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  1. Article: The Viral Hypothesis in Alzheimer's Disease: Novel Insights and Pathogen-Based Biomarkers.

    Naughton, Sean X / Raval, Urdhva / Pasinetti, Giulio M

    Journal of personalized medicine

    2020  Volume 10, Issue 3

    Abstract: Early diagnosis of Alzheimer's disease (AD) and the identification of significant risk factors are necessary to better understand disease progression, and to develop intervention-based therapies prior to significant neurodegeneration. There is thus a ... ...

    Abstract Early diagnosis of Alzheimer's disease (AD) and the identification of significant risk factors are necessary to better understand disease progression, and to develop intervention-based therapies prior to significant neurodegeneration. There is thus a critical need to establish biomarkers which can predict the risk of developing AD before the onset of cognitive decline. A number of studies have indicated that exposure to various microbial pathogens can accelerate AD pathology. Additionally, several studies have indicated that amyloid-β possess antimicrobial properties and may act in response to infection as a part of the innate immune system. These findings have led some to speculate that certain types of infections may play a significant role in AD pathogenesis. In this review, we will provide an overview of studies which suggest pathogen involvement in AD. Additionally, we will discuss a number of pathogen-associated biomarkers which may be effective in establishing AD risk. Infections that increase the risk of AD represent a modifiable risk factor which can be treated with therapeutic intervention. Pathogen-based biomarkers may thus be a valuable tool for evaluating and decreasing AD risk across the population.
    Language English
    Publishing date 2020-07-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm10030074
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Corrigendum to "Multifunctional compounds lithium chloride and methylene Blue attenuate the negative effects of diisopropylfluorophosphate on axonal transport in rat cortical neurons" [Toxicology 431 (2020): 152379].

    Naughton, Sean X / Beck, Wayne D / Wei, Zhe / Wu, Guangyu / Terry, Alvin V

    Toxicology

    2021  Volume 453, Page(s) 152745

    Language English
    Publishing date 2021-03-05
    Publishing country Ireland
    Document type Published Erratum
    ZDB-ID 184557-3
    ISSN 1879-3185 ; 0300-483X
    ISSN (online) 1879-3185
    ISSN 0300-483X
    DOI 10.1016/j.tox.2021.152745
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Potential Novel Role of COVID-19 in Alzheimer's Disease and Preventative Mitigation Strategies.

    Naughton, Sean X / Raval, Urdhva / Pasinetti, Giulio M

    Journal of Alzheimer's disease : JAD

    2020  Volume 76, Issue 1, Page(s) 21–25

    Abstract: There are a number of potential implications for the field of Alzheimer's disease (AD) stemming from the global spread of SARS-CoV-2. Neuroinflammation is known to be a prominent feature of neurodegeneration and plays a major role in AD pathology. Immune ...

    Abstract There are a number of potential implications for the field of Alzheimer's disease (AD) stemming from the global spread of SARS-CoV-2. Neuroinflammation is known to be a prominent feature of neurodegeneration and plays a major role in AD pathology. Immune response and excessive inflammation in COVID-19 may also accelerate the progression of brain inflammatory neurodegeneration, and elderly individuals are more susceptible to severe outcomes after SARS-CoV-2 infection. Individuals with type 2 diabetes (T2D) are at an increased risk for AD as well as severe outcomes after SARS-CoV-2 infection. Genetic and socioeconomic factors influencing the rates of T2D, AD, and COVID-19 severity may create an exceptionally high-risk profile for certain demographics such as African Americans and Hispanic Americans. Type I interferon response plays an important role in both host response to viral infection, as well as AD pathology and may be a sensible therapeutic target in both AD and COVID-19.
    MeSH term(s) Aged ; Alzheimer Disease ; Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Diabetes Mellitus, Type 2 ; Humans ; Interferon Type I ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Synapses
    Chemical Substances Interferon Type I
    Keywords covid19
    Language English
    Publishing date 2020-06-13
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Comment
    ZDB-ID 1440127-7
    ISSN 1875-8908 ; 1387-2877
    ISSN (online) 1875-8908
    ISSN 1387-2877
    DOI 10.3233/JAD-200537
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Neurotoxicity in acute and repeated organophosphate exposure.

