paul J

Inorganic chemistry

2014 Volume 53, Issue 24, Page(s) 13105–13111

Abstract: Novel ruthenium half-sandwich complexes containing (N,O)-bound pyrazolone-based β-ketoamine ligands ...

Abstract	Novel ruthenium half-sandwich complexes containing (N,O)-bound pyrazolone-based β-ketoamine ligands have been prepared, and the solid-state structures of one ligand and five complexes have been determined by single-crystal X-ray diffraction. Some of the complexes display moderate cytotoxicity toward the human ovarian cancer cell lines A2780 and A2780cisR, the latter line having acquired resistance to cisplatin.
MeSH term(s)	Amination ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Chelating Agents/chemistry ; Chelating Agents/pharmacology ; Coordination Complexes/chemistry ; Coordination Complexes/pharmacology ; Crystallography, X-Ray ; Drug Screening Assays, Antitumor ; Female ; Humans ; Models, Molecular ; Ovarian Neoplasms/drug therapy ; Pyrazolones/chemistry ; Pyrazolones/pharmacology ; Ruthenium/chemistry ; Ruthenium/pharmacology
Chemical Substances	Antineoplastic Agents ; Chelating Agents ; Coordination Complexes ; Pyrazolones ; Ruthenium (7UI0TKC3U5)
Language	English
Publishing date	2014-12-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1484438-2
ISSN	1520-510X ; 0020-1669
ISSN (online)	1520-510X
ISSN	0020-1669
DOI	10.1021/ic502274b
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Article ; Online: Sex differences in sleep architecture in a mouse model of Huntington's disease.

Chiem, Emily / Zhao, Kevin / Stark, Gemma / Ghiani, Cristina A / Colwell, Christopher S / Paul, Ketema N

Journal of neuroscience research

2024 Volume 102, Issue 1, Page(s) e25290

Abstract: Sleep and circadian rhythm disturbances are common features of Huntington's disease (HD). HD is an autosomal dominant neurodegenerative disorder that affects men and women in equal numbers, but some epidemiological studies as well as preclinical work ... ...

Abstract	Sleep and circadian rhythm disturbances are common features of Huntington's disease (HD). HD is an autosomal dominant neurodegenerative disorder that affects men and women in equal numbers, but some epidemiological studies as well as preclinical work indicate there may be sex differences in disease presentation and progression. Since sex differences in HD could provide important insights to understand cellular and molecular mechanism(s), we used the bacterial artificial chromosome transgenic mouse model of HD (BACHD) to examine whether sex differences in sleep/wake cycles are detectable in an animal model of the disease. Electroencephalography/electromyography (EEG/EMG) was used to measure sleep/wake states and polysomnographic patterns in young adult (12-week-old) male and female wild-type and BACHD mice. Our findings show that male, but not female, BACHD mice exhibited increased variation in phases of the rhythms as compared to age- and sex-matched wild-types. For both rapid-eye movement (REM) and non-rapid eye movement (NREM) sleep, genotypic and sex differences were detected. In particular, the BACHD males spent less time in NREM sleep and exhibited a more fragmented sleep than the other groups. Finally, in response to 6 h of sleep deprivation, both genotypes and sexes displayed the predicted homeostatic responses to sleep loss. These findings suggest that females are relatively protected early in disease progression in this HD model.
MeSH term(s)	Young Adult ; Female ; Male ; Humans ; Animals ; Mice ; Sex Characteristics ; Huntington Disease/genetics ; Sleep ; Disease Models, Animal ; Mice, Transgenic
Language	English
Publishing date	2024-01-29
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	195324-2
ISSN	1097-4547 ; 0360-4012
ISSN (online)	1097-4547
ISSN	0360-4012
DOI	10.1002/jnr.25290
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Zs.A 1232: Show issues

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Article: Sex Differences in Sleep Phenotypes in the BACHD Mouse Model of Huntington's Disease.

