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  1. Article ; Online: COVID-19 vaccination in individuals with inflammatory rheumatic diseases.

    Skapenko, Alla / Schulze-Koops, Hendrik

    Nature reviews. Rheumatology

    2022  Volume 19, Issue 2, Page(s) 76–77

    MeSH term(s) Humans ; COVID-19 Vaccines/therapeutic use ; COVID-19/prevention & control ; Vaccination ; Rheumatic Diseases/drug therapy
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2022-12-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2491532-4
    ISSN 1759-4804 ; 1759-4790
    ISSN (online) 1759-4804
    ISSN 1759-4790
    DOI 10.1038/s41584-022-00892-3
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    Zs.A 6338: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Spontaneous abortion as differential diagnosis of intermittent glomerular proteinuria in inactive systemic lupus erythematosus.

    Ullrich, Fabian T H / Skapenko, Alla / Schulze-Koops, Hendrik

    Clinical case reports

    2023  Volume 11, Issue 7, Page(s) e7686

    Abstract: In women of childbearing age, severe proteinuria in systemic lupus erythematosus raises concern for renal involvement and pregnancy complications. While persisting renal loss of protein is known to culminate in extensive interventions, intermittent ... ...

    Abstract In women of childbearing age, severe proteinuria in systemic lupus erythematosus raises concern for renal involvement and pregnancy complications. While persisting renal loss of protein is known to culminate in extensive interventions, intermittent proteinuria in inactive disease requires an adjusted approach. Contextual awareness of this urinary finding is thus essential.
    Language English
    Publishing date 2023-07-20
    Publishing country England
    Document type Case Reports
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.7686
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Thesis: Mechanisms of CD28 mediated antigen independent Th2 cell differentiation from memory T cells

    Skapenko, Alla

    implications for autoimmunity = Mechanismen der CD28-mediierten, Antigen-unabhängigen Th2-Zell-Differenzierung von Memory-T-Zellen : Bedeutung für Autoimmunität

    2001  

    Title variant Mechanismen der CD28-mediierten, Antigen-unabhängigen Th2-Zell-Differenzierung von Memory-T-Zellen
    Author's details vorgelegt von Alla Skapenko
    Language English ; German
    Size 120 S., Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Erlangen, Nürnberg, Univ., Diss., 2001
    HBZ-ID HT013203021
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2001 D 2704 order for loan Magazin

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  4. Article ; Online: Reactive arthritis after SARS-CoV-2 infection

    Alla Skapenko / Sophia Dombret

    RMD Open, Vol 8, Iss

    2022  Volume 2

    Abstract: SARS-CoV-2 has been recognised as a potential trigger of inflammatory arthritis in individuals with inflammatory rheumatic diseases as well as in previously unaffected individuals. However, new-onset arthritis after COVID-19 is a heterogeneous phenomenon ...

    Abstract SARS-CoV-2 has been recognised as a potential trigger of inflammatory arthritis in individuals with inflammatory rheumatic diseases as well as in previously unaffected individuals. However, new-onset arthritis after COVID-19 is a heterogeneous phenomenon that complicates differential diagnosis. For example, acute arthritis with features of viral arthritis has been reported after COVID-19, as has crystal-induced arthritis. Arthritides mimicking reactive arthritis (ReA) have also been described, but these patients often do not fulfil the typical features of ReA: several reports describe cases of patients older than 45 years at the onset of arthritis, and the characteristic genetic feature of ReA, HLA-B27, is rarely found. Because viral infections are much less likely to cause ReA than bacterial infections, and respiratory infections are rarely the cause of ReA, it is currently unknown whether SARS-CoV-2 can cause true ReA. Here, we report the case of a 30-year-old patient who presented with acute pain, swelling and redness in the left metatarsophalangeal (MTP) joint and ankle 7 days after resolution of a SARS-CoV-2 infection. Diagnostics revealed arthritis of the MTP2, synovitis of the upper ankle with significant joint effusion and peritendinitis of the flexor tendons. Based on the clinical manifestations and diagnostic test results, ReA appeared to be the most likely cause. A screening for typical ReA-associated infections was negative. The patient was treated with NSAIDs and intra-articular and systemic glucocorticoids. At a follow-up visit after discontinuation of glucocorticoids, the patient was symptom-free. Overall, we observed a ReA with typical clinical, genetic and patient characteristics after SARS-CoV-2 infection, and we conclude that a direct association with COVID-19 is highly plausible.
    Keywords Medicine ; R
    Subject code 610
    Language English
    Publishing date 2022-11-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Conference proceedings: Immundefekt – das Erstsymptom eines Thymoms?

