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  1. Book: Decision making, affect, and learning

    Delgado, Mauricio R.

    (Attention and performance ; 23)

    2011  

    Author's details ed. by Mauricio R. Delgado
    Series title Attention and performance ; 23
    Collection
    Keywords Entscheidung ; Affekt ; Lernen ; Neuropsychologie
    Subject Lernprozess ; Lernvorgang ; Affektenlehre ; Affektablauf ; Entscheiden ; Lebensentscheidung ; Wahlentscheidung ; Wahl ; Entscheidungen
    Language English
    Size XVII, 555 S. : Ill., graph. Darst., 25 cm
    Publisher Oxford Univ. Press
    Publishing place Oxford u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT016769058
    ISBN 978-0-19-960043-4 ; 0-19-960043-0
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2011 A 1325 order for loan Magazin

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  2. Article ; Online: Disability in the Fourth Industrial Revolution.

    Delgado, Mauricio R

    Developmental medicine and child neurology

    2019  Volume 61, Issue 9, Page(s) 993

    MeSH term(s) Artificial Intelligence ; Disabled Persons ; History, 21st Century ; Humans ; Industry ; Internet
    Language English
    Publishing date 2019-08-02
    Publishing country England
    Document type Editorial ; Historical Article
    ZDB-ID 80369-8
    ISSN 1469-8749 ; 0012-1622
    ISSN (online) 1469-8749
    ISSN 0012-1622
    DOI 10.1111/dmcn.14296
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Examining evolutionary scale modeling-derived different-dimensional embeddings in the antimicrobial peptide classification through a KNIME workflow.

    Martínez-Mauricio, Karla L / García-Jacas, César R / Cordoves-Delgado, Greneter

    Protein science : a publication of the Protein Society

    2023  Volume 33, Issue 4, Page(s) e4928

    Abstract: Molecular features play an important role in different bio-chem-informatics tasks, such as the Quantitative Structure-Activity Relationships (QSAR) modeling. Several pre-trained models have been recently created to be used in downstream tasks, either by ... ...

    Abstract Molecular features play an important role in different bio-chem-informatics tasks, such as the Quantitative Structure-Activity Relationships (QSAR) modeling. Several pre-trained models have been recently created to be used in downstream tasks, either by fine-tuning a specific model or by extracting features to feed traditional classifiers. In this regard, a new family of Evolutionary Scale Modeling models (termed as ESM-2 models) was recently introduced, demonstrating outstanding results in protein structure prediction benchmarks. Herein, we studied the usefulness of the different-dimensional embeddings derived from the ESM-2 models to classify antimicrobial peptides (AMPs). To this end, we built a KNIME workflow to use the same modeling methodology across experiments in order to guarantee fair analyses. As a result, the 640- and 1280-dimensional embeddings derived from the 30- and 33-layer ESM-2 models, respectively, are the most valuable  since statistically better performances were achieved by the QSAR models built from them. We also fused features of the different ESM-2 models, and it was concluded that the fusion contributes to getting better QSAR models than using features of a single ESM-2 model. Frequency studies revealed that only a portion of the ESM-2 embeddings is valuable for modeling tasks since between 43% and 66% of the features were never used. Comparisons regarding state-of-the-art deep learning (DL) models confirm that when performing methodologically principled studies in the prediction of AMPs, non-DL based QSAR models yield comparable-to-superior performances to DL-based QSAR models. The developed KNIME workflow is available-freely at https://github.com/cicese-biocom/classification-QSAR-bioKom. This workflow can be valuable to avoid unfair comparisons regarding new computational methods, as well as to propose new non-DL based QSAR models.
    MeSH term(s) Antimicrobial Peptides ; Workflow
    Chemical Substances Antimicrobial Peptides
    Language English
    Publishing date 2023-08-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1106283-6
    ISSN 1469-896X ; 0961-8368
    ISSN (online) 1469-896X
    ISSN 0961-8368
    DOI 10.1002/pro.4928
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Characterizing the mechanisms of social connection.

    Delgado, Mauricio R / Fareri, Dominic S / Chang, Luke J

    Neuron

    2023  Volume 111, Issue 24, Page(s) 3911–3925

    Abstract: Understanding how individuals form and maintain strong social networks has emerged as a significant public health priority as a result of the increased focus on the epidemic of loneliness and the myriad protective benefits conferred by social connection. ...

