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  1. Article: Yin and Yang of NADPH Oxidases in Myocardial Ischemia-Reperfusion.

    Matsushima, Shouji / Sadoshima, Junichi

    Antioxidants (Basel, Switzerland)

    2022  Volume 11, Issue 6

    Abstract: Oxidative stress is critically involved in the pathophysiology of myocardial ischemic-reperfusion (I/R) injury. NADPH oxidase (Nox) 2 and 4, major sources of reactive oxygen species (ROS) in cardiomyocytes, are upregulated in response to I/R. Suppression ...

    Abstract Oxidative stress is critically involved in the pathophysiology of myocardial ischemic-reperfusion (I/R) injury. NADPH oxidase (Nox) 2 and 4, major sources of reactive oxygen species (ROS) in cardiomyocytes, are upregulated in response to I/R. Suppression of Nox-derived ROS prevents mitochondrial dysfunction and endoplasmic reticulum (ER) stress, leading to attenuation of myocardial I/R injury. However, minimal levels of ROS by either Nox2 or Nox4 are required for energy metabolism during I/R in the heart, preserving hypoxia-inducible factor-1α (HIF-1α) and peroxisome proliferator-activated receptor-α (PPARα) levels. Furthermore, extreme suppression of Nox activity induces reductive stress, leading to paradoxical increases in ROS levels. Nox4 has distinct roles in organelles such as mitochondria, ER, and ER-mitochondria contact sites (MAMs). Mitochondrial Nox4 exerts a detrimental effect, causing ROS-induced mitochondrial dysfunction during I/R, whereas Nox4 in the ER and MAMs is potentially protective against I/R injury through regulation of autophagy and MAM function, respectively. Although Nox isoforms are potential therapeutic targets for I/R injury, to maximize the effect of intervention, it is likely important to optimize the ROS level and selectively inhibit Nox4 in mitochondria. Here, we discuss the 'Yin and Yang' functions of Nox isoforms during myocardial I/R.
    Language English
    Publishing date 2022-05-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox11061069
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Yin and Yang of NADPH Oxidases in Myocardial Ischemia-Reperfusion

    Matsushima, Shouji / Sadoshima, Junichi

    Antioxidants. 2022 May 27, v. 11, no. 6

    2022  

    Abstract: Oxidative stress is critically involved in the pathophysiology of myocardial ischemic-reperfusion (I/R) injury. NADPH oxidase (Nox) 2 and 4, major sources of reactive oxygen species (ROS) in cardiomyocytes, are upregulated in response to I/R. Suppression ...

    Abstract Oxidative stress is critically involved in the pathophysiology of myocardial ischemic-reperfusion (I/R) injury. NADPH oxidase (Nox) 2 and 4, major sources of reactive oxygen species (ROS) in cardiomyocytes, are upregulated in response to I/R. Suppression of Nox-derived ROS prevents mitochondrial dysfunction and endoplasmic reticulum (ER) stress, leading to attenuation of myocardial I/R injury. However, minimal levels of ROS by either Nox2 or Nox4 are required for energy metabolism during I/R in the heart, preserving hypoxia-inducible factor-1α (HIF-1α) and peroxisome proliferator-activated receptor-α (PPARα) levels. Furthermore, extreme suppression of Nox activity induces reductive stress, leading to paradoxical increases in ROS levels. Nox4 has distinct roles in organelles such as mitochondria, ER, and ER-mitochondria contact sites (MAMs). Mitochondrial Nox4 exerts a detrimental effect, causing ROS-induced mitochondrial dysfunction during I/R, whereas Nox4 in the ER and MAMs is potentially protective against I/R injury through regulation of autophagy and MAM function, respectively. Although Nox isoforms are potential therapeutic targets for I/R injury, to maximize the effect of intervention, it is likely important to optimize the ROS level and selectively inhibit Nox4 in mitochondria. Here, we discuss the ‘Yin and Yang’ functions of Nox isoforms during myocardial I/R.
    Keywords NAD(P)H oxidase (H2O2-forming) ; autophagy ; cardiomyocytes ; endoplasmic reticulum ; energy metabolism ; mitochondria ; oxidative stress ; pathophysiology ; reactive oxygen species ; therapeutics
    Language English
    Dates of publication 2022-0527
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox11061069
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: An increasing trend of gastric cancer deaths and inadequate preventive measures in elderly adults.

