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  1. Article: Safety and Complications Related to Emerging Technologies.

    Vadalà, Gianluca / Ambrosio, Luca / Denaro, Vincenzo

    Neurospine

    2024  Volume 21, Issue 1, Page(s) 6–7

    Language English
    Publishing date 2024-03-31
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 3031654-6
    ISSN 2586-6591 ; 2586-6583
    ISSN (online) 2586-6591
    ISSN 2586-6583
    DOI 10.14245/ns.2448162.081
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Commentary on "Robotics in Cervical Spine Surgery: Feasibility and Safety of Posterior Screw Placement".

    Vadalà, Gianluca / Ambrosio, Luca / Denaro, Vincenzo

    Neurospine

    2023  Volume 20, Issue 1, Page(s) 340–342

    Language English
    Publishing date 2023-03-31
    Publishing country Korea (South)
    Document type Journal Article ; Comment
    ZDB-ID 3031654-6
    ISSN 2586-6591 ; 2586-6583
    ISSN (online) 2586-6591
    ISSN 2586-6583
    DOI 10.14245/ns.2346312.156
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The NDR/LATS protein kinases in neurobiology: Key regulators of cell proliferation, differentiation and migration in the ocular and central nervous system.

    Santos, Paulo F / Fazendeiro, Beatriz / Luca, Francis C / Ambrósio, António Francisco / Léger, Hélène

    European journal of cell biology

    2023  Volume 102, Issue 2, Page(s) 151333

    Abstract: Nuclear Dbf2-related (NDR) kinases are a subgroup of evolutionarily conserved AGC protein kinases that regulate various aspects of cell growth and morphogenesis. There are 4 NDR protein kinases in mammals, LATS1, LATS2 and STTK8/NDR1, STK38L/NDR2 protein ...

    Abstract Nuclear Dbf2-related (NDR) kinases are a subgroup of evolutionarily conserved AGC protein kinases that regulate various aspects of cell growth and morphogenesis. There are 4 NDR protein kinases in mammals, LATS1, LATS2 and STTK8/NDR1, STK38L/NDR2 protein kinases. LATS1 and 2 are core components of the well-studied Hippo pathway, which play a critical role in the regulation of cell proliferation, differentiation, and cell migration via YAP/TAZ transcription factor. The Hippo pathways play an important role in nervous tissue development and homeostasis, especially with regard to the central nervous system (CNS) and the ocular system. The ocular system is a very complex system generated by the interaction in a very tightly coordinated manner of numerous and diverse developing tissues, such as, but not limited to choroidal and retinal blood vessels, the retinal pigmented epithelium and the retina, a highly polarized neuronal tissue. The retina development and maintenance require precise and coordinated regulation of cell proliferation, cell death, migration, morphogenesis, synaptic connectivity, and balanced homeostasis. This review highlights the emerging roles of NDR1 and NDR2 kinases in the regulation of retinal/neuronal function and homeostasis via a noncanonical branch of the Hippo pathway. We highlight a potential role of NDR1 and NDR2 kinases in regulating neuronal inflammation and as potential therapeutic targets for the treatment of neuronal diseases.
    MeSH term(s) Animals ; Protein Kinases ; Neurobiology ; Protein Serine-Threonine Kinases/metabolism ; Cell Proliferation ; Cell Differentiation ; Central Nervous System/metabolism ; Mammals/metabolism
    Chemical Substances Protein Kinases (EC 2.7.-) ; Protein Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2023-06-10
    Publishing country Germany
    Document type Review ; Journal Article
    ZDB-ID 391967-5
    ISSN 1618-1298 ; 0070-2463 ; 0171-9335
    ISSN (online) 1618-1298
    ISSN 0070-2463 ; 0171-9335
    DOI 10.1016/j.ejcb.2023.151333
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 667: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Anterior cruciate ligament repair augmented with dynamic intraligamentary stabilization is equivalent to hamstring autograft reconstruction at short and mid-term follow-up: a systematic review.

