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Article ; Online: Identification of NRF2 Activation as a Prognostic Biomarker in T-Cell Acute Lymphoblastic Leukaemia.

Villa-Morales, María / Pérez-Gómez, Laura / Pérez-Gómez, Eduardo / López-Nieva, Pilar / Fernández-Navarro, Pablo / Santos, Javier

International journal of molecular sciences

2023 Volume 24, Issue 12

Abstract: The standard-of-care treatment of T-cell acute lymphoblastic leukaemia (T-ALL) with chemotherapy usually achieves reasonable rates of initial complete response. However, patients who relapse or do not respond to conventional therapy show dismal outcomes, ...

Abstract	The standard-of-care treatment of T-cell acute lymphoblastic leukaemia (T-ALL) with chemotherapy usually achieves reasonable rates of initial complete response. However, patients who relapse or do not respond to conventional therapy show dismal outcomes, with cure rates below 10% and limited therapeutic options. To ameliorate the clinical management of these patients, it is urgent to identify biomarkers able to predict their outcomes. In this work, we investigate whether NRF2 activation constitutes a biomarker with prognostic value in T-ALL. Using transcriptomic, genomic, and clinical data, we found that T-ALL patients with high
MeSH term(s)	Humans ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/genetics ; NF-E2-Related Factor 2/genetics ; Prognosis ; Phosphatidylinositol 3-Kinases ; Neoplasm Recurrence, Local ; T-Lymphocytes
Chemical Substances	NF-E2-Related Factor 2 ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-)
Language	English
Publishing date	2023-06-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms241210350
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Identification of NRF2 Activation as a Prognostic Biomarker in T-Cell Acute Lymphoblastic Leukaemia

María Villa-Morales / Laura Pérez-Gómez / Eduardo Pérez-Gómez / Pilar López-Nieva / Pablo Fernández-Navarro / Javier Santos

International Journal of Molecular Sciences, Vol 24, Iss 10350, p

2023 Volume 10350

Abstract	The standard-of-care treatment of T-cell acute lymphoblastic leukaemia (T-ALL) with chemotherapy usually achieves reasonable rates of initial complete response. However, patients who relapse or do not respond to conventional therapy show dismal outcomes, with cure rates below 10% and limited therapeutic options. To ameliorate the clinical management of these patients, it is urgent to identify biomarkers able to predict their outcomes. In this work, we investigate whether NRF2 activation constitutes a biomarker with prognostic value in T-ALL. Using transcriptomic, genomic, and clinical data, we found that T-ALL patients with high NFE2L2 levels had shorter overall survival. Our results demonstrate that the PI3K-AKT-mTOR pathway is involved in the oncogenic signalling induced by NRF2 in T-ALL. Furthermore, T-ALL patients with high NFE2L2 levels displayed genetic programs of drug resistance that may be provided by NRF2-induced biosynthesis of glutathione. Altogether, our results indicate that high levels of NFE2L2 may be a predictive biomarker of poor treatment response in T-ALL patients, which would explain the poor prognosis associated with these patients. This enhanced understanding of NRF2 biology in T-ALL may allow a more refined stratification of patients and the proposal of targeted therapies, with the ultimate goal of improving the outcome of relapsed/refractory T-ALL patients.
Keywords	T-cell acute lymphoblastic leukaemia (T-ALL) ; NRF2 (nuclear factor erythroid 2-related factor 2) ; prognostic biomarker ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	610
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Fatty acid amide hydrolase drives adult mammary gland development by promoting luminal cell differentiation.

Tundidor, Isabel / Seijo-Vila, Marta / Blasco-Benito, Sandra / Rubert-Hernández, María / Moreno-Bueno, Gema / Bindila, Laura / de la Rosa, Rubén Fernández / Guzmán, Manuel / Sánchez, Cristina / Pérez-Gómez, Eduardo

Cell death discovery

2024 Volume 10, Issue 1, Page(s) 12

Abstract: Mammary gland development occurs primarily in adulthood, undergoing extensive expansion during puberty followed by cycles of functional specialization and regression with every round of pregnancy/lactation/involution. This process is ultimately driven by ...

Abstract	Mammary gland development occurs primarily in adulthood, undergoing extensive expansion during puberty followed by cycles of functional specialization and regression with every round of pregnancy/lactation/involution. This process is ultimately driven by the coordinated proliferation and differentiation of mammary epithelial cells. However, the endogenous molecular factors regulating these developmental dynamics are still poorly defined. Endocannabinoid signaling is known to determine cell fate-related events during the development of different organs in the central nervous system and the periphery. Here, we report that the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) plays a pivotal role in adult mammary gland development. Specifically, it is required for luminal lineage specification in the mammary gland, and it promotes hormone-driven secretory differentiation of mammary epithelial cells by controlling the endogenous levels of anandamide and the subsequent activation of cannabinoid CB
Language	English
Publishing date	2024-01-06
Publishing country	United States
Document type	Journal Article
ISSN	2058-7716
ISSN	2058-7716
DOI	10.1038/s41420-023-01788-1
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Article ; Online: Male starling floaters preferentially visit nests of males with reduced resource holding potential.

