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Article: Compressive Postoperative Seromas Causing Delayed Neurological Deterioration Following Cervical Laminectomy and Instrumented Fusion.

Lor, Kelvin Kah Ho / Decruz, Joshua / Ang, Mu Liang / Pang, Boon Chuan / Yang, Eugene

2023 Volume 15, Issue 10, Page(s) e46326

Abstract: Compressive postoperative seromas in the cervical spine are a rare but significant complication following cervical laminectomy and instrumented fusion. There is a paucity of cases reported in the literature, with a majority of the reported cases ... ...

Abstract	Compressive postoperative seromas in the cervical spine are a rare but significant complication following cervical laminectomy and instrumented fusion. There is a paucity of cases reported in the literature, with a majority of the reported cases attributing seroma formation to the use of recombinant human bone morphogenetic protein-2 (rhBMP-2). In this article, we report four cases of compressive postoperative seroma in the absence of rhBMP-2 use and highlight similarities in their clinical presentations. We postulate that seroma formation is a significant complication of the dead space that results following posterior instrumentation in the cervical spine, with or without the use of rhBMP-2. The typical presentation is one of the gradual delayed neurological deterioration several days following the index surgery and after drain removal. Neurological deterioration can be reversed rapidly with early recognition and drainage of the seroma.
Language	English
Publishing date	2023-10-01
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.46326
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Article: Diagnostic dilemma in acute neurological presentation of spinal arachnoid cysts: A case report.

Jain, Swati / Sun, Ira / Pang, Boon Chuan / Lim, Su Lone / Low, Shiong Wen

Frontiers in surgery

2023 Volume 10, Page(s) 1092345

Abstract: Background: Spinal arachnoid cysts are relatively uncommon, cerebrospinal fluid-filled sacs formed by arachnoid membranes that can be either idiopathic or acquired. The neurological presentation of these cysts is varied. Advances in imaging techniques ... ...

Abstract	Background: Spinal arachnoid cysts are relatively uncommon, cerebrospinal fluid-filled sacs formed by arachnoid membranes that can be either idiopathic or acquired. The neurological presentation of these cysts is varied. Advances in imaging techniques have allowed an improved characterization of these entities and excluded other possible causes of clinical manifestation. Their presentation remains varied, ranging from pain to progressive neurological deficits. Here, we present two cases of patients with thoracic arachnoid cysts that posed a diagnostic dilemma at initial presentation because of their acute neurological deficit, and their eventual recovery after surgical intervention. Case description: The first case is of a patient with end-stage renal failure, which prevented the administration of contrast during the workup. The differential diagnosis ranged from intradural abscess to arachnoid cyst. The second patient presented with non-remitting back pain that progressed to an acute neurological deficit. Both patients recovered well after decompression of the cyst. Conclusion: The decision to intervene is still patient-dependent and based on the extent of neurological deterioration at the time of presentation due to the relatively benign nature and lack of understanding of the temporal presentation of neurological symptoms, which are rapidly and almost completely reversed after surgery. However, further studies need to be done to understand the acute presentation of these cysts, which are apparently long-standing.
Language	English
Publishing date	2023-07-03
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2773823-1
ISSN	2296-875X
ISSN	2296-875X
DOI	10.3389/fsurg.2023.1092345
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Article ; Online: Fear of detachment from mobile phone: nomophobia and suicidality among Malaysian university students before and during the COVID-19 pandemic.

Pang, Khong Yun / Siau, Ching Sin / Ho, Meng Chuan / Ooi, Pei Boon / Tan, Yee Kee / Woi, Pui Juan / Lai, Samantha Arielle / Chan, Caryn Mei Hsien

Psychology, health & medicine

2023 , Page(s) 1–11

Abstract: The attachment to mobile devices during the COVID-19 pandemic has led to the possibility of increased nomophobia, which is the intense fear of losing access to one's mobile device. Therefore, this study aimed to determine if nomophobia was independently ... ...

Abstract	The attachment to mobile devices during the COVID-19 pandemic has led to the possibility of increased nomophobia, which is the intense fear of losing access to one's mobile device. Therefore, this study aimed to determine if nomophobia was independently associated with suicidality before and during the COVID-19 pandemic among university students in Malaysia. This cross-sectional study had two-time points in data collection: one year before and one year into the COVID-19 pandemic.
Language	English
Publishing date	2023-10-24
Publishing country	England
Document type	Journal Article
ZDB-ID	1477841-5
ISSN	1465-3966 ; 1354-8506
ISSN (online)	1465-3966
ISSN	1354-8506
DOI	10.1080/13548506.2023.2274315
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Article ; Online: A rare case of nodular mucinosis of the breast away from the nipple-areola complex.