    Ambrosio, Luca / Franco, Domenico / Vadalà, Gianluca / Russo, Fabrizio / Papalia, Rocco

    Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association

    2024  

    Abstract: Purpose: To compare clinical outcomes, knee stability and complication, failure and revision rates following anterior cruciate ligament repair (ACLr) with dynamic intraligamentary stabilization (DIS) vs. anterior cruciate ligament reconstruction (ACLR) ... ...

    Abstract Purpose: To compare clinical outcomes, knee stability and complication, failure and revision rates following anterior cruciate ligament repair (ACLr) with dynamic intraligamentary stabilization (DIS) vs. anterior cruciate ligament reconstruction (ACLR) with hamstring autograft for primary ACL ruptures at short and mid-term follow-up.
    Methods: A PRISMA-compliant systematic review of PubMed/MEDLINE and Scopus was performed. Studies that evaluated patients undergoing ACLr with DIS or ACLR with hamstring autograft were considered for inclusion. Studies were excluded if patients were affected by concomitant meniscal, ligamentous, or chondral injuries needing surgical treatment due to their potential confounding effect on postoperative outcomes. The RoB-2 tool was utilized to assess the risk of bias in the included studies. The quality of available evidence was rated according to GRADE recommendations. The study protocol was registered in the PROSPERO database (ID: CRD42023394558).
    Results: Five randomized controlled trials comparing the outcomes of ACLr with DIS vs. ACLR with hamstring autograft met the inclusion criteria. No major differences in terms of patient-reported outcomes (International Knee Documentation Committee subjective form [IKDC], Lysholm score, Tegner activity scale, Knee injury and Osteoarthritis Outcome Score, visual analogue scale satisfaction), as well as rates of complications, revisions, and failures were found in included studies at all timepoints. Repair showed higher IKDC scores at 5 years in one study, while ACLR displayed significantly increased knee stability at 6 months and 5 years in two different studies, although the clinical relevance of these differences is doubtful.
    Conclusions: The results of this study suggest that ACLr with DIS is not inferior to ACLR with hamstring autograft in terms of rates of clinical outcomes, knee stability, risk of failure, complications, and revision surgery. Therefore, ACLr with DIS may be a viable alternative to ACLR with hamstring autograft in selected patients.
    Language English
    Publishing date 2024-02-26
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 632528-2
    ISSN 1526-3231 ; 0749-8063
    ISSN (online) 1526-3231
    ISSN 0749-8063
    DOI 10.1016/j.arthro.2023.12.011
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2046: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Successful Treatment with Bimekizumab of a Psoriatic Patient Undergoing Hemodialysis: A Case Report and Review of the Literature.

    Bernardini, Nicoletta / Ambrosio, Luca / Tolino, Ersilia / Proietti, Ilaria / Skroza, Nevena / Potenza, Concetta

    Journal of clinical medicine

    2024  Volume 13, Issue 8

    Abstract: Background/ ... ...

    Abstract Background/Objectives
    Language English
    Publishing date 2024-04-12
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13082250
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  6. Article: Editorial: New perspectives and innovative techniques in contemporary spine surgery.

    Ambrosio, Luca / Vadalà, Gianluca / Russo, Fabrizio / Sakai, Daisuke / Denaro, Vincenzo

    Frontiers in surgery

    2023  Volume 10, Page(s) 1220181

    Language English
    Publishing date 2023-06-12
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2773823-1
    ISSN 2296-875X
    ISSN 2296-875X
    DOI 10.3389/fsurg.2023.1220181
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  7. Article ; Online: Threats and opportunities of using ChatGPT in scientific writing-The risk of getting spine

    Ambrosio, Luca / Schol, Jordy / La Pietra, Vincenzo Amedeo / Russo, Fabrizio / Vadalà, Gianluca / Sakai, Daisuke

    JOR spine

    2023  Volume 7, Issue 1, Page(s) e1296

    Abstract: ChatGPT and AI chatbots are revolutionizing several science fields, including medical writing. However, the inadequate use of such advantageous tools can raise numerous methodological and ethical issues. ...