    Abstract Understanding how individuals form and maintain strong social networks has emerged as a significant public health priority as a result of the increased focus on the epidemic of loneliness and the myriad protective benefits conferred by social connection. In this review, we highlight the psychological and neural mechanisms that enable us to connect with others, which in turn help buffer against the consequences of stress and isolation. Central to this process is the experience of rewards derived from positive social interactions, which encourage the sharing of perspectives and preferences that unite individuals. Sharing affective states with others helps us to align our understanding of the world with another's, thereby continuing to reinforce bonds and strengthen relationships. These psychological processes depend on neural systems supporting reward and social cognitive function. Lastly, we also consider limitations associated with pursuing healthy social connections and outline potential avenues of future research.
    MeSH term(s) Humans ; Emotions ; Cognition ; Reward
    Language English
    Publishing date 2023-10-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 808167-0
    ISSN 1097-4199 ; 0896-6273
    ISSN (online) 1097-4199
    ISSN 0896-6273
    DOI 10.1016/j.neuron.2023.09.012
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  5. Article: The Protective Effects of Perceived Control During Repeated Exposure to Aversive Stimuli.

    Wang, Kainan S / Delgado, Mauricio R

    Frontiers in neuroscience

    2021  Volume 15, Page(s) 625816

    Abstract: The ability to perceive and exercise control is a major contributor to our mental and physical wellbeing. When faced with uncontrollable aversive stimuli, organisms develop heightened anxiety and become unwilling to exert effort to avoid the stimuli. In ... ...

    Abstract The ability to perceive and exercise control is a major contributor to our mental and physical wellbeing. When faced with uncontrollable aversive stimuli, organisms develop heightened anxiety and become unwilling to exert effort to avoid the stimuli. In contrast, when faced with controllable aversive stimuli, organisms demonstrate behavioral vigor via avoidance attempts toward trying to seek and exercise control over the environment. As such, controllability confers protective effects against reduced avoidance motivation trigged by aversive environments. These observations beg the question of whether controllability can be potent enough to reverse passivity following repeated exposure to uncontrollable aversive stimuli and how this protective effect is encoded neurally. Human participants performed a Control in Aversive Domain (CAD) task where they were first subjected to a series of repeated uncontrollable aversive stimuli (i.e., aversive tones) across several contexts that were followed by a series of controllable aversive stimuli in a novel context. Faced with persistent uncontrollability, participants significantly reduced their avoidance attempts over time and biased toward giving up. However, the subsequent presence of controllability rescued participants' avoidance behavior. Strikingly, participants who responded more strongly to the protective effects of control also had greater ventromedial prefrontal cortical (vmPFC) activation-a region previously observed to be associated with encoding the subjective value of control. Taken together, these findings highlighted the protective effect conferred by perceived control against passivity and offered insights into the potential role of the vmPFC in controllable environments, with implications for understanding the beneficial influence of perceived control on adaptive behavior.
    Language English
    Publishing date 2021-02-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2021.625816
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The Mexican Academy for Cerebral Palsy and Neurodevelopmental Disorders: new kid on the block.

    Delgado, Mauricio R

    Developmental medicine and child neurology

    2016  Volume 58, Issue 2, Page(s) 109

    MeSH term(s) Academies and Institutes ; Cerebral Palsy ; Humans ; Mexico ; Neurodevelopmental Disorders
    Language English
    Publishing date 2016-02
    Publishing country England
    Document type Editorial
    ZDB-ID 80369-8
    ISSN 1469-8749 ; 0012-1622
    ISSN (online) 1469-8749
    ISSN 0012-1622
    DOI 10.1111/dmcn.13008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Neural responses to negative events and subsequent persistence behavior differ in individuals recovering from opioid use disorder compared to controls.

    Bhanji, Jamil P / Delgado, Mauricio R / Ray, Suchismita

    The American journal of drug and alcohol abuse

    2021  Volume 47, Issue 3, Page(s) 319–329

    Abstract: ... ...

    Abstract Background
    MeSH term(s) Adult ; Affect/physiology ; Brain/physiopathology ; Brain Mapping ; Case-Control Studies ; Craving ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; New Jersey ; Opioid-Related Disorders/physiopathology ; Young Adult
    Language English
    Publishing date 2021-03-18
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 193086-2
    ISSN 1097-9891 ; 0095-2990
    ISSN (online) 1097-9891
    ISSN 0095-2990
    DOI 10.1080/00952990.2021.1888960
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  8. Article ; Online: The unfairness of being prosocial.