    Matsushima, Rumiko / Matsushima, Shouji / Kobayashi, Masanobu / Fujimori, Kenji / Sakamoto, Naoya / Asaka, Masahiro

    Helicobacter

    2023  Volume 28, Issue 4, Page(s) e12988

    Abstract: Background: Japan became the world's first country to cover Helicobacter pylori eradication for chronic gastritis under its National Health Insurance (NHI) system in February 2013. Thereafter, H. pylori eradication dramatically increased and gastric ... ...

    Abstract Background: Japan became the world's first country to cover Helicobacter pylori eradication for chronic gastritis under its National Health Insurance (NHI) system in February 2013. Thereafter, H. pylori eradication dramatically increased and gastric cancer deaths began to decrease in Japan. However, the details of gastric cancer deaths and its prevention in the very elderly have not been fully elucidated.
    Methods: We analyzed the temporal trend of gastric cancer deaths referencing data from Ministry of Health, Labour and Welfare reports and "Cancer Statistics in Japan-2021" and assessed the numbers of H. pylori test and gastric cancer screening using a national database and a report of cancer screening in Shimane Prefecture, respectively.
    Results: Although gastric cancer deaths in total population have clearly decreased since 2013, those in people aged 80 years and older are still increasing. People aged 80 years and older represent 9% of the total population and accounted for half of all gastric cancer deaths in 2020. The numbers of H. pylori eradication and gastric cancer screening in people aged 80 years and older were 25% and 25% of those in other generations, respectively.
    Conclusion: In spite of a dramatic increase in H. pylori eradication and a clear decrease in gastric cancer deaths in Japan, gastric cancer deaths in people aged 80 years and older are increasing. This might be due to fewer H. pylori eradication in the elderly than in other generations, indicating the difficulty of gastric cancer prevention in the very elderly.
    MeSH term(s) Aged ; Humans ; Adult ; Stomach Neoplasms/epidemiology ; Stomach Neoplasms/prevention & control ; Stomach Neoplasms/diagnosis ; Helicobacter Infections/complications ; Helicobacter Infections/drug therapy ; Helicobacter Infections/epidemiology ; Helicobacter pylori ; Japan/epidemiology ; Early Detection of Cancer ; Anti-Bacterial Agents/therapeutic use
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-05-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 1330665-0
    ISSN 1523-5378 ; 1083-4389
    ISSN (online) 1523-5378
    ISSN 1083-4389
    DOI 10.1111/hel.12988
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Long-Term Outcomes of Heart Failure Patients With Preserved, Mildly Reduced, and Reduced Ejection Fraction.

    Nagata, Takuya / Ide, Tomomi / Tohyama, Takeshi / Kaku, Hidetaka / Enzan, Nobuyuki / Matsushima, Shouji / Ikeda, Masataka / Todaka, Koji / Tsutsui, Hiroyuki

    JACC. Asia

    2023  Volume 3, Issue 2, Page(s) 315–316

    Language English
    Publishing date 2023-03-07
    Publishing country United States
    Document type Journal Article
    ISSN 2772-3747
    ISSN (online) 2772-3747
    DOI 10.1016/j.jacasi.2022.11.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Beneficial Effects of Dipeptidyl Peptidase-4 Inhibitors on Heart Failure With Preserved Ejection Fraction and Diabetes.

    Enzan, Nobuyuki / Matsushima, Shouji / Kaku, Hidetaka / Tohyama, Takeshi / Nagata, Takuya / Ide, Tomomi / Tsutsui, Hiroyuki

    JACC. Asia

    2023  Volume 3, Issue 1, Page(s) 93–104

    Abstract: Background: Dipeptidyl peptidase-4 (DPP-4) inhibitors have been shown to exert pleiotropic effects on heart failure (HF) in animal experiments.: Objectives: This study sought to investigate the impact of DPP-4 inhibitors on HF patients with diabetes ... ...