    Naughton, Sean X / Terry, Alvin V

    Toxicology

    2018  Volume 408, Page(s) 101–112

    Abstract: The term organophosphate (OP) refers to a diverse group of chemicals that are found in hundreds of products worldwide. As pesticides, their most common use, OPs are clearly beneficial for agricultural productivity and the control of deadly vector-borne ... ...

    Abstract The term organophosphate (OP) refers to a diverse group of chemicals that are found in hundreds of products worldwide. As pesticides, their most common use, OPs are clearly beneficial for agricultural productivity and the control of deadly vector-borne illnesses. However, as a consequence of their widespread use, OPs are now among the most common synthetic chemicals detected in the environment as well as in animal and human tissues. This is an increasing environmental concern because many OPs are highly toxic and both accidental and intentional exposures to OPs resulting in deleterious health effects have been documented for decades. Some of these deleterious health effects include a variety of long-term neurological and psychiatric disturbances including impairments in attention, memory, and other domains of cognition. Moreover, some chronic illnesses that manifest these symptoms such as Gulf War Illness and Aerotoxic Syndrome have (at least in part) been attributed to OP exposure. In addition to acute acetylcholinesterase inhibition, OPs may affect a number of additional targets that lead to oxidative stress, axonal transport deficits, neuroinflammation, and autoimmunity. Some of these targets could be exploited for therapeutic purposes. The purpose of this review is thus to: 1) describe the important uses of organophosphate (OP)-based compounds worldwide, 2) provide an overview of the various risks and toxicology associated with OP exposure, particularly long-term neurologic and psychiatric symptoms, 3) discuss mechanisms of OP toxicity beyond cholinesterase inhibition, 4) review potential therapeutic strategies to reverse the acute toxicity and long term deleterious effects of OPs.
    MeSH term(s) Agricultural Workers' Diseases/chemically induced ; Agricultural Workers' Diseases/physiopathology ; Agricultural Workers' Diseases/psychology ; Animals ; Antidotes/therapeutic use ; Chemical Terrorism ; Chemical Warfare Agents/poisoning ; Cholinesterase Inhibitors/poisoning ; Dose-Response Relationship, Drug ; Humans ; Nervous System/drug effects ; Nervous System/immunology ; Nervous System/metabolism ; Nervous System/physiopathology ; Neurotoxicity Syndromes/drug therapy ; Neurotoxicity Syndromes/etiology ; Neurotoxicity Syndromes/physiopathology ; Neurotoxicity Syndromes/psychology ; Occupational Exposure/adverse effects ; Organophosphate Poisoning/drug therapy ; Organophosphate Poisoning/etiology ; Organophosphate Poisoning/physiopathology ; Organophosphate Poisoning/psychology ; Organophosphates/adverse effects ; Persian Gulf Syndrome/chemically induced ; Persian Gulf Syndrome/physiopathology ; Persian Gulf Syndrome/psychology ; Pesticides/poisoning ; Prognosis ; Risk Assessment ; Risk Factors ; Time Factors
    Chemical Substances Antidotes ; Chemical Warfare Agents ; Cholinesterase Inhibitors ; Organophosphates ; Pesticides
    Language English
    Publishing date 2018-08-23
    Publishing country Ireland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 184557-3
    ISSN 1879-3185 ; 0300-483X
    ISSN (online) 1879-3185
    ISSN 0300-483X
    DOI 10.1016/j.tox.2018.08.011
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  5. Article ; Online: The role of the exposome in promoting resilience or susceptibility after SARS-CoV-2 infection.

