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  1. Book: Local delivery of cytoreductive agents for the treatment of glioblastoma

    Kalkanis, Steven N.

    (Neuro-oncology ; 17, Suppl. 2)

    2015  

    Author's details physician ed.: Steven N. Kalkanis
    Series title Neuro-oncology ; 17, Suppl. 2
    Neuro-Oncology
    Collection Neuro-Oncology
    Language English
    Size ii36 S. : Ill., graph. Darst.
    Publisher Oxford Univ. Press
    Publishing place Cary, NC
    Publishing country United States
    Document type Book
    HBZ-ID HT018645022
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Zs A 5307 -17,Suppl.2- not available for loan Zeitschriften-Lesesaal

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  2. Article ; Online: Presidential Address to the 2021 Annual Meeting of the Congress of Neurological Surgeons.

    Kalkanis, Steven N

    Neurosurgery

    2022  Volume 68, Issue Suppl 1, Page(s) 1–5

    MeSH term(s) Humans ; Neurosurgeons ; Neurosurgery ; Societies, Medical
    Language English
    Publishing date 2022-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1227/NEU.0000000000001881
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Introduction. Update on brain metastases.

    Aghi, Manish K / Brastianos, Priscilla K / Kim, Albert H / Kalkanis, Steven N / Tonn, Joerg-Christian

    Neurosurgical focus

    2023  Volume 55, Issue 2, Page(s) E1

    MeSH term(s) Humans ; Brain Neoplasms/surgery ; Brain Neoplasms/secondary ; Radiosurgery
    Language English
    Publishing date 2023-08-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2026589-X
    ISSN 1092-0684 ; 1092-0684
    ISSN (online) 1092-0684
    ISSN 1092-0684
    DOI 10.3171/2023.6.FOCUS23343
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Setting the stage: local delivery of cytoreductive agents for the treatment of glioblastoma.

    Kalkanis, Steven N

    Neuro-oncology

    2015  Volume 17 Suppl 2, Page(s) ii1–ii2

    MeSH term(s) Antineoplastic Agents/therapeutic use ; Brain Neoplasms/drug therapy ; Drug Delivery Systems ; Glioblastoma/drug therapy ; Humans
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2015-03
    Publishing country England
    Document type Introductory Journal Article
    ZDB-ID 2028601-6
    ISSN 1523-5866 ; 1522-8517
    ISSN (online) 1523-5866
    ISSN 1522-8517
    DOI 10.1093/neuonc/nov001
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  5. Article ; Online: The CNS Mission and NEUROSURGERY® Publications.

    Shupak, Regina / Rao, Ganesh / Kalkanis, Steven N

    Neurosurgery

    2019  Volume 85, Issue 4, Page(s) 439–440

    Language English
    Publishing date 2019-09-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1093/neuros/nyz317
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Laser interstitial thermal therapy for deep-seated perivascular brain tumors is not associated with distal ischemia.

    Reese, Jared C / Fadel, Hassan A / Pawloski, Jacob A / Samir, Mariam / Haider, Sameah / Komatar, Ricardo J / Luther, Evan / Morell, Alexis A / Ivan, Mike E / Robin, Adam M / Kalkanis, Steven N / Lee, Ian Y

    Journal of neuro-oncology

    2024  Volume 166, Issue 2, Page(s) 265–272

    Abstract: Purpose: Laser interstitial thermal therapy (LITT) is a minimally invasive cytoreductive treatment option for brain tumors with a risk of vascular injury from catheter placement or thermal energy. This may be of concern with deep-seated tumors that have ...

    Abstract Purpose: Laser interstitial thermal therapy (LITT) is a minimally invasive cytoreductive treatment option for brain tumors with a risk of vascular injury from catheter placement or thermal energy. This may be of concern with deep-seated tumors that have surrounding end-artery perforators and critical microvasculature. The purpose of this study was to assess the risk of distal ischemia following LITT for deep-seated perivascular brain tumors.
    Methods: A retrospective review of a multi-institution database was used to identify patients who underwent LITT between 2013 and 2022 for tumors located within the insula, thalamus, basal ganglia, and anterior perforated substance. Demographic, clinical and volumetric tumor characteristics were collected. The primary outcome was radiographic evidence of distal ischemia on post-ablation magnetic resonance imaging (MRI).
    Results: 61 LITT ablations for deep-seated perivascular brain tumors were performed. Of the tumors treated, 24 (39%) were low-grade gliomas, 32 (52%) were high-grade gliomas, and 5 (8%) were metastatic. The principal location included 31 (51%) insular, 14 (23%) thalamic, 13 (21%) basal ganglia, and 3 (5%) anterior perforated substance tumors. The average tumor size was 19.6 cm
    Conclusion: We demonstrate that LITT for deep-seated perivascular brain tumors has minimal ischemic risks and is a feasible cytoreductive treatment option for otherwise difficult to access intracranial tumors.
    MeSH term(s) Humans ; Laser Therapy/methods ; Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/surgery ; Glioma/surgery ; Magnetic Resonance Imaging/methods ; Retrospective Studies ; Lasers
    Language English
    Publishing date 2024-01-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604875-4
    ISSN 1573-7373 ; 0167-594X
    ISSN (online) 1573-7373
    ISSN 0167-594X
    DOI 10.1007/s11060-023-04546-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines for the Treatment of Adults With Metastatic Brain Tumors: Executive Summary.