    Abstract Background: Dipeptidyl peptidase-4 (DPP-4) inhibitors have been shown to exert pleiotropic effects on heart failure (HF) in animal experiments.
    Objectives: This study sought to investigate the impact of DPP-4 inhibitors on HF patients with diabetes mellitus (DM).
    Methods: We analyzed hospitalized patients with HF and DM enrolled in the JROADHF (Japanese Registry Of Acute Decompensated Heart Failure) registry, a nationwide registry of acute decompensated HF. Primary exposure was the use of a DPP-4 inhibitor. The primary outcome was a composite of cardiovascular death or HF hospitalization during the median follow-up of 3.6 years according to left ventricular ejection fraction.
    Results: Out of 2,999 eligible patients, 1,130 had heart failure with preserved ejection fraction (HFpEF), 572 had heart failure with midrange ejection fraction (HFmrEF), and 1,297 had heart failure with reduced ejection fraction (HFrEF). In each cohort, 444, 232, and 574 patients received a DPP-4 inhibitor, respectively. A multivariable Cox regression model showed that DPP-4 inhibitor use was associated with a lower composite of cardiovascular death or HF hospitalization in HFpEF (HR: 0.69; 95% CI: 0.55-0.87;
    Conclusions: DPP-4 inhibitor use was associated with better long-term outcomes in HFpEF patients with DM.
    Language English
    Publishing date 2023-01-03
    Publishing country United States
    Document type Journal Article
    ISSN 2772-3747
    ISSN (online) 2772-3747
    DOI 10.1016/j.jacasi.2022.09.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Evaluation of the A

    Kyodo, Atsushi / Nakada, Yasuki / Nogi, Maki / Nogi, Kazutaka / Ishihara, Satomi / Ueda, Tomoya / Tohyama, Takeshi / Enzan, Nobuyuki / Ide, Tomomi / Matsushima, Shouji / Tsutsui, Hiroyuki / Saito, Yoshihiko

    Journal of the American Heart Association

    2024  Volume 13, Issue 4, Page(s) e031104

    Abstract: Background: Although a tool for sharing patient prognosis among all medical staff is desirable in heart failure (HF) cases, only a few simple HF prognostic scores are available. We previously presented the A: Methods and results: We examined the 2- ... ...

    Abstract Background: Although a tool for sharing patient prognosis among all medical staff is desirable in heart failure (HF) cases, only a few simple HF prognostic scores are available. We previously presented the A
    Methods and results: We examined the 2-year mortality in relation to the A
    Conclusions: The A
    MeSH term(s) Humans ; Aged ; Japan/epidemiology ; Natriuretic Peptide, Brain ; Heart Failure/diagnosis ; Prognosis ; Anemia/diagnosis ; Hemoglobins ; Peptide Fragments ; Biomarkers
    Chemical Substances Natriuretic Peptide, Brain (114471-18-0) ; Hemoglobins ; Peptide Fragments ; Biomarkers
    Language English
    Publishing date 2024-02-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2653953-6
    ISSN 2047-9980 ; 2047-9980
    ISSN (online) 2047-9980
    ISSN 2047-9980
    DOI 10.1161/JAHA.123.031104
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Association of baseline electrocardiographic left ventricular hypertrophy with future renal function decline in the general population.

    Ikeda, Shota / Shinohara, Keisuke / Tagawa, Koshiro / Tohyama, Takeshi / Kishimoto, Junji / Kazurayama, Masaya / Tanaka, Shinji / Yamaizumi, Masamitsu / Nagayoshi, Hirokazu / Toyama, Kensuke / Matsushima, Shouji / Tsutsui, Hiroyuki / Kinugawa, Shintaro

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 301

    Abstract: Electrocardiographic left ventricular hypertrophy (LVH) could predict adverse renal outcomes in patients with hypertension. This study aimed to investigate the association between electrocardiographic LVH and future decline in renal function in the ... ...

    Abstract Electrocardiographic left ventricular hypertrophy (LVH) could predict adverse renal outcomes in patients with hypertension. This study aimed to investigate the association between electrocardiographic LVH and future decline in renal function in the general population using a dataset of population-based health checkups from 2010 to 2019 including 19,825 participants. Electrocardiographic LVH was defined according to the Minnesota code. Renal function decline was defined as a decrease of ≥ 25% in the estimated glomerular filtration rate from baseline to < 60 mL/min/1.73 m
    MeSH term(s) Humans ; Hypertrophy, Left Ventricular/diagnosis ; Hypertension ; Kidney ; Blood Pressure ; Incidence ; Electrocardiography ; Risk Factors
    Language English
    Publishing date 2024-01-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-51085-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Overview of the 87

    Matoba, Tetsuya / Nakano, Yasuhiro / Katsuki, Shunsuke / Ide, Tomomi / Matsushima, Shouji / Fujino, Takeo / Hashimoto, Toru / Shinohara, Keisuke / Abe, Kohtaro / Hosokawa, Kazuya / Sakamoto, Takafumi / Sakamoto, Ichiro / Kakino, Takamori / Ishikita, Ayako / Nishizaki, Akiko / Sakamoto, Kazuo / Takase, Susumu / Nagayama, Tomomi / Tohyama, Takeshi /
    Nagata, Takuya / Kinugawa, Shintaro / Tsutsui, Hiroyuki

    Circulation journal : official journal of the Japanese Circulation Society

    2024  Volume 88, Issue 4, Page(s) 615–619

    Abstract: ... The ... ...