Gómez-Llanos, Eduardo / Redondo, Iraida / Pérez-Rodríguez, Lorenzo / Gil, Diego

Biology letters

2024 Volume 20, Issue 3, Page(s) 20230376

Abstract: Floaters are sexually mature individuals that are not able to reproduce by defending breeding resources. Floaters often visit active nests, probably to gather public information or to compete for a nesting site. We tested the hypothesis that floaters ... ...

Abstract	Floaters are sexually mature individuals that are not able to reproduce by defending breeding resources. Floaters often visit active nests, probably to gather public information or to compete for a nesting site. We tested the hypothesis that floaters preferentially prospect nests in which they have a better chance of taking over, and that they do so by assessing the owners' resource holding potential (RHP). We manipulated the flight capacity of male and female breeders in a population of spotless starlings (
MeSH term(s)	Humans ; Animals ; Female ; Male ; Starlings ; Breeding ; Feathers ; Oviposition ; Reproduction
Language	English
Publishing date	2024-03-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2135022-X
ISSN	1744-957X ; 1744-9561
ISSN (online)	1744-957X
ISSN	1744-9561
DOI	10.1098/rsbl.2023.0376
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Article: Assessing Ecogeographic Rules in Two Sigmodontine Rodents along an Elevational Gradient in Central Chile.

Valladares-Gómez, Alejandro / Torres-Pérez, Fernando / Palma, R Eduardo

Animals : an open access journal from MDPI

2024 Volume 14, Issue 6

Abstract: Bergmann's and Allen's rules are two classic ecogeographic rules concerning the physiological mechanisms employed by endotherm vertebrates for heat conservation in cold environments, which correlate with adaptive morphological changes. Thus, larger body ... ...

Abstract	Bergmann's and Allen's rules are two classic ecogeographic rules concerning the physiological mechanisms employed by endotherm vertebrates for heat conservation in cold environments, which correlate with adaptive morphological changes. Thus, larger body sizes (Bergmann's rule) and shorter appendages and limbs (Allen's rule) are expected in mammals inhabiting cold environments (higher latitudes). Both rules may also apply to elevational gradients, due to the decrease in external temperature as elevation increases. In this study, we evaluated whether these patterns were true in two coexisting sigmodontine rodents across an elevational gradient in central Chile. We analyzed whether the size of the skull, body, and appendages of
Language	English
Publishing date	2024-03-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani14060830
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Article: The Multifaceted Manifestations of Multisystem Inflammatory Syndrome during the SARS-CoV-2 Pandemic.

Pérez-Gómez, Héctor Raúl / Morfín-Otero, Rayo / González-Díaz, Esteban / Esparza-Ahumada, Sergio / León-Garnica, Gerardo / Rodríguez-Noriega, Eduardo

Pathogens (Basel, Switzerland)

2022 Volume 11, Issue 5

Abstract: The novel coronavirus SARS-CoV-2, which has similarities to the 2002-2003 severe acute respiratory syndrome coronavirus known as SARS-CoV-1, causes the infectious disease designated COVID-19 by the World Health Organization (Coronavirus Disease 2019). ... ...

Abstract	The novel coronavirus SARS-CoV-2, which has similarities to the 2002-2003 severe acute respiratory syndrome coronavirus known as SARS-CoV-1, causes the infectious disease designated COVID-19 by the World Health Organization (Coronavirus Disease 2019). Although the first reports indicated that activity of the virus is centered in the lungs, it was soon acknowledged that SARS-CoV-2 causes a multisystem disease. Indeed, this new pathogen causes a variety of syndromes, including asymptomatic disease; mild disease; moderate disease; a severe form that requires hospitalization, intensive care, and mechanical ventilation; multisystem inflammatory disease; and a condition called long COVID or postacute sequelae of SARS-CoV-2 infection. Some of these syndromes resemble previously described disorders, including those with no confirmed etiology, such as Kawasaki disease. After recognition of a distinct multisystem inflammatory syndrome in children, followed by a similar syndrome in adults, various multisystem syndromes occurring during the pandemic associated or related to SARS-CoV-2 began to be identified. A typical pattern of cytokine and chemokine dysregulation occurs in these complex syndromes; however, the disorders have distinct immunological determinants that may help to differentiate them. This review discusses the origins of the different trajectories of the inflammatory syndromes related to SARS-CoV-2 infection.
Language	English
Publishing date	2022-05-08
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens11050556
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Article: Amivantamab, the first epidermal growth factor receptor and mesenchymal-epithelial transition factor inhibitor, associated with penile and inguinal ulcers and paronychia.