    Speer, Megan E / Delgado, Mauricio R

    Nature human behaviour

    2017  Volume 1, Issue 10, Page(s) 711–712

    Language English
    Publishing date 2017-10-02
    Publishing country England
    Document type Journal Article
    ISSN 2397-3374
    ISSN (online) 2397-3374
    DOI 10.1038/s41562-017-0222-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Social feedback promotes positive social sharing, trust, and closeness.

    Brudner, Emily G / Fareri, Dominic S / Shehata, Sandy G / Delgado, Mauricio R

    Emotion (Washington, D.C.)

    2022  Volume 23, Issue 6, Page(s) 1536–1548

    Abstract: Positive social sharing is an interpersonal emotion regulation strategy that enhances positive affect and social belonging, particularly when met with positive social feedback. Despite the ubiquity of positive social sharing both in person and online, ... ...

    Abstract Positive social sharing is an interpersonal emotion regulation strategy that enhances positive affect and social belonging, particularly when met with positive social feedback. Despite the ubiquity of positive social sharing both in person and online, what drives this behavior is not well understood. We hypothesized that positive social feedback serves as a reward that reinforces sharing behavior and strengthens social bonds. Participants made trial-by-trial choices about whether to share social media photos with peers who returned positive ("likes") or negative ("dislikes") feedback. Unbeknownst to participants, peer conditions were manipulated to yield varying amounts of positive and negative feedback. Social bonding was subsequently measured using a trust game and subjective closeness ratings. Participants shared more with peers who provided greater rates of positive feedback. This effect generalized to trust decisions and subjective feelings of closeness and varied individually as a function of interpersonal emotion regulation in daily life. (PsycInfo Database Record (c) 2023 APA, all rights reserved).
    MeSH term(s) Humans ; Trust ; Feedback ; Emotions/physiology ; Social Behavior ; Reward ; Interpersonal Relations
    Language English
    Publishing date 2022-11-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2102391-8
    ISSN 1931-1516 ; 1528-3542
    ISSN (online) 1931-1516
    ISSN 1528-3542
    DOI 10.1037/emo0001182
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The social value of positive autobiographical memory retrieval.

    Speer, Megan E / Delgado, Mauricio R

    Journal of experimental psychology. General

    2019  Volume 149, Issue 4, Page(s) 790–799

    Abstract: Positive memory retrieval generates pleasant feelings that can counteract negative affective states and improve mood. However, not all positive memories are created equal. Our most treasured memories are likely experiences we shared with other people (e ... ...

    Abstract Positive memory retrieval generates pleasant feelings that can counteract negative affective states and improve mood. However, not all positive memories are created equal. Our most treasured memories are likely experiences we shared with other people (e.g., birthday party) rather than something we did alone (e.g., receiving good grades). Here, we explored whether the social context within a positive memory enhanced its subjective value and contributed to an individual's well-being. In Study 1, participants were asked how much they would be willing to pay to reexperience positive memories that occurred with socially close others (high-social), with acquaintances (low-social) or alone (nonsocial). When controlling for the memory's positivity, participants were still willing to pay 1.5 times as much for high-social than for low-social or nonsocial memories. Likewise, participants chose to reminisce about high-social memories more frequently than less social ones of equal positive feeling. In Study 2, recalling memories rich in social context recruited regions previously implicated in mentalizing and reward (e.g., caudate), which further correlated with greater ability to savor positive emotions in daily life. Finally, we examined the benefit of social context by asking participants to recall positive memories that varied in social context after acute stress exposure. In Study 3, recalling memories that included higher social context led to a greater dampening of the physiological stress response (i.e., cortisol). Taken together, these findings suggest that social context inherent in a positive memory enhances its value, providing a possible mechanism by which positive reminiscence aids stress coping and enhances well-being. (PsycINFO Database Record (c) 2020 APA, all rights reserved).
    MeSH term(s) Adolescent ; Adult ; Affect/physiology ; Emotions/physiology ; Female ; Humans ; Male ; Memory, Episodic ; Reward ; Social Environment ; Young Adult
    Language English
    Publishing date 2019-08-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 189732-9
    ISSN 1939-2222 ; 0096-3445
    ISSN (online) 1939-2222
    ISSN 0096-3445
    DOI 10.1037/xge0000671
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