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  1. Article ; Online: Comment.

    Linskey, Mark E

    Neurosurgery

    2012  Volume 71, Issue 4, Page(s) 899

    Language English
    Publishing date 2012-10
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Exploiting Cancer's Tactics to Make Cancer a Manageable Chronic Disease.

    Afrasiabi, Kambiz / Linskey, Mark E / Zhou, Yi-Hong

    Cancers

    2020  Volume 12, Issue 6

    Abstract: ... markedly increased our ability to safely remove ≥90% of tumor cells. While we have advanced our ability ...

    Abstract The history of modern oncology started around eighty years ago with the introduction of cytotoxic agents such as nitrogen mustard into the clinic, followed by multi-agent chemotherapy protocols. Early success in radiation therapy in Hodgkin lymphoma gave birth to the introduction of radiation therapy into different cancer treatment protocols. Along with better understanding of cancer biology, we developed drugs targeting cancer-related cellular and genetic aberrancies. Discovery of the crucial role of vasculature in maintenance, survival, and growth of a tumor opened the way to the development of anti-angiogenic agents. A better understanding of T-cell regulatory pathways advanced immunotherapy. Awareness of stem-like cancer cells and their role in cancer metastasis and local recurrence led to the development of drugs targeting them. At the same time, sequential and rapidly accelerating advances in imaging and surgical technology have markedly increased our ability to safely remove ≥90% of tumor cells. While we have advanced our ability to kill cells from multiple directions, we have still failed to stop most types of cancer from recurring. Here we analyze the tactics employed in cancer evolution; namely, chromosomal instability (CIN), intra-tumoral heterogeneity (ITH), and cancer-specific metabolism. These tactics govern the resistance to current cancer therapeutics. It is time to focus on maximally delaying the time to recurrence, with drugs that target these fundamental tactics of cancer evolution. Understanding the control of CIN and the optimal state of ITH as the most important tactics in cancer evolution could facilitate the development of improved cancer therapeutic strategies designed to transform cancer into a manageable chronic disease.
    Language English
    Publishing date 2020-06-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers12061649
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Mixed gangliocytoma-pituitary adenoma in MEN1 syndrome: A case report and literature review.

    Martin, Elaine C / Bitner, Benjamin F / Perez-Rosendahl, Mari / Kuan, Edward C / Linskey, Mark E

    Neuropathology : official journal of the Japanese Society of Neuropathology

    2022  Volume 42, Issue 2, Page(s) 155–159

    Abstract: Pituitary adenoma is one of the three most common neoplasms described in multiple endocrine neoplasia type 1 (MEN1), and patients with pituitary adenoma occupies 30-50% of those with MEN1-related tumor. Mixed gangliocytoma-pituitary adenoma (MGPA) is a ... ...

    Abstract Pituitary adenoma is one of the three most common neoplasms described in multiple endocrine neoplasia type 1 (MEN1), and patients with pituitary adenoma occupies 30-50% of those with MEN1-related tumor. Mixed gangliocytoma-pituitary adenoma (MGPA) is a rare clinical entity in which gangliomatous cells are intermixed with adenomatous cells. This tumor has been estimated to account for 0.52-1.26% of all pituitary tumors. We report a rare case of MGPA in a patient with MEN1. A retrospective chart review was conducted on a patient with MEN1 diagnosed with MGPA in 2019 at a single tertiary academic medical center. A review of the literature was performed on MGPA and pituitary adenoma in MEN1. MGPA is rare, with only 174 cases previously reported in the literature and only three prior case reported in a patient with MEN1. There are multiple hypotheses regarding their pathogenesis, and it is unclear whether the MEN1 gene (menin) plays a role in the pathogenesis of MGPA. This tumor in MEN1 is a rare clinical entity of unknown etiology. Further studies are required with difficulty due to its low incidence.
    MeSH term(s) Adenoma/complications ; Adenoma/diagnosis ; Ganglioneuroma/complications ; Ganglioneuroma/pathology ; Humans ; Multiple Endocrine Neoplasia Type 1/complications ; Multiple Endocrine Neoplasia Type 1/diagnosis ; Multiple Endocrine Neoplasia Type 1/genetics ; Pituitary Neoplasms/genetics ; Retrospective Studies
    Language English
    Publishing date 2022-02-08
    Publishing country Australia
    Document type Case Reports ; Review
    ZDB-ID 1483794-8
    ISSN 1440-1789 ; 0919-6544
    ISSN (online) 1440-1789
    ISSN 0919-6544
    DOI 10.1111/neup.12788
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Editorial critique.

    Linskey, Mark E

    The journal of trauma and acute care surgery

    2012  Volume 72, Issue 4, Page(s) 1029–1030

    MeSH term(s) Brain Injuries/complications ; Evoked Potentials, Somatosensory/physiology ; Female ; Humans ; Male ; Persistent Vegetative State/diagnosis ; Unconsciousness/etiology
    Language English
    Publishing date 2012-04
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 2651070-4
    ISSN 2163-0763 ; 2163-0755
    ISSN (online) 2163-0763
    ISSN 2163-0755
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 127: Show issues Location:
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  5. Article ; Online: Trigeminal Neuralgia.