Feng, Ting Ting / Oh, Han Boon / Pang, Yin Huei / Tan, Chuan Chien

The breast journal

2019 Volume 25, Issue 6, Page(s) 1280–1281

MeSH term(s)	Adult ; Biopsy, Large-Core Needle/methods ; Breast/diagnostic imaging ; Breast Neoplasms/pathology ; Breast Neoplasms/surgery ; Diagnosis, Differential ; Female ; Humans ; Image-Guided Biopsy/methods ; Mammography/methods ; Margins of Excision ; Mucinoses/pathology ; Mucinoses/surgery ; Treatment Outcome ; Ultrasonography, Mammary/methods
Language	English
Publishing date	2019-07-08
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	1289960-4
ISSN	1524-4741 ; 1075-122X
ISSN (online)	1524-4741
ISSN	1075-122X
DOI	10.1111/tbj.13449
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Zs.A 4483: Show issues

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Article ; Online: Endovascular coiling versus neurosurgical clipping in the management of aneurysmal subarachnoid haemorrhage in the elderly: a multicenter cohort study.

Neurosurgical review

2024 Volume 47, Issue 1, Page(s) 100

Abstract: The comparability of endovascular coiling over neurosurgical clipping has not been firmly established in elderly patients with aneurysmal subarachnoid haemorrhage (aSAH). Data were obtained from all patients with aSAH aged ≥60 across three tertiary ... ...

Abstract	The comparability of endovascular coiling over neurosurgical clipping has not been firmly established in elderly patients with aneurysmal subarachnoid haemorrhage (aSAH). Data were obtained from all patients with aSAH aged ≥60 across three tertiary hospitals in Singapore from 2014 to 2019. Outcome measures included modified Rankin Scale (mRS) score at 3 and at 6 months, and in-hospital mortality. Of the 134 patients analyzed, 84 (62.7%) underwent coiling and 50 (37.3%) underwent clipping. The endovascular group showed a higher incidence of good mRS score 0-2 at 3 months (OR = 2.45 [95%CI:1.16-5.20];p = 0.018), and a lower incidence of in-hospital mortality (OR = 0.31 [95%CI:0.10-0.91];p = 0.026). There were no significant difference between the two treatment groups in terms of good mRS score at 6 months (OR = 1.98 [95%CI:0.97-4.04];p = 0.060). There were no significant differences in the incidence of complications, such as aneurysm rebleed, delayed hydrocephalus, delayed ischemic neurological deficit and venous thromboembolism between the two treatment groups. However, fewer patients in the coiling group developed large infarcts requiring decompressive craniectomy (OR = 0.32 [95%CI:0.12-0.90];p = 0.025). Age, admission WFNS score I-III, and coiling were independent predictors of good functional outcomes at 3 months. Only age and admission WFNS score I-III remained significant predictors of good functional outcomes at 6 months. Endovascular coiling, compared with neurosurgical clipping, is associated with significantly better short term outcomes in carefully selected elderly patients with aSAH. Maximal intervention is recommended for aSAH in the young elderly age group and those with favorable WFNS scores.
MeSH term(s)	Humans ; Middle Aged ; Aneurysm, Ruptured/surgery ; Cohort Studies ; Endovascular Procedures ; Intracranial Aneurysm/therapy ; Neurosurgical Procedures ; Subarachnoid Hemorrhage/complications ; Treatment Outcome
Language	English
Publishing date	2024-03-01
Publishing country	Germany
Document type	Multicenter Study ; Journal Article
ZDB-ID	6907-3
ISSN	1437-2320 ; 0344-5607
ISSN (online)	1437-2320
ISSN	0344-5607
DOI	10.1007/s10143-024-02325-z
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Zs.A 1445: Show issues

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Article: Social support as a mediator in the relationship between perceived stress and nomophobia: An Investigation among Malaysian university students during the COVID-19 pandemic.

Lai, Samantha Arielle / Pang, Khong Yun / Siau, Ching Sin / Chan, Caryn Mei Hsien / Tan, Yee Kee / Ooi, Pei Boon / Ridzuan, Mohamad Ikhram Bin Mohamad / Ho, Meng Chuan

Current psychology (New Brunswick, N.J.)

2022 , Page(s) 1–8

Abstract: This study examined the mediating role of social support in the relationship between perceived stress and nomophobia among Malaysian university students during the COVID-19 pandemic. A cross-sectional study was conducted with N = 547 university students. ...

Abstract	This study examined the mediating role of social support in the relationship between perceived stress and nomophobia among Malaysian university students during the COVID-19 pandemic. A cross-sectional study was conducted with N = 547 university students. Participants answered a self-administered questionnaire measuring nomophobia, social support, and perceived stress. Exploratory analyses were conducted using partial least square structural equation modelling. We found that perceived stress was positively associated with nomophobia during the COVID-19 pandemic, whilst social support partially mediated the relationship between perceived stress and nomophobia. The results of this study indicated that stress may be buffered by social support in individuals with higher levels of nomophobia.
Language	English
Publishing date	2022-06-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	2021598-8
ISSN	1936-4733 ; 1046-1310
ISSN (online)	1936-4733
ISSN	1046-1310
DOI	10.1007/s12144-022-03256-y
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Article: The role of surgery in high-grade glioma--is surgical resection justified? A review of the current knowledge.