    Olson, Jeffrey J / Kalkanis, Steven N / Ryken, Timothy C

    Neurosurgery

    2019  Volume 84, Issue 3, Page(s) 550–552

    Abstract: Background: The Congress of Neurological Surgeons systematic review and evidence-based clinical practice parameter guidelines for the treatment of adults with metastatic brain tumors was first published in 2010. Because of the time elapsed since that ... ...

    Abstract Background: The Congress of Neurological Surgeons systematic review and evidence-based clinical practice parameter guidelines for the treatment of adults with metastatic brain tumors was first published in 2010. Because of the time elapsed since that publication, an update of this set of guidelines based on literature published since is now indicated.
    Objective: To establish the best evidence-based management of metastatic brain tumors over all commonly used diagnostic and treatment modalities in regularly encountered clinical situations.
    Methods: Literature searches regarding management of metastatic brain tumors with whole brain radiation therapy, surgery, stereotactic radiosurgery, chemotherapy, prophylactic anticonvulsants, steroids, instances of multiple brain metastases, and emerging and investigational therapies were carried out to answer questions designed by consensus of a multidisciplinary writing group.
    Results: Recommendations were created and their strength linked to the quality of the literature data available thus creating an evidence-based guideline. Importantly, shortcomings and biases to the literature data are brought out so as to provide guidance for future investigation and improvements in the management of patients with metastatic brain tumors.
    Conclusion: This series of guidelines was constructed to assess the most current and clinically relevant evidence for management of metastatic brain tumors. They set a benchmark regarding the current evidence base for this management while also highlighting important key areas for future basic and clinical research, particularly on those topics for which no recommendations could be formulated.The full guideline can be found at: https://www.cns.org/guidelines-treatment-adults-metastatic-brain-tumors/chapter_1.
    MeSH term(s) Adult ; Brain Neoplasms/secondary ; Brain Neoplasms/surgery ; Congresses as Topic/standards ; Consensus ; Evidence-Based Medicine/standards ; Female ; Humans ; Male ; Neurosurgeons/standards ; Radiosurgery ; Therapies, Investigational
    Language English
    Publishing date 2019-01-10
    Publishing country United States
    Document type Journal Article ; Systematic Review
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1093/neuros/nyy540
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1424: Show issues Location:
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  8. Article ; Online: Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines on the Treatment of Adults With Vestibular Schwannomas: Executive Summary.

    Olson, Jeffrey J / Kalkanis, Steven N / Ryken, Timothy C

    Neurosurgery

    2018  Volume 82, Issue 2, Page(s) 129–134

    Abstract: Background: Vestibular schwannomas (VS) are uncommon lesions that are a substantial challenge to the neurosurgeons, otologists, and radiation oncologists who undertake their clinical management. A starting point to improving the current knowledge is to ... ...

    Abstract Background: Vestibular schwannomas (VS) are uncommon lesions that are a substantial challenge to the neurosurgeons, otologists, and radiation oncologists who undertake their clinical management. A starting point to improving the current knowledge is to define the benchmarks of the current research studying VS management using evidence-based techniques in order to allow meaningful points of departure for future scientific and clinical research.
    Objective: To establish the best evidence-based management of VS, including initial otologic evaluation, imaging diagnosis, use of surgical techniques, assessment of tumor pathology, and the administration of radiation therapy.
    Methods: Multidisciplinary writing groups were identified to design questions, literature searches, and collection and classification of relevant findings. This information was then translated to recommendations based on the strength of the available literature.
    Results: This guideline series yielded some level 2 recommendations and a greater number of level 3 recommendations directed at the management of VS. Importantly, in some cases, a number of well-designed questions and subsequent searches did not yield information that allowed creation of a meaningful and justifiable recommendation.
    Conclusion: This series of guidelines was constructed to assess the most current and clinically relevant evidence for the management of VS. They set a benchmark regarding the current evidence base for this type of tumor while also highlighting important key areas for future basic and clinical research, particularly on those topics for which no recommendations could be formulated.  The full guidelines can be found at: https://www.cns.org/guidelines/guidelines-management-patients-vestibular-schwannoma.
    MeSH term(s) Adult ; Guidelines as Topic ; Humans ; Neuroma, Acoustic/therapy ; Systematic Reviews as Topic
    Language English
    Publishing date 2018-02-05
    Publishing country United States
    Document type Introductory Journal Article
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1093/neuros/nyx586
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Congress of neurological surgeons systematic review and evidence-based guidelines update on the role of chemotherapeutic management and antiangiogenic treatment of newly diagnosed glioblastoma in adults.