    Abstract ChatGPT and AI chatbots are revolutionizing several science fields, including medical writing. However, the inadequate use of such advantageous tools can raise numerous methodological and ethical issues.
    Language English
    Publishing date 2023-12-13
    Publishing country United States
    Document type Journal Article
    ISSN 2572-1143
    ISSN (online) 2572-1143
    DOI 10.1002/jsp2.1296
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  8. Article: Intraoperative Cone-Beam Computed Tomography Navigation Versus 2-Dimensional Fluoroscopy in Single-Level Lumbar Spinal Fusion: A Comparative Analysis.

    Vadalà, Gianluca / Papalia, Giuseppe Francesco / Russo, Fabrizio / Brigato, Paolo / Ambrosio, Luca / Papalia, Rocco / Denaro, Vincenzo

    Neurospine

    2024  Volume 21, Issue 1, Page(s) 76–82

    Abstract: Objective: Several studies have advocated for the higher accuracy of transpedicular screw placement under cone-beam computed tomography (CBCT) compared to conventional 2-dimensional (2D) fluoroscopy. The superiority of navigation systems in ... ...

    Abstract Objective: Several studies have advocated for the higher accuracy of transpedicular screw placement under cone-beam computed tomography (CBCT) compared to conventional 2-dimensional (2D) fluoroscopy. The superiority of navigation systems in perioperative and postoperative outcomes remains a topic of debate. This study aimed to compare operative time, screw placement time and accuracy, total radiation dose, perioperative and postoperative outcomes in patients who underwent transpedicular screw fixation for degenerative lumbar spondylolisthesis (DLS) using intraoperative CBCT navigation versus 2D fluoroscopy.
    Methods: A retrospective analysis was conducted on patients affected by single-level DLS who underwent posterior lumbar instrumentation with transpedicular screw fixation using surgical CBCT navigation (NV group) or 2D fluoroscopy-assisted freehand technique (FH group). Demographics, screw placement time and accuracy, operative time, total radiation dose, intraoperative blood loss, screw revision rate, complications, and length of stay (LOS) were assessed.
    Results: The study included a total of 30 patients (NV group: n = 15; FH group: n = 15). The mean screw placement time, operative time, and LOS were significantly reduced in the NV group compared to the FH group (p < 0.05). The total radiation dose was significantly higher in the NV group (p < 0.0001). No significant difference was found in terms of blood loss and postoperative complications.
    Conclusion: This study suggests that intraoperative CBCT-navigated single-level lumbar transpedicular screw fixation is superior in terms of mean screw placement time, operative time, and LOS compared to 2D fluoroscopy, despite a higher intraoperative radiation exposure.
    Language English
    Publishing date 2024-03-31
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 3031654-6
    ISSN 2586-6591 ; 2586-6583
    ISSN (online) 2586-6591
    ISSN 2586-6583
    DOI 10.14245/ns.2347106.553
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Dermoscopic, Histological, Confocal Microscopy Correlation of Atypical-Dysplastic Melanocytic Nevi.

    Cantisani, Carmen / Ambrosio, Luca / Annessi, Emanuele / Longo, Caterina / Farnetani, Francesca / Pezzini, Claudia / Condorelli, Alessandra / Annessi, Giorgio / Bonetti, Luca Reggiani / Guida, Stefania / Cota, Carlo / Tammaro, Antonella / Chello, Camilla / Pellacani, Giovanni

    Dermatology practical & conceptual

    2024  Volume 14, Issue 1

    Abstract: Introduction: The term "atypical melanocytic nevus" (AMN) is used as a synonym for dysplastic nevus (DN) in clinical practice. Although the criteria for diagnosis of AMN/DN by the Agency for Research on Cancer helps to differentiate AMN/DN from common ... ...