Chiem, Emily / Zhao, Kevin / Stark, Gemma / Ghiani, Cristina A / Colwell, Christopher S / Paul, Ketema N

bioRxiv : the preprint server for biology

2023

Abstract	Sleep and circadian rhythm disturbances are common features of Huntington's disease (HD). HD is an autosomal dominant neurodegenerative disorder that affects men and women in equal numbers, but some epidemiological studies as well as preclinical work indicate there may be sex differences in disease progression. Since sex differences in HD could provide important insights to understand cellular and molecular mechanism(s), we used the bacterial artificial chromosome transgenic mouse model of HD (BACHD) to examine whether sex differences in sleep/wake cycles are detectable in an animal model of the disease. Electroencephalography/electromyography (EEG/EMG) was used to measure sleep/wake states and polysomnographic patterns in young adult (12 week-old) male and female wild-type and BACHD mice. Our findings show that male, but not female, BACHD mice exhibited increased variation in phases of the rhythms as compared to age and sex matched wild-types. For both Rapid-eye movement (REM) and Non-rapid eye movement (NREM) sleep, genotypic and sex differences were detected. In particular, the BACHD males spent less time in NREM and exhibited a more fragmented sleep than the other groups. Both male and female BACHD mice exhibited significant changes in delta but not in gamma power compared to wild-type mice. Finally, in response to a 6-hrs sleep deprivation, both genotypes and sexes displayed predicted homeostatic responses to sleep loss. These findings suggest that females are relatively protected early in disease progression in this HD model.
Language	English
Publishing date	2023-04-28
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.04.28.538324
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Article ; Online: Serotonin and sleep: breaking the cycle (Commentary on Nakamaru-Ogiso et al.).

Paul, Ketema N

The European journal of neuroscience

2012 Volume 35, Issue 11, Page(s) 1761

MeSH term(s)	Animals ; Brain/physiology ; Brain Chemistry/physiology ; Circadian Rhythm/physiology ; Male ; Serotonin/physiology ; Sleep/physiology ; Wakefulness/physiology
Chemical Substances	Serotonin (333DO1RDJY)
Language	English
Publishing date	2012-06
Publishing country	France
Document type	Comment ; Journal Article
ZDB-ID	645180-9
ISSN	1460-9568 ; 0953-816X
ISSN (online)	1460-9568
ISSN	0953-816X
DOI	10.1111/j.1460-9568.2012.08155.x
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Zs.A 2548: Show issues

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Article ; Online: Hydrogen-rich water improves sleep consolidation and enhances forebrain neuronal activation in mice.

Vincent, Scott M / Madani, Melika / Dikeman, Dante / Golden, Kyle / Crocker, Naomi / Jackson, Cameron / Wimmer, Sam P / Dover, Mary / Tucker, Alexis / Ghiani, Cristina A / Colwell, Christopher S / LeBaron, Tyler W / Tarnava, Alex / Paul, Ketema N

Sleep advances : a journal of the Sleep Research Society

2023 Volume 5, Issue 1, Page(s) zpad057

Abstract: Study objectives: Sleep loss contributes to various health issues and impairs neurological function. Molecular hydrogen has recently gained popularity as a nontoxic ergogenic and health promoter. The effect of molecular hydrogen on sleep and sleep- ... ...

Abstract	Study objectives: Sleep loss contributes to various health issues and impairs neurological function. Molecular hydrogen has recently gained popularity as a nontoxic ergogenic and health promoter. The effect of molecular hydrogen on sleep and sleep-related neural systems remains unexplored. This study investigates the impact of hydrogen-rich water (HRW) on sleep behavior and neuronal activation in sleep-deprived mice. Methods: Adult C57BL/6J mice were implanted with electroencephalography (EEG) and electromyography (EMG) recording electrodes and given HRW (0.7-1.4 mM) or regular water for 7 days ad libitum. Sleep-wake cycles were recorded under baseline conditions and after acute sleep loss. Neuronal activation in sleep- and wake-related regions was assessed using cFos immunostaining. Results: HRW increased sleep consolidation in undisturbed mice and increased non-rapid-eye movement and rapid-eye-movement sleep amount in sleep-deprived mice. HRW also decreased the average amount of time for mice to fall asleep after light onset. Neuronal activation in the lateral septum, medial septum, ventrolateral preoptic area, and median preoptic area was significantly altered in all mice treated with HRW. Conclusions: HRW improves sleep consolidation and increases neuronal activation in sleep-related brain regions. It may serve as a simple, effective treatment to improve recovery after sleep loss.
Language	English
Publishing date	2023-12-30
Publishing country	United States
Document type	Journal Article
ISSN	2632-5012
ISSN (online)	2632-5012
DOI	10.1093/sleepadvances/zpad057
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: N-Mesityl-C-acylketenimines: 1,5-Sigmatropic Shifts and Electrocyclization to Quinolines.