    Abstract The 87
    MeSH term(s) Humans ; Japan ; Artificial Intelligence ; Pandemics ; Cardiovascular System ; Cardiology
    Language English
    Publishing date 2024-03-07
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2068090-9
    ISSN 1347-4820 ; 1346-9843
    ISSN (online) 1347-4820
    ISSN 1346-9843
    DOI 10.1253/circj.CJ-24-0127
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  9. Article ; Online: Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity.

    Tadokoro, Tomonori / Ikeda, Masataka / Ide, Tomomi / Deguchi, Hiroko / Ikeda, Soichiro / Okabe, Kosuke / Ishikita, Akihito / Matsushima, Shouji / Koumura, Tomoko / Yamada, Ken-Ichi / Imai, Hirotaka / Tsutsui, Hiroyuki

    JCI insight

    2023  Volume 8, Issue 6

    MeSH term(s) Humans ; Cardiotoxicity/etiology ; Ferroptosis ; Doxorubicin/adverse effects ; Mitochondria
    Chemical Substances Doxorubicin (80168379AG)
    Language English
    Publishing date 2023-03-22
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ISSN 2379-3708
    ISSN (online) 2379-3708
    DOI 10.1172/jci.insight.169756
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  10. Article ; Online: Regional Variation in the Clinical Practice and Prognosis in Patients With Heart Failure With Reduced Ejection Fraction in Japan　- A Report From the Japanese Registry of Acute Decompensated Heart Failure (JROADHF).

    Sato, Yu / Yoshihisa, Akiomi / Ide, Tomomi / Tohyama, Takeshi / Enzan, Nobuyuki / Matsushima, Shouji / Tsutsui, Hiroyuki / Takeishi, Yasuchika

    Circulation journal : official journal of the Japanese Circulation Society

    2023  Volume 87, Issue 10, Page(s) 1380–1391

    Abstract: Background: The present study aimed to clarify the regional variations in clinical practice and the prognosis of patients with heart failure with reduced ejection fraction (HFrEF) in Japan using the Japanese Registry of Acute Decompensated Heart Failure ...

    Abstract Background: The present study aimed to clarify the regional variations in clinical practice and the prognosis of patients with heart failure with reduced ejection fraction (HFrEF) in Japan using the Japanese Registry of Acute Decompensated Heart Failure (JROADHF).Methods and Results: We recruited data of hospitalized patients with HFrEF (n=4,329) from the JROADHF. The patients were divided into 6 groups based on the region of Japan where they were hospitalized: Hokkaido-Tohoku (n=504), Kanto (n=958), Chubu (n=779), Kinki (n=902), Chugoku-Shikoku (n=446), and Kyushu (n=740). We compared the patients' characteristics, including etiology of HF and prognosis after discharge. The age of the patients was lowest in the Kanto and Kinki regions. In contrast, there were no differences in the prevalence of comorbidities, levels of B-type natriuretic peptide, or left ventricular EF among the 6 groups. Post-discharge cardiospecific prognosis, specifically, the composite of cardiac death or HF hospitalization, cardiac death, and HF hospitalization, was comparable among the 6 regions.
    Conclusions: There were no differences in cardiospecific prognosis in patients with HFrEF among the 6 regions in Japan.
    MeSH term(s) Humans ; Aftercare ; Death ; East Asian People ; Heart Failure/diagnosis ; Heart Failure/epidemiology ; Heart Failure/therapy ; Hospitalization ; Japan/epidemiology ; Patient Discharge ; Prognosis ; Registries ; Stroke Volume ; Ventricular Dysfunction, Left ; Ventricular Function, Left
    Language English
    Publishing date 2023-04-28
    Publishing country Japan
    Document type Journal Article ; Multicenter Study
    ZDB-ID 2068090-9
    ISSN 1347-4820 ; 1346-9843
    ISSN (online) 1347-4820
    ISSN 1346-9843
    DOI 10.1253/circj.CJ-22-0774
    Database MEDical Literature Analysis and Retrieval System OnLINE

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