    Zakrzewska, Joanna M / Linskey, Mark E

    American family physician

    2016  Volume 94, Issue 2, Page(s) 133–135

    MeSH term(s) Analgesics, Non-Narcotic/therapeutic use ; Carbamazepine/analogs & derivatives ; Carbamazepine/therapeutic use ; Electrocoagulation ; Humans ; Microvascular Decompression Surgery ; Radiosurgery ; Trigeminal Neuralgia/physiopathology ; Trigeminal Neuralgia/therapy
    Chemical Substances Analgesics, Non-Narcotic ; oxcarbamazepine ; Carbamazepine (33CM23913M)
    Language English
    Publishing date 2016-07-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 412694-4
    ISSN 1532-0650 ; 0002-838X ; 0572-3612
    ISSN (online) 1532-0650
    ISSN 0002-838X ; 0572-3612
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  6. Article ; Online: Trigeminal neuralgia.

    Zakrzewska, Joanna M / Linskey, Mark E

    BMJ (Clinical research ed.)

    2015  Volume 350, Page(s) h1238

    MeSH term(s) Humans ; Trigeminal Neuralgia/diagnosis ; Trigeminal Neuralgia/therapy
    Language English
    Publishing date 2015-03-12
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.h1238
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Implementing traumatic cervical spine clearance clinical practice guidelines.

    Linskey, Mark E

    The Journal of trauma

    2010  Volume 68, Issue 6, Page(s) 1451–1452

    MeSH term(s) Cervical Vertebrae/diagnostic imaging ; Cervical Vertebrae/injuries ; England ; Humans ; Immobilization/methods ; Intensive Care Units ; Practice Guidelines as Topic ; Practice Patterns, Physicians'/statistics & numerical data ; Spinal Injuries/diagnostic imaging ; Spinal Injuries/therapy ; Surveys and Questionnaires ; Tomography, X-Ray Computed ; Unconsciousness ; Wounds, Nonpenetrating/diagnostic imaging ; Wounds, Nonpenetrating/therapy
    Language English
    Publishing date 2010-06
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 219302-4
    ISSN 1529-8809 ; 0022-5282 ; 1079-6061
    ISSN (online) 1529-8809
    ISSN 0022-5282 ; 1079-6061
    DOI 10.1097/TA.0b013e3181dc999b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Defining excellence in evidence-based medicine clinical practice guidelines.

    Linskey, Mark E

    Clinical neurosurgery

    2010  Volume 57, Page(s) 28–37

    MeSH term(s) Evidence-Based Medicine/economics ; Evidence-Based Medicine/legislation & jurisprudence ; Evidence-Based Medicine/standards ; Guideline Adherence/economics ; Guideline Adherence/legislation & jurisprudence ; Guideline Adherence/standards ; Health Care Costs ; Humans ; Neurosurgery/legislation & jurisprudence ; Neurosurgery/standards ; Practice Guidelines as Topic/standards ; Quality of Health Care/economics ; Quality of Health Care/legislation & jurisprudence ; Quality of Health Care/standards ; Spinal Fusion/economics ; Spinal Fusion/legislation & jurisprudence ; Spinal Fusion/standards ; United States
    Language English
    Publishing date 2010
    Publishing country United States
    Document type Journal Article
    ZDB-ID 127548-3
    ISSN 0069-4827
    ISSN 0069-4827
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uk III 1072: Show issues Location:
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    Einzelsignatur: Show issues

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  9. Article ; Online: Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines on the Role of Emerging and Investigational Therapties for the Treatment of Adults With Metastatic Brain Tumors.

    Elder, J Bradley / Nahed, Brian V / Linskey, Mark E / Olson, Jeffrey J

    Neurosurgery

    2019  Volume 84, Issue 3, Page(s) E201–E203

    MeSH term(s) Adult ; Antineoplastic Combined Chemotherapy Protocols/administration & dosage ; Brain Neoplasms/diagnosis ; Brain Neoplasms/secondary ; Brain Neoplasms/therapy ; Breast Neoplasms/diagnosis ; Breast Neoplasms/surgery ; Congresses as Topic/standards ; Drugs, Investigational/administration & dosage ; Female ; Humans ; Neurosurgeons/standards ; Practice Guidelines as Topic/standards ; Protein Kinase Inhibitors/administration & dosage ; Treatment Outcome
    Chemical Substances Drugs, Investigational ; Protein Kinase Inhibitors
    Language English
    Publishing date 2019-01-10
    Publishing country United States
    Document type Journal Article ; Systematic Review
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1093/neuros/nyy547
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Trigeminal neuralgia.

    Zakrzewska, Joanna M / Linskey, Mark E

    BMJ (Clinical research ed.)

    2014  Volume 348, Page(s) g474

    MeSH term(s) Analgesics, Non-Narcotic/therapeutic use ; Carbamazepine/analogs & derivatives ; Carbamazepine/therapeutic use ; Diagnosis, Differential ; Humans ; Magnetic Resonance Imaging/methods ; Prognosis ; Radiosurgery/methods ; Trigeminal Neuralgia/diagnosis ; Trigeminal Neuralgia/therapy ; Voltage-Gated Sodium Channel Blockers/therapeutic use
    Chemical Substances Analgesics, Non-Narcotic ; Voltage-Gated Sodium Channel Blockers ; Carbamazepine (33CM23913M) ; oxcarbazepine (VZI5B1W380)
    Language English
    Publishing date 2014-02-17
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.g474
    Database MEDical Literature Analysis and Retrieval System OnLINE

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