Rao, V. V. Ramana / Fulloon, Belinda E. / Bernhardt, Paul V. / Koch, Rainer / Wentrup, Curt

The Journal of organic chemistry

1998 Volume 63, Issue 17, Page(s) 5779–5786

Abstract: ... an energy barrier of ca. 38 kcal mol(-)(1) (161 kJ mol(-)(1)) for the 1,5-H shift in N-(o-methylphenyl ... Flash vacuum thermolysis (FVT) of triazoles 6a-c generates alpha-oxoketenimines 10, the ester 10a ... being isolable. FVT of pyrroledione 8 generates the isomeric imidoylketene 9a. Ketenes 9 and ketenimines ...

Abstract	Flash vacuum thermolysis (FVT) of triazoles 6a-c generates alpha-oxoketenimines 10, the ester 10a being isolable. FVT of pyrroledione 8 generates the isomeric imidoylketene 9a. Ketenes 9 and ketenimines 10 undergo thermal interconversion by 1,3-shifts of methoxy and dimethylamino groups under mild FVT conditions (ca. 350-400 degrees C). Both 9 and 10 are directly observable by IR spectroscopy at either 77 K or on Ar matrix isolation at 12 K. On FVT at temperatures above ca. 400 degrees C, the ketenimines 10 undergo a 1,5-H shift to o-quinoid imines 12/13, followed by electrocyclization to dihydroquinolines 14 (unobserved) and 15 (observed by NMR). The latter are easily oxidized to alkylquinoline-3-carboxylates or quinoline-3-carboxamides 16 by atmospheric oxygen. Ab initio calculations on model compounds 18-23 predict an energy barrier of ca. 38 kcal mol(-)(1) (161 kJ mol(-)(1)) for the 1,5-H shift in N-(o-methylphenyl)ketenimines via the transition state TS19 followed by an electrocyclization barrier to dihydroquinoline 23a via TS22a of ca. 16 kcal mol(-)(1).
Language	English
Publishing date	1998-08-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	123490-0
ISSN	1520-6904 ; 0022-3263
ISSN (online)	1520-6904
ISSN	0022-3263
DOI	10.1021/jo9722562
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Zs.A 4473: Show issues

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Article ; Online: Non-rapid eye movement sleep determines resilience to social stress.

Bush, Brittany J / Donnay, Caroline / Andrews, Eva-Jeneé A / Lewis-Sanders, Darielle / Gray, Cloe L / Qiao, Zhimei / Brager, Allison J / Johnson, Hadiya / Brewer, Hamadi C S / Sood, Sahil / Saafir, Talib / Benveniste, Morris / Paul, Ketema N / Ehlen, J Christopher

eLife

2022 Volume 11

Abstract: Resilience, the ability to overcome stressful conditions, is found in most mammals and varies significantly among individuals. A lack of resilience can lead to the development of neuropsychiatric and sleep disorders, often within the same individual. ... ...

Abstract	Resilience, the ability to overcome stressful conditions, is found in most mammals and varies significantly among individuals. A lack of resilience can lead to the development of neuropsychiatric and sleep disorders, often within the same individual. Despite extensive research into the brain mechanisms causing maladaptive behavioral-responses to stress, it is not clear why some individuals exhibit resilience. To examine if sleep has a determinative role in maladaptive behavioral-response to social stress, we investigated individual variations in resilience using a social-defeat model for male mice. Our results reveal a direct, causal relationship between sleep amount and resilience-demonstrating that sleep increases after social-defeat stress only occur in resilient mice. Further, we found that within the prefrontal cortex, a regulator of maladaptive responses to stress, pre-existing differences in sleep regulation predict resilience. Overall, these results demonstrate that increased NREM sleep, mediated cortically, is an active response to social-defeat stress that plays a determinative role in promoting resilience. They also show that differences in resilience are strongly correlated with inter-individual variability in sleep regulation.
MeSH term(s)	Animals ; Mice ; Male ; Mice, Inbred C57BL ; Eye Movements ; Stress, Psychological/psychology ; Prefrontal Cortex ; Sleep ; Mammals
Language	English
Publishing date	2022-09-23
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.80206
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