    Gailis, Didzis / Schulze-Koops, Hendrik / Skapenko, Alla

    2023  , Page(s) FA.14

    Event/congress Deutscher Rheumatologiekongress 2023, 51. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 37. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), 33. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR); Leipzig; ; Gesellschaft für Kinder- und Jugendrheumatologie; 2023
    Keywords Medizin, Gesundheit
    Publishing date 2023-08-30
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/23dgrh081
    Database German Medical Science

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  6. Conference proceedings: Seltene Checkpointinhibitortherapie-induzierte axiale inflammatorische Veränderungen

    Dombret, Sophia / Skapenko, Alla / Schulze-Koops, Hendrik

    2023  , Page(s) DI.02

    Event/congress Deutscher Rheumatologiekongress 2023, 51. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 37. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), 33. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR); Leipzig; ; Gesellschaft für Kinder- und Jugendrheumatologie; 2023
    Keywords Medizin, Gesundheit
    Publishing date 2023-08-30
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/23dgrh006
    Database German Medical Science

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  7. Article ; Online: A rare side effect of methotrexate therapy: drug-induced osteopathy with multiple fractures of the lower limb.

    Singh, Delila / Hesse, Nina / Skapenko, Alla / Schulze-Koops, Hendrik

    RMD open

    2023  Volume 9, Issue 1

    Abstract: Methotrexate is associated with bone lesions that are rare and, although presenting with a typical localisation to the lower extremities and appearing with a characteristic radiologic morphology, largely unknown and often misdiagnosed as osteoporotic ... ...

    Abstract Methotrexate is associated with bone lesions that are rare and, although presenting with a typical localisation to the lower extremities and appearing with a characteristic radiologic morphology, largely unknown and often misdiagnosed as osteoporotic insufficiency fractures. The correct and early diagnosis, however, is key for treatment and prevention of further osteopathology. Here, we present a patient with rheumatoid arthritis who developed multiple painful insufficiency fractures in the left foot (processus anterior calcanei, tuber calcanei) and in the right lower leg and foot (anterior and dorsal calcaneus and at the cuboid and distal tibia) during therapy with methotrexate, which were all misdiagnosed as osteoporotic. The fractures occurred between 8 months and 35 months after starting methotrexate. Discontinuation of methotrexate resulted in rapid pain relief and no further fractures have occurred. This case powerfully demonstrates the importance of raising awareness of methotrexate osteopathy in order to take appropriate therapeutic measures, including and perniciously discontinuing methotrexate.
    MeSH term(s) Humans ; Methotrexate/therapeutic use ; Fractures, Stress/chemically induced ; Fractures, Stress/drug therapy ; Fractures, Multiple/chemically induced ; Fractures, Multiple/drug therapy ; Arthritis, Rheumatoid/drug therapy ; Osteoporotic Fractures ; Lower Extremity
    Chemical Substances Methotrexate (YL5FZ2Y5U1)
    Language English
    Publishing date 2023-02-21
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2812592-7
    ISSN 2056-5933 ; 2056-5933
    ISSN (online) 2056-5933
    ISSN 2056-5933
    DOI 10.1136/rmdopen-2023-002982
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Conference proceedings: Spontaneous abortion as differential diagnosis of intermittent glomerular proteinuria in clinically and serologically inactive SLE