Pang, Boon-Chuan / Wan, Wei-Hwang / Lee, Cheng-Kiang / Khu, Kathleen Joy / Ng, Wai-Hoe

Annals of the Academy of Medicine, Singapore

2007 Volume 36, Issue 5, Page(s) 358–363

Abstract: Introduction: The aims of this article were to review the role of surgical resection in the management of high-grade gliomas and to determine whether there is any survival benefit from surgical resection.: Methods: A literature review of the ... ...

Abstract	Introduction: The aims of this article were to review the role of surgical resection in the management of high-grade gliomas and to determine whether there is any survival benefit from surgical resection. Methods: A literature review of the influence of surgical resection on outcome was carried out. Relevant original and review papers were obtained through a PubMed search using the following keywords: glioma, resection, prognosis and outcome. Results: Presently, there is a lack of evidence to support a survival benefit with aggressive glioma resection, but this should not detract patients from undergoing surgery as there are many other clinical benefits of glioma excision. In addition, limiting surgical morbidity through the use of adjuvant techniques such as intraoperative magnetic resonance imaging (MRI), functional MRI and awake craniotomy is becoming increasingly important. Conclusions: Ideally, a randomised controlled trial would be the best way to resolve the issue of whether (and to what extent) surgical resection leads to improvements in patient outcome and survival, but this would not be ethical. The second best option would be well-controlled retrospective studies with a multivariate analysis of all potential confounding factors.
MeSH term(s)	Glioma/classification ; Glioma/surgery ; Humans ; Singapore ; Survival Analysis
Language	English
Publishing date	2007-05-16
Publishing country	Singapore
Document type	Journal Article ; Review
ZDB-ID	604527-3
ISSN	0304-4602
ISSN	0304-4602
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Zs.B 2420: Show issues

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Article ; Online: Development of a prognostic scoring system to predict risk of reoperation for contralateral hematoma growth after unilateral evacuation of bilateral chronic subdural hematoma.

Zhang, John J Y / Wang, Shilin / Foo, Aaron Song Chuan / Yang, Ming / Quah, Boon Leong / Sun, Ira Siyang / Ng, Zhi Xu / Teo, Kejia / Pang, Boon Chuan / Yang, Eugene Weiren / Lwin, Sein / Chou, Ning / Low, Shiong Wen / Yeo, Tseng Tsai / Santarius, Thomas / Nga, Vincent Diong Weng

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

2020 Volume 78, Page(s) 79–85

Abstract: Bilateral chronic subdural hematoma (bCSDH) is frequently drained unilaterally when the contralateral CSDH is small and asymptomatic. However, reoperation rates for contralateral CSDH growth can be high. We aimed to develop a prognostic scoring system to ...

Abstract	Bilateral chronic subdural hematoma (bCSDH) is frequently drained unilaterally when the contralateral CSDH is small and asymptomatic. However, reoperation rates for contralateral CSDH growth can be high. We aimed to develop a prognostic scoring system to guide the selection of suitable patients for unilateral drainage of bCSDH. Data were collected retrospectively across three tertiary hospitals from 2010 to 2017 on all consecutive bCSDH patients aged 21 or above. Predictors of reoperation were identified using multivariable logistic regression. A prognostic score was developed and internally validated. 240 bCSDH patients were analyzed. 98 (40.8%) underwent unilateral and 142 (59.2%) underwent bilateral evacuation. Clinical outcomes were comparable between the unilateral and bilateral evacuation groups. Within the unilateral evacuation group, 4 (4.1%) had a reoperation for contralateral CSDH growth. Reoperation for contralateral CSDH was predicted by preoperative use of anticoagulants (OR = 15.0, 95% CI: 1.49-169.15, p = 0.017). Complete resolution of contralateral CSDH was predicted by its preoperative maximum width, with a cut-off of 9 mm producing the highest sensitivity and specificity (OR = 4.17 for ≤9 mm, 95% CI: 1.54-11.11, p = 0.004). Using our prognostic score, reoperation rate for contralateral CSDH was 1.6%, 3.6%, 16.7%, and 50.0% in low-risk, moderate-risk, high-risk and very high-risk patients, respectively. With each increase of 1 in the prognostic score, patients were 4 times as likely to undergo reoperation for contralateral CSDH (OR = 3.98, 95% CI: 1.36-13.53, p = 0.013). Our proposed risk score may be used as an adjunct in clinical decision making for bCSDH patients undergoing unilateral evacuation.
MeSH term(s)	Adult ; Aged ; Anticoagulants ; Clinical Decision-Making ; Drainage ; Female ; Hematoma, Subdural, Chronic/diagnosis ; Hematoma, Subdural, Chronic/surgery ; Humans ; Logistic Models ; Male ; Middle Aged ; Prognosis ; Reoperation/statistics & numerical data ; Retrospective Studies ; Sensitivity and Specificity ; Tertiary Care Centers ; Young Adult
Chemical Substances	Anticoagulants
Language	English
Publishing date	2020-06-30
Publishing country	Scotland
Document type	Journal Article
ZDB-ID	1193674-5
ISSN	1532-2653 ; 0967-5868
ISSN (online)	1532-2653
ISSN	0967-5868
DOI	10.1016/j.jocn.2020.06.009
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Zs.A 3999: Show issues