    Naughton, Sean X / Raval, Urdhva / Harary, Joyce M / Pasinetti, Giulio M

    Journal of exposure science & environmental epidemiology

    2020  Volume 30, Issue 5, Page(s) 776–777

    MeSH term(s) Air Pollution ; Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Exposome ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Severe Acute Respiratory Syndrome
    Keywords covid19
    Language English
    Publishing date 2020-05-12
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Extramural
    ZDB-ID 2218551-3
    ISSN 1559-064X ; 1559-0631
    ISSN (online) 1559-064X
    ISSN 1559-0631
    DOI 10.1038/s41370-020-0232-4
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  6. Article ; Online: The Viral Hypothesis in Alzheimer’s Disease

    Sean X Naughton / Urdhva Raval / Giulio M. Pasinetti

    Journal of Personalized Medicine, Vol 10, Iss 74, p

    Novel Insights and Pathogen-Based Biomarkers

    2020  Volume 74

    Abstract: Early diagnosis of Alzheimer’s disease (AD) and the identification of significant risk factors are necessary to better understand disease progression, and to develop intervention-based therapies prior to significant neurodegeneration. There is thus a ... ...

    Abstract Early diagnosis of Alzheimer’s disease (AD) and the identification of significant risk factors are necessary to better understand disease progression, and to develop intervention-based therapies prior to significant neurodegeneration. There is thus a critical need to establish biomarkers which can predict the risk of developing AD before the onset of cognitive decline. A number of studies have indicated that exposure to various microbial pathogens can accelerate AD pathology. Additionally, several studies have indicated that amyloid-β possess antimicrobial properties and may act in response to infection as a part of the innate immune system. These findings have led some to speculate that certain types of infections may play a significant role in AD pathogenesis. In this review, we will provide an overview of studies which suggest pathogen involvement in AD. Additionally, we will discuss a number of pathogen-associated biomarkers which may be effective in establishing AD risk. Infections that increase the risk of AD represent a modifiable risk factor which can be treated with therapeutic intervention. Pathogen-based biomarkers may thus be a valuable tool for evaluating and decreasing AD risk across the population.
    Keywords Alzheimer’s disease ; virus ; bacteria ; dementia ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: The Carbamate, Physostigmine does not Impair Axonal Transport in Rat Cortical Neurons.

    Naughton, Sean X / Beck, Wayne D / Wei, Zhe / Wu, Guangyu / Baas, Peter W / Terry, Alvin V

    Neuroscience insights

    2021  Volume 16, Page(s) 26331055211020289

    Abstract: Among the various chemicals that are commonly used as pesticides, organophosphates (OPs), and to a lesser extent, carbamates, are most frequently associated with adverse long-term neurological consequences. OPs and the carbamate, pyridostigmine, used as ... ...

    Abstract Among the various chemicals that are commonly used as pesticides, organophosphates (OPs), and to a lesser extent, carbamates, are most frequently associated with adverse long-term neurological consequences. OPs and the carbamate, pyridostigmine, used as a prophylactic drug against potential nerve agent attacks, have also been implicated in Gulf War Illness (GWI), which is often characterized by chronic neurological symptoms. While most OP- and carbamate-based pesticides, and pyridostigmine are relatively potent acetylcholinesterase inhibitors (AChEIs), this toxicological mechanism is inadequate to explain their long-term health effects, especially when no signs of acute cholinergic toxicity are exhibited. Our previous work suggests that a potential mechanism of the long-term neurological deficits associated with OPs is impairment of axonal transport (AXT); however, we had not previously evaluated carbamates for this effect. Here we thus evaluated the carbamate, physostigmine (PHY), a highly potent AChEI, on AXT using an
    Language English
    Publishing date 2021-05-24
    Publishing country United States
    Document type Journal Article
    ISSN 2633-1055
    ISSN (online) 2633-1055
    DOI 10.1177/26331055211020289
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Potential Novel Role of COVID-19 in Alzheimer's Disease and Preventative Mitigation Strategies

    Naughton, Sean X / Raval, Urdhva / Pasinetti, Giulio M

    J Alzheimers Dis

    Abstract: There are a number of potential implications for the field of Alzheimer's disease (AD) stemming from the global spread of SARS-CoV-2. Neuroinflammation is known to be a prominent feature of neurodegeneration and plays a major role in AD pathology. Immune ...