Cancel-Artau, Karina J / Marrero-Pérez, Angélica C / Michelén-Gómez, Eduardo A / Sánchez-Flores, Xavier

JAAD case reports

2024 Volume 45, Page(s) 113–116

Language	English
Publishing date	2024-01-27
Publishing country	United States
Document type	Case Reports
ZDB-ID	2834220-3
ISSN	2352-5126
ISSN	2352-5126
DOI	10.1016/j.jdcr.2024.01.014
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Article: Neuronal Cannabinoid CB

Costas-Insua, Carlos / Seijo-Vila, Marta / Blázquez, Cristina / Blasco-Benito, Sandra / Rodríguez-Baena, Francisco Javier / Marsicano, Giovanni / Pérez-Gómez, Eduardo / Sánchez, Cristina / Sánchez-Laorden, Berta / Guzmán, Manuel

Cancers

2023 Volume 15, Issue 9

Abstract: Melanoma is one of the deadliest forms of cancer. Most melanoma deaths are caused by distant metastases in several organs, especially the brain, the so-called melanoma brain metastases (MBMs). However, the precise mechanisms that sustain the growth of ... ...

Abstract	Melanoma is one of the deadliest forms of cancer. Most melanoma deaths are caused by distant metastases in several organs, especially the brain, the so-called melanoma brain metastases (MBMs). However, the precise mechanisms that sustain the growth of MBMs remain elusive. Recently, the excitatory neurotransmitter glutamate has been proposed as a brain-specific, pro-tumorigenic signal for various types of cancers, but how neuronal glutamate shuttling onto metastases is regulated remains unknown. Here, we show that the cannabinoid CB
Language	English
Publishing date	2023-04-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15092439
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Article ; Online: Supernumerary breast in vulva.

Rosell Echevarría, María José / Hernández Rodríguez, Raquel Angélica / Perez-Etchepare, Eduardo / Gómez Culebras, Mario Alberto

Anales de pediatria

2024 Volume 100, Issue 4, Page(s) e15–e16

MeSH term(s)	Humans ; Female ; Breast/abnormalities ; Vulva/abnormalities ; Vulva/pathology ; Child
Language	English
Publishing date	2024-04-04
Publishing country	Spain
Document type	Case Reports ; Journal Article
ZDB-ID	2830901-7
ISSN	2341-2879 ; 2341-2879
ISSN (online)	2341-2879
ISSN	2341-2879
DOI	10.1016/j.anpede.2024.03.035
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Article ; Online: The Multifaceted Manifestations of Multisystem Inflammatory Syndrome during the SARS-CoV-2 Pandemic

Héctor Raúl Pérez-Gómez / Rayo Morfín-Otero / Esteban González-Díaz / Sergio Esparza-Ahumada / Gerardo León-Garnica / Eduardo Rodríguez-Noriega

Pathogens, Vol 11, Iss 556, p

2022 Volume 556

Abstract: The novel coronavirus SARS-CoV-2, which has similarities to the 2002–2003 severe acute respiratory syndrome coronavirus known as SARS-CoV-1, causes the infectious disease designated COVID-19 by the World Health Organization (Coronavirus Disease 2019). ... ...

Abstract	The novel coronavirus SARS-CoV-2, which has similarities to the 2002–2003 severe acute respiratory syndrome coronavirus known as SARS-CoV-1, causes the infectious disease designated COVID-19 by the World Health Organization (Coronavirus Disease 2019). Although the first reports indicated that activity of the virus is centered in the lungs, it was soon acknowledged that SARS-CoV-2 causes a multisystem disease. Indeed, this new pathogen causes a variety of syndromes, including asymptomatic disease; mild disease; moderate disease; a severe form that requires hospitalization, intensive care, and mechanical ventilation; multisystem inflammatory disease; and a condition called long COVID or postacute sequelae of SARS-CoV-2 infection. Some of these syndromes resemble previously described disorders, including those with no confirmed etiology, such as Kawasaki disease. After recognition of a distinct multisystem inflammatory syndrome in children, followed by a similar syndrome in adults, various multisystem syndromes occurring during the pandemic associated or related to SARS-CoV-2 began to be identified. A typical pattern of cytokine and chemokine dysregulation occurs in these complex syndromes; however, the disorders have distinct immunological determinants that may help to differentiate them. This review discusses the origins of the different trajectories of the inflammatory syndromes related to SARS-CoV-2 infection.
Keywords	SARS-CoV-2 ; COVID-19 ; coronavirus ; multisystem inflammatory syndrome ; MIS-C ; MIS-A ; Medicine ; R
Subject code	610
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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