    Ullrich, Fabian / Schulze-Koops, Hendrik / Skapenko, Alla

    2023  , Page(s) FA.53

    Event/congress Deutscher Rheumatologiekongress 2023, 51. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 37. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), 33. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR); Leipzig; ; Gesellschaft für Kinder- und Jugendrheumatologie; 2023
    Keywords Medizin, Gesundheit
    Publishing date 2023-08-30
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/23dgrh119
    Database German Medical Science

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  9. Article ; Online: Reactive arthritis after SARS-CoV-2 infection.

    Dombret, Sophia / Skapenko, Alla / Schulze-Koops, Hendrik

    RMD open

    2022  Volume 8, Issue 2

    Abstract: SARS-CoV-2 has been recognised as a potential trigger of inflammatory arthritis in individuals with inflammatory rheumatic diseases as well as in previously unaffected individuals. However, new-onset arthritis after COVID-19 is a heterogeneous phenomenon ...

    Abstract SARS-CoV-2 has been recognised as a potential trigger of inflammatory arthritis in individuals with inflammatory rheumatic diseases as well as in previously unaffected individuals. However, new-onset arthritis after COVID-19 is a heterogeneous phenomenon that complicates differential diagnosis. For example, acute arthritis with features of viral arthritis has been reported after COVID-19, as has crystal-induced arthritis. Arthritides mimicking reactive arthritis (ReA) have also been described, but these patients often do not fulfil the typical features of ReA: several reports describe cases of patients older than 45 years at the onset of arthritis, and the characteristic genetic feature of ReA, HLA-B27, is rarely found. Because viral infections are much less likely to cause ReA than bacterial infections, and respiratory infections are rarely the cause of ReA, it is currently unknown whether SARS-CoV-2 can cause true ReA. Here, we report the case of a 30-year-old patient who presented with acute pain, swelling and redness in the left metatarsophalangeal (MTP) joint and ankle 7 days after resolution of a SARS-CoV-2 infection. Diagnostics revealed arthritis of the MTP2, synovitis of the upper ankle with significant joint effusion and peritendinitis of the flexor tendons. Based on the clinical manifestations and diagnostic test results, ReA appeared to be the most likely cause. A screening for typical ReA-associated infections was negative. The patient was treated with NSAIDs and intra-articular and systemic glucocorticoids. At a follow-up visit after discontinuation of glucocorticoids, the patient was symptom-free. Overall, we observed a ReA with typical clinical, genetic and patient characteristics after SARS-CoV-2 infection, and we conclude that a direct association with COVID-19 is highly plausible.
    MeSH term(s) Adult ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Arthritis, Reactive/diagnosis ; Arthritis, Reactive/drug therapy ; Arthritis, Reactive/etiology ; COVID-19/complications ; COVID-19/diagnosis ; HLA-B27 Antigen ; Humans ; SARS-CoV-2
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal ; HLA-B27 Antigen
    Language English
    Publishing date 2022-09-12
    Publishing country England
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2812592-7
    ISSN 2056-5933 ; 2056-5933
    ISSN (online) 2056-5933
    ISSN 2056-5933
    DOI 10.1136/rmdopen-2022-002519
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Conference proceedings: Multiple atraumatische Frakturen – nicht immer ist es eine Osteoporose oder ein Tumor

    Singh, Delila / Hesse, Nina / Skapenko, Alla / Schulze-Koops, Hendrik

    2023  , Page(s) FA.39

    Event/congress Deutscher Rheumatologiekongress 2023, 51. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 37. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), 33. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR); Leipzig; ; Gesellschaft für Kinder- und Jugendrheumatologie; 2023
    Keywords Medizin, Gesundheit
    Publishing date 2023-08-30
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/23dgrh105
    Database German Medical Science

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