    Abstract Introduction: The term "atypical melanocytic nevus" (AMN) is used as a synonym for dysplastic nevus (DN) in clinical practice. Although the criteria for diagnosis of AMN/DN by the Agency for Research on Cancer helps to differentiate AMN/DN from common acquired nevi, they do not have high degrees of specificity, as they are similar to those used for the diagnosis of melanoma.
    Objectives: In this retrospective study we evaluated the correlation and diagnostic concordance of dermoscopy, confocal microscopy, and histological examination in 50 AMN.
    Methods: A graded scale was used to compare histological examination with dermoscopy and confocal microscopy. Low magnification histological images of only the central part of lesions were examined. This allowed histological diagnoses based almost exclusively on architectural criteria instead of simultaneously architectural and cytological, as in the global histological examination.
    Results: Our data demonstrate that the diagnostic accuracy of dermoscopy and confocal microscopy diagnosis of the clinical aspects of AMN/DN as nevi or melanomas tends to be equivalent, being fair for nevi and excellent for melanomas. The total percentage of AMN suggested that the accuracy of confocal microscopy in the diagnosis of melanoma (86.7%) is greater than that of dermoscopy (73.3%).
    Conclusions: This study demonstrated that diagnostic assessments of AMN/DN by dermoscopy and confocal microscopy are accurate and often coincide with those of histological examination and that their combined use helps to better manage and monitor these patients by facilitating early detection of melanomas and reducing unnecessary excisions of benign melanocytic lesions.
    Language English
    Publishing date 2024-01-01
    Publishing country Austria
    Document type Journal Article
    ZDB-ID 2685397-8
    ISSN 2160-9381
    ISSN 2160-9381
    DOI 10.5826/dpc.1401a36
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Artificial Intelligence and Computer Aided Diagnosis in Chronic Low Back Pain: A Systematic Review.

    D'Antoni, Federico / Russo, Fabrizio / Ambrosio, Luca / Bacco, Luca / Vollero, Luca / Vadalà, Gianluca / Merone, Mario / Papalia, Rocco / Denaro, Vincenzo

    International journal of environmental research and public health

    2022  Volume 19, Issue 10

    Abstract: Low Back Pain (LBP) is currently the first cause of disability in the world, with a significant socioeconomic burden. Diagnosis and treatment of LBP often involve a multidisciplinary, individualized approach consisting of several outcome measures and ... ...

    Abstract Low Back Pain (LBP) is currently the first cause of disability in the world, with a significant socioeconomic burden. Diagnosis and treatment of LBP often involve a multidisciplinary, individualized approach consisting of several outcome measures and imaging data along with emerging technologies. The increased amount of data generated in this process has led to the development of methods related to artificial intelligence (AI), and to computer-aided diagnosis (CAD) in particular, which aim to assist and improve the diagnosis and treatment of LBP. In this manuscript, we have systematically reviewed the available literature on the use of CAD in the diagnosis and treatment of chronic LBP. A systematic research of PubMed, Scopus, and Web of Science electronic databases was performed. The search strategy was set as the combinations of the following keywords: “Artificial Intelligence”, “Machine Learning”, “Deep Learning”, “Neural Network”, “Computer Aided Diagnosis”, “Low Back Pain”, “Lumbar”, “Intervertebral Disc Degeneration”, “Spine Surgery”, etc. The search returned a total of 1536 articles. After duplication removal and evaluation of the abstracts, 1386 were excluded, whereas 93 papers were excluded after full-text examination, taking the number of eligible articles to 57. The main applications of CAD in LBP included classification and regression. Classification is used to identify or categorize a disease, whereas regression is used to produce a numerical output as a quantitative evaluation of some measure. The best performing systems were developed to diagnose degenerative changes of the spine from imaging data, with average accuracy rates >80%. However, notable outcomes were also reported for CAD tools executing different tasks including analysis of clinical, biomechanical, electrophysiological, and functional imaging data. Further studies are needed to better define the role of CAD in LBP care.
    MeSH term(s) Artificial Intelligence ; Computers ; Diagnosis, Computer-Assisted ; Humans ; Intervertebral Disc Degeneration ; Low Back Pain/diagnostic imaging ; Low Back Pain/therapy
    Language English
    Publishing date 2022-05-14
    Publishing country Switzerland
    Document type Journal Article ; Review ; Systematic Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph19105971
    Database MEDical Literature Analysis and Retrieval System OnLINE

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