    Redjal, Navid / Nahed, Brian V / Dietrich, Jorg / Kalkanis, Steven N / Olson, Jeffrey J

    Journal of neuro-oncology

    2020  Volume 150, Issue 2, Page(s) 165–213

    Abstract: Question: What is the role of temozolomide in the management of adult patients (aged 65 and under) with newly diagnosed glioblastoma?: Target population: These recommendations apply to adult patients diagnosed with newly diagnosed glioblastoma.: ... ...

    Abstract Question: What is the role of temozolomide in the management of adult patients (aged 65 and under) with newly diagnosed glioblastoma?
    Target population: These recommendations apply to adult patients diagnosed with newly diagnosed glioblastoma.
    Recommendation: Level I: Concurrent and post-irradiation Temozolomide (TMZ) in combination with radiotherapy and post-radiotherapy as described by Stupp et al. is recommended to improve both PFS and OS in adult patients with newly diagnosed GBM. There is no evidence that alterations in the dosing regimen have additional beneficial effect.
    Question: Is there benefit to adjuvant temozolomide treatment in elderly patients (> 65 years old?).
    Target population: These recommendations apply to adult patients diagnosed with newly diagnosed glioblastoma.
    Recommendation: Level III: Adjuvant TMZ treatment is suggested as a treatment option to improve PFS and OS in adult patients (over 70 years of age) with newly diagnosed GBM.
    Question: What is the role of local regional chemotherapy with BCNU biodegradable polymeric wafers in adult patients with newly diagnosed glioblastoma?
    Target population: These recommendations apply to adult patients diagnosed with newly diagnosed glioblastoma.
    Recommendation: Level III: There is insufficient evidence for the use of BCNU wafers following resection in patients with newly diagnosed glioblastoma who undergo the Stupp protocol after surgery. Further studies of higher quality are suggested to understand the role of BCNU wafer and other locoregional therapy in the setting of Stupp Protocol.
    Question: What is the role of bevacizumab in the adult patient with newly diagnosed glioblastoma?
    Target population: These recommendations apply to adult patients diagnosed with newly diagnosed glioblastoma.
    Recommendation: Level I: Bevacizumab in general is not recommended in the initial treatment of adult patients with newly diagnosed GBM. It continues to be strongly recommended that patients with newly diagnosed GBM be enrolled in properly designed clinical trials to assess the benefit of novel chemotherapeutic agents compared to standard therapy.
    MeSH term(s) Adult ; Angiogenesis Inhibitors/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Disease Management ; Evidence-Based Practice/standards ; Glioblastoma/diagnosis ; Glioblastoma/drug therapy ; Humans ; Practice Guidelines as Topic/standards
    Chemical Substances Angiogenesis Inhibitors
    Language English
    Publishing date 2020-11-19
    Publishing country United States
    Document type Journal Article ; Systematic Review
    ZDB-ID 604875-4
    ISSN 1573-7373 ; 0167-594X
    ISSN (online) 1573-7373
    ISSN 0167-594X
    DOI 10.1007/s11060-020-03601-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  10. Article ; Online: Reoperation for Recurrent Glioblastoma Multiforme.

    Robin, Adam M / Lee, Ian / Kalkanis, Steven N

    Neurosurgery clinics of North America

    2017  Volume 28, Issue 3, Page(s) 407–428

    Abstract: The role of reoperation for glioblastoma multiforme (GBM) recurrence is currently unknown. However, multiple studies have indicated that survival and quality of life are improved with a repeat operation at the time of disease recurrence. Prognosis is ... ...

    Abstract The role of reoperation for glioblastoma multiforme (GBM) recurrence is currently unknown. However, multiple studies have indicated that survival and quality of life are improved with a repeat operation at the time of disease recurrence. Prognosis is likely interdependent on several factors, including age, functional status, initial resection status, disease location, and surgical efficacy. However, there are significant data indicating no survival benefit for reoperation. This comprehensive literature review considering the controversial question of whether to operate for progressive or recurrent GBM seeks to evaluate the current available evidence and report on its conclusions.
    Language English
    Publishing date 2017-07
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1196855-2
    ISSN 1558-1349 ; 1042-3680
    ISSN (online) 1558-1349
    ISSN 1042-3680
    DOI 10.1016/j.nec.2017.02.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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