    Abstract There are a number of potential implications for the field of Alzheimer's disease (AD) stemming from the global spread of SARS-CoV-2. Neuroinflammation is known to be a prominent feature of neurodegeneration and plays a major role in AD pathology. Immune response and excessive inflammation in COVID-19 may also accelerate the progression of brain inflammatory neurodegeneration, and elderly individuals are more susceptible to severe outcomes after SARS-CoV-2 infection. Individuals with type 2 diabetes (T2D) are at an increased risk for AD as well as severe outcomes after SARS-CoV-2 infection. Genetic and socioeconomic factors influencing the rates of T2D, AD, and COVID-19 severity may create an exceptionally high-risk profile for certain demographics such as African Americans and Hispanic Americans. Type I interferon response plays an important role in both host response to viral infection, as well as AD pathology and may be a sensible therapeutic target in both AD and COVID-19.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #601164
    Database COVID19

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  9. Article ; Online: Rab43 GTPase directs postsynaptic trafficking and neuron-specific sorting of G protein-coupled receptors.

    Wei, Zhe / Xu, Xin / Fang, Yinquan / Khater, Mostafa / Naughton, Sean X / Hu, Gang / Terry, Alvin V / Wu, Guangyu

    The Journal of biological chemistry

    2021  Volume 296, Page(s) 100517

    Abstract: G protein-coupled receptors (GPCRs) are important modulators of synaptic functions. A fundamental but poorly addressed question in neurobiology is how targeted GPCR trafficking is achieved. Rab GTPases are the master regulators of vesicle-mediated ... ...

    Abstract G protein-coupled receptors (GPCRs) are important modulators of synaptic functions. A fundamental but poorly addressed question in neurobiology is how targeted GPCR trafficking is achieved. Rab GTPases are the master regulators of vesicle-mediated membrane trafficking, but their functions in the synaptic presentation of newly synthesized GPCRs are virtually unknown. Here, we investigate the role of Rab43, via dominant-negative inhibition and CRISPR-Cas9-mediated KO, in the export trafficking of α
    MeSH term(s) Animals ; Cell Membrane/metabolism ; Endoplasmic Reticulum/metabolism ; Golgi Apparatus/metabolism ; HEK293 Cells ; Humans ; Neurons/metabolism ; Protein Transport ; Rats ; Rats, Sprague-Dawley ; Receptors, G-Protein-Coupled/genetics ; Receptors, G-Protein-Coupled/metabolism ; Synaptic Transmission ; rab GTP-Binding Proteins/genetics ; rab GTP-Binding Proteins/metabolism
    Chemical Substances Receptors, G-Protein-Coupled ; rab11 protein (EC 3.6.1.-) ; rab GTP-Binding Proteins (EC 3.6.5.2)
    Language English
    Publishing date 2021-03-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1016/j.jbc.2021.100517
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  10. Article ; Online: The role of the exposome in promoting resilience or susceptibility after SARS-CoV-2 infection

    Naughton, Sean X. / Raval, Urdhva / Harary, Joyce M. / Pasinetti, Giulio M.

    Journal of Exposure Science & Environmental Epidemiology

    2020  Volume 30, Issue 5, Page(s) 776–777

    Keywords Toxicology ; Public Health, Environmental and Occupational Health ; Epidemiology ; Pollution ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2218551-3
    ISSN 1559-064X ; 1559-0631
    ISSN (online) 1559-064X
    ISSN 1559-0631
    DOI 10.1038/s41370-020-0232-4
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    In stock of ZB MED Bonn / Germany

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