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Article ; Online: Impact of time to resumption of antithrombotic therapy on outcomes after surgical evacuation of chronic subdural hematoma: A multicenter cohort study.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

2021 Volume 89, Page(s) 389–396

Abstract: Background: The decision to resume antithrombotic therapy after surgical evacuation of chronic subdural hematoma (CSDH) requires judicious weighing of the risk of bleeding against that of thromboembolism. This study aimed to investigate the impact of ... ...

Abstract	Background: The decision to resume antithrombotic therapy after surgical evacuation of chronic subdural hematoma (CSDH) requires judicious weighing of the risk of bleeding against that of thromboembolism. This study aimed to investigate the impact of time to resumption of antithrombotic therapy on outcomes of patients after CSDH drainage. Methods: Data were obtained retrospectively from three tertiary hospitals in Singapore from 2010 to 2017. Outcome measures analyzed were CSDH recurrence and any thromboembolic events. Logistic and Cox regression tests were used to identify associations between time to resumption and outcomes. Results: A total of 621 patients underwent 761 CSDH surgeries. Preoperative antithrombotic therapy was used in 139 patients. 110 (79.1%) were on antiplatelets and 35 (25.2%) were on anticoagulants, with six patients (4.3%) being on both antiplatelet and anticoagulant therapy. Antithrombotic therapy was resumed in 84 patients (60.4%) after the surgery. Median time to resumption was 71 days (IQR 29 - 201). Recurrence requiring reoperation occurred in 15 patients (10.8%), of which 12 had recurrence before and three after resumption. Median time to recurrence was 35 days (IQR 27 - 47, range 4 - 82 days). Recurrence rates were similar between patients that were restarted on antithrombotic therapy before and after 14, 21, 28, 42, 56, 70 and 84 days, respectively. Thromboembolic events occurred in 12 patients (8.6%), of which five had the event prior to restarting antithrombosis. Conclusions: Time to antithrombotic resumption did not significantly affect CSDH recurrence. Early resumption of antithrombotic therapy can be safe for patients with a high thromboembolic risk.
MeSH term(s)	Adult ; Aged ; Anticoagulants/administration & dosage ; Anticoagulants/therapeutic use ; Cohort Studies ; Drainage/adverse effects ; Drainage/methods ; Fibrinolytic Agents/administration & dosage ; Fibrinolytic Agents/therapeutic use ; Hematoma, Subdural, Chronic/drug therapy ; Hematoma, Subdural, Chronic/surgery ; Humans ; Middle Aged ; Neurosurgical Procedures/adverse effects ; Neurosurgical Procedures/methods ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Reoperation/statistics & numerical data ; Thromboembolism/drug therapy ; Thromboembolism/epidemiology
Chemical Substances	Anticoagulants ; Fibrinolytic Agents
Language	English
Publishing date	2021-06-01
Publishing country	Scotland
Document type	Journal Article ; Multicenter Study
ZDB-ID	1193674-5
ISSN	1532-2653 ; 0967-5868
ISSN (online)	1532-2653
ISSN	0967-5868
DOI	10.1016/j.jocn.2021.05.036
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Zs.A 3999: Show issues

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Conference proceedings: Predictive factors of mortality for primary pontine haemorrhage in an Asian population

Munusamy, Thangaraj / Surentheran, S. / Nasir, Aisyah / Pang, Boon Chuan / Yang, Eugene / Kirollos, Ramez

2017 , Page(s) Mi.24.05

Event/congress	68. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 7. Joint Meeting mit der Society of British Neurological Surgeons (SBNS); Magdeburg; ; Society of British Neurological Surgeons; 2017
Keywords	Medizin, Gesundheit
Publishing date	2017-06-09
Publisher	German Medical Science GMS Publishing House; Düsseldorf
Document type	Conference proceedings
DOI	10.3205/17dgnc531
Database	German Medical Science

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